XX
XX
XX
FA GCNF-1
XX
SY NR6A1; RTR; NCNF;
GCNF; GCN; NCN; germ cell nuclear factor; retinoid acid
SY
receptor-related testis-associated receptor; neuronal cell nuclear
SY receptor; hGCNF; orphan nuclear receptor GCNF.
XX
OS
human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
OC eutheria; primates
XX
XX
CL C0002; CC (rec).
XX
SZ 476 AA; 54.0 kDa
(cDNA)
XX
XX
SC translated from EMBL #S83309
XX
FT 48 48 replaced with 48-52 (ISVSD) in isoform GNCF-2 .
FT 53 124 SM00399; ZnF_C4.
FT 54 129 PF00105; zf-C4.
FT
56 76 zinc finger 1 (C-X2-C-X13-C-X2-C).
FT 56 121 putative
DNA-binding domain [2].
FT 92 111 zinc finger 2 (C-X5-C-X9-C-X2-C).
FT 242 476 putative ligand-binding domain [3].
FT 253 259
helical region H1.
FT 264 270 helical region H2.
FT 279
298 helical region H3.
FT 285 447 SM00430; HOLI.
FT 288
466 PF00104; hormone_rec.
FT 309 319 helical region H4.
FT 320 331 helical region H5.
FT 352 357 helical region H6.
FT 362 375 helical region H7.
FT 380 393 helical region H8.
FT 405 425 helical region H9.
FT 429 450 helical region H10.
FT 429 449 putative dimerization interface in ligand-binding domain
[2].
FT 455 461 helical region H11.
FT 462 474 helical
region H12.
XX
CP (adult:) strong in testis [1] [2]; in
situ: in seminiferous tubules
CP restricted to spermatogenic
cells, appears strongest in late spermatocytes
CP [4]
CN heart, brain, placenta, lung, liver, skeletal muscle, kidney,
pancreas,
CN spleen, thymus, prostate, ovary, small intestine,
colon, peripheral blood
CN leucocytes [1]
EX adrenal cortex,,,adult;none;
northern blot; mRNA (poly-A); [2].
EX adrenal medulla,,,adult;none;
northern blot; mRNA (poly-A); [2].
EX blood,basophil granulocyte,Circulatory
System & Hematopoietic
EX System,adult;none; northern blot;
RNA (undefined); [1].
EX blood,eosinophil granulocyte,Circulatory
System & Hematopoietic
EX System,adult;none; northern blot;
RNA (undefined); [1].
EX blood,lymphocyte,Circulatory System
& Hematopoietic System,adult;none;
EX northern blot; RNA (undefined);
[1].
EX blood,monocyte,Circulatory System & Hematopoietic
System,adult;none;
EX northern blot; RNA (undefined); [1].
EX blood,neutrophil granulocyte,Circulatory System & Hematopoietic
EX System,adult;none; northern blot; RNA (undefined); [1].
EX brain,,,adult;none; northern blot; RNA (undefined); [1].
EX colon,,,adult;none; northern blot; RNA (undefined); [1].
EX heart,,,adult;none; northern blot; RNA (undefined); [1].
EX kidney (right and left),,,adult;none; northern blot; RNA (undefined);
[1].
EX liver,,,adult;none; northern blot; RNA (undefined);
[1].
EX lung (right and left),,,adult;none; northern blot;
RNA (undefined); [1].
EX muscles,,,adult;none; northern blot;
RNA (undefined); [1].
EX ovary (right and left),,,adult;none;
northern blot; RNA (undefined); [1].
EX pancreas,,,adult;none;
northern blot; RNA (undefined); [1].
EX pancreas,,,adult;none;
northern blot; mRNA (poly-A); [2].
EX placenta,,,adult;none;
northern blot; RNA (undefined); [1].
EX prostate gland,,,adult;none;
northern blot; RNA (undefined); [1].
EX small intestine,,,adult;none;
northern blot; RNA (undefined); [1].
EX small intestine,,,adult;none;
northern blot; mRNA (poly-A); [2].
EX spleen,,,adult;none;
northern blot; RNA (undefined); [1].
EX stomach,,,adult;none;
northern blot; mRNA (poly-A); [2].
EX testis (right and left),,,adult;detectable;
northern blot; RNA (undefined);
EX [1].
EX testis (right
and left),,,adult;high; northern blot; mRNA (poly-A); [2].
EX thymus,,,adult;none; northern blot; RNA (undefined); [1].
EX thymus,,,adult;none; northern blot; mRNA (poly-A); [2].
EX thyroid gland,,,adult;low; northern blot; mRNA (poly-A); [2].
XX
XX
XX
XX
RN [1]; RE0015992.
RX MEDLINE;
97320626.
RA Kapelle M., Kratzschmar J., Husemann M., Schleuning
W. D.
RT cDNA cloning of two closely related forms of human
germ cell nuclear factor
RT (GCNF)
RL Biochem. Biophys.
Acta 1352:13-17 (1997).
RN [2]; RE0015995.
RX MEDLINE;
97136874.
RA Suesens U., Borgmeyer U.
RT Characterization
of the human germ cell nuclear factor gene
RL Biochem. Biophys.
Acta 1309:179-182 (1996).
RN [3]; RE0016011.
RX MEDLINE;
99078006.
RA Greschik H., Wurtz J. M., Hublitz P., Kohler
F., Moras D., Schule R.
RT Characterization of the DNA-binding
and dimerization properties of the
RT nuclear orphan receptor
germ cell nuclear factor
RL Mol. Cell. Biol. 19:690-703 (1999).
RN [4]; RE0015993.
RX MEDLINE; 98196867.
RA Agoulnik I.
Y., Cho Y., Niederberger C., Kieback D. G., Cooney A. J.
RT
Cloning, expression analysis and chromosomal localization of the
human
RT nuclear receptor gene GCNF
RL FEBS Lett. 424:73-78
(1998).
XX