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Gene set: V$IRF_Q6 (C3:TFAC:0375)
Standard nameV$IRF_Q6
Systematic nameC3:TFAC:0375
Brief descriptionGenes with 3'UTR containing motif BNCRSTTTCANTTYY which matches annotation for IRF1: interferon regulatory factor 1
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA IRF-10
 XX
 SY IRF10; Interferon
regulatory factor 10.
 XX
 OS chick, Gallus gallus
 OC
eukaryota; animalia; metazoa; chordata; vertebrata; aves; neornithes;

OC neognathae; galliformes; phasianidae
 XX
 XX
 CL C0022;
trp.
 XX
 SZ 416 AA; 47.6 kDa (calc), 46 kDa (SDS) [1]

XX
 XX
 SC translated from EMBL #AF380350
 XX
 FT
3 116 PF00605; IRF.
 FT 3 116 SM00348; IRF.
 FT 6 116 DNA-binding
domain (DBD) [1].
 FT 203 379 interaction domain (IAD) [1].

XX
 SF amino acid identity to mammalian and avian paralogs:
about 43% to IRF-4
 SF , 36% to IRF-8 , less than 30% to
 SF other IRFs [1]
 XX

FF expression inducible by interferons (IFN1 and IFNgamma: primary

FF fibroblasts) and concanavalin A (splenic culture) and dependent
on protein
 FF synthesis (blockable by cycloheximide) [1];

FF seems mainly located in the nucleus (when expressed in chicken
embryonic
 FF fibroblasts) [1];
 FF expression was maintained
for several weeks in fibroblast an DT40 line
 FF (contrast
to IRF-1 and IRF-8) [1]: modulates expression of IFN-induced

FF genes: increase of GBP  expression and decrease of
OAS 
 FF expression [1];
 FF contributes to the
regulation of MHC I expression [1];
 FF expressed in a variety
of hematopoietic transformed cell lines with very
 FF high
level in v-rel-transformed cell lines [1];
 FF expression inducible
by v-Rel and to a lesser degree by c-Rel (in lymphoid
 FF cells)
[1];
 FF IRF-4 also induces expression which is enhanced by
v-Rel [1];
 XX
 XX
 XX
 XX
 RN [1]; RE0017882.

RX MEDLINE; 21993151.
 RA Nehyba J., Hrdlickova R., Burnside
J., Bose HR J. r.
 RT A novel interferon regulatory factor
(IRF), IRF-10, has a unique role in
 RT immune defense and
is induced by the v-Rel oncoprotein
 RL Mol. Cell. Biol. 22:3942-3957
(2002).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

247 genes, 247 accessions (Toggle view)

AccessionGeneTitleLinks
TCEB3BTCEB3Btranscription elongation factor B polypeptide 3B (elongin A2)Source|GeneCards
CDK6CDK6cyclin-dependent kinase 6Source|GeneCards
EXT1EXT1Exostoses (multiple) 1Source|GeneCards
HTR2CHTR2C5-hydroxytryptamine (serotonin) receptor 2CSource|GeneCards
RAPGEF6RAPGEF6Rap guanine nucleotide exchange factor (GEF) 6Source|GeneCards
TLK2TLK2tousled-like kinase 2Source|GeneCards
FLJ11783FLJ11783hypothetical protein FLJ11783Source|GeneCards
MAML2MAML2Mastermind-like 2 (Drosophila)Source|GeneCards
ARHGAP5ARHGAP5Rho GTPase activating protein 5Source|GeneCards
FCGR2BFCGR2BFc fragment of IgG, low affinity IIb, receptor for (CD32)Source|GeneCards
KYNUKYNUkynureninase (L-kynurenine hydrolase)Source|GeneCards
NFATC1NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1Source|GeneCards
NRP1NRP1Neuropilin 1Source|GeneCards
MEIS2MEIS2Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)Source|GeneCards
DD5EDD1E3 ubiquitin protein ligase, HECT domain containing, 1Source|GeneCards
PITX2PITX2paired-like homeodomain transcription factor 2Source|GeneCards
FLJ25323FLJ25323FLJ25323 proteinSource|GeneCards
RTN4RTN4reticulon 4Source|GeneCards
TFDP2TFDP2transcription factor Dp-2 (E2F dimerization partner 2)Source|GeneCards
TOP1TOP1topoisomerase (DNA) ISource|GeneCards
SSB1SSB1SPRY domain-containing SOCS box protein SSB-1Source|GeneCards
IFIT2IFIT2interferon-induced protein with tetratricopeptide repeats 2Source|GeneCards
LNKLNKlymphocyte adaptor proteinSource|GeneCards
FLJ38753KLHDC7Akelch domain containing 7ASource|GeneCards
DIO2DIO2deiodinase, iodothyronine, type IISource|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
CBX4CBX4chromobox homolog 4 (Pc class homolog, Drosophila)Source|GeneCards
KIAA0082KIAA0082KIAA0082Source|GeneCards
CPEB4CPEB4cytoplasmic polyadenylation element binding protein 4Source|GeneCards
MS4A1MS4A1membrane-spanning 4-domains, subfamily A, member 1Source|GeneCards
HIPK1HIPK1homeodomain interacting protein kinase 1Source|GeneCards
ADORA3ADORA3adenosine A3 receptorSource|GeneCards
ADARADARadenosine deaminase, RNA-specificSource|GeneCards
CIG5RSAD2radical S-adenosyl methionine domain containing 2Source|GeneCards
ETV6ETV6ets variant gene 6 (TEL oncogene)Source|GeneCards
CXCL10CXCL10chemokine (C-X-C motif) ligand 10Source|GeneCards
CCND1CCND1cyclin D1 (PRAD1: parathyroid adenomatosis 1)Source|GeneCards
FBXL11FBXL11F-box and leucine-rich repeat protein 11Source|GeneCards
SLC15A3SLC15A3solute carrier family 15, member 3Source|GeneCards
IRA1TBL1XR1transducin (beta)-like 1X-linked receptor 1Source|GeneCards
ROXANROXANubiquitous tetratricopeptide containing protein RoXaNSource|GeneCards
SERHLSERHLserine hydrolase-likeSource|GeneCards
EGFL6EGFL6EGF-like-domain, multiple 6Source|GeneCards
DUSP10DUSP10dual specificity phosphatase 10Source|GeneCards
MGC2941PHF23PHD finger protein 23Source|GeneCards
SEMA3ASEMA3Asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3ASource|GeneCards
BST2BST2bone marrow stromal cell antigen 2Source|GeneCards
FCGR2CFCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32)Source|GeneCards
FMR1FMR1fragile X mental retardation 1Source|GeneCards
DNASE1L3DNASE1L3deoxyribonuclease I-like 3Source|GeneCards
C10ORF56C10ORF56chromosome 10 open reading frame 56Source|GeneCards
SIX1SIX1sine oculis homeobox homolog 1 (Drosophila)Source|GeneCards
PSMB8PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7)Source|GeneCards
KIAA1468KIAA1468KIAA1468 proteinSource|GeneCards
RARGRARGretinoic acid receptor, gammaSource|GeneCards
RRBP1RRBP1ribosome binding protein 1 homolog 180kDa (dog)Source|GeneCards
HPCAL1HPCAL1hippocalcin-like 1Source|GeneCards
HPSE2HPSE2heparanase 2Source|GeneCards
TWIST1TWIST1twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila)Source|GeneCards
GABARAPGABARAPGABA(A) receptor-associated proteinSource|GeneCards
PRO2730PRO2730hypothetical protein PRO2730Source|GeneCards
PTPROPTPROprotein tyrosine phosphatase, receptor type, OSource|GeneCards
PURAPURApurine-rich element binding protein ASource|GeneCards
ZNF342ZNF342zinc finger protein 342Source|GeneCards
CASP7CASP7caspase 7, apoptosis-related cysteine proteaseSource|GeneCards
TAPBPLTAPBPLTAP binding protein-likeSource|GeneCards
MAP3K11MAP3K11mitogen-activated protein kinase kinase kinase 11Source|GeneCards
MSX1MSX1msh homeo box homolog 1 (Drosophila)Source|GeneCards
IFI35IFI35interferon-induced protein 35Source|GeneCards
T2BPT2BPTRAF2 binding proteinSource|GeneCards
ADAM15ADAM15a disintegrin and metalloproteinase domain 15 (metargidin)Source|GeneCards
SNX22SNX22sorting nexin 22Source|GeneCards
NT5C3NT5C35'-nucleotidase, cytosolic IIISource|GeneCards
PTMAPTMAprothymosin, alpha (gene sequence 28)Source|GeneCards
MYBMYBv-myb myeloblastosis viral oncogene homolog (avian)Source|GeneCards
ZNFN1A2ZNFN1A2zinc finger protein, subfamily 1A, 2 (Helios)Source|GeneCards
IRF2IRF2interferon regulatory factor 2Source|GeneCards
GRIA3GRIA3glutamate receptor, ionotrophic, AMPA 3Source|GeneCards
STAT6STAT6signal transducer and activator of transcription 6, interleukin-4 inducedSource|GeneCards
CGI-119TMBIM4transmembrane BAX inhibitor motif containing 4Source|GeneCards
ECM2ECM2extracellular matrix protein 2, female organ and adipocyte specificSource|GeneCards
TCIRG1TCIRG1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3Source|GeneCards
ZBP1ZBP1Z-DNA binding protein 1Source|GeneCards
RBMS2RBMS2RNA binding motif, single stranded interacting protein 2Source|GeneCards
G1P2G1P2interferon, alpha-inducible protein (clone IFI-15K)Source|GeneCards
ETV5ETV5ets variant gene 5 (ets-related molecule)Source|GeneCards
FUT8FUT8fucosyltransferase 8 (alpha (1,6) fucosyltransferase)Source|GeneCards
EOMESEOMESeomesodermin homolog (Xenopus laevis)Source|GeneCards
NYREN18NYREN18NEDD8 ultimate buster-1Source|GeneCards
LOC91937LOC91937hypothetical protein BC008988Source|GeneCards
ESR1ESR1estrogen receptor 1Source|GeneCards
SIAT4CSIAT4Csialyltransferase 4C (beta-galactoside alpha-2,3-sialyltransferase)Source|GeneCards
SYNE2SYNE2spectrin repeat containing, nuclear envelope 2Source|GeneCards
SFRS12SFRS12splicing factor, arginine/serine-rich 12Source|GeneCards
ZFPM1ZFPM1zinc finger protein, multitype 1Source|GeneCards
TLR7TLR7toll-like receptor 7Source|GeneCards
MOV10MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)Source|GeneCards
CCNT2CCNT2cyclin T2Source|GeneCards
PLP1PLP1proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)Source|GeneCards
HAPLN1HAPLN1hyaluronan and proteoglycan link protein 1Source|GeneCards
PRKD2PRKD2protein kinase D2Source|GeneCards
UNQ689UNQ689RSTI689Source|GeneCards
FLJ20811ARMCX6armadillo repeat containing, X-linked 6Source|GeneCards
FLJ20035FLJ20035hypothetical protein FLJ20035Source|GeneCards
ZNF385ZNF385zinc finger protein 385Source|GeneCards
IL28AIL28Ainterleukin 28A (interferon, lambda 2)Source|GeneCards
THBS1THBS1thrombospondin 1Source|GeneCards
CNTFRCNTFRciliary neurotrophic factor receptorSource|GeneCards
C12ORF4C12ORF4chromosome 12 open reading frame 4Source|GeneCards
CSENCSENcalsenilin, presenilin binding protein, EF hand transcription factorSource|GeneCards
DLL1DLL1delta-like 1 (Drosophila)Source|GeneCards
DAPP1DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositidesSource|GeneCards
MIA2MIA2melanoma inhibitory activity 2Source|GeneCards
GRIPAP1GRIPAP1GRIP1 associated protein 1Source|GeneCards
PYMWIBGwithin bgcn homolog (Drosophila)Source|GeneCards
C20ORF18C20ORF18chromosome 20 open reading frame 18Source|GeneCards
HOXB4HOXB4homeo box B4Source|GeneCards
PIP5K2BPIP5K2Bphosphatidylinositol-4-phosphate 5-kinase, type II, betaSource|GeneCards
CCDC6CCDC6coiled-coil domain containing 6Source|GeneCards
MGC20410MGC20410hypothetical protein BC012330Source|GeneCards
KIAA0999KIAA0999KIAA0999 proteinSource|GeneCards
MGC10772PRR7proline rich 7 (synaptic)Source|GeneCards
F3F3coagulation factor III (thromboplastin, tissue factor)Source|GeneCards
CHST1CHST1carbohydrate (keratan sulfate Gal-6) sulfotransferase 1Source|GeneCards
ARPP-21ARPP-21cyclic AMP-regulated phosphoprotein, 21 kDSource|GeneCards
ZFHX1BZFHX1Bzinc finger homeobox 1bSource|GeneCards
ARF3ARF3ADP-ribosylation factor 3Source|GeneCards
SOCS1SOCS1suppressor of cytokine signaling 1Source|GeneCards
KCNQ4KCNQ4potassium voltage-gated channel, KQT-like subfamily, member 4Source|GeneCards
ACSL5ACSL5acyl-CoA synthetase long-chain family member 5Source|GeneCards
IL1RAPL1IL1RAPL1interleukin 1 receptor accessory protein-like 1Source|GeneCards
TAPBPTAPBPTAP binding protein (tapasin)Source|GeneCards
PTK2PTK2PTK2 protein tyrosine kinase 2Source|GeneCards
HH114HH114hypothetical protein HH114Source|GeneCards
BHLHB5BHLHB5basic helix-loop-helix domain containing, class B, 5Source|GeneCards
LGI1LGI1leucine-rich, glioma inactivated 1Source|GeneCards
FIBL-6FIBL-6hemicentinSource|GeneCards
TNFSF15TNFSF15tumor necrosis factor (ligand) superfamily, member 15Source|GeneCards
RNF159PCGF5polycomb group ring finger 5Source|GeneCards
MHC2TAMHC2TAMHC class II transactivatorSource|GeneCards
NEDD4NEDD4neural precursor cell expressed, developmentally down-regulated 4Source|GeneCards
PRKAG1PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunitSource|GeneCards
LSP1LSP1lymphocyte-specific protein 1Source|GeneCards
ITGB7ITGB7integrin, beta 7Source|GeneCards
FLJ33387FLJ33387hypothetical protein FLJ33387Source|GeneCards
HOXB3HOXB3homeo box B3Source|GeneCards
SEMA6DSEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6DSource|GeneCards
CYB5-MCYB5-Mcytochrome b5 outer mitochondrial membrane precursorSource|GeneCards
RORBRORBRAR-related orphan receptor BSource|GeneCards
MYOGMYOGmyogenin (myogenic factor 4)Source|GeneCards
FLJ20477PIGVphosphatidylinositol glycan, class VSource|GeneCards
KIAA2028PLEKHH2pleckstrin homology domain containing, family H (with MyTH4 domain) member 2Source|GeneCards
OSMOSMoncostatin MSource|GeneCards
FLJ14054FLJ14054hypothetical protein FLJ14054Source|GeneCards
PSMB10PSMB10proteasome (prosome, macropain) subunit, beta type, 10Source|GeneCards
ZADH2ZADH2zinc binding alcohol dehydrogenase, domain containing 2Source|GeneCards
IL22RA1IL22RA1interleukin 22 receptor, alpha 1Source|GeneCards
TBX1TBX1T-box 1Source|GeneCards
SLC2A5SLC2A5solute carrier family 2 (facilitated glucose/fructose transporter), member 5Source|GeneCards
DGKADGKAdiacylglycerol kinase, alpha 80kDaSource|GeneCards
MUSKMUSKmuscle, skeletal, receptor tyrosine kinaseSource|GeneCards
STAG2STAG2stromal antigen 2Source|GeneCards
ZFZFHCF-binding transcription factor ZhangfeiSource|GeneCards
NCF1NCF1neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1)Source|GeneCards
CXCR4CXCR4chemokine (C-X-C motif) receptor 4Source|GeneCards
KLHL13KLHL13kelch-like 13 (Drosophila)Source|GeneCards
OK/SW-CL.56TUBBTubulin, beta polypeptideSource|GeneCards
GATA6GATA6GATA binding protein 6Source|GeneCards
GSDMDC1GSDMDC1gasdermin domain containing 1Source|GeneCards
NPEPPSNPEPPSaminopeptidase puromycin sensitiveSource|GeneCards
C9ORF150C9ORF150chromosome 9 open reading frame 150Source|GeneCards
BBAPDTX3Ldeltex 3-like (Drosophila)Source|GeneCards
TZFPZBTB32zinc finger and BTB domain containing 32Source|GeneCards
CARD15CARD15caspase recruitment domain family, member 15Source|GeneCards
EHD1EHD1EH-domain containing 1Source|GeneCards
BCORBCORBCL6 co-repressorSource|GeneCards
FLI1FLI1Friend leukemia virus integration 1Source|GeneCards
CASKCASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)Source|GeneCards
USP44USP44ubiquitin specific protease 44Source|GeneCards
EREGEREGepiregulinSource|GeneCards
PRDM16PRDM16PR domain containing 16Source|GeneCards
LZTS2LZTS2leucine zipper, putative tumor suppressor 2Source|GeneCards
PDGFRBPDGFRBplatelet-derived growth factor receptor, beta polypeptideSource|GeneCards
LGALS8LGALS8lectin, galactoside-binding, soluble, 8 (galectin 8)Source|GeneCards
PCDHGC3PCDHGC3protocadherin gamma subfamily C, 3Source|GeneCards
MLLT3MLLT3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3Source|GeneCards
ATP13AATP13A1ATPase type 13A1Source|GeneCards
FLJ12666C1ORF108chromosome 1 open reading frame 108Source|GeneCards
SSA1TRIM21tripartite motif-containing 21Source|GeneCards
PRKACAPRKACAProtein kinase, cAMP-dependent, catalytic, alphaSource|GeneCards
CDH3CDH3Cadherin 3, type 1, P-cadherin (placental)Source|GeneCards
MGC33190ATXN7L4ataxin 7-like 4Source|GeneCards
ISL1ISL1ISL1 transcription factor, LIM/homeodomain, (islet-1)Source|GeneCards
SATSATspermidine/spermine N1-acetyltransferaseSource|GeneCards
LAP1BTOR1AIP1torsin A interacting protein 1Source|GeneCards
DCAMKL1DCAMKL1doublecortin and CaM kinase-like 1Source|GeneCards
NAALADL2NAALADL2N-acetylated alpha-linked acidic dipeptidase 2Source|GeneCards
IL18BPIL18BPinterleukin 18 binding proteinSource|GeneCards
IFNB1IFNB1interferon, beta 1, fibroblastSource|GeneCards
HLA-FHLA-Fmajor histocompatibility complex, class I, FSource|GeneCards
IFRG28IFRG2828kD interferon responsive proteinSource|GeneCards
TNFSF13BTNFSF13Btumor necrosis factor (ligand) superfamily, member 13bSource|GeneCards
LGP2LGP2likely ortholog of mouse D11lgp2Source|GeneCards
TCF7L2TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
IFI44IFI44interferon-induced protein 44Source|GeneCards
LGALS9LGALS9lectin, galactoside-binding, soluble, 9 (galectin 9)Source|GeneCards
MAPK10MAPK10mitogen-activated protein kinase 10Source|GeneCards
GJC1GJC1gap junction protein, chi 1, 31.9kDa (connexin 31.9)Source|GeneCards
PIR51RAD51AP1RAD51 associated protein 1Source|GeneCards
KLF14KLF14Kruppel-like factor 14Source|GeneCards
BALPARP9poly (ADP-ribose) polymerase family, member 9Source|GeneCards
CD80CD80CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)Source|GeneCards
MGC3040MGC3040hypothetical protein MGC3040Source|GeneCards
MGC24125MGC24125hypothetical protein MGC24125Source|GeneCards
ZNF366ZNF366zinc finger protein 366Source|GeneCards
IL28BIL28Binterleukin 28B (interferon, lambda 3)Source|GeneCards
B2MB2Mbeta-2-microglobulinSource|GeneCards
ADAM12ADAM12a disintegrin and metalloproteinase domain 12 (meltrin alpha)Source|GeneCards
UBE2L6UBE2L6ubiquitin-conjugating enzyme E2L 6Source|GeneCards
BBXBBXbobby sox homolog (Drosophila)Source|GeneCards
USF1USF1upstream transcription factor 1Source|GeneCards
FGF9FGF9fibroblast growth factor 9 (glia-activating factor)Source|GeneCards
TCF15TCF15transcription factor 15 (basic helix-loop-helix)Source|GeneCards
PCDH7PCDH7BH-protocadherin (brain-heart)Source|GeneCards
LMO2LMO2LIM domain only 2 (rhombotin-like 1)Source|GeneCards
ISGF3GISGF3Ginterferon-stimulated transcription factor 3, gamma 48kDaSource|GeneCards
LY86LY86lymphocyte antigen 86Source|GeneCards
SLC40A1SLC40A1solute carrier family 40 (iron-regulated transporter), member 1Source|GeneCards
ZC3HDC1PARP12poly (ADP-ribose) polymerase family, member 12Source|GeneCards
SLC11A2SLC11A2solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2Source|GeneCards
ARHGEF6ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6Source|GeneCards
SELLSELLselectin L (lymphocyte adhesion molecule 1)Source|GeneCards
UPF2UPF2UPF2 regulator of nonsense transcripts homolog (yeast)Source|GeneCards
BTAF1BTAF1BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae)Source|GeneCards
CYBBCYBBcytochrome b-245, beta polypeptide (chronic granulomatous disease)Source|GeneCards
ZFP29ZSCAN2zinc finger and SCAN domain containing 2Source|GeneCards
BCL11ABCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Source|GeneCards
PSMA5PSMA5proteasome (prosome, macropain) subunit, alpha type, 5Source|GeneCards
SIMPSIMPsource of immunodominant MHC-associated peptidesSource|GeneCards
HLA-CHLA-Cmajor histocompatibility complex, class I, CSource|GeneCards
PLXNC1PLXNC1plexin C1Source|GeneCards
PSMA3PSMA3proteasome (prosome, macropain) subunit, alpha type, 3Source|GeneCards
FLJ41841FLJ41841FLJ41841 proteinSource|GeneCards
FLJ20321CASZ1castor homolog 1, zinc finger (Drosophila)Source|GeneCards
EIF4A2EIF4A2eukaryotic translation initiation factor 4A, isoform 2Source|GeneCards
NLGN2NLGN2neuroligin 2Source|GeneCards
SLC39A7SLC39A7solute carrier family 39 (zinc transporter), member 7Source|GeneCards

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