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Gene set: V$EFC_Q6 (C3:TFAC:0301)
Standard nameV$EFC_Q6
Systematic nameC3:TFAC:0301
Brief descriptionGenes with 3'UTR containing motif MGTTACYAGGCAAM which matches annotation for RFX1: regulatory factor X, 1 (influences HLA class II expression)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA RFX1
 XX
 SY EF-C; RFX; RF-X; enhancer
factor C; hRFX1.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 HO TGT3, EP protein, MDBP,
CeRFX (C.elegans), Sak1 (S.pombe), Crt1
 HO (S.cerevisiae)

 XX
 CL C0023; fork head; 3.3.4.1.1.
 XX

SZ 979 AA; 104.7 kDa (cDNA)
 XX
 XX
 SC SwissProt #P22670

XX
 FT 4 73 glutamine-rich region (16/70).
 FT 13 97 proline-rich
region (34/85).
 FT 85 126 serine-/threonine-rich region (13/42).

FT 127 212 glutamine-rich region (20/86).
 FT 215 227 serine-/threonine-rich
region (7/13).
 FT 215 378 PF04589; RFX1_trans_act.
 FT
230 296 glutamine-rich region (18/67).
 FT 304 380 serine-/threonine-rich
region (31/77).
 FT 381 411 glycine-rich region (25/31).

FT 421 503 PF02257; RFX_DNA_binding.
 FT 438 528 DNA-binding
domain (DBD) [14].
 FT 439 445 alpha-helix 1, H1 [2].
 FT
446 455 beta-strand, S1 [2].
 FT 456 469 alpha-helix 2, H2
[2].
 FT 470 475 connecting loop 1, L1 [2].
 FT 476 486
alpha-helix 3, H3 [2].
 FT 487 490 connecting loop 2, L2 [2].

FT 491 495 beta-strand 2, S2 [2].
 FT 496 501 wing, W1 [2].

FT 502 511 beta-strand 3, S3 [2].
 FT 621 739 domains B and
C, autoinhibitory domains [4].
 FT 621 979 extended dimerization
domain, EDD [5] [6].
 FT 744 979 dimerization domain, repression
domain [7].
 FT 913 936 acidic region, Ac [1].
 FT 937 979
nuclear localization signal, NLS [1].
 XX
 SF member of
winged-helix class of helix-turn-helix superclass of factors [2];

SF the DBD exhibits a weak sequence similarity to the bHLH domain
consensus
 SF and is predicted to constitute two amphipathic
helices and a linking loop
 SF [14];
 SF it binds to DNA
as a dimer, but dimerization is not a prerequisite for
 SF
DNA-binding [14];
 SF both RF-X subunits interact independently
with the X-box(es) [14];
 SF together with MIBP1 ,
RFX1 constitutes the DNA-binding activity
 SF MIF-1 
[9];
 SF secondary structure exhibits three alpha-helical and
one beta-stranded
 SF segments within the DNA-binding domain,
the potential helix III region
 SF being responsible for sequence
specific binding [8];
 SF DNA binding domain has been identified
as winged-helix, hRFX1 uses a
 SF beta-hairpin (or wing) for
DNA recognition instead of recognition helix [2];
 SF DBD consistis
of 3 alpha-helices, 3 beta-strands and 3 connecting loops [2];

SF new mode of DNA binding: beta-strands S2 and S3 and wing W1
make extensive
 SF contacts with the major groove of one half-site
of the symmetric X-box,
 SF alpha-helix H3 interacts with the
minor groove of the other half-site [2];
 SF N-terminal transactivation
domain, but activation potential can be masked
 SF by autoinhibitory
domain [4];
 SF can bind DNA as a homodimer or heterodimer
with RFX2 or RFX3 [4];
 SF possesses a split, extended dimerization
domain which mediated formation of
 SF alternative homodimeric
complexes [5] [6];
 SF EDD is similar to the LBD of nuclear
receptors by several features, it is
 SF independent on DBD,
mediates dimerization and can function in alternative
 SF conformations
[5] [6];
 SF C-terminal acidic region may work as an autoinhibitory
domain relating DNA
 SF binding by RFX1 [1];
 XX
 CP
ubiquitous, highly expressed in primary eosinophils [4]
 XX

FF homodimers can function as activators or repressors depending
on the nature
 FF of interactions between two subunits, two
distinct types of homodimers can
 FF be formed which are different
in their function [5] [7] [6];
 FF preferential binding to
methylated sequences;
 FF binds to X boxes of MHC class II
alpha-chain gene promoters [15] and the
 FF HBV enhancer I
[11];
 FF identical to EF-C [11], but different from NF-X;

FF at the HBV enhancer I, it has to cooperate with liver-specific
factors [11];
 FF it cooperatively binds to the X-Y-box pattern
of MHC gene promoters with
 FF NF-Y [10];
 FF inhibitory
role in the regulation of proliferating cell nuclear antigen

FF (PCNA) expression [3];
 FF DNA binding activity may be regulated
by phosphorylation [1];
 XX
 IN T02313; MIBP1; rat, Rattus
norvegicus.
 IN T01667; RFX2; human, Homo sapiens.
 IN T01669;
RFX2; mouse, Mus musculus.
 IN T01670; RFX3; human, Homo sapiens.

XX
 XX
 XX
 XX
 RN [1]; RE0022531.
 RX MEDLINE;
11358531.
 RA Katan-Khaykovich Y., Shaul Y.
 RT Nuclear
import and DNA-binding activity of RFX1. Evidence for an
 RT
autoinhibitory mechanism.
 RL Eur. J. Biochem. 268:3108-3116
(2001).
 RN [2]; RE0022520.
 RX MEDLINE; 10706293.
 RA
Gajiwala K. S., Chen H., Cornille F., Roques B. P., Reith W.,
Mach B.,
 RA Burley S. K.
 RT Structure of the winged-helix
protein hRFX1 reveals a new mode of DNA
 RT binding.
 RL
Nature 403:916-921 (2000).
 RN [3]; RE0017028.
 RX MEDLINE;
99269075.
 RA Liu M., Lee B. H., Mathews M. B.
 RT Involvement
of RFX1 protein in the regulation of the human proliferating

RT cell nuclear antigen promoter
 RL J. Biol. Chem. 274:15433-15439
(1999).
 RN [4]; RE0022525.
 RX MEDLINE; 10330134.
 RA
Iwama A., Pan J., Zhang P., Reith W., Mach B., Tenen D. G., Sun
Z.
 RT Dimeric RFX proteins contribute to the activity and
lineage specificity of
 RT the interleukin-5 receptor alpha
promoter through activation and repression
 RT domains.

RL Mol. Cell. Biol. 19:3940-3950 (1999).
 RN [5]; RE0022527.

RX MEDLINE; 10556033.
 RA Katan-Khaykovich Y., Spiegel I.,
Shaul Y.
 RT The dimerization/repression domain of RFX1 is
related to a conserved region
 RT of its yeast homologues Crt1
and Sak1: a new function for an ancient motif.
 RL J. Mol.
Biol. 294:121-137 (1999).
 RN [6]; RE0022530.
 RX MEDLINE;
9733744.
 RA Katan-Khaykovich Y., Shaul Y.
 RT RFX1, a single
DNA-binding protein with a split dimerization domain,
 RT generates
alternative complexes.
 RL J. Biol. Chem. 273:24504-24512 (1998).

RN [7]; RE0022528.
 RX MEDLINE; 9278482.
 RA Katan Y., Agami
R., Shaul Y.
 RT The transcriptional activation and repression
domains of RFX1, a
 RT context-dependent regulator, can mutually
neutralize their activities.
 RL Nucleic Acids Res. 25:3621-3628
(1997).
 RN [8]; RE0006617.
 RX MEDLINE; 96315675.
 RA
Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W.

RT A consensus motif in the RFX DNA binding domain and binding
domain mutants
 RT with altered specificity
 RL Mol. Cell.
Biol. 16:4486-4494 (1996).
 RN [9]; RE0006616.
 RX MEDLINE;
95280902.
 RA Reinhold W., Emens L., Itkes A., Blake M., Ichinose
I., Zajac-Kaye M.
 RT The myc intron-binding polypeptide associates
with RFX1 in vivo and binds
 RT to the major histocompatibility
complex class II promoter region, to the
 RT hepatitis B virus
enhancer, and to regulatory regions of several distinct
 RT
viral genes
 RL Mol. Cell. Biol. 15:3041-3048 (1995).
 RN
[10]; RE0003796.
 RX MEDLINE; 94119925.
 RA Reith W., Siegrist
C. A., Durand B., Barras E., Mach B.
 RT Function of major
histocompatibility complex class II promoters requires
 RT
cooperative binding between factors RFX and NF-Y
 RL Proc.
Natl. Acad. Sci. USA 91:554-558 (1994).
 RN [11]; RE0003798.

RX MEDLINE; 94019311.
 RA Siegrist C. A., Durand B., Emery
P., David E., Hearing P., Mach B., Reith W.
 RT RFX1 is identical
to enhancer factor C and functions as a transactivator of

RT the hepatitis B virus enhancer
 RL Mol. Cell. Biol. 13:6375-6384
(1993).
 RN [12]; RE0002144.
 RX MEDLINE; 91232904.

RA Hasegawa S. L., Sloan J. H., Reith W., Mach B., Boss J. M.

RT Regulatory factor-X binding to mutant HLA-DRA promoter sequences

RL Nucleic Acids Res. 19:1243-1248 (1991).
 RN [13]; RE0002729.

RX MEDLINE; 91220738.
 RA Garcia A. D., Ostapchuk P., Hearing
P.
 RT Methylation-dependent and -independent DNA binding of
nuclear factor EF-C
 RL Virology 182:857-860 (1991).
 RN
[14]; RE0000690.
 RX MEDLINE; 91071581.
 RA Reith W., Herrero-Sanchez
C., Kobr M., Silacci P., Berte C., Barras E., Fey
 RA S., Mach
B.
 RT MHC class II regulatory factor RFX has a novel DNA-binding
domain and a
 RT functionally independent dimerization domain

RL Genes Dev. 4:1528-1540 (1990).
 RN [15]; RE0001485.

RX MEDLINE; 90158612.
 RA Kobr M., Reith W., Herrero-Sanchez
C., Mach B.
 RT Two DNA-binding proteins discriminate between
the promoters of different
 RT members of the major histocompatibility
complex class II multigene family
 RL Mol. Cell. Biol. 10:965-971
(1990).
 RN [16]; RE0002442.
 RX MEDLINE; 91017573.

RA Cogswell J. P., Basta P. V., Ting J. P.-Y.
 RT X-box-binding
proteins positively and negatively regulate transcription of

RT the HLA-DRA gene through interaction with discrete upstream
W and V elements
 RL Proc. Natl. Acad. Sci. USA 87:7703-7707
(1990).
 RN [17]; RE0001429.
 RX MEDLINE; 89384536.

RA Ostapchuk P., Scheirle G., Hearing P.
 RT Binding of Nuclear
Factor EF-C to a Functional Domain of the Hepatitis B
 RT Virus
Enhancer Region
 RL Mol. Cell. Biol. 9:2787-2797 (1989).

RN [18]; RE0002392.
 RX MEDLINE; 89264585.
 RA Reith W.,
Barras E., Satola S., Kobr M., Reinhardt D., Sanchez C. H., Mach

RA B.
 RT Cloning of the major histocompatibility complex class
II promoter binding
 RT protein affected in a hereditary defect
in class II gene regulation
 RL Proc. Natl. Acad. Sci. USA
86:4200-4204 (1989).
 RN [19]; RE0000111.
 RX MEDLINE; 88253410.

RA Reith W., Satola S., Herrero-Sanchez C., Amaldi I., Lisowska-Grospierre
B.,
 RA Griscelli C., Hadam M. R., Mach B.
 RT Congenital
Immunodeficiency with a Regulatory Defect in MHC Class II Gene

RT Expression Lacks a Specific HLA-DR Promoter Binding Protein,
RF-X
 RL Cell 53:897-906 (1988).
 RN [20]; RE0000351.

RX MEDLINE; 88004398.
 RA Shaul Y., Ben-Levy R.
 RT Multiple
nuclear proteins in liver cells are bound to hepatitis B virus

RT enhancer element and its upstream sequences
 RL EMBO J.
6:1913-1920 (1987).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

278 genes, 278 accessions (Toggle view)

AccessionGeneTitleLinks
PDCL2PDCL2phosducin-like 2Source|GeneCards
C10ORF11C10ORF11chromosome 10 open reading frame 11Source|GeneCards
SLC17A6SLC17A6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6Source|GeneCards
C8ORF13C8ORF13chromosome 8 open reading frame 13Source|GeneCards
RREB1RREB1ras responsive element binding protein 1Source|GeneCards
FOXD3FOXD3forkhead box D3Source|GeneCards
PAK6PAK6p21(CDKN1A)-activated kinase 6Source|GeneCards
CD68CD68CD68 antigenSource|GeneCards
BDNFBDNFbrain-derived neurotrophic factorSource|GeneCards
PPIL4PPIL4peptidylprolyl isomerase (cyclophilin)-like 4Source|GeneCards
LMO3LMO3LIM domain only 3 (rhombotin-like 2)Source|GeneCards
TMEM24TMEM24transmembrane protein 24Source|GeneCards
PDZK4PDZK4PDZ domain containing 4Source|GeneCards
DDX17DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
MEIS2MEIS2Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)Source|GeneCards
SEP15SEP1515 kDa selenoproteinSource|GeneCards
MGC8407CAMKVCaM kinase-like vesicle-associatedSource|GeneCards
GPR119GPR119G protein-coupled receptor 119Source|GeneCards
HOXA4HOXA4homeo box A4Source|GeneCards
PSDPSDpleckstrin and Sec7 domain proteinSource|GeneCards
HCA127KIAA1166KIAA1166Source|GeneCards
MR-1MR-1myofibrillogenesis regulator 1Source|GeneCards
AKAP1AKAP1A kinase (PRKA) anchor protein 1Source|GeneCards
MGC13024MGC13024hypothetical protein MGC13024Source|GeneCards
FLJ25467CCDC13coiled-coil domain containing 13Source|GeneCards
BCL2L1BCL2L1BCL2-like 1Source|GeneCards
PACSIN2PACSIN2protein kinase C and casein kinase substrate in neurons 2Source|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
ROBO3ROBO3roundabout, axon guidance receptor, homolog 3 (Drosophila)Source|GeneCards
CRIP2CRIP2cysteine-rich protein 2Source|GeneCards
DKFZP566M1046DKFZP566M1046hypothetical protein DKFZp566M1046Source|GeneCards
SENP1SENP1sentrin/SUMO-specific proteaseSource|GeneCards
FLJ38964FLJ38964hypothetical protein FLJ38964Source|GeneCards
HOXA3HOXA3homeo box A3Source|GeneCards
ASCL4ASCL4class II bHLH protein ASCL4Source|GeneCards
FLJ45832FLJ45832FLJ45832 proteinSource|GeneCards
CCND2CCND2cyclin D2Source|GeneCards
PME-1PME-1protein phosphatase methylesterase-1Source|GeneCards
EYA1EYA1eyes absent homolog 1 (Drosophila)Source|GeneCards
HNRPFHNRPFheterogeneous nuclear ribonucleoprotein FSource|GeneCards
FIBCD1FIBCD1fibrinogen C domain containing 1Source|GeneCards
MYCL2MYCL2v-myc myelocytomatosis viral oncogene homolog 2 (avian)Source|GeneCards
MGC26594C1ORF169chromosome 1 open reading frame 169Source|GeneCards
ETS2ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)Source|GeneCards
ELAVL4ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)Source|GeneCards
LDB2LDB2LIM domain binding 2Source|GeneCards
PCDH17PCDH17protocadherin 17Source|GeneCards
DKFZP547C176ELMOD1ELMO domain containing 1Source|GeneCards
DHX30DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 30Source|GeneCards
PRDM12PRDM12PR domain containing 12Source|GeneCards
C10ORF63C10ORF63chromosome 10 open reading frame 63Source|GeneCards
NEUROD2NEUROD2neurogenic differentiation 2Source|GeneCards
ARID1AARID1AAT rich interactive domain 1A (SWI- like)Source|GeneCards
SIX1SIX1sine oculis homeobox homolog 1 (Drosophila)Source|GeneCards
KIRREL2KIRREL2kin of IRRE like 2 (Drosophila)Source|GeneCards
TCEAL1TCEAL1transcription elongation factor A (SII)-like 1Source|GeneCards
KCNRGKCNRGpotassium channel regulatorSource|GeneCards
TAO1TAOK2TAO kinase 2Source|GeneCards
ARL4AARL4ADP-ribosylation factor-like 4Source|GeneCards
NRGNNRGNneurogranin (protein kinase C substrate, RC3)Source|GeneCards
COPS5COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)Source|GeneCards
THNSL1THNSL1threonine synthase-like 1 (bacterial)Source|GeneCards
ZA20D1ZA20D1zinc finger, A20 domain containing 1Source|GeneCards
ADCK4ADCK4aarF domain containing kinase 4Source|GeneCards
SEMA5BSEMA5Bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5BSource|GeneCards
GRCC10GRCC10likely ortholog of mouse gene rich cluster, C10 geneSource|GeneCards
CELSR2CELSR2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)Source|GeneCards
METMETmet proto-oncogene (hepatocyte growth factor receptor)Source|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
FLRT1FLRT1fibronectin leucine rich transmembrane protein 1Source|GeneCards
BMP6BMP6bone morphogenetic protein 6Source|GeneCards
HMGN3HMGN3high mobility group nucleosomal binding domain 3Source|GeneCards
MGC39827MGC39827hypothetical protein MGC39827Source|GeneCards
PTCHPTCHpatched homolog (Drosophila)Source|GeneCards
GDPD2GDPD2glycerophosphodiester phosphodiesterase domain containing 2Source|GeneCards
LOC64744LOC64744hypothetical protein AL133206Source|GeneCards
CACNA1DCACNA1Dcalcium channel, voltage-dependent, L type, alpha 1D subunitSource|GeneCards
IGSF8IGSF8immunoglobulin superfamily, member 8Source|GeneCards
OSR2OSR2odd-skipped-related 2A proteinSource|GeneCards
SLKSLKSTE20-like kinase (yeast)Source|GeneCards
KLHL1KLHL1kelch-like 1 (Drosophila)Source|GeneCards
EBF2EBF2early B-cell factor 2Source|GeneCards
BMPR2BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)Source|GeneCards
FERD3LFERD3LFer3-like (Drosophila)Source|GeneCards
STAT5BSTAT5Bsignal transducer and activator of transcription 5BSource|GeneCards
FLJ13197FLJ13197hypothetical protein FLJ13197Source|GeneCards
SLC39A12SLC39A12solute carrier family 39 (zinc transporter), member 12Source|GeneCards
CBX6CBX6chromobox homolog 6Source|GeneCards
MITFMITFmicrophthalmia-associated transcription factorSource|GeneCards
PHTF1PHTF1putative homeodomain transcription factor 1Source|GeneCards
MGC14376MGC14376hypothetical protein MGC14376Source|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
KCNA2KCNA2potassium voltage-gated channel, shaker-related subfamily, member 2Source|GeneCards
RNF141RNF141ring finger protein 141Source|GeneCards
WARS2WARS2tryptophanyl tRNA synthetase 2 (mitochondrial)Source|GeneCards
PPT2PPT2palmitoyl-protein thioesterase 2Source|GeneCards
AP1M1AP1M1adaptor-related protein complex 1, mu 1 subunitSource|GeneCards
GRCAGPR162G protein-coupled receptor 162Source|GeneCards
MGC21688MGC21688hypothetical protein MGC21688Source|GeneCards
FOSBFOSBFBJ murine osteosarcoma viral oncogene homolog BSource|GeneCards
USP12USP12ubiquitin specific protease 12Source|GeneCards
TNKS1BP1TNKS1BP1tankyrase 1 binding protein 1, 182kDaSource|GeneCards
GALNT14GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)Source|GeneCards
KIAA0663ZC3H11Azinc finger CCCH-type containing 11ASource|GeneCards
MSPLMLNleishmanolysin-like (metallopeptidase M8 family)Source|GeneCards
BMP5BMP5bone morphogenetic protein 5Source|GeneCards
KIAA1324KIAA1324maba1Source|GeneCards
GGNGGNgametogenetinSource|GeneCards
TBPL1TBPL1TBP-like 1Source|GeneCards
DKFZP547K1113DKFZP547K1113hypothetical protein DKFZp547K1113Source|GeneCards
STK36STK36serine/threonine kinase 36 (fused homolog, Drosophila)Source|GeneCards
PPP3CBPPP3CBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
MT4MT4metallothionein IVSource|GeneCards
FAF1FAF1Fas (TNFRSF6) associated factor 1Source|GeneCards
PRIC285PRIC285peroxisomal proliferator-activated receptor A interacting complex 285Source|GeneCards
PDZRN4PDZRN4PDZ domain containing RING finger 4Source|GeneCards
C10ORF61C10ORF61chromosome 10 open reading frame 61Source|GeneCards
EBNA1BP2EBNA1BP2EBNA1 binding protein 2Source|GeneCards
LOC90799LOC90799hypothetical protein BC009518Source|GeneCards
CD69CD69CD69 antigen (p60, early T-cell activation antigen)Source|GeneCards
CYP26B1CYP26B1cytochrome P450, family 26, subfamily B, polypeptide 1Source|GeneCards
KCNQ1DNKCNQ1DNKCNQ1 downstream neighborSource|GeneCards
GRIN3AGRIN3Aglutamate receptor, ionotropic, N-methyl-D-aspartate 3ASource|GeneCards
TGFB1I4TSC22D1TSC22 domain family, member 1Source|GeneCards
RGL1RGL1Ral guanine nucleotide dissociation stimulator-like 1Source|GeneCards
SCNN1ASCNN1Asodium channel, nonvoltage-gated 1 alphaSource|GeneCards
HOXB6HOXB6homeo box B6Source|GeneCards
FLJ45235ANKRD45ankyrin repeat domain 45Source|GeneCards
RPL32RPL32ribosomal protein L32Source|GeneCards
PHCAPHCAphytoceramidase, alkalineSource|GeneCards
HKR3HKR3GLI-Kruppel family member HKR3Source|GeneCards
SMCR7SMCR7Smith-Magenis syndrome chromosome region, candidate 7Source|GeneCards
C6ORF31C6ORF31chromosome 6 open reading frame 31Source|GeneCards
KCNA1KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)Source|GeneCards
CCDC6CCDC6coiled-coil domain containing 6Source|GeneCards
RCD-8RCD-8autoantigenSource|GeneCards
EIF2C1EIF2C1eukaryotic translation initiation factor 2C, 1Source|GeneCards
C10ORF53C10ORF53chromosome 10 open reading frame 53Source|GeneCards
TENC1TENC1tensin like C1 domain-containing phosphataseSource|GeneCards
KLF3KLF3Kruppel-like factor 3 (basic)Source|GeneCards
FLJ21827FLJ21827hypothetical protein FLJ21827Source|GeneCards
ITGB8ITGB8integrin, beta 8Source|GeneCards
GLAGLAgalactosidase, alphaSource|GeneCards
JMJD1AJMJD1Ajumonji domain containing 1ASource|GeneCards
FLJ14803FLJ14803hypothetical protein FLJ14803Source|GeneCards
EN2EN2engrailed homolog 2Source|GeneCards
TSGA14TSGA14testis specific, 14Source|GeneCards
GPP34RGOLPH3Lgolgi phosphoprotein 3-likeSource|GeneCards
ARPC5ARPC5actin related protein 2/3 complex, subunit 5, 16kDaSource|GeneCards
XPOTXPOTexportin, tRNA (nuclear export receptor for tRNAs)Source|GeneCards
HES1HES1hairy and enhancer of split 1, (Drosophila)Source|GeneCards
MRPL32MRPL32mitochondrial ribosomal protein L32Source|GeneCards
NUDCNUDCnuclear distribution gene C homolog (A. nidulans)Source|GeneCards
RRM1RRM1ribonucleotide reductase M1 polypeptideSource|GeneCards
PRKCBP1PRKCBP1protein kinase C binding protein 1Source|GeneCards
FLJ35976C1ORF104chromosome 1 open reading frame 104Source|GeneCards
GTF3C4GTF3C4general transcription factor IIIC, polypeptide 4, 90kDaSource|GeneCards
ALMS1ALMS1Alstrom syndrome 1Source|GeneCards
KCNE1KCNE1potassium voltage-gated channel, Isk-related family, member 1Source|GeneCards
ZNF407ZNF407zinc finger protein 407Source|GeneCards
CARSCARScysteinyl-tRNA synthetaseSource|GeneCards
MGC16186MGC16186hypothetical protein MGC16186Source|GeneCards
NPAS3NPAS3neuronal PAS domain protein 3Source|GeneCards
FKRPFKRPfukutin related proteinSource|GeneCards
DIO3DIO3deiodinase, iodothyronine, type IIISource|GeneCards
SNPHSNPHsyntaphilinSource|GeneCards
CCRKCCRKcell cycle related kinaseSource|GeneCards
MPRP-1OMA1OMA1 homolog, zinc metallopeptidase (S. cerevisiae)Source|GeneCards
KRT6LKRT6Lkeratin 6LSource|GeneCards
GBF1GBF1Golgi-specific brefeldin A resistance factor 1Source|GeneCards
FLJ22688FLJ22688hypothetical protein FLJ22688Source|GeneCards
PCYT1APCYT1Aphosphate cytidylyltransferase 1, choline, alpha isoformSource|GeneCards
HM13HM13histocompatibility (minor) 13Source|GeneCards
BCL6BCL6B-cell CLL/lymphoma 6 (zinc finger protein 51)Source|GeneCards
NTRK1NTRK1neurotrophic tyrosine kinase, receptor, type 1Source|GeneCards
CDX4CDX4caudal type homeo box transcription factor 4Source|GeneCards
NONONONOnon-POU domain containing, octamer-bindingSource|GeneCards
YWHAEYWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideSource|GeneCards
FLJ14103CXORF36chromosome X open reading frame 36Source|GeneCards
ZFP36L1ZFP36L1zinc finger protein 36, C3H type-like 1Source|GeneCards
PRRX1PRRX1paired related homeobox 1Source|GeneCards
PHF15PHF15PHD finger protein 15Source|GeneCards
NDUFS4NDUFS4NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)Source|GeneCards
STRN4STRN4striatin, calmodulin binding protein 4Source|GeneCards
ARMC3ARMC3Armadillo repeat containing 3Source|GeneCards
MORF4L2MORF4L2mortality factor 4 like 2Source|GeneCards
CDK11CDC2L6cell division cycle 2-like 6 (CDK8-like)Source|GeneCards
BLOC1S2BLOC1S2biogenesis of lysosome-related organelles complex-1, subunit 2Source|GeneCards
MAP1AMAP1Amicrotubule-associated protein 1ASource|GeneCards
JM1CCDC22coiled-coil domain containing 22Source|GeneCards
NEK2NEK2NIMA (never in mitosis gene a)-related kinase 2Source|GeneCards
TTC16TTC16tetratricopeptide repeat domain 16Source|GeneCards
CACNA2D3CACNA2D3calcium channel, voltage-dependent, alpha 2/delta 3 subunitSource|GeneCards
FLJ20259FLJ20259FLJ20259 proteinSource|GeneCards
P101-PI3KPIK3R5phosphoinositide-3-kinase, regulatory subunit 5, p101Source|GeneCards
FLJ10159FLJ10159hypothetical protein FLJ10159Source|GeneCards
SERPINB3SERPINB3serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3Source|GeneCards
FLJ32000WDR65WD repeat domain 65Source|GeneCards
SLC7A1SLC7A1solute carrier family 7 (cationic amino acid transporter, y+ system), member 1Source|GeneCards
PCYT1BPCYT1Bphosphate cytidylyltransferase 1, choline, beta isoformSource|GeneCards
YWHAGYWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideSource|GeneCards
ST13ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)Source|GeneCards
UBE2L3UBE2L3ubiquitin-conjugating enzyme E2L 3Source|GeneCards
SASH1SASH1SAM and SH3 domain containing 1Source|GeneCards
PAX6PAX6paired box gene 6 (aniridia, keratitis)Source|GeneCards
SLC22A8SLC22A8solute carrier family 22 (organic anion transporter), member 8Source|GeneCards
DDX31DDX31DEAD (Asp-Glu-Ala-Asp) box polypeptide 31Source|GeneCards
PDE1APDE1Aphosphodiesterase 1A, calmodulin-dependentSource|GeneCards
KCNN3KCNN3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3Source|GeneCards
PSMF1PSMF1proteasome (prosome, macropain) inhibitor subunit 1 (PI31)Source|GeneCards
ABI2ABI2abl interactor 2Source|GeneCards
STMN4STMN4stathmin-like 4Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
TRIM39TRIM39tripartite motif-containing 39Source|GeneCards
SELOSELOselenoprotein OSource|GeneCards
BTG4BTG4B-cell translocation gene 4Source|GeneCards
BARHL2BARHL2BarH-like 2 (Drosophila)Source|GeneCards
RAD9ARAD9ARAD9 homolog A (S. pombe)Source|GeneCards
FLJ39779FLJ39779FLJ39779 proteinSource|GeneCards
GPR22GPR22G protein-coupled receptor 22Source|GeneCards
AMHR2AMHR2anti-Mullerian hormone receptor, type IISource|GeneCards
LOC63929LOC63929hypothetical protein LOC63929Source|GeneCards
VITVITvitrinSource|GeneCards
LRRC8LRRC8leucine rich repeat containing 8Source|GeneCards
ARC92MED25mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)Source|GeneCards
MGC44287VSIG1V-set and immunoglobulin domain containing 1Source|GeneCards
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)Source|GeneCards
GRIK5GRIK5glutamate receptor, ionotropic, kainate 5Source|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
VEGFVEGFvascular endothelial growth factorSource|GeneCards
LOC164153LOC164153similar to RIKEN cDNA 4930522D07Source|GeneCards
INSRRINSRRinsulin receptor-related receptorSource|GeneCards
RNF25RNF25ring finger protein 25Source|GeneCards
HAMPHAMPhepcidin antimicrobial peptideSource|GeneCards
NOS1NOS1nitric oxide synthase 1 (neuronal)Source|GeneCards
MTA2MTA2metastais-associated gene family, member 2Source|GeneCards
GTF3C1GTF3C1general transcription factor IIIC, polypeptide 1, alpha 220kDaSource|GeneCards
SHANK1SHANK1SH3 and multiple ankyrin repeat domains 1Source|GeneCards
CITED2CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2Source|GeneCards
PTPN22PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)Source|GeneCards
FGF9FGF9fibroblast growth factor 9 (glia-activating factor)Source|GeneCards
LOC84661LOC84661dpy-30-like proteinSource|GeneCards
HNRPH2HNRPH2heterogeneous nuclear ribonucleoprotein H2 (H')Source|GeneCards
THRATHRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)Source|GeneCards
SOX2SOX2SRY (sex determining region Y)-box 2Source|GeneCards
FLJ45950FLJ45950FLJ45950 proteinSource|GeneCards
MAGED1MAGED1melanoma antigen, family D, 1Source|GeneCards
TP53BP1TP53BP1tumor protein p53 binding protein, 1Source|GeneCards
LSM6LSM6LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)Source|GeneCards
SYT6SYT6synaptotagmin VISource|GeneCards
FLJ33817FLJ33817hypothetical protein FLJ33817Source|GeneCards
HOXA10HOXA10homeo box A10Source|GeneCards
RPP21RPP21ribonuclease P 21kDa subunitSource|GeneCards
HOXD4HOXD4homeo box D4Source|GeneCards
SIN3ASIN3ASIN3 homolog A, transcriptional regulator (yeast)Source|GeneCards
TM9SF1TM9SF1transmembrane 9 superfamily member 1Source|GeneCards
DPYSL5DPYSL5dihydropyrimidinase-like 5Source|GeneCards
PDE6DPDE6Dphosphodiesterase 6D, cGMP-specific, rod, deltaSource|GeneCards
BNC2BNC2basonuclin 2Source|GeneCards
KIAA0256KIAA0256KIAA0256 gene productSource|GeneCards
NLGN3NLGN3neuroligin 3Source|GeneCards
CAMK2ACAMK2Acalcium/calmodulin-dependent protein kinase (CaM kinase) II alphaSource|GeneCards
LOC56965LOC56965hypothetical protein from EUROIMAGE 1977056Source|GeneCards
TDRD7TDRD7tudor domain containing 7Source|GeneCards
BTRCBTRCbeta-transducin repeat containingSource|GeneCards
FXYD6FXYD6FXYD domain containing ion transport regulator 6Source|GeneCards
DFNB31DFNB31deafness, autosomal recessive 31Source|GeneCards
PSMA2PSMA2proteasome (prosome, macropain) subunit, alpha type, 2Source|GeneCards
HS2ST1HS2ST1heparan sulfate 2-O-sulfotransferase 1Source|GeneCards
IRS2IRS2insulin receptor substrate 2Source|GeneCards
BCL2L2BCL2L2BCL2-like 2Source|GeneCards
BTBD3BTBD3BTB (POZ) domain containing 3Source|GeneCards
TBC1D16TBC1D16TBC1 domain family, member 16Source|GeneCards
SLC4A2SLC4A2solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)Source|GeneCards
EFNB3EFNB3ephrin-B3Source|GeneCards
NCOA5NCOA5nuclear receptor coactivator 5Source|GeneCards
DNAH9DNAH9dynein, axonemal, heavy polypeptide 9Source|GeneCards

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