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Gene set: V$CDP_01 (C3:TFAC:0054)
Standard nameV$CDP_01
Systematic nameC3:TFAC:0054
Brief descriptionGenes with 3'UTR containing motif CCAATAATCGAT which matches annotation for CUTL1: cut-like 1, CCAAT displacement protein (Drosophila)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA CUTL1
 XX
 SY CDP; CCAAT displacement
protein; cut homeodomain protein; Cux; cut-like
 SY homeodomain
protein; Clox.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 HO cut (Drosophila) 

XX
 CL C0006; homeo; 3.1.1.4.1.
 XX
 SZ 1505 AA; 164.4
kDa (cDNA), 180-200 kDa (SDS)
 XX
 XX
 SC SwissProt #P39880

XX
 FT 542 629 PF02376; CUT.
 FT 551 610 Cut-repeat 1 (CR1).

FT 551 610 involved in binding to S/MAR-binding factor SATB1 

FT [1].
 FT 632 653 missing in putative splice variant.

FT 934 1021 PF02376; CUT.
 FT 943 1007 Cut-repeat 2 (CR2).

FT 943 1007 involved in binding to S/MAR-binding factor SATB1

 FT [1].
 FT 1117 1204 PF02376; CUT.
 FT 1135
1190 Cut-repeat 3 (CR3).
 FT 1244 1306 SM00389; HOX.
 FT
1245 1301 homeo domain.
 FT 1245 1301 involved in binding to
S/MAR-binding factor SATB1 
 FT [1].
 FT 1245
1301 PF00046; homeobox.
 XX
 SF the Clox homolog is a splice
variant [5];
 SF the 3 cut repeats also contribute to DNA-binding,
each individual repeat
 SF and each combination exhibiting
slightly different DNA-binding specificity
 SF [4] [2] [5];

SF CR1 exhibits the most restricted resognition pattern [4];

SF KD (CR3-homeo domain) = 0.03 nM, isolated CR3 at least 100-fold
lower
 SF affinity [2];
 XX
 FF repressor [13] [12] [9]
[8] [6] [3];
 FF may regulate S/MAR-binding factor SATB1 
and may be regulated by
 FF it via protein-protein interaction
[1];
 XX
 XX
 XX
 XX
 RN [1]; RE0015021.
 RX
MEDLINE; 99303784.
 RA Liu J., Barnett A., Neufeld E. J., Dudley
J. P.
 RT Homeoproteins CDP and SATB1interact: potential for
tissue-specific
 RT regulation
 RL Mol. Cell. Biol. 19:4918-4926
(1999).
 RN [2]; RE0002973.
 RX MEDLINE; 95097984.
 RA
Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A.

RT DNA-binding specificity of the cut repeats from the human cut-like
protein
 RL Mol. Cell. Biol. 15:129-140 (1995).
 RN [3];
RE0003999.
 RX MEDLINE; 95279415.
 RA Lievens P. M., Donady
J. J., Tufarelli C., Neufeld E. J.
 RT Repressor activity of
CCAAT displacement protein in HL-60 myeloid leukemia
 RT cells

RL J. Biol. Chem. 270:12745-12750 (1995).
 RN [4]; RE0002967.

RX MEDLINE; 94329595.
 RA Aufiero B., Neufeld E. J., Orkin
S. H.
 RT Sequence-specific DNA binding of individual cut repeats
of the human CCAAT
 RT displacement/ cut homeodomain protein

RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994).
 RN [5];
RE0002972.
 RX MEDLINE; 94131277.
 RA Andres V., Chiara
M. D., Mahdavi V.
 RT A new bipartite DNA-binding domain: cooperative
interaction between the cut
 RT repeat and homeo domain of
the cut homeo proteins
 RL Genes Dev. 8:245-257 (1994).

RN [6]; RE0003358.
 RX MEDLINE; 94254882.
 RA Dufort D.,
Nepveu A.
 RT The human Cut homeodomain protein represses transcription
from the c-myc
 RT promoter
 RL Mol. Cell. Biol. 14:4251-4257
(1994).
 RN [7]; RE0005004.
 RX MEDLINE; 94124559.
 RA
Harada R., Dufort D., Denis-Larose C., Nepveu A.
 RT Conserved
cut repeats in the human cut homeodomain protein function as DNA

RT binding domains
 RL J. Biol. Chem. 269:2062-2067 (1994).

RN [8]; RE0005002.
 RX MEDLINE; 93250973.
 RA Neufeld E.
J., Skalnik D. G., Lievens P. M., Orkin S. H.
 RT Human CCAAT
dis-placement protein is homologous to the Drosophila
 RT homeoprotein,
cut
 RL Nat. Genet. 1:50-55 (1992).
 RN [9]; RE0001031.

RX MEDLINE; 91358470.
 RA Skalnik D. G., Strauss E. C., Orkin
S. H.
 RT CCAAT displacement protein as a repressor of the
myelomonocytic-specific
 RT gp91-phox gene promoter
 RL
J. Biol. Chem. 266:16736-16744 (1991).
 RN [10]; RE0002047.

RX MEDLINE; 89385992.
 RA Mantovani R., Superti-Furga G., Gilman
J., Ottolenghi S.
 RT The deletion of the distal CCAAT box
region of the Agamma-globin gene in
 RT black HPFH abolishes
the binding of the erythroid specific protein NFE3 and
 RT
of the CCAAT displacement protein
 RL Nucleic Acids Res. 17:6681-6691
(1989).
 RN [11]; RE0005005.
 RX MEDLINE; 89150259.

RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.

RT The protein CDP, but not CP1, footprints on the CCAAT region
of the
 RT g-globin gene in unfractionated B-cell extracts

RL Biochim. Biophys. Acta 1007:237-242 (1989).
 RN [12]; RE0000346.

RX MEDLINE; 89030605.
 RA Superti-Furga G., Barberis A., Schaffner
G., Busslinger M.
 RT The -117 mutation in Greek HPFH affects
the binding of three nuclear
 RT factors to the CCAAT region
of the gamma-globin gene
 RL EMBO J. 7:3099-3107 (1988).

RN [13]; RE0000079.
 RX MEDLINE; 87273497.
 RA Barberis
A., Superti-Furga G., Busslinger M.
 RT Mutually Exclusive
Interaction of the CCAAT-Binding Factor and of a
 RT Displacement
Protein with Overlapping Sequences of a Histone Gene Promoter

RL Cell 50:347-359 (1987).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

96 genes, 96 accessions (Toggle view)

AccessionGeneTitleLinks
SIAT7ESIAT7Esialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) ESource|GeneCards
MN1MN1meningioma (disrupted in balanced translocation) 1Source|GeneCards
CUGBP2CUGBP2CUG triplet repeat, RNA binding protein 2Source|GeneCards
EDEM1EDEM1ER degradation enhancer, mannosidase alpha-like 1Source|GeneCards
PHCAPHCAphytoceramidase, alkalineSource|GeneCards
HTR4HTR45-hydroxytryptamine (serotonin) receptor 4Source|GeneCards
SLC17A6SLC17A6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6Source|GeneCards
ZNF238ZNF238zinc finger protein 238Source|GeneCards
FLJ26443FLJ26443FLJ26443 proteinSource|GeneCards
RREB1RREB1ras responsive element binding protein 1Source|GeneCards
MEIS1MEIS1Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)Source|GeneCards
TMSL1TMSL1thymosin-like 1Source|GeneCards
REREREREarginine-glutamic acid dipeptide (RE) repeatsSource|GeneCards
IRX4IRX4iroquois homeobox protein 4Source|GeneCards
CASTCASTcalpastatinSource|GeneCards
CIB3CIB3calcium and integrin binding family member 3Source|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
EGR1EGR1early growth response 1Source|GeneCards
STMN4STMN4stathmin-like 4Source|GeneCards
ME3ME3malic enzyme 3, NADP(+)-dependent, mitochondrialSource|GeneCards
FGF12FGF12fibroblast growth factor 12Source|GeneCards
C9ORF39C9ORF39chromosome 9 open reading frame 39Source|GeneCards
AFPAFPAlpha-fetoproteinSource|GeneCards
NEUROD6NEUROD6neurogenic differentiation 6Source|GeneCards
MYO1BMYO1Bmyosin IBSource|GeneCards
LOC283514LOC283514similar to seven in absentia 2Source|GeneCards
TAC1TAC1tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)Source|GeneCards
HS3ST3A1HS3ST3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1Source|GeneCards
KIAA1747LOC57795hypothetical protein from clone 24828Source|GeneCards
EBF2EBF2early B-cell factor 2Source|GeneCards
PTMAPTMAprothymosin, alpha (gene sequence 28)Source|GeneCards
CEAL1CEACAM19carcinoembryonic antigen-related cell adhesion molecule 19Source|GeneCards
SCRT2SCRT2scratch homolog 2, zinc finger protein (Drosophila)Source|GeneCards
DD5EDD1E3 ubiquitin protein ligase, HECT domain containing, 1Source|GeneCards
LOC138046LOC138046hypothetical protein LOC138046Source|GeneCards
LOC56901LOC56901NADH:ubiquinone oxidoreductase MLRQ subunit homologSource|GeneCards
PIPOXPIPOXpipecolic acid oxidaseSource|GeneCards
PHC2PHC2polyhomeotic-like 2 (Drosophila)Source|GeneCards
HICMDFICMyoD family inhibitor domain containingSource|GeneCards
NKX2-2NKX2-2NK2 transcription factor related, locus 2 (Drosophila)Source|GeneCards
LOC51057LOC51057hypothetical protein LOC51057Source|GeneCards
BAZ1ABAZ1Abromodomain adjacent to zinc finger domain, 1ASource|GeneCards
DESR1ZCSL2Zinc finger, CSL domain containing 2Source|GeneCards
SULF2SULF2sulfatase 2Source|GeneCards
HGNT-IV-HHGNT-IV-HUDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologSource|GeneCards
TP73LTP73Ltumor protein p73-likeSource|GeneCards
KLF14KLF14Kruppel-like factor 14Source|GeneCards
MITFMITFmicrophthalmia-associated transcription factorSource|GeneCards
FOXF2FOXF2forkhead box F2Source|GeneCards
FYNFYNFYN oncogene related to SRC, FGR, YESSource|GeneCards
HBXAPHBXAPhepatitis B virus x associated proteinSource|GeneCards
ATP6V1B2ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 2Source|GeneCards
CHD2CHD2chromodomain helicase DNA binding protein 2Source|GeneCards
TMSL3TMSL3thymosin-like 3Source|GeneCards
HOXA3HOXA3homeo box A3Source|GeneCards
SLICKKCNT2potassium channel, subfamily T, member 2Source|GeneCards
TMSL4TMSL4thymosin-like 4Source|GeneCards
CSF2CSF2colony stimulating factor 2 (granulocyte-macrophage)Source|GeneCards
FLJ46154FLJ46154FLJ46154 proteinSource|GeneCards
CASKIN1CASKIN1CASK interacting protein 1Source|GeneCards
OTPOTPorthopedia homolog (Drosophila)Source|GeneCards
MGC15763MGC15763hypothetical protein BC008322Source|GeneCards
CCND1CCND1cyclin D1 (PRAD1: parathyroid adenomatosis 1)Source|GeneCards
GCGCGroup-specific component (vitamin D binding protein)Source|GeneCards
HERC4HERC4hect domain and RLD 4Source|GeneCards
CDK11CDC2L6cell division cycle 2-like 6 (CDK8-like)Source|GeneCards
FLJ39075FLJ39075hypothetical protein FLJ39075Source|GeneCards
GABRA6GABRA6gamma-aminobutyric acid (GABA) A receptor, alpha 6Source|GeneCards
SKB1SKB1SKB1 homolog (S. pombe)Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
MGC40178MGC40178hypothetical protein MGC40178Source|GeneCards
MGC52019SLC5A12Solute carrier family 5 (sodium/glucose cotransporter), member 12Source|GeneCards
CALCRCALCRcalcitonin receptorSource|GeneCards
SVILSVILsupervillinSource|GeneCards
ADAM11ADAM11a disintegrin and metalloproteinase domain 11Source|GeneCards
PRDM12PRDM12PR domain containing 12Source|GeneCards
HOXB8HOXB8homeo box B8Source|GeneCards
ALBALBalbuminSource|GeneCards
TTRTTRtransthyretin (prealbumin, amyloidosis type I)Source|GeneCards
SOATSLC10A6solute carrier family 10 (sodium/bile acid cotransporter family), member 6Source|GeneCards
PPP2R5DPPP2R5Dprotein phosphatase 2, regulatory subunit B (B56), delta isoformSource|GeneCards
CACNA2D3CACNA2D3calcium channel, voltage-dependent, alpha 2/delta 3 subunitSource|GeneCards
FOXA2FOXA2forkhead box A2Source|GeneCards
LOC345667LOC345667similar to ADAMTS-10 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 10) (ADAM-TS 10) (ADAM-TS10)Source|GeneCards
HOXA9HOXA9homeo box A9Source|GeneCards
TMSL6TMSL6thymosin-like 6Source|GeneCards
NFIXNFIXnuclear factor I/X (CCAAT-binding transcription factor)Source|GeneCards
THPOTHPOthrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor)Source|GeneCards
SMOC1SMOC1SPARC related modular calcium binding 1Source|GeneCards
POU2F1POU2F1POU domain, class 2, transcription factor 1Source|GeneCards
FLJ39743FLJ39743hypothetical protein FLJ39743Source|GeneCards
TAF15TAF15TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaSource|GeneCards
STMN2STMN2stathmin-like 2Source|GeneCards
FGF13FGF13fibroblast growth factor 13Source|GeneCards
ESRRGESRRGestrogen-related receptor gammaSource|GeneCards
PTD015PTD015PTD015 proteinSource|GeneCards

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