XX
XX
XX
FA CUTL1
XX
SY CDP; CCAAT displacement
protein; cut homeodomain protein; Cux; cut-like
SY homeodomain
protein; Clox.
XX
OS human, Homo sapiens
OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; primates
XX
XX
HO cut (Drosophila)
XX
CL C0006; homeo; 3.1.1.4.1.
XX
SZ 1505 AA; 164.4
kDa (cDNA), 180-200 kDa (SDS)
XX
XX
SC SwissProt #P39880
XX
FT 542 629 PF02376; CUT.
FT 551 610 Cut-repeat 1 (CR1).
FT 551 610 involved in binding to S/MAR-binding factor SATB1
FT [1].
FT 632 653 missing in putative splice variant.
FT 934 1021 PF02376; CUT.
FT 943 1007 Cut-repeat 2 (CR2).
FT 943 1007 involved in binding to S/MAR-binding factor SATB1
FT [1].
FT 1117 1204 PF02376; CUT.
FT 1135
1190 Cut-repeat 3 (CR3).
FT 1244 1306 SM00389; HOX.
FT
1245 1301 homeo domain.
FT 1245 1301 involved in binding to
S/MAR-binding factor SATB1
FT [1].
FT 1245
1301 PF00046; homeobox.
XX
SF the Clox homolog is a splice
variant [5];
SF the 3 cut repeats also contribute to DNA-binding,
each individual repeat
SF and each combination exhibiting
slightly different DNA-binding specificity
SF [4] [2] [5];
SF CR1 exhibits the most restricted resognition pattern [4];
SF KD (CR3-homeo domain) = 0.03 nM, isolated CR3 at least 100-fold
lower
SF affinity [2];
XX
FF repressor [13] [12] [9]
[8] [6] [3];
FF may regulate S/MAR-binding factor SATB1
and may be regulated by
FF it via protein-protein interaction
[1];
XX
XX
XX
XX
RN [1]; RE0015021.
RX
MEDLINE; 99303784.
RA Liu J., Barnett A., Neufeld E. J., Dudley
J. P.
RT Homeoproteins CDP and SATB1interact: potential for
tissue-specific
RT regulation
RL Mol. Cell. Biol. 19:4918-4926
(1999).
RN [2]; RE0002973.
RX MEDLINE; 95097984.
RA
Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A.
RT DNA-binding specificity of the cut repeats from the human cut-like
protein
RL Mol. Cell. Biol. 15:129-140 (1995).
RN [3];
RE0003999.
RX MEDLINE; 95279415.
RA Lievens P. M., Donady
J. J., Tufarelli C., Neufeld E. J.
RT Repressor activity of
CCAAT displacement protein in HL-60 myeloid leukemia
RT cells
RL J. Biol. Chem. 270:12745-12750 (1995).
RN [4]; RE0002967.
RX MEDLINE; 94329595.
RA Aufiero B., Neufeld E. J., Orkin
S. H.
RT Sequence-specific DNA binding of individual cut repeats
of the human CCAAT
RT displacement/ cut homeodomain protein
RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994).
RN [5];
RE0002972.
RX MEDLINE; 94131277.
RA Andres V., Chiara
M. D., Mahdavi V.
RT A new bipartite DNA-binding domain: cooperative
interaction between the cut
RT repeat and homeo domain of
the cut homeo proteins
RL Genes Dev. 8:245-257 (1994).
RN [6]; RE0003358.
RX MEDLINE; 94254882.
RA Dufort D.,
Nepveu A.
RT The human Cut homeodomain protein represses transcription
from the c-myc
RT promoter
RL Mol. Cell. Biol. 14:4251-4257
(1994).
RN [7]; RE0005004.
RX MEDLINE; 94124559.
RA
Harada R., Dufort D., Denis-Larose C., Nepveu A.
RT Conserved
cut repeats in the human cut homeodomain protein function as DNA
RT binding domains
RL J. Biol. Chem. 269:2062-2067 (1994).
RN [8]; RE0005002.
RX MEDLINE; 93250973.
RA Neufeld E.
J., Skalnik D. G., Lievens P. M., Orkin S. H.
RT Human CCAAT
dis-placement protein is homologous to the Drosophila
RT homeoprotein,
cut
RL Nat. Genet. 1:50-55 (1992).
RN [9]; RE0001031.
RX MEDLINE; 91358470.
RA Skalnik D. G., Strauss E. C., Orkin
S. H.
RT CCAAT displacement protein as a repressor of the
myelomonocytic-specific
RT gp91-phox gene promoter
RL
J. Biol. Chem. 266:16736-16744 (1991).
RN [10]; RE0002047.
RX MEDLINE; 89385992.
RA Mantovani R., Superti-Furga G., Gilman
J., Ottolenghi S.
RT The deletion of the distal CCAAT box
region of the Agamma-globin gene in
RT black HPFH abolishes
the binding of the erythroid specific protein NFE3 and
RT
of the CCAAT displacement protein
RL Nucleic Acids Res. 17:6681-6691
(1989).
RN [11]; RE0005005.
RX MEDLINE; 89150259.
RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.
RT The protein CDP, but not CP1, footprints on the CCAAT region
of the
RT g-globin gene in unfractionated B-cell extracts
RL Biochim. Biophys. Acta 1007:237-242 (1989).
RN [12]; RE0000346.
RX MEDLINE; 89030605.
RA Superti-Furga G., Barberis A., Schaffner
G., Busslinger M.
RT The -117 mutation in Greek HPFH affects
the binding of three nuclear
RT factors to the CCAAT region
of the gamma-globin gene
RL EMBO J. 7:3099-3107 (1988).
RN [13]; RE0000079.
RX MEDLINE; 87273497.
RA Barberis
A., Superti-Furga G., Busslinger M.
RT Mutually Exclusive
Interaction of the CCAAT-Binding Factor and of a
RT Displacement
Protein with Overlapping Sequences of a Histone Gene Promoter
RL Cell 50:347-359 (1987).
XX