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Gene set: V$CDP_02 (C3:TFAC:0059)
Standard nameV$CDP_02
Systematic nameC3:TFAC:0059
Brief descriptionGenes with 3'UTR containing motif NWNATCGATTANYNN which matches annotation for CUTL1: cut-like 1, CCAAT displacement protein (Drosophila)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA CUTL1
 XX
 SY CDP; CCAAT displacement
protein; cut homeodomain protein; Cux; cut-like
 SY homeodomain
protein; Clox.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 HO cut (Drosophila) 

XX
 CL C0006; homeo; 3.1.1.4.1.
 XX
 SZ 1505 AA; 164.4
kDa (cDNA), 180-200 kDa (SDS)
 XX
 XX
 SC SwissProt #P39880

XX
 FT 542 629 PF02376; CUT.
 FT 551 610 Cut-repeat 1 (CR1).

FT 551 610 involved in binding to S/MAR-binding factor SATB1 

FT [1].
 FT 632 653 missing in putative splice variant.

FT 934 1021 PF02376; CUT.
 FT 943 1007 Cut-repeat 2 (CR2).

FT 943 1007 involved in binding to S/MAR-binding factor SATB1

 FT [1].
 FT 1117 1204 PF02376; CUT.
 FT 1135
1190 Cut-repeat 3 (CR3).
 FT 1244 1306 SM00389; HOX.
 FT
1245 1301 homeo domain.
 FT 1245 1301 involved in binding to
S/MAR-binding factor SATB1 
 FT [1].
 FT 1245
1301 PF00046; homeobox.
 XX
 SF the Clox homolog is a splice
variant [5];
 SF the 3 cut repeats also contribute to DNA-binding,
each individual repeat
 SF and each combination exhibiting
slightly different DNA-binding specificity
 SF [4] [2] [5];

SF CR1 exhibits the most restricted resognition pattern [4];

SF KD (CR3-homeo domain) = 0.03 nM, isolated CR3 at least 100-fold
lower
 SF affinity [2];
 XX
 FF repressor [13] [12] [9]
[8] [6] [3];
 FF may regulate S/MAR-binding factor SATB1 
and may be regulated by
 FF it via protein-protein interaction
[1];
 XX
 XX
 XX
 XX
 RN [1]; RE0015021.
 RX
MEDLINE; 99303784.
 RA Liu J., Barnett A., Neufeld E. J., Dudley
J. P.
 RT Homeoproteins CDP and SATB1interact: potential for
tissue-specific
 RT regulation
 RL Mol. Cell. Biol. 19:4918-4926
(1999).
 RN [2]; RE0002973.
 RX MEDLINE; 95097984.
 RA
Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A.

RT DNA-binding specificity of the cut repeats from the human cut-like
protein
 RL Mol. Cell. Biol. 15:129-140 (1995).
 RN [3];
RE0003999.
 RX MEDLINE; 95279415.
 RA Lievens P. M., Donady
J. J., Tufarelli C., Neufeld E. J.
 RT Repressor activity of
CCAAT displacement protein in HL-60 myeloid leukemia
 RT cells

RL J. Biol. Chem. 270:12745-12750 (1995).
 RN [4]; RE0002967.

RX MEDLINE; 94329595.
 RA Aufiero B., Neufeld E. J., Orkin
S. H.
 RT Sequence-specific DNA binding of individual cut repeats
of the human CCAAT
 RT displacement/ cut homeodomain protein

RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994).
 RN [5];
RE0002972.
 RX MEDLINE; 94131277.
 RA Andres V., Chiara
M. D., Mahdavi V.
 RT A new bipartite DNA-binding domain: cooperative
interaction between the cut
 RT repeat and homeo domain of
the cut homeo proteins
 RL Genes Dev. 8:245-257 (1994).

RN [6]; RE0003358.
 RX MEDLINE; 94254882.
 RA Dufort D.,
Nepveu A.
 RT The human Cut homeodomain protein represses transcription
from the c-myc
 RT promoter
 RL Mol. Cell. Biol. 14:4251-4257
(1994).
 RN [7]; RE0005004.
 RX MEDLINE; 94124559.
 RA
Harada R., Dufort D., Denis-Larose C., Nepveu A.
 RT Conserved
cut repeats in the human cut homeodomain protein function as DNA

RT binding domains
 RL J. Biol. Chem. 269:2062-2067 (1994).

RN [8]; RE0005002.
 RX MEDLINE; 93250973.
 RA Neufeld E.
J., Skalnik D. G., Lievens P. M., Orkin S. H.
 RT Human CCAAT
dis-placement protein is homologous to the Drosophila
 RT homeoprotein,
cut
 RL Nat. Genet. 1:50-55 (1992).
 RN [9]; RE0001031.

RX MEDLINE; 91358470.
 RA Skalnik D. G., Strauss E. C., Orkin
S. H.
 RT CCAAT displacement protein as a repressor of the
myelomonocytic-specific
 RT gp91-phox gene promoter
 RL
J. Biol. Chem. 266:16736-16744 (1991).
 RN [10]; RE0002047.

RX MEDLINE; 89385992.
 RA Mantovani R., Superti-Furga G., Gilman
J., Ottolenghi S.
 RT The deletion of the distal CCAAT box
region of the Agamma-globin gene in
 RT black HPFH abolishes
the binding of the erythroid specific protein NFE3 and
 RT
of the CCAAT displacement protein
 RL Nucleic Acids Res. 17:6681-6691
(1989).
 RN [11]; RE0005005.
 RX MEDLINE; 89150259.

RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.

RT The protein CDP, but not CP1, footprints on the CCAAT region
of the
 RT g-globin gene in unfractionated B-cell extracts

RL Biochim. Biophys. Acta 1007:237-242 (1989).
 RN [12]; RE0000346.

RX MEDLINE; 89030605.
 RA Superti-Furga G., Barberis A., Schaffner
G., Busslinger M.
 RT The -117 mutation in Greek HPFH affects
the binding of three nuclear
 RT factors to the CCAAT region
of the gamma-globin gene
 RL EMBO J. 7:3099-3107 (1988).

RN [13]; RE0000079.
 RX MEDLINE; 87273497.
 RA Barberis
A., Superti-Furga G., Busslinger M.
 RT Mutually Exclusive
Interaction of the CCAAT-Binding Factor and of a
 RT Displacement
Protein with Overlapping Sequences of a Histone Gene Promoter

RL Cell 50:347-359 (1987).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

113 genes, 113 accessions (Toggle view)

AccessionGeneTitleLinks
PPM1LPPM1Lprotein phosphatase 1 (formerly 2C)-likeSource|GeneCards
LRCH2LRCH2leucine-rich repeats and calponin homology (CH) domain containing 2Source|GeneCards
MLNMLNmotilinSource|GeneCards
FLJ40243FLJ40243hypothetical protein FLJ40243Source|GeneCards
LSAMPLSAMPlimbic system-associated membrane proteinSource|GeneCards
MEIS1MEIS1Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)Source|GeneCards
FOXD3FOXD3forkhead box D3Source|GeneCards
C9ORF9C9ORF9chromosome 9 open reading frame 9Source|GeneCards
FLJ13912FLJ13912hypothetical protein FLJ13912Source|GeneCards
NSE2FAM84Bfamily with sequence similarity 84, member BSource|GeneCards
SLITRK2SLITRK2SLIT and NTRK-like family, member 2Source|GeneCards
SYT1SYT1synaptotagmin ISource|GeneCards
FLJ11088FLJ11088GGA binding partnerSource|GeneCards
KIF1BKIF1Bkinesin family member 1BSource|GeneCards
LOC283514LOC283514similar to seven in absentia 2Source|GeneCards
IL1RAPL1IL1RAPL1interleukin 1 receptor accessory protein-like 1Source|GeneCards
NRXN3NRXN3neurexin 3Source|GeneCards
PTGS2PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Source|GeneCards
FLJ14437
SP8SP8Sp8 transcription factorSource|GeneCards
CEAL1CEACAM19carcinoembryonic antigen-related cell adhesion molecule 19Source|GeneCards
BHLHB5BHLHB5basic helix-loop-helix domain containing, class B, 5Source|GeneCards
PITX2PITX2paired-like homeodomain transcription factor 2Source|GeneCards
GPM6AGPM6Aglycoprotein M6ASource|GeneCards
GPX1GPX1glutathione peroxidase 1Source|GeneCards
TFAP2BL1TFAP2Dtranscription factor AP-2 delta (activating enhancer binding protein 2 delta)Source|GeneCards
C20ORF17C20ORF17chromosome 20 open reading frame 17Source|GeneCards
CDH9CDH9cadherin 9, type 2 (T1-cadherin)Source|GeneCards
CNIHCNIHcornichon homolog (Drosophila)Source|GeneCards
HNF4GHNF4Ghepatocyte nuclear factor 4, gammaSource|GeneCards
ALS2CR8ALS2CR8amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8Source|GeneCards
ERGERGv-ets erythroblastosis virus E26 oncogene like (avian)Source|GeneCards
PRKAG1PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunitSource|GeneCards
DOCK4DOCK4dedicator of cytokinesis 4Source|GeneCards
LPHN2LPHN2latrophilin 2Source|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
CPEB4CPEB4cytoplasmic polyadenylation element binding protein 4Source|GeneCards
TFR2TFR2transferrin receptor 2Source|GeneCards
MAB21L2MAB21L2mab-21-like 2 (C. elegans)Source|GeneCards
GTF2IRD1GTF2IRD1GTF2I repeat domain containing 1Source|GeneCards
MYH10MYH10myosin, heavy polypeptide 10, non-muscleSource|GeneCards
ANKRD2ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)Source|GeneCards
DGKBDGKBdiacylglycerol kinase, beta 90kDaSource|GeneCards
FLJ45832FLJ45832FLJ45832 proteinSource|GeneCards
DACH1DACH1dachshund homolog 1 (Drosophila)Source|GeneCards
NDST4NDST4N-deacetylase/N-sulfotransferase 4Source|GeneCards
CCND2CCND2cyclin D2Source|GeneCards
GCGCGroup-specific component (vitamin D binding protein)Source|GeneCards
RNF110PCGF2polycomb group ring finger 2Source|GeneCards
HCN1HCN1hyperpolarization activated cyclic nucleotide-gated potassium channel 1Source|GeneCards
SALL1SALL1sal-like 1 (Drosophila)Source|GeneCards
C9ORF98C9ORF98chromosome 9 open reading frame 98Source|GeneCards
TBX3TBX3T-box 3 (ulnar mammary syndrome)Source|GeneCards
DUSP10DUSP10dual specificity phosphatase 10Source|GeneCards
ACVR2ACVR2activin A receptor, type IISource|GeneCards
LOC115509LOC115509hypothetical protein BC014000Source|GeneCards
MARCKSMARCKSmyristoylated alanine-rich protein kinase C substrateSource|GeneCards
STAG2STAG2stromal antigen 2Source|GeneCards
SLC5A10SLC5A10Solute carrier family 5 (sodium/glucose cotransporter), member 10Source|GeneCards
CSCScitrate synthaseSource|GeneCards
SIX1SIX1sine oculis homeobox homolog 1 (Drosophila)Source|GeneCards
CACNA2D3CACNA2D3calcium channel, voltage-dependent, alpha 2/delta 3 subunitSource|GeneCards
BIRC8BIRC8baculoviral IAP repeat-containing 8Source|GeneCards
PHACTR3PHACTR3Phosphatase and actin regulator 3Source|GeneCards
A2BP1A2BP1ataxin 2-binding protein 1Source|GeneCards
TCF4TCF4Transcription factor 4Source|GeneCards
IGSF4IGSF4immunoglobulin superfamily, member 4Source|GeneCards
OTX1OTX1orthodenticle homolog 1 (Drosophila)Source|GeneCards
DCXDCXdoublecortex; lissencephaly, X-linked (doublecortin)Source|GeneCards
SEMA5BSEMA5Bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5BSource|GeneCards
FLJ45803FLJ45803FLJ45803 proteinSource|GeneCards
HNRPA2B1HNRPA2B1heterogeneous nuclear ribonucleoprotein A2/B1Source|GeneCards
SLC6A9SLC6A9solute carrier family 6 (neurotransmitter transporter, glycine), member 9Source|GeneCards
WDR12WDR12WD repeat domain 12Source|GeneCards
TOB1TOB1transducer of ERBB2, 1Source|GeneCards
MGC39827MGC39827hypothetical protein MGC39827Source|GeneCards
CDCA7CDCA7cell division cycle associated 7Source|GeneCards
FLJ20716FAM70Afamily with sequence similarity 70, member ASource|GeneCards
SREBF2SREBF2sterol regulatory element binding transcription factor 2Source|GeneCards
MGC33190ATXN7L4ataxin 7-like 4Source|GeneCards
URKL1UCKL1Uridine-cytidine kinase 1-like 1Source|GeneCards
HOXA2HOXA2homeo box A2Source|GeneCards
GNAQGNAQguanine nucleotide binding protein (G protein), q polypeptideSource|GeneCards
PTMAPTMAprothymosin, alpha (gene sequence 28)Source|GeneCards
ZNFN1A2ZNFN1A2zinc finger protein, subfamily 1A, 2 (Helios)Source|GeneCards
MBNL1MBNL1muscleblind-like (Drosophila)Source|GeneCards
GRIA3GRIA3glutamate receptor, ionotrophic, AMPA 3Source|GeneCards
GBX2GBX2gastrulation brain homeo box 2Source|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
SRPK2SRPK2SFRS protein kinase 2Source|GeneCards
JARID2JARID2Jumonji, AT rich interactive domain 2Source|GeneCards
SOX9SOX9SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal)Source|GeneCards
EPHA3EPHA3EphA3Source|GeneCards
LCP1LCP1lymphocyte cytosolic protein 1 (L-plastin)Source|GeneCards
POU3F4POU3F4POU domain, class 3, transcription factor 4Source|GeneCards
A1BGA1BGalpha-1-B glycoproteinSource|GeneCards
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide OSource|GeneCards
LIFLIFleukemia inhibitory factor (cholinergic differentiation factor)Source|GeneCards
FGF9FGF9fibroblast growth factor 9 (glia-activating factor)Source|GeneCards
OGG1OGG18-oxoguanine DNA glycosylaseSource|GeneCards
ETV4ETV4ets variant gene 4 (E1A enhancer binding protein, E1AF)Source|GeneCards
SHRMLSHRMLShroom-related proteinSource|GeneCards
HOXB7HOXB7homeo box B7Source|GeneCards
PDZRN4PDZRN4PDZ domain containing RING finger 4Source|GeneCards
MEF2CMEF2CMADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C)Source|GeneCards
HOXB8HOXB8homeo box B8Source|GeneCards
HOXA7HOXA7homeo box A7Source|GeneCards
PTF1APTF1Apancreas specific transcription factor, 1aSource|GeneCards
RPA3RPA3replication protein A3, 14kDaSource|GeneCards
FLJ11280FAM63Afamily with sequence similarity 63, member ASource|GeneCards
PKD2L2PKD2L2polycystic kidney disease 2-like 2Source|GeneCards
SLC1A3SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Source|GeneCards
SEMA6ASEMA6Asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6ASource|GeneCards

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