XX
XX
XX
FA AR
XX
SY androgen receptor; AR;
NR3C4; dihydrotestosterone receptor.
XX
OS rat, Rattus
norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata;
tetrapoda; mammalia;
OC eutheria; rodentia; myomorpha; muridae;
murinae
XX
XX
CL C0002; CC (rec); 2.1.1.3.1.
XX
SZ 902 AA; 98.2 kDa (cDNA), 98.9 kDa (SDS)
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XX
SC
SwissProt #P15207
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FT 6 445 PF02166; Androgen_recep.
FT 539 610 SM00399; ZnF_C4.
FT 540 606 region C, DNA-binding
domain (DBD).
FT 540 615 PF00105; zf-C4.
FT 689 853 SM00430;
HOLI.
FT 692 878 PF00104; hormone_rec.
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SF can form
multimeric complexes [3]
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FF regulates androgen-dependent
gene expression by binding to
FF androgen-responsive elements
(ARE) [4];
FF its DNA-binding domain can interact with leucine
zipper of AP1 to result in
FF mutual transrepression [2].;
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XX
XX
XX
RN [1]; RE0002368.
RX MEDLINE;
89017168.
RA Chang C., Kokontis J., Liao S.
RT Structural
analysis of complementary DNA and amino acid sequences of human
RT and rat androgen receptors
RL Proc. Natl. Acad. Sci. USA
85:7211-7215 (1988).
RN [2]; RE0023374.
RX MEDLINE; 9211894.
RA Sato N., Sadar M. D., Bruchovsky N., Saatcioglu F., Rennie
P. S., Sato S.,
RA Lange P. H., Gleave M. E.
RT Androgenic
induction of prostate-specific antigen gene is repressed by
RT protein-protein interaction between the androgen receptor and
AP-1/c-Jun in
RT the human prostate cancer cell line LNCaP.
RL J. Biol. Chem. 272:17485-17494 (1997).
RN [3]; RE0010237.
RA Kasper S., Rennie P. S., Bruchovsky N., Sheppard P. C., Cheng
H., Lin L.,
RA Shiu R. P. C., Snoek R., Matusik R. J.
RT Cooperative binding of androgen receptors to two DNA sequences
is required
RT for androgen induction of the probasin gene
RL J. Biol. Chem. 269:31763-31769 (1994).
RN [4]; RE0001011.
RX MEDLINE; 91139625.
RA de Vos P., Claessens F., Winderickx
J., van Dijck P., Celis L., Peeters B.,
RA Rombauts W., Heyns
W., Verhoeven G.
RT Interaction of androgen response elements
with the DNA-binding domain of
RT the rat androgen receptor
expressed in Escherichia coli
RL J. Biol. Chem. 266:3439-3443
(1991).
RN [5]; RE0003759.
RX MEDLINE; 91309548.
RA
Danzo B. J., Parrot J. A., Skinner M. K.
RT Analysis of the
steroid binding domain of rat androgen-binding protein
RL
Endocrinology 129:690-696 (1991).
RN [6]; RE0001752.
RX
MEDLINE; 91042631.
RA Forman B. M., Samuels H. H.
RT Interactions
among a subfamily of nuclear hormone receptors: the regulatory
RT zipper model
RL Mol. Endocrinol. 4:1293-1301 (1990).
RN [7]; RE0002369.
RX MEDLINE; 89098909.
RA Tilley W.,
Marcelli M., Wilson J. D., McPhaul M. J.
RT Characterization
and expression of a cDNA encoding the human androgen
RT receptor
RL Proc. Natl. Acad. Sci. USA 86:327-331 (1989).
XX