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Gene set: V$DR3_Q4 (C3:TFAC:0442)
Standard nameV$DR3_Q4
Systematic nameC3:TFAC:0442
Brief descriptionGenes with 3'UTR containing motif RRTGNMCYTNNTGAMCCNYNT which matches annotation for VDR: Vitamin D (1,25- dihydroxyvitamin D3) receptor
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
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FA CAR:RXR-alpha
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; primates
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CL C0002; CC (rec).
XX
SF heterodimer;
SF for individual polypeptides see human CAR and human RXR-alpha
SF ;
XX
FF activator;
FF binds to and activates transcription through different types of response
FF elements: DR5/RARE, DR4 [2] [1] [4], DR3 [3], ER6/IR6 [3] [4];
FF activates cyp2b and cyp3a genes in response to phenobarbital [4];
FF regulator of xenobiotic response in a complex interplay with PXR:RXR-alpha
FF [2] [3] [1];
FF regulator of CYP2B, CYP3A, CYP2C cytochrome genes [2] [3] [1] [4];
FF CAR:RXR-alpha and PXR:RXR-alpha in several cases regulate common genes
FF through the same DNA elements [2] [3] [1].;
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RN [1]; RE0023246.
RX MEDLINE; 11679585.
RA Gerbal-Chaloin S., Daujat M., Pascussi J. M., Pichard-Garcia L., Vilarem M.
RA J., Maurel P.
RT Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor
RT and constitutive androstane receptor.
RL J. Biol. Chem. 277:209-217 (2002).
RN [2]; RE0023235.
RX MEDLINE; 11502872.
RA Goodwin B., Moore L. B., Stoltz C. M., McKee D. D., Kliewer S. A.
RT Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.
RL Mol. Pharmacol. 60:427-431 (2001).
RN [3]; RE0016457.
RX MEDLINE; 20566645.
RA Xie W., Barwick J. L., Simon C. M., Pierce A. M., Safe S., Blumberg B.,
RA Guzelian P. S., Evans R. M.
RT Reciprocal activation of xenobiotic response genes by nuclear receptors
RT SXR/PXR and CAR
RL Genes Dev. 14:3014-3023 (2000).
RN [4]; RE0023334.
RX MEDLINE; 10037683.
RA Sueyoshi T., Kawamoto T., Zelko I., Honkakoski P., Negishi M.
RT The repressed nuclear receptor CAR responds to phenobarbital in activating
RT the human CYP2B6 gene.
RL J. Biol. Chem. 274:6043-6046 (1999).
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Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

149 genes, 149 accessions (Toggle view)

AccessionGeneTitleLinks
NDUFS2NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)Source|GeneCards
EPN1EPN1epsin 1Source|GeneCards
LOC148898LOC148898hypothetical protein BC007899Source|GeneCards
CTNNBIP1CTNNBIP1catenin, beta interacting protein 1Source|GeneCards
PRKAG2PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunitSource|GeneCards
PRLRPRLRprolactin receptorSource|GeneCards
MGC14161FRMD5FERM domain containing 5Source|GeneCards
C14ORF162C14ORF162chromosome 14 open reading frame 162Source|GeneCards
BTF3L1BTF3L1basic transcription factor 3, like 1Source|GeneCards
SP192GPBP1L1GC-rich promoter binding protein 1-like 1Source|GeneCards
OPRS1OPRS1opioid receptor, sigma 1Source|GeneCards
GPC3GPC3glypican 3Source|GeneCards
SLC35E1SLC35E1solute carrier family 35, member E1Source|GeneCards
ARNTLARNTLaryl hydrocarbon receptor nuclear translocator-likeSource|GeneCards
CYP24A1CYP24A1cytochrome P450, family 24, subfamily A, polypeptide 1Source|GeneCards
LMO3LMO3LIM domain only 3 (rhombotin-like 2)Source|GeneCards
KCNB1KCNB1potassium voltage-gated channel, Shab-related subfamily, member 1Source|GeneCards
AQP1AQP1aquaporin 1 (channel-forming integral protein, 28kDa)Source|GeneCards
YBX2YBX2germ cell specific Y-box binding proteinSource|GeneCards
CTDSP1CTDSP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1Source|GeneCards
SYNCOILINSYNC1syncoilin, intermediate filament 1 /// syncoilin, intermediate filament 1Source|GeneCards
CPA2CPA2carboxypeptidase A2 (pancreatic)Source|GeneCards
PITX2PITX2paired-like homeodomain transcription factor 2Source|GeneCards
DD5EDD1E3 ubiquitin protein ligase, HECT domain containing, 1Source|GeneCards
FLJ43855FLJ43855similar to sodium- and chloride-dependent creatine transporterSource|GeneCards
SLC7A3SLC7A3solute carrier family 7 (cationic amino acid transporter, y+ system), member 3Source|GeneCards
LOC284058LOC284058LOC284058 proteinSource|GeneCards
ZNF278ZNF278zinc finger protein 278Source|GeneCards
SLC38A3SLC38A3solute carrier family 38, member 3Source|GeneCards
TFAP2BL1TFAP2Dtranscription factor AP-2 delta (activating enhancer binding protein 2 delta)Source|GeneCards
CDC27CDC27cell division cycle 27Source|GeneCards
HOXC13HOXC13homeo box C13Source|GeneCards
ARHGEF5ARHGEF5Rho guanine nucleotide exchange factor (GEF) 5Source|GeneCards
MAGEH1MAGEH1APR-1 proteinSource|GeneCards
GPR52GPR52G protein-coupled receptor 52Source|GeneCards
RIS1UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1Source|GeneCards
NBEANBEAneurobeachinSource|GeneCards
FLJ21347SPATA20spermatogenesis associated 20Source|GeneCards
CHD2CHD2chromodomain helicase DNA binding protein 2Source|GeneCards
LIN28LIN28lin-28 homolog (C. elegans)Source|GeneCards
TITF1TITF1thyroid transcription factor 1Source|GeneCards
SLC26A3SLC26A3solute carrier family 26, member 3Source|GeneCards
FLJ23436FLJ23436hypothetical protein FLJ23436Source|GeneCards
MGC4606C16ORF53chromosome 16 open reading frame 53Source|GeneCards
DIAPH1DIAPH1diaphanous homolog 1 (Drosophila)Source|GeneCards
MGC3169TMEM38Atransmembrane protein 38ASource|GeneCards
GGTL3GGTL3gamma-glutamyltransferase-like 3Source|GeneCards
MYO1EMYO1EMyosin IESource|GeneCards
FKBP11FKBP11FK506 binding protein 11, 19 kDaSource|GeneCards
HSPB7HSPB7heat shock 27kDa protein family, member 7 (cardiovascular)Source|GeneCards
ELAVL3ELAVL3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)Source|GeneCards
COL11A2COL11A2collagen, type XI, alpha 2Source|GeneCards
LOC150236LOC150236similar to hypothetical protein DKFZp434K191 (H. sapiens)Source|GeneCards
SALL1SALL1sal-like 1 (Drosophila)Source|GeneCards
SGKSGKserum/glucocorticoid regulated kinaseSource|GeneCards
ARID4AARID4AAT rich interactive domain 4A (RBP1-like)Source|GeneCards
FBS1FBS1Fibrosin 1Source|GeneCards
ACVR2ACVR2activin A receptor, type IISource|GeneCards
HYAL2HYAL2hyaluronoglucosaminidase 2Source|GeneCards
XPO1XPO1exportin 1 (CRM1 homolog, yeast)Source|GeneCards
ZFXZFXzinc finger protein, X-linkedSource|GeneCards
SSBP3SSBP3single stranded DNA binding protein 3Source|GeneCards
AQP9AQP9aquaporin 9Source|GeneCards
STIM1STIM1stromal interaction molecule 1Source|GeneCards
FLJ12442FLJ12442hypothetical protein FLJ12442Source|GeneCards
C20ORF103C20ORF103chromosome 20 open reading frame 103Source|GeneCards
TLX1TLX1T-cell leukemia, homeobox 1Source|GeneCards
ATP2A2ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2Source|GeneCards
IL11IL11interleukin 11Source|GeneCards
FLJ10330PRPF38BPRP38 pre-mRNA processing factor 38 (yeast) domain containing BSource|GeneCards
YWHAGYWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideSource|GeneCards
SIAT7ESIAT7Esialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) ESource|GeneCards
ERBB2IPERBB2IPerbb2 interacting proteinSource|GeneCards
CIP29CIP29cytokine induced protein 29 kDaSource|GeneCards
DDAH2DDAH2dimethylarginine dimethylaminohydrolase 2Source|GeneCards
HOXA13HOXA13homeo box A13Source|GeneCards
PAX6PAX6paired box gene 6 (aniridia, keratitis)Source|GeneCards
FLI1FLI1Friend leukemia virus integration 1Source|GeneCards
TMPOTMPOthymopoietinSource|GeneCards
TTC3TTC3tetratricopeptide repeat domain 3Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
PTCHPTCHpatched homolog (Drosophila)Source|GeneCards
SSBP2SSBP2single-stranded DNA binding protein 2Source|GeneCards
FGRFGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologSource|GeneCards
ASXL2ASXL2additional sex combs like 2 (Drosophila)Source|GeneCards
PPP4R1PPP4R1protein phosphatase 4, regulatory subunit 1Source|GeneCards
LOC92162LOC92162similar to RIKEN cDNA 2600017H02Source|GeneCards
ADAMTS4ADAMTS4a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4Source|GeneCards
KCNC1KCNC1potassium voltage-gated channel, Shaw-related subfamily, member 1Source|GeneCards
SIGLEC7SIGLEC7sialic acid binding Ig-like lectin 7Source|GeneCards
USH1CUSH1CUsher syndrome 1C (autosomal recessive, severe)Source|GeneCards
AZ2AZI25-azacytidine induced 2Source|GeneCards
ZNF436ZNF436zinc finger protein 436Source|GeneCards
GRM1GRM1glutamate receptor, metabotropic 1Source|GeneCards
SLC25A28SLC25A28solute carrier family 25, member 28Source|GeneCards
PCBP4PCBP4poly(rC) binding protein 4Source|GeneCards
TRIM8TRIM8tripartite motif-containing 8Source|GeneCards
ZNFN1A2ZNFN1A2zinc finger protein, subfamily 1A, 2 (Helios)Source|GeneCards
RBM14RBM14RNA binding motif protein 14Source|GeneCards
MIG-6ERRFI1ERBB receptor feedback inhibitor 1Source|GeneCards
NR6A1NR6A1nuclear receptor subfamily 6, group A, member 1Source|GeneCards
SREB3GPR173G-protein coupled receptor 173Source|GeneCards
TGFB3TGFB3transforming growth factor, beta 3Source|GeneCards
KPNB1KPNB1karyopherin (importin) beta 1Source|GeneCards
VEGFVEGFvascular endothelial growth factorSource|GeneCards
ROCK1ROCK1Rho-associated, coiled-coil containing protein kinase 1Source|GeneCards
CDHJDCHS2Dachsous 2 (Drosophila)Source|GeneCards
LOC55974LOC55974stromal cell proteinSource|GeneCards
ZBTB10ZBTB10Zinc finger and BTB domain containing 10Source|GeneCards
HPCAHPCAhippocalcinSource|GeneCards
TFAP4TFAP4transcription factor AP-4 (activating enhancer binding protein 4)Source|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
HBXAPHBXAPhepatitis B virus x associated proteinSource|GeneCards
LRRC17LRRC17leucine rich repeat containing 17Source|GeneCards
BCL9BCL9B-cell CLL/lymphoma 9Source|GeneCards
IDN3NIPBLNipped-B homolog (Drosophila)Source|GeneCards
SFRS12SFRS12splicing factor, arginine/serine-rich 12Source|GeneCards
PKP3PKP3plakophilin 3Source|GeneCards
PTPN22PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)Source|GeneCards
BAHD1BAHD1bromo adjacent homology domain containing 1Source|GeneCards
PCDH7PCDH7BH-protocadherin (brain-heart)Source|GeneCards
RORCRORCRAR-related orphan receptor CSource|GeneCards
PNUTL2SEPT4septin 4Source|GeneCards
MGC3207MGC3207hypothetical protein MGC3207Source|GeneCards
KCNK3KCNK3potassium channel, subfamily K, member 3Source|GeneCards
RBBP6RBBP6retinoblastoma binding protein 6Source|GeneCards
RBM24RBM24RNA binding motif protein 24Source|GeneCards
FLJ90834FLJ90834hypothetical protein FLJ90834Source|GeneCards
PDGFBPDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)Source|GeneCards
SIAT8BSIAT8Bsialyltransferase 8B (alpha-2, 8-sialyltransferase)Source|GeneCards
DSIPIDSIPIdelta sleep inducing peptide, immunoreactorSource|GeneCards
C5ORF13C5ORF13chromosome 5 open reading frame 13Source|GeneCards
FLJ20811ARMCX6armadillo repeat containing, X-linked 6Source|GeneCards
HOXB7HOXB7homeo box B7Source|GeneCards
EIF5AEIF5Aeukaryotic translation initiation factor 5ASource|GeneCards
PRIC285PRIC285peroxisomal proliferator-activated receptor A interacting complex 285Source|GeneCards
COL12A1COL12A1collagen, type XII, alpha 1Source|GeneCards
SLC26A9SLC26A9solute carrier family 26, member 9Source|GeneCards
TRIM41TRIM41tripartite motif-containing 41Source|GeneCards
ZNF385ZNF385zinc finger protein 385Source|GeneCards
ZNF198ZNF198zinc finger protein 198Source|GeneCards
ASXL1ASXL1additional sex combs like 1 (Drosophila)Source|GeneCards
RKHD3RKHD3ring finger and KH domain containing 3Source|GeneCards
CACNG2CACNG2calcium channel, voltage-dependent, gamma subunit 2Source|GeneCards
POU2F1POU2F1POU domain, class 2, transcription factor 1Source|GeneCards
HOXB6HOXB6homeo box B6Source|GeneCards
FLJ37478FLJ37478hypothetical protein FLJ37478Source|GeneCards
PPP2R5BPPP2R5Bprotein phosphatase 2, regulatory subunit B (B56), beta isoformSource|GeneCards
PTD015PTD015PTD015 proteinSource|GeneCards


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