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Gene set: V$FREAC4_01 (C3:TFAC:0182)
Standard nameV$FREAC4_01
Systematic nameC3:TFAC:0182
Brief descriptionGenes with 3'UTR containing motif CTWAWGTAAACANWGN which matches annotation for FOXD1: forkhead box D1
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA FOXD1
 XX
 SY Forkhead RElated ACtivator-4;
FKHL8; FREAC4.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 CL C0023; fork head.

XX
 SZ 465 AA; 46.1 kDa (cDNA)
 XX
 XX
 SC SwissProt
#Q16676
 XX
 FT 24 38 acidic region (14/15).
 FT 51 57
arginine-rich region (7/7).
 FT 62 76 acidic region (13/15).

FT 97 118 glycine-rich region (16/22).
 FT 123 213 SM00339;
FH.
 FT 125 222 fork head domain [1].
 FT 125 220 PF00250;
Fork_head.
 FT 231 434 alanine-/proline-rich region (99/204).

XX
 SF gene is loacated on chromosome 5q12-q13 [3]
 XX

CP (fetal) kidney (highest expression); (adult) kidney, testis,
cells of the
 CP monocyte lineage [4]
 CN (fetal) heart,
brain, lung, liver; (adult) heart, brain, placenta, lung,

CN liver, skeletal muscle, pancreas, spleen, thymus, prostate,
ovary, small
 CN intestine, colon, blood leukocytes
 XX

FF binding of Freac-4/GST fusion protein to recognition sites
induced bending
 FF of the DNA at an angle of 80-90 degrees
[4];
 FF WT-1  and p53 are potential regulators of
Freac-4 expression [2];
 XX
 XX
 XX
 XX
 RN [1];
RE0006655.
 RA TRANSFAC_Team.
 RT Revisions of transcription
factor domains
 RL TRANSFAC Reports 1:0002 (1998).
 RN [2];
RE0006885.
 RX MEDLINE; 96355467.
 RA Ernstsson S., Pierrou
S., Hulander M., Cederberg A., Hellqvist M., Carlsson
 RA P.,
Enerbaeck S.
 RT Characterization of the human forkhead gene
FREAC-4. Evidence for
 RT regulation by Wilms' tumor supressor
gene (WT-1) and p53
 RL J. Biol. Chem. 271:21094-21099 (1996).

RN [3]; RE0006884.
 RX MEDLINE; 96423031.
 RA Larsson C.,
Hellqvist M., Pierrou S., White I., Enerbaeck S., Carlsson P.

RT Chromosomal localization of six human forkhead genes, freac-1(FKHL5),
-3
 RT (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8
(FKHL12)
 RL Genomics 30:464-469 (1995).
 RN [4]; RE0006883.

RX MEDLINE; 95045392.
 RA Pierrou S., Hellqvist M., Samuelsson
L., Enerbaeck S., Carlsson P.
 RT Cloning and characterization
of seven human forkhead proteins: binding site
 RT specificity
and DNA bending
 RL EMBO J. 13:5002-5012 (1994).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

155 genes, 155 accessions (Toggle view)

AccessionGeneTitleLinks
LMO4LMO4LIM domain only 4Source|GeneCards
LOC283807FBXL22F-box and leucine-rich repeat protein 22Source|GeneCards
ZNF533ZNF533Zinc finger protein 533Source|GeneCards
TBX4TBX4T-box 4Source|GeneCards
ODZ1ODZ1odz, odd Oz/ten-m homolog 1(Drosophila)Source|GeneCards
FOXD3FOXD3forkhead box D3Source|GeneCards
ULK1ULK1unc-51-like kinase 1 (C. elegans)Source|GeneCards
CYLN2CYLN2cytoplasmic linker 2Source|GeneCards
FLJ13725FAM65Afamily with sequence similarity 65, member ASource|GeneCards
KBTBD10KBTBD10kelch repeat and BTB (POZ) domain containing 10Source|GeneCards
TLE3TLE3transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)Source|GeneCards
FLJ32112C1ORF83chromosome 1 open reading frame 83Source|GeneCards
LMO3LMO3LIM domain only 3 (rhombotin-like 2)Source|GeneCards
CXORF23CXORF23Chromosome X open reading frame 23Source|GeneCards
GPP34RGOLPH3Lgolgi phosphoprotein 3-likeSource|GeneCards
SHOX2SHOX2short stature homeobox 2Source|GeneCards
PPP2R3APPP2R3Aprotein phosphatase 2 (formerly 2A), regulatory subunit B'', alphaSource|GeneCards
FLJ22494NUDT18nudix (nucleoside diphosphate linked moiety X)-type motif 18Source|GeneCards
PITX2PITX2paired-like homeodomain transcription factor 2Source|GeneCards
ETHE1ETHE1ethylmalonic encephalopathy 1Source|GeneCards
FIBL-6FIBL-6hemicentinSource|GeneCards
UBE2HUBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)Source|GeneCards
SNX13SNX13sorting nexin 13Source|GeneCards
NEDD4NEDD4neural precursor cell expressed, developmentally down-regulated 4Source|GeneCards
KCNJ13KCNJ13potassium inwardly-rectifying channel, subfamily J, member 13Source|GeneCards
C7ORF33C7ORF33chromosome 7 open reading frame 33Source|GeneCards
SLC31A1SLC31A1solute carrier family 31 (copper transporters), member 1Source|GeneCards
ERGERGv-ets erythroblastosis virus E26 oncogene like (avian)Source|GeneCards
ID2ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinSource|GeneCards
KCNQ5KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5Source|GeneCards
MSCMSCmusculin (activated B-cell factor-1)Source|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
KIAA0140FAM53Bfamily with sequence similarity 53, member BSource|GeneCards
PKD1-LIKEPKD1-LIKEpolycystic kidney disease 1-likeSource|GeneCards
TM4SF3TM4SF3transmembrane 4 superfamily member 3Source|GeneCards
UBXD3UBXD3UBX domain containing 3Source|GeneCards
PDCD1LG2PDCD1LG2programmed cell death 1 ligand 2Source|GeneCards
RNPC2RNPC2RNA-binding region (RNP1, RRM) containing 2Source|GeneCards
OTOP3OTOP3otopetrin 3Source|GeneCards
ROR1ROR1receptor tyrosine kinase-like orphan receptor 1Source|GeneCards
EYA1EYA1eyes absent homolog 1 (Drosophila)Source|GeneCards
PRPS1L1PRPS1L1phosphoribosyl pyrophosphate synthetase 1-like 1Source|GeneCards
FLJ14816FLJ14816hypothetical protein FLJ14816Source|GeneCards
FLJ20032FLJ20032hypothetical protein FLJ20032Source|GeneCards
ALDH1A2ALDH1A2aldehyde dehydrogenase 1 family, member A2Source|GeneCards
ZADH2ZADH2zinc binding alcohol dehydrogenase, domain containing 2Source|GeneCards
SPRY4SPRY4sprouty homolog 4 (Drosophila)Source|GeneCards
TAF5LTAF5LTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDaSource|GeneCards
NR4A1NR4A1nuclear receptor subfamily 4, group A, member 1Source|GeneCards
GABRR1GABRR1gamma-aminobutyric acid (GABA) receptor, rho 1Source|GeneCards
EVX1EVX1eve, even-skipped homeo box homolog 1 (Drosophila)Source|GeneCards
LOC126147LOC126147hypothetical protein BC018697Source|GeneCards
FLJ45187FLJ45187FLJ45187 proteinSource|GeneCards
TNMDTNMDtenomodulin proteinSource|GeneCards
ZFXZFXzinc finger protein, X-linkedSource|GeneCards
ADAMTS13ADAMTS13a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13Source|GeneCards
COLEC12COLEC12collectin sub-family member 12Source|GeneCards
CAMK1DCAMK1Dcalcium/calmodulin-dependent protein kinase IDSource|GeneCards
IBSPIBSPintegrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)Source|GeneCards
13CDNA7313CDNA73hypothetical protein CG003Source|GeneCards
INHBAINHBAinhibin, beta A (activin A, activin AB alpha polypeptide)Source|GeneCards
TLX1TLX1T-cell leukemia, homeobox 1Source|GeneCards
C6ORF188C6ORF188chromosome 6 open reading frame 188Source|GeneCards
DGKIDGKIdiacylglycerol kinase, iotaSource|GeneCards
CLDN18CLDN18claudin 18Source|GeneCards
EMP1EMP1epithelial membrane protein 1Source|GeneCards
MYH2MYH2myosin, heavy polypeptide 2, skeletal muscle, adultSource|GeneCards
RARGRARGretinoic acid receptor, gammaSource|GeneCards
IGSF4IGSF4immunoglobulin superfamily, member 4Source|GeneCards
PDE7APDE7Aphosphodiesterase 7ASource|GeneCards
MLC1SAMLC1SAmyosin light chain 1 slow aSource|GeneCards
OTX1OTX1orthodenticle homolog 1 (Drosophila)Source|GeneCards
PELI2PELI2pellino homolog 2 (Drosophila)Source|GeneCards
SCML1SCML1sex comb on midleg-like 1 (Drosophila)Source|GeneCards
LOC375449LOC375449similar to microtubule associated testis specific serine/threonine protein kinaseSource|GeneCards
FOXB1FOXB1forkhead box B1Source|GeneCards
USP34USP34ubiquitin specific protease 34Source|GeneCards
SEMA5BSEMA5Bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5BSource|GeneCards
MCCMCCmutated in colorectal cancersSource|GeneCards
PURAPURApurine-rich element binding protein ASource|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
SH3MD2SH3MD2SH3 multiple domains 2Source|GeneCards
POU3F3POU3F3POU domain, class 3, transcription factor 3Source|GeneCards
NNATNNATneuronatinSource|GeneCards
TECTATECTAtectorin alphaSource|GeneCards
NCDNNCDNneurochondrinSource|GeneCards
NDPNDPNorrie disease (pseudoglioma)Source|GeneCards
TAFA1TAFA1TAFA1 proteinSource|GeneCards
C1ORF8TMEM59transmembrane protein 59Source|GeneCards
OSR2OSR2odd-skipped-related 2A proteinSource|GeneCards
HOXD9HOXD9homeo box D9Source|GeneCards
KIAA0779TMCC1transmembrane and coiled-coil domain family 1Source|GeneCards
LOXLOXlysyl oxidaseSource|GeneCards
VITVITvitrinSource|GeneCards
ZNFN1A2ZNFN1A2zinc finger protein, subfamily 1A, 2 (Helios)Source|GeneCards
FERD3LFERD3LFer3-like (Drosophila)Source|GeneCards
AP1G2AP1G2adaptor-related protein complex 1, gamma 2 subunitSource|GeneCards
NAALADL2NAALADL2N-acetylated alpha-linked acidic dipeptidase 2Source|GeneCards
TCF1TCF1Transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factorSource|GeneCards
CALD1CALD1caldesmon 1Source|GeneCards
NICE-1C1ORF42chromosome 1 open reading frame 42Source|GeneCards
TGFB3TGFB3transforming growth factor, beta 3Source|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
TCF7L2TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
IGF1IGF1insulin-like growth factor 1 (somatomedin C)Source|GeneCards
PLEKHE1PLEKHE1pleckstrin homology domain containing, family E (with leucine rich repeats) member 1Source|GeneCards
PNRC1PNRC1proline-rich nuclear receptor coactivator 1Source|GeneCards
FLJ30296PTCHD1Patched domain containing 1Source|GeneCards
HSPG2HSPG2heparan sulfate proteoglycan 2 (perlecan)Source|GeneCards
GFRA1GFRA1GDNF family receptor alpha 1Source|GeneCards
MGC2629ZBTB37zinc finger and BTB domain containing 37Source|GeneCards
SYT10SYT10synaptotagmin 10Source|GeneCards
TMOD3TMOD3tropomodulin 3 (ubiquitous)Source|GeneCards
NIFIE14NIFIE14seven transmembrane domain proteinSource|GeneCards
CITED2CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2Source|GeneCards
SLC24A2SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 2Source|GeneCards
FGF9FGF9fibroblast growth factor 9 (glia-activating factor)Source|GeneCards
MGC29875C1ORF107chromosome 1 open reading frame 107Source|GeneCards
HRHRhairless homolog (mouse)Source|GeneCards
TARSHABI3BPABI gene family, member 3 (NESH) binding proteinSource|GeneCards
ZC3HDC6ZC3H6zinc finger CCCH-type containing 6Source|GeneCards
PHTF2PHTF2putative homeodomain transcription factor 2Source|GeneCards
HEPHHEPHhephaestinSource|GeneCards
TRPS1TRPS1trichorhinophalangeal syndrome ISource|GeneCards
MGC46534ATXN7L2ataxin 7-like 2Source|GeneCards
SIN3ASIN3ASIN3 homolog A, transcriptional regulator (yeast)Source|GeneCards
PRDM1PRDM1PR domain containing 1, with ZNF domainSource|GeneCards
ADRB1ADRB1adrenergic, beta-1-, receptorSource|GeneCards
LOC114990LOC114990hypothetical protein BC013767Source|GeneCards
PHEXPHEXphosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets)Source|GeneCards
DUSP1DUSP1dual specificity phosphatase 1Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
PLS3PLS3plastin 3 (T isoform)Source|GeneCards
KLF12KLF12Kruppel-like factor 12Source|GeneCards
R-SPONDINR-SPONDINR-spondin homolog (Xenopus laevis)Source|GeneCards
PDZRN4PDZRN4PDZ domain containing RING finger 4Source|GeneCards
CD109CD109CD109 antigen (Gov platelet alloantigens)Source|GeneCards
LEF1LEF1lymphoid enhancer-binding factor 1Source|GeneCards
BTBD8BTBD8BTB (POZ) domain containing 8Source|GeneCards
BRAFBRAFv-raf murine sarcoma viral oncogene homolog B1Source|GeneCards
CTCFCTCFCCCTC-binding factor (zinc finger protein)Source|GeneCards
PLUNCPLUNCpalate, lung and nasal epithelium carcinoma associatedSource|GeneCards
IER5IER5immediate early response 5Source|GeneCards
PTHR1PTHR1parathyroid hormone receptor 1Source|GeneCards
MBNL2MBNL2muscleblind-like 2 (Drosophila)Source|GeneCards
HS3ST4HS3ST4heparan sulfate (glucosamine) 3-O-sulfotransferase 4Source|GeneCards
PUM2PUM2pumilio homolog 2 (Drosophila)Source|GeneCards
FOXP2FOXP2forkhead box P2Source|GeneCards
KBTBD2KBTBD2kelch repeat and BTB (POZ) domain containing 2Source|GeneCards
PER2PER2period homolog 2 (Drosophila)Source|GeneCards
BTBD3BTBD3BTB (POZ) domain containing 3Source|GeneCards
PTAFRPTAFRplatelet-activating factor receptorSource|GeneCards
CDKN1ACDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Source|GeneCards
FLJ39827FLJ39827hypothetical protein FLJ39827Source|GeneCards
SLC34A3SLC34A3solute carrier family 34 (sodium phosphate), member 3Source|GeneCards

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