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Gene set: V$HNF3B_01 (C3:TFAC:0081)
Standard nameV$HNF3B_01
Systematic nameC3:TFAC:0081
Brief descriptionGenes with 3'UTR containing motif KGNANTRTTTRYTTW which matches annotation for FOXA2: forkhead box A2
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA HNF-3B
 XX
 SY HNF3B; HNF3beta.

XX
 OS rat, Rattus norvegicus
 OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria; rodentia;
myomorpha; muridae; murinae
 XX
 CL C0023; fork head; 3.3.2.0.2.

XX
 SZ 458 AA; 48.5 kDa (cDNA), 46 kDa (SDS)
 XX
 XX

SC SwissProt #P32182
 XX
 FT 14 93 transcriptional activation
domain, contains two putative CKI
 FT phosphorylation sites
[3].
 FT 157 255 fork head domain [1].
 FT 157 257 DNA-binding
domain, contains NLS (nuclear localization signal).
 FT 157
246 SM00339; FH.
 FT 159 253 PF00250; Fork_head.
 FT 186
205 contributes to DNA binding specificity.
 FT 372 458 primary
transcription activation domain.
 XX
 CP liver (intestine,
lung, stomach, ovary)
 XX
 FF involved in regulation of
liver and intestinal gene expression [2]
 XX
 XX
 XX

XX
 RN [1]; RE0006655.
 RA TRANSFAC_Team.
 RT Revisions
of transcription factor domains
 RL TRANSFAC Reports 1:0002
(1998).
 RN [2]; RE0014471.
 RX MEDLINE; 97042457.
 RA
Samadani U., Costa R. H.
 RT The transcriptional activator
hepatocyte nuclear factor 6 regulates liver
 RT gene expression

RL Mol. Cell. Biol. 16:6273-6284 (1996).
 RN [3]; RE0006536.

RX MEDLINE; 95258327.
 RA Qian X., Costa R. H.
 RT Analysis
of hepatocyte nuclear factor-3beta protein domains required for

RT transcriptional activation and nuclear targeting
 RL Nucleic
Acids Res. 23:1184-1191 (1995).
 RN [4]; RE0003012.
 RX
MEDLINE; 94187745.
 RA Overdier D. G., Porcella A., Costa R.
H.
 RT The DNA-binding specificity of the hepatocyte nuclear
factor 3/forkhead
 RT domain is influenced by amino acid residues
adjacent to the recognition
 RT helix
 RL Mol. Cell. Biol.
14:2755-2766 (1994).
 RN [5]; RE0000288.
 RX MEDLINE; 92345837.

RA Sladek F. M., Darnell J. E.
 RT Mechanisms of liver-specific
gene expression
 RL Curr. Opin. Gen. Dev. 2:256-259 (1992).

RN [6]; RE0001695.
 RX MEDLINE; 92375039.
 RA Pani L., Overdier
D. G., Porcella A., Qian X., Lai E., Costa R. H.
 RT Hepatocyte
nuclear factor 3beta contains two transcriptional activation

RT domains, one of which is novel and conserved with the Drosophila
fork head
 RT protein
 RL Mol. Cell. Biol. 12:3723-3732
(1992).
 RN [7]; RE0000676.
 RX MEDLINE; 91032994.
 RA
Lai E., Prezioso V. R., Smith E., Litvin O., Costa R. H., Darnell
J. E.
 RT HNF-3A, a hepatocyte-enriched transcription factor
of novel structure is
 RT regulated transcriptionally
 RL
Genes Dev. 4:1427-1436 (1990).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

228 genes, 228 accessions (Toggle view)

AccessionGeneTitleLinks
PGBD3PGBD3piggyBac transposable element derived 3Source|GeneCards
LMO4LMO4LIM domain only 4Source|GeneCards
RUNX2RUNX2runt-related transcription factor 2Source|GeneCards
CDK6CDK6cyclin-dependent kinase 6Source|GeneCards
RAB6CRAB6CRAB6C, member RAS oncogene familySource|GeneCards
ODZ1ODZ1odz, odd Oz/ten-m homolog 1(Drosophila)Source|GeneCards
BCL11BBCL11BB-cell CLL/lymphoma 11B (zinc finger protein)Source|GeneCards
LOC284123LOC284123hypothetical gene supported by BC031617Source|GeneCards
C9ORF24C9ORF24chromosome 9 open reading frame 24Source|GeneCards
ISG20ISG20interferon stimulated gene 20kDaSource|GeneCards
IL17EIL17Einterleukin 17ESource|GeneCards
DRD3DRD3dopamine receptor D3Source|GeneCards
SERPIND1SERPIND1serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1Source|GeneCards
CYLN2CYLN2cytoplasmic linker 2Source|GeneCards
RAB3IPRAB3IPRAB3A interacting protein (rabin3)Source|GeneCards
HESX1HESX1homeo box (expressed in ES cells) 1Source|GeneCards
LMO3LMO3LIM domain only 3 (rhombotin-like 2)Source|GeneCards
BAZ2BBAZ2Bbromodomain adjacent to zinc finger domain, 2BSource|GeneCards
BHC80PHF21APHD finger protein 21ASource|GeneCards
FRMD4FRMD4AFERM domain containing 4ASource|GeneCards
PIK3C2APIK3C2Aphosphoinositide-3-kinase, class 2, alpha polypeptideSource|GeneCards
LPPLPPLIM domain containing preferred translocation partner in lipomaSource|GeneCards
HOXA4HOXA4homeo box A4Source|GeneCards
TFDP2TFDP2transcription factor Dp-2 (E2F dimerization partner 2)Source|GeneCards
ABL2ABL2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)Source|GeneCards
TLE4TLE4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)Source|GeneCards
ZHX2ZHX2transcription factor ZHX2Source|GeneCards
PPP1R10PPP1R10protein phosphatase 1, regulatory subunit 10Source|GeneCards
SULF2SULF2sulfatase 2Source|GeneCards
ANXA1ANXA1annexin A1Source|GeneCards
LOC285513LOC285513hypothetical protein LOC285513Source|GeneCards
ACCN5ACCN5amiloride-sensitive cation channel 5, intestinalSource|GeneCards
TRA1TRA1tumor rejection antigen (gp96) 1Source|GeneCards
SLITRK6SLITRK6SLIT and NTRK-like family, member 6Source|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
CYR61CYR61cysteine-rich, angiogenic inducer, 61Source|GeneCards
PKD1-LIKEPKD1-LIKEpolycystic kidney disease 1-likeSource|GeneCards
CPEB4CPEB4cytoplasmic polyadenylation element binding protein 4Source|GeneCards
UBXD3UBXD3UBX domain containing 3Source|GeneCards
GIPC2GIPC2PDZ domain protein GIPC2Source|GeneCards
SLC6A4SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 4Source|GeneCards
MRPS18BMRPS18Bmitochondrial ribosomal protein S18BSource|GeneCards
ARTNARTNarteminSource|GeneCards
WHSC1L1WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 1Source|GeneCards
ZFPM2ZFPM2zinc finger protein, multitype 2Source|GeneCards
TNMDTNMDtenomodulin proteinSource|GeneCards
BUB1BUB1BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)Source|GeneCards
GABRA1GABRA1gamma-aminobutyric acid (GABA) A receptor, alpha 1Source|GeneCards
LAF4LAF4lymphoid nuclear protein related to AF4Source|GeneCards
IBSPIBSPintegrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)Source|GeneCards
NEUROD2NEUROD2neurogenic differentiation 2Source|GeneCards
RARGRARGretinoic acid receptor, gammaSource|GeneCards
TNRC11MED12mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)Source|GeneCards
PLAG1PLAG1pleiomorphic adenoma gene 1Source|GeneCards
LOC90768LOC90768hypothetical protein LOC90768Source|GeneCards
FOXB1FOXB1forkhead box B1Source|GeneCards
CHN2CHN2chimerin (chimaerin) 2Source|GeneCards
TOB1TOB1transducer of ERBB2, 1Source|GeneCards
VAX1VAX1ventral anterior homeobox 1Source|GeneCards
NCDNNCDNneurochondrinSource|GeneCards
FLJ23865FLJ23865hypothetical protein FLJ23865Source|GeneCards
SLC16A6SLC16A6solute carrier family 16 (monocarboxylic acid transporters), member 6Source|GeneCards
KRTAP11-1KRTAP11-1keratin associated protein 11-1Source|GeneCards
NFIBNFIBnuclear factor I/BSource|GeneCards
PLA1APLA1Aphospholipase A1 member ASource|GeneCards
ENPEPENPEPglutamyl aminopeptidase (aminopeptidase A)Source|GeneCards
TAC1TAC1tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)Source|GeneCards
ZNF537ZNF537zinc finger protein 537Source|GeneCards
TWIST2TWIST2twist homolog 2 (Drosophila)Source|GeneCards
KLHL1KLHL1kelch-like 1 (Drosophila)Source|GeneCards
SSH3SSH3slingshot homolog 3 (Drosophila)Source|GeneCards
PDCD4PDCD4programmed cell death 4 (neoplastic transformation inhibitor)Source|GeneCards
ZNFN1A2ZNFN1A2zinc finger protein, subfamily 1A, 2 (Helios)Source|GeneCards
FLJ13197FLJ13197hypothetical protein FLJ13197Source|GeneCards
CYP2J2CYP2J2cytochrome P450, family 2, subfamily J, polypeptide 2Source|GeneCards
CDHJDCHS2Dachsous 2 (Drosophila)Source|GeneCards
ZNF521ZNF521zinc finger protein 521Source|GeneCards
DNAJA4DNAJA4DnaJ (Hsp40) homolog, subfamily A, member 4Source|GeneCards
MITFMITFmicrophthalmia-associated transcription factorSource|GeneCards
FUT8FUT8fucosyltransferase 8 (alpha (1,6) fucosyltransferase)Source|GeneCards
TFAP4TFAP4transcription factor AP-4 (activating enhancer binding protein 4)Source|GeneCards
ABT1ABT1activator of basal transcription 1Source|GeneCards
MGC2629ZBTB37zinc finger and BTB domain containing 37Source|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
ORC4LORC4Lorigin recognition complex, subunit 4-like (yeast)Source|GeneCards
EPHB1EPHB1EphB1Source|GeneCards
POU3F4POU3F4POU domain, class 3, transcription factor 4Source|GeneCards
OPRM1OPRM1opioid receptor, mu 1Source|GeneCards
NKD1NKD1naked cuticle homolog 1 (Drosophila)Source|GeneCards
TBL1XTBL1Xtransducin (beta)-like 1X-linkedSource|GeneCards
ITGA8ITGA8integrin, alpha 8Source|GeneCards
IER3IER3immediate early response 3Source|GeneCards
KCTD15KCTD15potassium channel tetramerisation domain containing 15Source|GeneCards
SPRR4SPRR4small proline rich protein 4Source|GeneCards
LHX5LHX5LIM homeobox 5Source|GeneCards
FLJ10945FLJ10945hypothetical protein FLJ10945Source|GeneCards
IL21IL21Interleukin 21Source|GeneCards
PRDM1PRDM1PR domain containing 1, with ZNF domainSource|GeneCards
PHEXPHEXphosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets)Source|GeneCards
UTXUTXubiquitously transcribed tetratricopeptide repeat gene, X chromosomeSource|GeneCards
ITPKBITPKBinositol 1,4,5-trisphosphate 3-kinase BSource|GeneCards
CHCHD7CHCHD7coiled-coil-helix-coiled-coil-helix domain containing 7Source|GeneCards
FOXN1FOXN1forkhead box N1Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
R-SPONDINR-SPONDINR-spondin homolog (Xenopus laevis)Source|GeneCards
PDZRN4PDZRN4PDZ domain containing RING finger 4Source|GeneCards
CYP26B1CYP26B1cytochrome P450, family 26, subfamily B, polypeptide 1Source|GeneCards
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)Source|GeneCards
ELMO3ELMO3engulfment and cell motility 3 (ced-12 homolog, C. elegans)Source|GeneCards
NFATC4NFATC4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4Source|GeneCards
PNMA1PNMA1paraneoplastic antigen MA1Source|GeneCards
FOXP2FOXP2forkhead box P2Source|GeneCards
EGR2EGR2early growth response 2 (Krox-20 homolog, Drosophila)Source|GeneCards
HAS2HAS2hyaluronan synthase 2Source|GeneCards
ZNF297ZNF297zinc finger protein 297Source|GeneCards
CDAN1CDAN1congenital dyserythropoietic anemia, type ISource|GeneCards
TBX4TBX4T-box 4Source|GeneCards
C22ORF19C22ORF19chromosome 22 open reading frame 19Source|GeneCards
F11F11coagulation factor XI (plasma thromboplastin antecedent)Source|GeneCards
MGC41816ANKRD39ankyrin repeat domain 39Source|GeneCards
CPNE1CPNE1RNA binding motif protein 12Source|GeneCards
KLF3KLF3Kruppel-like factor 3 (basic)Source|GeneCards
ZFHX1BZFHX1Bzinc finger homeobox 1bSource|GeneCards
DAAM1DAAM1dishevelled associated activator of morphogenesis 1Source|GeneCards
BAIAP2BAIAP2BAI1-associated protein 2Source|GeneCards
ANGPTL1ANGPTL1angiopoietin-like 1Source|GeneCards
CDW92CDW92CDW92 antigenSource|GeneCards
TNFTNFtumor necrosis factor (TNF superfamily, member 2)Source|GeneCards
LOC146174LOC146174hypothetical protein LOC146174Source|GeneCards
SP8SP8Sp8 transcription factorSource|GeneCards
RORARORARAR-related orphan receptor ASource|GeneCards
GPM6AGPM6Aglycoprotein M6ASource|GeneCards
ID1ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix proteinSource|GeneCards
NEDD4NEDD4neural precursor cell expressed, developmentally down-regulated 4Source|GeneCards
UTYUTYubiquitously transcribed tetratricopeptide repeat gene, Y-linkedSource|GeneCards
GAL3ST4GAL3ST4galactose-3-O-sulfotransferase 4Source|GeneCards
RNF17RNF17ring finger protein 17Source|GeneCards
ID2ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinSource|GeneCards
HMP19HMP19HMP19 proteinSource|GeneCards
FOXG1BFOXG1Bforkhead box G1BSource|GeneCards
LTALTAlymphotoxin alpha (TNF superfamily, member 1)Source|GeneCards
TM4SF3TM4SF3transmembrane 4 superfamily member 3Source|GeneCards
SCARF2SCARF2scavenger receptor class F, member 2Source|GeneCards
CTNNAL1CTNNAL1catenin (cadherin-associated protein), alpha-like 1Source|GeneCards
LOC152485LOC152485hypothetical protein LOC152485Source|GeneCards
MGC34919MGC34919hypothetical protein MGC34919Source|GeneCards
C21ORF94C21ORF94chromosome 21 open reading frame 94Source|GeneCards
LCP2LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)Source|GeneCards
MCART1MCART1mitochondrial carrier triple repeat 1Source|GeneCards
BAI3BAI3brain-specific angiogenesis inhibitor 3Source|GeneCards
FAM20AFAM20Afamily with sequence similarity 20, member ASource|GeneCards
FLJ46154FLJ46154FLJ46154 proteinSource|GeneCards
TBX2TBX2T-box 2Source|GeneCards
C14ORF116CHES1checkpoint suppressor 1Source|GeneCards
FLOT1FLOT1Flotillin 1Source|GeneCards
IFNA17IFNA17interferon, alpha 17Source|GeneCards
ZADH2ZADH2zinc binding alcohol dehydrogenase, domain containing 2Source|GeneCards
RASSF6RASSF6Ras association (RalGDS/AF-6) domain family 6Source|GeneCards
OSBPL6OSBPL6oxysterol binding protein-like 6Source|GeneCards
TYRO3TYRO3TYRO3 protein tyrosine kinaseSource|GeneCards
C15ORF12C15ORF12chromosome 15 open reading frame 12Source|GeneCards
FLJ45187FLJ45187FLJ45187 proteinSource|GeneCards
IL5IL5interleukin 5 (colony-stimulating factor, eosinophil)Source|GeneCards
ANKRD28ANKRD28ankyrin repeat domain 28Source|GeneCards
TTRTTRtransthyretin (prealbumin, amyloidosis type I)Source|GeneCards
GTF2A1GTF2A1general transcription factor IIA, 1, 19/37kDaSource|GeneCards
FOXA2FOXA2forkhead box A2Source|GeneCards
INHBAINHBAinhibin, beta A (activin A, activin AB alpha polypeptide)Source|GeneCards
NFIXNFIXnuclear factor I/X (CCAAT-binding transcription factor)Source|GeneCards
FLJ36874FLJ36874hypothetical protein FLJ36874Source|GeneCards
PVRL1PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)Source|GeneCards
FGF13FGF13fibroblast growth factor 13Source|GeneCards
WNT4WNT4wingless-type MMTV integration site family, member 4Source|GeneCards
PELI2PELI2pellino homolog 2 (Drosophila)Source|GeneCards
ONECUT2ONECUT2one cut domain, family member 2Source|GeneCards
ATP1B4ATP1B4ATPase, (Na+)/K+ transporting, beta 4 polypeptideSource|GeneCards
LBX1LBX1transcription factor similar to D. melanogaster homeodomain protein lady bird lateSource|GeneCards
HRMT1L6HRMT1L6HMT1 hnRNP methyltransferase-like 6 (S. cerevisiae)Source|GeneCards
FLJ13842ZMAT4zinc finger, matrin type 4Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
BAMBIBAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)Source|GeneCards
C9ORF39C9ORF39chromosome 9 open reading frame 39Source|GeneCards
FLJ37543FLJ37543hypothetical protein FLJ37543Source|GeneCards
C2ORF11C2ORF11chromosome 2 open reading frame 11Source|GeneCards
MLLT6MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6Source|GeneCards
NDPNDPNorrie disease (pseudoglioma)Source|GeneCards
CYB561D1CYB561D1cytochrome b-561 domain containing 1Source|GeneCards
C10ORF117NOC3Lnucleolar complex associated 3 homolog (S. cerevisiae)Source|GeneCards
SCUBE3SCUBE3signal peptide, CUB domain, EGF-like 3Source|GeneCards
AP1G2AP1G2adaptor-related protein complex 1, gamma 2 subunitSource|GeneCards
MIG-6ERRFI1ERBB receptor feedback inhibitor 1Source|GeneCards
PPP1CBPPP1CBprotein phosphatase 1, catalytic subunit, beta isoformSource|GeneCards
CALD1CALD1caldesmon 1Source|GeneCards
FLJ39739FLJ39739FLJ39739 proteinSource|GeneCards
NICE-1C1ORF42chromosome 1 open reading frame 42Source|GeneCards
NR6A1NR6A1nuclear receptor subfamily 6, group A, member 1Source|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
ATP2A3ATP2A3ATPase, Ca++ transporting, ubiquitousSource|GeneCards
CDC42EP3CDC42EP3CDC42 effector protein (Rho GTPase binding) 3Source|GeneCards
TRIKKCNK18potassium channel, subfamily K, member 18Source|GeneCards
LOC124402LOC124402LOC124402Source|GeneCards
MGC47816FAM80Afamily with sequence similarity 80, member ASource|GeneCards
CACNA1HCACNA1Hcalcium channel, voltage-dependent, alpha 1H subunitSource|GeneCards
LOC375616LOC375616Cysteine rich BMP regulator 2 (chordin-like)Source|GeneCards
GFRA1GFRA1GDNF family receptor alpha 1Source|GeneCards
ZNF366ZNF366zinc finger protein 366Source|GeneCards
FLJ38716C1ORF161chromosome 1 open reading frame 161Source|GeneCards
PCDH9PCDH9protocadherin 9Source|GeneCards
CITED2CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2Source|GeneCards
SOX2SOX2SRY (sex determining region Y)-box 2Source|GeneCards
OLIG3OLIG3oligodendrocyte transcription factor 3Source|GeneCards
COL13A1COL13A1collagen, type XIII, alpha 1Source|GeneCards
KIAA1318RGAG1retrotransposon gag domain containing 1Source|GeneCards
SIN3ASIN3ASIN3 homolog A, transcriptional regulator (yeast)Source|GeneCards
DUSP1DUSP1dual specificity phosphatase 1Source|GeneCards
C16ORF34C16ORF34chromosome 16 open reading frame 34Source|GeneCards
LOC257106LOC257106hypothetical protein LOC257106Source|GeneCards
KLF12KLF12Kruppel-like factor 12Source|GeneCards
BRUNOL4BRUNOL4bruno-like 4, RNA binding protein (Drosophila)Source|GeneCards
OTX2OTX2orthodenticle homolog 2 (Drosophila)Source|GeneCards
HOXA7HOXA7homeo box A7Source|GeneCards
FLJ38507FLJ38507colon carcinoma related proteinSource|GeneCards
NMNAT2NMNAT2nicotinamide nucleotide adenylyltransferase 2Source|GeneCards
RBP4RBP4retinol binding protein 4, plasmaSource|GeneCards
PPARGC1APPARGC1Aperoxisome proliferative activated receptor, gamma, coactivator 1, alphaSource|GeneCards
DNAJB7DNAJB7DnaJ (Hsp40) homolog, subfamily B, member 7Source|GeneCards
SOX14SOX14SRY (sex determining region Y)-box 14Source|GeneCards
FEZLZNF312zinc finger protein 312Source|GeneCards

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