XX
XX
XX
FA CRE-BP1
XX
SY ATF-2; CRE-BP1;
HB16; XBP4 (mouse); TREB-7; CREBP1.
XX
OS human, Homo
sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata;
tetrapoda; mammalia;
OC eutheria; primates
XX
XX
CL C0008; bZIP; 1.1.1.6.3.1.
XX
SZ 505 AA; 54.5 kDa (cDNA),
69 kDa (SDS)
XX
XX
SC SwissProt #P15336
XX
FT 1 143 region supporting E1A responsiveness [22].
FT 1 109
minimal trans-activation domain [3].
FT 25 49 PF00096; zf-C2H2.
FT 27 49 potential zinc finger (Cys2His2 type) [22].
FT 62
62 serine, PKA phosphorylation site in vitro [21].
FT 69 69
threonine phosphorylated by JNK [8].
FT 71 71 threonine phosphorylated
by JNK [8].
FT 100 100 potential PKA phosphorylation site
[26].
FT 110 195 modulation of intramolecular inhibition [3].
FT 121 121 potential PKC phosphorylation site [26].
FT 150
247 missing in CRE-BP2 [23].
FT 320 340 serine-/threonine-rich
region (12/21).
FT 340 340 serine, PKC phosphorylation site
in vitro [21].
FT 350 414 PF00170; bZIP.
FT 350 414 SM00338;
BRLZ.
FT 353 377 basic region [26].
FT 367 367 serine,
PKC phosphorylation site in vitro [21].
FT 380 408 leucine
zipper (L5) [26].
FT 387 417 serine-/threonine-rich region
(15/31).
XX
SF Tax interacts with the basic domain and
thereby enhances homodimerization
SF [11] [5] [6];
SF
this contact alters also the DNA-binding selectivity [5];
SF the zinc finger structure is important for trans-activation
by the
SF homodimer [15];
SF bound to DNA, CRE-BP1 interacts
with E1A via N-terminal regions comprising
SF the zinc finger
motif as essential element [22] [16];
SF in the heterodimer
with c-Jun, trans-activation is mainly achieved by the
SF
c-Jun moiety [15];
SF no heterodimerization with deltaCREB
[24];
SF DNA-bending towards the minor groove when heterodimerized
with c-Fos or
SF Fra-2 [19];
SF with c-Jun: beinding in
the opposite direction, similar to that caused by
SF CRE-BP1
homodimers [19];
XX
EX adrenal gland (right and left),,,adult;very
low; northern blot; mRNA
EX (poly-A); [1].
EX amygdaloid
body,,,adult;none; northern blot; mRNA (poly-A); [1].
EX brain,,,adult;very
high; northern blot; mRNA (poly-A); [1].
EX cerebellum,,,adult;high;
northern blot; mRNA (poly-A); [1].
EX heart,,,adult;none;
northern blot; mRNA (poly-A); [1].
EX kidney (right and left),,,adult;high;
northern blot; mRNA (poly-A); [1].
EX liver,,,adult;none;
northern blot; mRNA (poly-A); [1].
EX lung (right and left),,,adult;high;
northern blot; mRNA (poly-A); [1].
EX meninges of brain,,,adult;high;
northern blot; mRNA (poly-A); [1].
EX meninges of spinal cord,,,adult;high;
northern blot; mRNA (poly-A); [1].
EX muscles,,,adult;high;
northern blot; mRNA (poly-A); [1].
EX spinal cord,,,adult;high;
northern blot; mRNA (poly-A); [1].
EX spleen,,,adult;high;
northern blot; mRNA (poly-A); [1].
EX stomach,,,adult;high;
northern blot; mRNA (poly-A); [1].
EX thalamus,,,adult;very
low; northern blot; mRNA (poly-A); [1].
EX thymus,,,adult;high;
northern blot; mRNA (poly-A); [1].
XX
FF activator, cAMP-independent
[15];
FF stronger activator as heterodimer with c-Jun than
as homodimer [15];
FF activation capability is masked by the
bZIP domain by direct intramolecular
FF interaction [22] [3];
FF release of this inhibition depends on an intermediate sequence
and works in
FF a cell-specific manner [3];
FF transcriptional
activation is stimulated by Rb involving CRE-BP1 in cell
FF
cycle control [14];
FF interacts with E1A and places its transactivation
domain at a viral
FF promoter;
FF mediates E1A-induced
trans-activation through the potential zinc finger
FF (part.
important: C27 and C32) and the leucine zipper (in particular
3rd
FF and 4th Leu) [22] [16];
FF altered DNA-binding
specificity after complexing with HBV pX [20] or with
FF HTLV-I
Tax [11];
FF in vitro phosphorylation by PKA and PKC, function
unclear;
FF phosphorylation by a JNK/SAPK kinase of the MAPK
family at Thr-69 and
FF Thr-71 is essential for trans-activation
[8];
FF it mediates activation in response to UV or other
cellular stresses [7] and
FF to Rb as well as E1A [8];
FF binding activity can be induced by IL-1 and TPA [2];
XX
IN T01313; ATF3; human, Homo sapiens.
IN T00051; ATF; human,
Homo sapiens.
IN T00122; c-Fos; mouse, Mus musculus.
IN
T00123; c-Fos; human, Homo sapiens.
IN T00131; c-Jun; mouse,
Mus musculus.
IN T00132; c-Jun; rat, Rattus norvegicus.
IN T00133; c-Jun; human, Homo sapiens.
IN T00134; c-Jun; chick,
Gallus gallus.
IN T00135; c-Jun; hamster.
IN T00167; CRE-BP1;
human, Homo sapiens.
IN T01017; CRE-BP2; mouse, Mus musculus.
IN T01308; CRE-BPa; human, Homo sapiens.
IN T00967; E1A 12S
protein; adenovirus.
IN T00209; E1A 13S protein; adenovirus
type 2.
IN T01991; Fra-2; human, Homo sapiens.
IN T01980;
HMG Y; human, Homo sapiens.
IN T00593; NF-kappaB1; human,
Homo sapiens.
IN T00722; pRb; human, Homo sapiens.
IN
T01384; pX; HBV, human hepatitis B virus.
IN T00594; RelA;
human, Homo sapiens.
IN T00793; Tax; HTLV-I, human T-cell
lymphotropic virus type I.
XX
XX
XX
XX
RN
[1]; RE0001462.
RX MEDLINE; 90205810.
RA Kara C. J., Liou
H.-C., Ivashkiv L. B., Glimcher L. H.
RT A cDNA for a human
cyclic AMP response element-binding protein which is
RT distinct
from CREB and expressed preferentially in brain
RL Mol. Cell.
Biol. 10:1347-1357 (1990).
RN [2]; RE0013940.
RX MEDLINE;
99384291.
RA Cirillo G., Casalino L., Vallone D., Caracciolo
A., De Cesare D., Verde P.
RT Role of distinct mitogen-activated
protein kinase pathways and cooperation
RT between Ets-2,
ATF-2, and Jun family members in human urokinase-type
RT plasminogen
activator gene induction by interleukin-1 and tetradecanoyl
RT phorbol acetate
RL Mol. Cell. Biol. 19:6340-6252 (1999).
RN [3]; RE0006672.
RX MEDLINE; 96173617.
RA Li X.-Y.,
Green M. R.
RT Intramolecular inhibition of activating transcription
factor-2 function by
RT its DNA-binding domain
RL Genes
Dev. 10:517-527 (1996).
RN [4]; RE0004148.
RX MEDLINE;
95145592.
RA Nakamura T., Okuyama S., Okamoto S., Nakajima
T., Sekiya S., Oda K.
RT Down-regulation of the cyclin A promoter
in differentiating human embryonal
RT carcinoma cells is mediated
by depletion of ATF-1 and ATF-2 in the complex
RL Exp. Cell
Res. 216:422-430 (1995).
RN [5]; RE0005255.
RX MEDLINE;
95364956.
RA Perini G., Wagner S., Green M. R.
RT Recognition
of bZIP proteins by the human T-cell leukemia virus
RT transactivator
Tax
RL Nature 376:602-605 (1995).
RN [6]; RE0005256.
RX MEDLINE; 95364957.
RA Baranger A. M., Palmer C. R., Hamm
M. K., Giebler H. A., Brauweiler A.,
RA Nyborg J. K., Schepartz
A.
RT Mechanism of DNA-binding enhancement by the human T-cell
leukaemia virus
RT transcativator Tax
RL Nature 376:606-608
(1995).
RN [7]; RE0005263.
RX MEDLINE; 95255237.
RA
van Dam H., Wilhelm D., Herr I., Steffen A., Herrlich P., Angel
P.
RT ATF-2 is preferentially activated by stress-activated
protein kinases to
RT mediate c-jun induction in response
to genotoxic agents
RL EMBO J. 14:1798-1811 (1995).
RN
[8]; RE0006670.
RX MEDLINE; 95125448.
RA Gupta S., Campbell
D., Derijard B., Davis R. J.
RT Transcription factor ATF2
regulation by the JNK signal transduction pathway
RL Science
267:389-393 (1995).
RN [9]; RE0013937.
RX MEDLINE; 95349959.
RA De Cesare D., Vallone D., Caracciolo A., Sassone-Corsi P.,
Nerlov C., Verde
RA P.
RT Heterodimerization of c-Jun
with ATF-2 and c-Fos is required for positive
RT and negative
regulation of the human urokinase enhancer
RL Oncogene 11:365-376
(1995).
RN [10]; RE0001081.
RX MEDLINE; 93179432.
RA Nomura N., Zu Y.-L., Maekawa T., Tabata S., Akiyama T., Ishii
S.
RT Isolation and characterization of a novel member of
the gene family
RT encoding the cAMP response element-binding
protein CRE-BP1
RL J. Biol. Chem. 268:4259-4266 (1993).
RN [11]; RE0002710.
RX MEDLINE; 94023981.
RA Wagner S.,
Green M. R.
RT HTLV-I Tax protein stimulation of DNA binding
of bZIP proteins by enhancing
RT dimerization
RL Science
262:395-399 (1993).
RN [12]; RE0004521.
RX MEDLINE; 94019389.
RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., DeRaemy-Schenk
A.-M.,
RA Chen B. P. C., Hai T., DeLamarter J. F., Whelan
J.
RT Cyclic AMP-independent ATF family members interact with
NF-kappaB and
RT function in the activation of the E-selectin
promoter in response to
RT cytokines
RL Mol. Cell. Biol.
13:7180-7190 (1993).
RN [13]; RE0004643.
RX MEDLINE; 93360983.
RA Kerppola T. K., Curran T.
RT Selective DNA bending by a
variety of bZIP proteins
RL Mol. Cell. Biol. 13:5479-5489
(1993).
RN [14]; RE0001911.
RX MEDLINE; 92350254.
RA Kim S.-J., Wagner S., Liu F., O'Reilly M. A., Robbins P. D.,
Green M. R.
RT Retinoblastoma gene product activates expressionof
the human TGF-beta2 gene
RT through transcription factor ATF-2
RL Nature 358:331-334 (1992).
RN [15]; RE0001029.
RX MEDLINE;
92011551.
RA Matsuda S., Maekawa T., Ishii S.
RT Identification
of the functional domains of the transcriptional regulator
RT CRE-BP1
RL J. Biol. Chem. 266:18188-18193 (1991).
RN
[16]; RE0001107.
RX MEDLINE; 92084723.
RA Zu Y.-L., Maekawa
T., Matsuda S., Ishii S.
RT Complete putative metal finger
and leucine zipper structures of CRE-BP1 are
RT required for
the E1A-induced trans-activation
RL J. Biol. Chem. 266:24134-24139
(1991).
RN [17]; RE0001663.
RX MEDLINE; 91342628.
RA Jones C., Lee K. A. W.
RT E1A-mediated activation of the
adenovirus E4 promoter can occur
RT independently of the cellular
transcription factor E4F
RL Mol. Cell. Biol. 11:4297-4305
(1991).
RN [18]; RE0002247.
RX MEDLINE; 91360276.
RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg
M., Weinmann R.
RT Interactions between adenovirus E1A and
members of the AP-1 family of
RT cellular transcription factors
RL Oncogene 6:1417-1422 (1991).
RN [19]; RE0002561.
RX
MEDLINE; 91219443.
RA Hai T., Curran T.
RT Cross-family
dimerization of transcription factors Fos/Jun and ATF/CREB
RT alters DNA binding specificity
RL Proc. Natl. Acad. Sci.
USA 88:3720-3724 (1991).
RN [20]; RE0002717.
RX MEDLINE;
91227910.
RA Maguire H. F., Hoeffler J. P., Siddiqui A.
RT HBV X protein alters the DNA binding specificity of CREB and
ATF-2 by
RT protein-protein interactions
RL Science 252:842-844
(1991).
RN [21]; RE0003151.
RX MEDLINE; 92095966.
RA Sakurai A., Maekawa T., Sudo T., Ishii S., Kishimoto A.
RT Phosphorylation of cAMP response element-binding protein, CRE-BP1,
by
RT cAMP-dependent protein kinase and protein kinase c*
RL Biochem. Biophys. Res. Commun. 181:629-635 (1991).
RN [22];
RE0000186.
RX MEDLINE; 90304881.
RA Liu F., Green M. R.
R.
RT A specific member of the ATF transcription factor family
can mediate
RT transcription activation by the adenovirus
E1a protein
RL Cell 61:1217-1224 (1990).
RN [23]; RE0001241.
RX MEDLINE; 90205841.
RA Ivashkiv L. B., Liou H.-C., Kara
C. J., Lamph W. W., Verma I. M., Glimcher
RA L. H.
RT
mXBP/CRE-BP2 and c-Jun form a complex which binds to the cyclic
AMP, but
RT not to the 12-O-tetradecanoylphorbol-13-acetate,
response element
RL Mol. Cell. Biol. 10:1609-1621 (1990).
RN [24]; RE0002246.
RX MEDLINE; 90191714.
RA Benbrook
D. M., Jones N. C.
RT Heterodimer formation between CREB and
JUN proteins
RL Oncogene 5:295-302 (1990).
RN [25]; RE0003157.
RX MEDLINE; 90316112.
RA Yoshimura T., Fujisawa J.-I., Yoshida
M.
RT Multiple cDNA clones encoding nuclear proteins that
bind to the
RT tax-dependent enhancer of HTLV-1: all contain
a leucine zipper structure
RT and basic amino acid domain
RL EMBO J. 9:2537-2542 (1990).
RN [26]; RE0000335.
RX
MEDLINE; 90005408.
RA Maekawa T., Sakura H., Kanei-Ishii C.,
Sudo T., Yoshimura T., Fujisawa
RA J.-I., Yoshida M., Ishii
S.
RT Leucine zipper structure of the protein CRE-BP1 binding
to the cyclic AMP
RT response element in brain
RL EMBO
J. 8:2023-2328 (1989).
RN [27]; RE0000666.
RX MEDLINE;
90185187.
RA Hai T., Liu F., Coukos W. J., Green M. R.
RT Transcription factor ATF cDNA clones: an extensive family of
leucine zipper
RT proteins able to selectively form DNA-binding
heterodimers
RL Genes Dev. 3:2083-2090 (1989).
XX