XX
XX
XX
FA Hmx3
XX
SY H6 homeobox 3; NKX5-1;
Nkx-5.1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia;
metazoa; chordata; vertebrata; tetrapoda; mammalia;
OC eutheria;
rodentia; myomorpha; muridae; murinae
XX
XX
CL C0006;
homeo.
XX
SZ 458 AA; 49.2 kDa (cDNA)
XX
XX
SC translated from EMBL #X75330
XX
FT 329 388 homeo domain.
FT 329 391 SM00389; HOX.
FT 330 386 PF00046; homeobox.
FT 421 427 alanine-rich region (6/7).
XX
SF 92% amino
acid identity to the homeo domain of Hmx2 [2];
SF
Hmx3 and Hmx2 are clustered on chromosome 7 [2];
SF Hmx3 and Hmx2 have overlapping spatial expression
patterns but the
SF onset of Hmx3 transcription begins much
earlier [1];
SF represents an early and probably the earliest
marker for inner ear
SF development [1];
SF Hmx3 -/- mice
hava a diminished postnatal viability, show circling
SF behavior,
inner ear defects and reproductive defects (perturbed embryo
SF implantation) and altered Wnt expression [4];
SF glutamine
residue at position 50 (Gln50) of the homeo domain is responsible
SF for binding a CAAG core instead of the common TAAT core [3];
SF a 3' flanking TG dinucleotide contributes to an optimal DNA
binding [3];
SF Titf1 and Nkx2-5 (both with
Gln50) have the same CAAGTG
SF binding consensus [3];
XX
CP uterus [4]
EX brain,,,Theiler Stage 17;medium; RNAse
protection assay; RNA (undefined);
EX [2].
EX brain,,,Theiler
Stage 21;very high; RNAse protection assay; RNA
EX (undefined);
[2].
EX brain,,,Theiler Stage 24;high; RNAse protection assay;
RNA (undefined);
EX [2].
EX brain,,,Theiler Stage 26;medium;
RNAse protection assay; RNA (undefined);
EX [2].
EX brain,,,Theiler
Stage 28;medium; RNAse protection assay; RNA (undefined);
EX [2].
EX brain,,,adult;none; RNAse protection assay; RNA
(undefined); [2].
EX cochlea,,,Theiler Stage 22;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [2].
EX diencephalon,,,Theiler Stage 19;high;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [2].
EX dorsal root ganglion,,,Theiler Stage
17;high; RNA-in situ hybridization
EX (not further specified);
RNA (undefined); [2].
EX dorsal root ganglion,,,Theiler Stage
19;medium; RNA-in situ hybridization
EX (not further specified);
RNA (undefined); [2].
EX ear,,,Theiler Stage 19;high; RNA-in
situ hybridization (not further
EX specified); RNA (undefined);
[2].
EX eye and related structures (right and left),,,Theiler
Stage 19;medium;
EX RNA-in situ hybridization (not further
specified); RNA (undefined); [2].
EX facio-acoustic complex
[VII VIII],,,Theiler Stage 19;detectable; RNA-in
EX situ hybridization
(not further specified); RNA (undefined); [2].
EX first pharyngeal
arch,,,Theiler Stage 19;detectable; RNA-in situ
EX hybridization
(not further specified); RNA (undefined); [2].
EX fourth pharyngeal
arch,,,Theiler Stage 19;detectable; RNA-in situ
EX hybridization
(not further specified); RNA (undefined); [2].
EX head mesenchyme,,,Theiler
Stage 19;medium; RNA-in situ hybridization (not
EX further
specified); RNA (undefined); [2].
EX hypothalamus,,,Theiler
Stage 22;high; RNA-in situ hybridization (not
EX further specified);
RNA (undefined); [2].
EX hypothalamus,,,Theiler Stage 23;high;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [2].
EX internal ear,,,Theiler Stage 23;detectable;
RNA-in situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX intramural ganglia of stomach,,,Theiler Stage 22;detectable;
RNA-in situ
EX hybridization (not further specified); RNA
(undefined); [2].
EX intramural ganglia of the oesophagus,,,Theiler
Stage 22;detectable; RNA-in
EX situ hybridization (not further
specified); RNA (undefined); [2].
EX mammillary area,,,Theiler
Stage 23;detectable; RNA-in situ hybridization
EX (non-radioactive);
RNA (undefined); [1].
EX mammillary area,,,Theiler Stage 24;detectable;
RNA-in situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX mesencephalon,,,Theiler Stage 19;high; RNA-in situ
hybridization (not
EX further specified); RNA (undefined);
[2].
EX mesencephalon,,,Theiler Stage 22;detectable; RNA-in
situ hybridization (not
EX further specified); RNA (undefined);
[2].
EX mesencephalon,,,Theiler Stage 23;detectable; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX mesencephalon,,,Theiler Stage 23;detectable; RNA-in
situ hybridization (not
EX further specified); RNA (undefined);
[2].
EX mesencephalon,,,Theiler Stage 24;detectable; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX mouse, Mus musculus,,,Theiler Stage 12;none; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX myelencephalon,,,Theiler Stage 19;detectable; RNA-in
situ hybridization
EX (not further specified); RNA (undefined);
[2].
EX myelencephalon,,,Theiler Stage 23;detectable; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX myelencephalon,,,Theiler Stage 23;detectable; RNA-in
situ hybridization
EX (not further specified); RNA (undefined);
[2].
EX neural crest of otocyst,,,Theiler Stage 14;low; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX neural crest of otocyst,,,Theiler Stage 15;high; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX neural crest of otocyst,,,Theiler Stage 17;detectable;
RNA-in situ
EX hybridization (non-radioactive); RNA (undefined);
[1].
EX neural crest of otocyst,,,Theiler Stage 17;detectable;
RNA-in situ
EX hybridization (not further specified); RNA
(undefined); [2].
EX neural crest of otocyst,,,Theiler Stage
18;detectable; RNA-in situ
EX hybridization (non-radioactive);
RNA (undefined); [1].
EX neural crest of otocyst,,,Theiler
Stage 19;detectable; RNA-in situ
EX hybridization (non-radioactive);
RNA (undefined); [1].
EX neural retinal epithelium,,,Theiler
Stage 19;low; RNA-in situ hybridization
EX (not further specified);
RNA (undefined); [2].
EX neural tube,,,Theiler Stage 19;medium;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [2].
EX optic cup,,,Theiler Stage 17;low; RNA-in
situ hybridization (not further
EX specified); RNA (undefined);
[2].
EX optic cup,,,Theiler Stage 19;detectable; RNA-in situ
hybridization (not
EX further specified); RNA (undefined);
[2].
EX otic placode,,,Theiler Stage 13;detectable; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX pharyngeal arches,,,Theiler Stage 13;detectable; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX pharyngeal arches,,,Theiler Stage 18;detectable; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX pharyngeal cleft of first pharyngeal arch,,,Theiler
Stage 14;high; RNA-in
EX situ hybridization (non-radioactive);
RNA (undefined); [1].
EX pons,,,Theiler Stage 22;detectable;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [2].
EX pons,,,Theiler Stage 23;detectable; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX pons,,,Theiler Stage 23;detectable; RNA-in situ hybridization
(not further
EX specified); RNA (undefined); [2].
EX pons,,,Theiler
Stage 24;detectable; RNA-in situ hybridization
EX (non-radioactive);
RNA (undefined); [1].
EX preoptic area,,,Theiler Stage 23;detectable;
RNA-in situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX preoptic area,,,Theiler Stage 24;detectable; RNA-in
situ hybridization
EX (non-radioactive); RNA (undefined);
[1].
EX second pharyngeal arch,,,Theiler Stage 19;detectable;
RNA-in situ
EX hybridization (not further specified); RNA
(undefined); [2].
EX spinal cord,,,Theiler Stage 17;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [2].
EX subthalamus,,,Theiler Stage 22;high;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [2].
EX subthalamus,,,Theiler Stage 23;high;
RNA-in situ hybridization (not further
EX specified); RNA
(undefined); [2].
EX third pharyngeal arch,,,Theiler Stage
19;detectable; RNA-in situ
EX hybridization (not further specified);
RNA (undefined); [2].
EX tongue,,,Theiler Stage 22;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [2].
EX tongue,,,Theiler Stage 23;detectable;
RNA-in situ hybridization (not
EX further specified); RNA
(undefined); [2].
EX trigeminal ganglion [V],,,Theiler Stage
19;detectable; RNA-in situ
EX hybridization (not further specified);
RNA (undefined); [2].
EX trigeminal ganglion [V],,,Theiler
Stage 23;detectable; RNA-in situ
EX hybridization (not further
specified); RNA (undefined); [2].
EX wall of atrium,,,Theiler
Stage 22;detectable; RNA-in situ hybridization
EX (not further
specified); RNA (undefined); [2].
XX
FF probably involved
in cell type specification of neuronal cells [2] [1];
FF involved
in development of the inner ear [2];
FF important role in
vestibular sensory organ development and maternal
FF reproduction
[4];
XX
XX
XX
XX
RN [1]; RE0016066.
RX
MEDLINE; 96081377.
RA Rinkwitz-Brandt S., Justus M., Oldenettel
I., Arnold H. H., Bober E.
RT Distinct temporal expression
of mouse Nkx-5.1 and Nkx-5.2 homeobox genes
RT during brain
and ear development
RL Mech. Dev. 52:371-381 (1995).
RN
[2]; RE0016077.
RX MEDLINE; 94170918.
RA Bober E., Baum
C., Braun T., Arnold H. H.
RT A novel NK-related mouse homeobox
gene: expression in central and
RT peripheral nervous structures
during embryonic development
RL Dev. Biol. 162:288-303 (1994).
RN [3]; RE0016078.
RX MEDLINE; 99223479.
RA Amendt B.
A., Sutherland L. B., Russo A. F.
RT Transcriptional antagonism
between Hmx1 and Nkx2.5 for a shared DNA-binding
RT site
RL J. Biol. Chem. 274:11635-11642 (1999).
RN [4]; RE0016068.
RX MEDLINE; 98167889.
RA Wang W., Van De Water T., Lufkin
T.
RT Inner ear and maternal reproductive defects in mice
lacking the Hmx3
RT homeobox gene
RL Development 125:621-634
(1998).
XX