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Gene set: V$EN1_01 (C3:TFAC:0204)
Standard nameV$EN1_01
Systematic nameC3:TFAC:0204
Brief descriptionGenes with 3'UTR containing motif GTANTNN which matches annotation for EN1: engrailed homolog 1
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA En-1
 XX
 SY Engrailed 1; Hu-en.1
(human); Gg-en.1 (chick); Mo-en.1.
 XX
 OS mouse, Mus musculus

OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda;
mammalia;
 OC eutheria; rodentia; myomorpha; muridae; murinae

XX
 XX
 HO En (Drosophila) 
 XX
 CL C0006;
homeo; 3.1.1.7.2.
 XX
 SZ 401 AA; 41.0 kDa (cDNA)
 XX

XX
 SC SwissProt #P09065
 XX
 FT 52 99 proline-rich region
(26/48).
 FT 207 228 alanine-rich region (21/22).
 FT 312
371 homeo domain.
 FT 312 374 SM00389; HOX.
 FT 313 369
PF00046; homeobox.
 XX
 SF tightly linked to Gbx-2 
[4]
 XX
 CP embryo: highest levels in posterior brain, low
in carcass, limbs, placenta,
 CP spinal cord, very low in yolk
sac [8] [5]
 CN anterior brain, face, viscera [8] [5]
 XX

FF required for normal development of mid- and hindbrain, mutations
cause
 FF lethal brain deletions [2];
 FF despite a different
expression pattern, En-2 may substitute for En1 when
 FF placed
under control of the En-1 promoter [1];
 XX
 XX
 XX

XX
 RN [1]; RE0005048.
 RX MEDLINE; 95350658.
 RA Hanks
M., Wurst W., Anson-Cartwright L., Auerbach A. B., Joyner A. L.

RT Rescue of the En-1 mutant phenotype by replacement of En-1
with En-2
 RL Science 269:679-682 (1995).
 RN [2]; RE0005498.

RX MEDLINE; 95009535.
 RA Wurst W., Auerbach A. B., Joyner
A. L.
 RT Multiple developmental defects in Engrailed-1 mutant
mice: an early
 RT mid-hindbrain deletion and patterning defects
in forelimbs and sternum
 RL Development 120:2065-2075 (1994).

RN [3]; RE0003871.
 RX MEDLINE; 93204981.
 RA Catron K.
M., Iller N., Abate C.
 RT Nucleotides flanking a conserved
TAAT core dictate the DNA binding
 RT specifity of three murine
homeodomain proteins
 RL Mol. Cell. Biol. 13:2354-2365 (1993).

RN [4]; RE0015359.
 RA Frohman M. A., Dickinson M. E., Hogan
B. L. M., Martin G. R.
 RT Mapping of Gbx-1 to mouse chromosome
5 and Gbx-2 to mouse chromosome 1
 RL Mouse Genome 91:323-325
(1993).
 RN [5]; RE0005045.
 RX MEDLINE; 93185339.
 RA
Logan C., Hanks M. C., Noble-Topham S., Nallainathan D., Provart
N. J.,
 RA Joyner A. L.
 RT Cloning and sequence comparison
of the mouse, human, and chicken engrailed
 RT genes reveal
potential functional domains and regulatory regions
 RL Develop.
Genet. 13:345-358 (1992).
 RN [6]; RE0005050.
 RX MEDLINE;
92266390.
 RA McMahon A. P., Joyner A. L., Bradley A., McMahon
J. A.
 RT The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1-
mice results from
 RT stepwise deletion of engrailed-expressing
cells by 9.5 days postcoitum
 RL Cell 69:581-595 (1992).

RN [7]; RE0005047.
 RX MEDLINE; 91099509.
 RA Holland P.
W. H., Williams N. A.
 RT Conservation of engrailed-like homeobox
sequences during vertebrate
 RT evolution
 RL FEBS Lett.
277:250-252 (1990).
 RN [8]; RE0005044.
 RX MEDLINE; 88112776.

RA Joyner A. L., Martin G. R.
 RT En-1 and En-2, two mouse
genes with sequence homology to the Drosophila
 RT engrailed
gene: expression during embryogenesis
 RL Genes Dev. 1:29-38
(1987).
 RN [9]; RE0005046.
 RX MEDLINE; 86079501.
 RA
Joyner L. A., Kornberg T., Coleman K. G., Cox D. R., Martin G.
R.
 RT Expression during embryogenesis of a mouse gene with
sequence homology to
 RT the Drosophila engrailed gene

RL Cell 43:29-37 (1985).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

114 genes, 114 accessions (Toggle view)

AccessionGeneTitleLinks
GREM1GREM1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)Source|GeneCards
DKFZP761I1011ATP13A4ATPase type 13A4Source|GeneCards
FHL1FHL1four and a half LIM domains 1Source|GeneCards
IRX4IRX4iroquois homeobox protein 4Source|GeneCards
RGS6RGS6regulator of G-protein signalling 6Source|GeneCards
CDX2CDX2caudal type homeo box transcription factor 2Source|GeneCards
GPC3GPC3glypican 3Source|GeneCards
BDNFBDNFbrain-derived neurotrophic factorSource|GeneCards
FLJ33651FLJ33651hypothetical protein FLJ33651Source|GeneCards
GPC4GPC4glypican 4Source|GeneCards
TFCP2L3GRHL2grainyhead-like 2 (Drosophila)Source|GeneCards
ERBB4ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)Source|GeneCards
IL1RAPL1IL1RAPL1interleukin 1 receptor accessory protein-like 1Source|GeneCards
DAFDAFdecay accelerating factor for complement (CD55, Cromer blood group system)Source|GeneCards
FLJ37266FLJ37266hypothetical protein FLJ37266Source|GeneCards
C5ORF6FAM53Cfamily with sequence similarity 53, member CSource|GeneCards
ARHGAP6ARHGAP6Rho GTPase activating protein 6Source|GeneCards
RBM4RBM4RNA binding motif protein 4Source|GeneCards
HOXA4HOXA4homeo box A4Source|GeneCards
PXMP3PXMP3peroxisomal membrane protein 3, 35kDa (Zellweger syndrome)Source|GeneCards
GAP43GAP43growth associated protein 43Source|GeneCards
LAKARL7ADP-ribosylation factor-like 7Source|GeneCards
UBE2HUBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)Source|GeneCards
SH3BGRL2SH3BGRL2SH3 domain binding glutamic acid-rich protein like 2Source|GeneCards
UTYUTYubiquitously transcribed tetratricopeptide repeat gene, Y-linkedSource|GeneCards
PAMCIPAMCIpeptidylglycine alpha-amidating monooxygenase COOH-terminal interactorSource|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
KIAA0140FAM53Bfamily with sequence similarity 53, member BSource|GeneCards
NEO1NEO1neogenin homolog 1 (chicken)Source|GeneCards
NXF1NXF1nuclear RNA export factor 1Source|GeneCards
MYOGMYOGmyogenin (myogenic factor 4)Source|GeneCards
RAPGEF5RAPGEF5Rap guanine nucleotide exchange factor (GEF) 5Source|GeneCards
TTC12TTC12tetratricopeptide repeat domain 12Source|GeneCards
FLJ46154FLJ46154FLJ46154 proteinSource|GeneCards
FIBCD1FIBCD1fibrinogen C domain containing 1Source|GeneCards
MORF4L2MORF4L2mortality factor 4 like 2Source|GeneCards
ZADH2ZADH2zinc binding alcohol dehydrogenase, domain containing 2Source|GeneCards
CLCCLCCharcot-Leyden crystal proteinSource|GeneCards
FLJ42957FLJ42957FLJ42957 proteinSource|GeneCards
RARBRARBretinoic acid receptor, betaSource|GeneCards
SIPA1L1SIPA1L1signal-induced proliferation-associated 1 like 1Source|GeneCards
HOXD3HOXD3homeo box D3Source|GeneCards
ELNELNelastin (supravalvular aortic stenosis, Williams-Beuren syndrome)Source|GeneCards
GNRH1GNRH1gonadotropin-releasing hormone 1 (leutinizing-releasing hormone)Source|GeneCards
LOC51136LOC51136PTD016 proteinSource|GeneCards
KIAA0555KIAA0555KIAA0555 gene productSource|GeneCards
SYNJ2BPSYNJ2BPsynaptojanin 2 binding proteinSource|GeneCards
A2BP1A2BP1ataxin 2-binding protein 1Source|GeneCards
TCF4TCF4Transcription factor 4Source|GeneCards
ANK2ANK2ankyrin 2, neuronalSource|GeneCards
HTR7HTR75-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)Source|GeneCards
BCORBCORBCL6 co-repressorSource|GeneCards
PAX6PAX6paired box gene 6 (aniridia, keratitis)Source|GeneCards
ATP9BATP9BATPase, Class II, type 9BSource|GeneCards
PDGFRAPDGFRAplatelet-derived growth factor receptor, alpha polypeptideSource|GeneCards
MAPK14MAPK14mitogen-activated protein kinase 14Source|GeneCards
HOXD10HOXD10homeo box D10Source|GeneCards
FGF17FGF17fibroblast growth factor 17Source|GeneCards
RAB2BRAB2BRAB2B, member RAS oncogene familySource|GeneCards
EFEMP1EFEMP1EGF-containing fibulin-like extracellular matrix protein 1Source|GeneCards
SLC6A9SLC6A9solute carrier family 6 (neurotransmitter transporter, glycine), member 9Source|GeneCards
NOTCH1NOTCH1Notch homolog 1, translocation-associated (Drosophila)Source|GeneCards
PDZK3PDZK3PDZ domain containing 3Source|GeneCards
FLJ20315FLJ20315hypothetical protein FLJ20315Source|GeneCards
RTKNRTKNrhotekinSource|GeneCards
NPR3NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)Source|GeneCards
ARGBP2SORBS2sorbin and SH3 domain containing 2Source|GeneCards
RBM21RBM21RNA binding motif protein 21Source|GeneCards
CAMLGCAMLGcalcium modulating ligandSource|GeneCards
ZNF537ZNF537zinc finger protein 537Source|GeneCards
HOXC11HOXC11homeo box C11Source|GeneCards
ODDGJA1gap junction protein, alpha 1, 43kDa (connexin 43)Source|GeneCards
ISL1ISL1ISL1 transcription factor, LIM/homeodomain, (islet-1)Source|GeneCards
SATSATspermidine/spermine N1-acetyltransferaseSource|GeneCards
NRASNRASneuroblastoma RAS viral (v-ras) oncogene homologSource|GeneCards
AF5Q31AFF4AF4/FMR2 family, member 4Source|GeneCards
TFEBTFEBtranscription factor EBSource|GeneCards
RPL38RPL38ribosomal protein L38Source|GeneCards
NKX2-2NKX2-2NK2 transcription factor related, locus 2 (Drosophila)Source|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
MAP3K5MAP3K5mitogen-activated protein kinase kinase kinase 5Source|GeneCards
RALPRALPrai-like proteinSource|GeneCards
CDC14ACDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
MITFMITFmicrophthalmia-associated transcription factorSource|GeneCards
CREMCREMcAMP responsive element modulatorSource|GeneCards
EOMESEOMESeomesodermin homolog (Xenopus laevis)Source|GeneCards
NOS1NOS1nitric oxide synthase 1 (neuronal)Source|GeneCards
MMP14MMP14matrix metalloproteinase 14 (membrane-inserted)Source|GeneCards
RDH10RDH10retinol dehydrogenase 10 (all-trans)Source|GeneCards
PCDH9PCDH9protocadherin 9Source|GeneCards
SFRS12SFRS12splicing factor, arginine/serine-rich 12Source|GeneCards
CDV-1CDV-1carnitine deficiency-associated gene expressed in ventricle 1Source|GeneCards
EYA4EYA4eyes absent homolog 4 (Drosophila)Source|GeneCards
NRG1NRG1neuregulin 1Source|GeneCards
FNDC3FNDC3Afibronectin type III domain containing 3ASource|GeneCards
LMO1LMO1LIM domain only 1 (rhombotin 1)Source|GeneCards
C19ORF4C19ORF4chromosome 19 open reading frame 4Source|GeneCards
OTPOTPorthopedia homolog (Drosophila)Source|GeneCards
SLC6A14SLC6A14solute carrier family 6 (neurotransmitter transporter), member 14Source|GeneCards
GRIA1GRIA1glutamate receptor, ionotropic, AMPA 1Source|GeneCards
MAP4K4MAP4K4mitogen-activated protein kinase kinase kinase kinase 4Source|GeneCards
LAPTM4BLAPTM4Blysosomal associated protein transmembrane 4 betaSource|GeneCards
HSPC148HSPC148hypothetical protein HSPC148Source|GeneCards
UTXUTXubiquitously transcribed tetratricopeptide repeat gene, X chromosomeSource|GeneCards
KLF15KLF15Kruppel-like factor 15Source|GeneCards
HOXB8HOXB8homeo box B8Source|GeneCards
OTX2OTX2orthodenticle homolog 2 (Drosophila)Source|GeneCards
SAV1SAV1salvador homolog 1 (Drosophila)Source|GeneCards
CTCFCTCFCCCTC-binding factor (zinc finger protein)Source|GeneCards
JMJD2DJMJD2Djumonji domain containing 2DSource|GeneCards
NR4A3NR4A3nuclear receptor subfamily 4, group A, member 3Source|GeneCards
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)Source|GeneCards
FOXP2FOXP2forkhead box P2Source|GeneCards
RNF39RNF39ring finger protein 39Source|GeneCards

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