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Gene set: V$MSX1_01 (C3:TFAC:0202)
Standard nameV$MSX1_01
Systematic nameC3:TFAC:0202
Brief descriptionGenes with 3'UTR containing motif CNGTAWNTG which matches annotation for MSX1: msh homeo box homolog 1 (Drosophila)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA Msx-1
 XX
 SY Chox-7 (chick); Ghox-7
(chick); Hox-7; Hox-7.1.
 XX
 OS mouse, Mus musculus

OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda;
mammalia;
 OC eutheria; rodentia; myomorpha; muridae; murinae

XX
 XX
 HO Msh (Drosophila) 
 XX
 CL C0006;
homeo; 3.1.1.14.1.
 XX
 SZ 293 AA; 30.8 kDa (cDNA)
 XX

XX
 SC SwissProt #P13297
 XX
 FT 166 225 homeo domain.

FT 166 228 SM00389; HOX.
 FT 167 223 PF00046; homeobox.

XX
 SF 90% identity with human Msx-1 [7];
 SF for DNA-binding,
the three alpha-helices of the homeo domain are sufficient;

SF however, the less conserved N-terminal 10 AA residues of the
homeo domain
 SF significantly stabilize DNA-binding by ensuring
optimal folding of the
 SF whole domain [5];
 XX
 CP
distal mesoderm of forelimb [11] [12], precursors of ciliary body
in the
 CP optic cup [8]
 XX
 FF may play an important
role in limb-pattern formation [10] and for early
 FF differentiation
of eye epithelium / development of ciliary body [8];
 FF can
also function as repressor: for this function it does not require

FF homeodomain DNA-binding sites [4];
 FF interacts with protein
complexes composed of TBP and TFIIA (DA) and TBP,
 FF TFIIA,
and TFIIB (DAB) (in gel retardation assays), suggesting that the

FF mechanism of repression is mediated through interactions with
one or
 FF several components of the core transcription complex
[4];
 FF gene is induced in limb bud by a apical ectodermal
signal [10];
 FF expression in the neural plate (embryonal)
is induced by BMP7 [2];
 FF for expression in teeth, see [3];

FF part of signaling cascade of branchial arch development: Edn1

FF (endothelin-1) secretion stimulates Hand2  expression
which
 FF regulates Msx1 expression in growing, distal brachial
arches [1];
 XX
 XX
 XX
 XX
 RN [1]; RE0015954.

RX MEDLINE; 98337821.
 RA Thomas T., Kurihara H., Yamagishi
H., Kurihara Y., Yazaki Y., Olson E. N.,
 RA Srivastava D.

RT A signaling cascade involving endothelin-1, dHAND and Msx1
regulates
 RT development of neural-crest-derived branchial
arch mesenchyme
 RL Development 125:3005-3014 (1998).
 RN
[2]; RE0006697.
 RX MEDLINE; 97370001.
 RA Shimamura K.,
Rubenstein J. L. R.
 RT Inductive interactions direct early
regionalization of the mouse forebrain
 RL Development 124:2709-2718
(1997).
 RN [3]; RE0014818.
 RA Pekkanen M., Nieminen P.,
Sahlberg C., Aberg T., Thesleff I.
 RT Gene expression in tooth
(WWW database); URL:
 RT http://bite-it.helsinki.fi/MSX1.htm

RL Internet : (1996).
 RN [4]; RE0010105.
 RA Catron K.
M., Zhang H., Marshall S. C., Inostroza J. A., Wilson J. M.,

RA Abate C.
 RT Transcriptional repression by Msx-1 does not
require homeodomain
 RT DNA-binding sites
 RL Mol. Cell.
Biol. 15:861-871 (1995).
 RN [5]; RE0005160.
 RX MEDLINE;
94359933.
 RA Shang Z., Isaac V. E., Li H., Patel L., Catron
K. M., Curran T., Montelione
 RA G. T., Abate C.
 RT Design
of a 'minimAl' homeodomain: The N-terminal arm modulates DNA binding

RT affinity and stabilizes homeodomain structure
 RL Proc.
Natl. Acad. Sci. USA 91:8373-8377 (1994).
 RN [6]; RE0003871.

RX MEDLINE; 93204981.
 RA Catron K. M., Iller N., Abate C.

RT Nucleotides flanking a conserved TAAT core dictate the DNA
binding
 RT specifity of three murine homeodomain proteins

RL Mol. Cell. Biol. 13:2354-2365 (1993).
 RN [7]; RE0005151.

RX MEDLINE; 92128949.
 RA Hewitt J. E., Clarke L. E., Iven
A., Williamson R.
 RT Structure and sequence of the human homeobox
gene HOX7
 RL Genomics 11:670-678 (1991).
 RN [8]; RE0005152.

RX MEDLINE; 92037197.
 RA Monaghan A. P., Davidson D. R., Sime
C. M., Graham E., Baldock R.,
 RA Bhattacharya S. S., Hill
R. E.
 RT The Msh-like homeobox genes define domains in the
developing vertebrate eye
 RL Development 112:1053-1061 (1991).

RN [9]; RE0005155.
 RX MEDLINE; 91200674.
 RA Holland P.
W.
 RT Cloning and evolutionary analysis of msh-like homeobox
genes from mouse,
 RT zebrafish and ascidian
 RL Gene 98:253-257
(1991).
 RN [10]; RE0005159.
 RX MEDLINE; 91319208.

RA Davidson D. R., Crawley A., Hill R. E., Tickle C.
 RT Position-dependent
expression of two related homeobox genes in developing
 RT
vertebrate limbs
 RL Nature 352:429-431 (1991).
 RN [11];
RE0005153.
 RX MEDLINE; 89211889.
 RA Hill R. E., Jones
P. F., Rees A. R., Sime C. M., Justice M. J., Copeland N.

RA G., Jenkins N. A., Graham E., Davidson D. R.
 RT A new family
of mouse homeo box-containing genes: molecular structure,

RT chromosomal location, and developmental expression of Hox-7.1

RL Genes Dev. 3:26-37 (1989).
 RN [12]; RE0005154.
 RX MEDLINE;
89231641.
 RA Robert B., Sassoon D., Jacq B., Gehring W., Buckingham
M.
 RT Hox-7, a mouse homeobox gene with a novel pattern of
expression during
 RT embryogenesis
 RL EMBO J. 8:91-100
(1989).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

180 genes, 180 accessions (Toggle view)

AccessionGeneTitleLinks
KIF9KIF9kinesin family member 9Source|GeneCards
PLAC1PLAC1placenta-specific 1Source|GeneCards
FLNAFLNAfilamin A, alpha (actin binding protein 280)Source|GeneCards
SPAG5SPAG5sperm associated antigen 5Source|GeneCards
HOXB4HOXB4homeo box B4Source|GeneCards
ADAMTSL1ADAMTSL1ADAMTS-like 1Source|GeneCards
JMJD2AJMJD2Ajumonji domain containing 2ASource|GeneCards
CBFA2T2CBFA2T2core-binding factor, runt domain, alpha subunit 2; translocated to, 2Source|GeneCards
EN1EN1engrailed homolog 1Source|GeneCards
RREB1RREB1ras responsive element binding protein 1Source|GeneCards
SPRY2SPRY2sprouty homolog 2 (Drosophila)Source|GeneCards
ELMO1ELMO1engulfment and cell motility 1 (ced-12 homolog, C. elegans)Source|GeneCards
SOX4SOX4SRY (sex determining region Y)-box 4Source|GeneCards
KIAA0999KIAA0999KIAA0999 proteinSource|GeneCards
COL27A1COL27A1collagen, type XXVII, alpha 1Source|GeneCards
IMP-3IMP-3IGF-II mRNA-binding protein 3Source|GeneCards
PRDM9PRDM9PR domain containing 9Source|GeneCards
GPR12GPR12G protein-coupled receptor 12Source|GeneCards
CALM1CALM1calmodulin 1 (phosphorylase kinase, delta)Source|GeneCards
DRD3DRD3dopamine receptor D3Source|GeneCards
MAML2MAML2Mastermind-like 2 (Drosophila)Source|GeneCards
KIF1BKIF1Bkinesin family member 1BSource|GeneCards
BDNFBDNFbrain-derived neurotrophic factorSource|GeneCards
ARNTLARNTLaryl hydrocarbon receptor nuclear translocator-likeSource|GeneCards
NMUNMUneuromedin USource|GeneCards
ZNF532ZNF532zinc finger protein 532Source|GeneCards
MAP2K7MAP2K7mitogen-activated protein kinase kinase 7Source|GeneCards
NEUROD6NEUROD6neurogenic differentiation 6Source|GeneCards
FLJ20582FLJ20582hypothetical protein FLJ20582Source|GeneCards
THUMPD2THUMPD2THUMP domain containing 2Source|GeneCards
TSGA14TSGA14testis specific, 14Source|GeneCards
ELL2ELL2elongation factor, RNA polymerase II, 2Source|GeneCards
IL1RAPL1IL1RAPL1interleukin 1 receptor accessory protein-like 1Source|GeneCards
SHOX2SHOX2short stature homeobox 2Source|GeneCards
FLJ37266FLJ37266hypothetical protein FLJ37266Source|GeneCards
FLJ25323FLJ25323FLJ25323 proteinSource|GeneCards
KCTD5KCTD5potassium channel tetramerisation domain containing 5Source|GeneCards
ACTA1ACTA1actin, alpha 1, skeletal muscleSource|GeneCards
MDGA1MDGA1MAM domain containing glycosylphosphatidylinositol anchor 1Source|GeneCards
NTSNTSneurotensinSource|GeneCards
GNA13GNA13guanine nucleotide binding protein (G protein), alpha 13Source|GeneCards
JAK3JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)Source|GeneCards
TP53TP53tumor protein p53 (Li-Fraumeni syndrome)Source|GeneCards
AIG1AIG1androgen-induced 1Source|GeneCards
SH3BGRL2SH3BGRL2SH3 domain binding glutamic acid-rich protein like 2Source|GeneCards
LIMS1LIMS1LIM and senescent cell antigen-like domains 1Source|GeneCards
PCDH12PCDH12protocadherin 12Source|GeneCards
ARXARXaristaless related homeoboxSource|GeneCards
FOXG1BFOXG1Bforkhead box G1BSource|GeneCards
CBFA2T1RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Source|GeneCards
PKD1-LIKEPKD1-LIKEpolycystic kidney disease 1-likeSource|GeneCards
MAB21L2MAB21L2mab-21-like 2 (C. elegans)Source|GeneCards
TITF1TITF1thyroid transcription factor 1Source|GeneCards
VAV1VAV1vav 1 oncogeneSource|GeneCards
TRERF1TRERF1transcriptional regulating factor 1Source|GeneCards
APINAPINAPin proteinSource|GeneCards
MAB21L1MAB21L1mab-21-like 1 (C. elegans)Source|GeneCards
NXF1NXF1nuclear RNA export factor 1Source|GeneCards
H2AFYH2AFYH2A histone family, member YSource|GeneCards
EYA1EYA1eyes absent homolog 1 (Drosophila)Source|GeneCards
VCAM1VCAM1vascular cell adhesion molecule 1Source|GeneCards
CIRH1ACIRH1Acirrhosis, autosomal recessive 1A (cirhin)Source|GeneCards
GRK6GRK6G protein-coupled receptor kinase 6Source|GeneCards
PMP22PMP22peripheral myelin protein 22Source|GeneCards
SALL1SALL1sal-like 1 (Drosophila)Source|GeneCards
ING3ING3inhibitor of growth family, member 3Source|GeneCards
NOL4NOL4nucleolar protein 4Source|GeneCards
RAB2RAB2RAB2, member RAS oncogene familySource|GeneCards
NOGNOGnogginSource|GeneCards
RARBRARBretinoic acid receptor, betaSource|GeneCards
LOC92799LOC92799hypothetical protein BC007653Source|GeneCards
KRT25AKRT25Atype I inner root sheath specific keratin 25 irs1Source|GeneCards
CBX5CBX5chromobox homolog 5 (HP1 alpha homolog, Drosophila)Source|GeneCards
MCTS1MCTS1malignant T cell amplified sequence 1Source|GeneCards
HSD3B7HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7Source|GeneCards
LPXNLPXNleupaxinSource|GeneCards
CAP1CAP1CAP, adenylate cyclase-associated protein 1 (yeast)Source|GeneCards
FLJ12442FLJ12442hypothetical protein FLJ12442Source|GeneCards
HOXD3HOXD3homeo box D3Source|GeneCards
LAF4LAF4lymphoid nuclear protein related to AF4Source|GeneCards
INHBAINHBAinhibin, beta A (activin A, activin AB alpha polypeptide)Source|GeneCards
SPOCK2SPOCK2sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2Source|GeneCards
CCKARCCKARcholecystokinin A receptorSource|GeneCards
LOC143425LOC143425similar to synaptotagmin VSource|GeneCards
HABP2HABP2hyaluronan binding protein 2Source|GeneCards
A2BP1A2BP1ataxin 2-binding protein 1Source|GeneCards
BNIP3LBNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-likeSource|GeneCards
POU4F2POU4F2POU domain, class 4, transcription factor 2Source|GeneCards
POSTNPOSTNperiostin, osteoblast specific factorSource|GeneCards
KCNAB1KCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 1Source|GeneCards
FSCN2FSCN2fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)Source|GeneCards
EPHA7EPHA7EphA7Source|GeneCards
GTPBP2GTPBP2GTP binding protein 2Source|GeneCards
NR2F1NR2F1nuclear receptor subfamily 2, group F, member 1Source|GeneCards
GAD1GAD1glutamate decarboxylase 1 (brain, 67kDa)Source|GeneCards
DLX5DLX5distal-less homeo box 5Source|GeneCards
GRIN2BGRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2BSource|GeneCards
MGC26816MGC26816hypothetical protein MGC26816Source|GeneCards
HT007HT007uncharacterized hypothalamus protein HT007Source|GeneCards
PDZK3PDZK3PDZ domain containing 3Source|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
DNAJB4DNAJB4DnaJ (Hsp40) homolog, subfamily B, member 4Source|GeneCards
MLLMLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Source|GeneCards
PCDHGC3PCDHGC3protocadherin gamma subfamily C, 3Source|GeneCards
CBLN2CBLN2cerebellin 2 precursorSource|GeneCards
BTBD9BTBD9BTB (POZ) domain containing 9Source|GeneCards
STMN4STMN4stathmin-like 4Source|GeneCards
MSX1MSX1msh homeo box homolog 1 (Drosophila)Source|GeneCards
ZIC1ZIC1Zic family member 1 (odd-paired homolog, Drosophila)Source|GeneCards
NCDNNCDNneurochondrinSource|GeneCards
BARHL2BARHL2BarH-like 2 (Drosophila)Source|GeneCards
ESRRAESRRAestrogen-related receptor alphaSource|GeneCards
NDPNDPNorrie disease (pseudoglioma)Source|GeneCards
RBM21RBM21RNA binding motif protein 21Source|GeneCards
ZIC4ZIC4Zic family member 4Source|GeneCards
CRXCRXcone-rod homeoboxSource|GeneCards
ELAVL2ELAVL2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)Source|GeneCards
SPTBSPTBspectrin, beta, erythrocytic (includes spherocytosis, clinical type I)Source|GeneCards
EBF2EBF2early B-cell factor 2Source|GeneCards
SMAD1SMAD1SMAD, mothers against DPP homolog 1 (Drosophila)Source|GeneCards
PHOX2BPHOX2Bpaired-like homeobox 2bSource|GeneCards
FLJ10385WDR79WD repeat domain 79Source|GeneCards
CHERPCHERPcalcium homeostasis endoplasmic reticulum proteinSource|GeneCards
SND1SND1staphylococcal nuclease domain containing 1Source|GeneCards
PIPOXPIPOXpipecolic acid oxidaseSource|GeneCards
MPPE1MPPE1metallophosphoesterase 1Source|GeneCards
PKHD1PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive)Source|GeneCards
NR6A1NR6A1nuclear receptor subfamily 6, group A, member 1Source|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
C5ORF5C5ORF5chromosome 5 open reading frame 5Source|GeneCards
NKX2-2NKX2-2NK2 transcription factor related, locus 2 (Drosophila)Source|GeneCards
RTN4RL1RTN4RL1reticulon 4 receptor-like 1Source|GeneCards
SYTL2SYTL2synaptotagmin-like 2Source|GeneCards
DLX1DLX1distal-less homeo box 1Source|GeneCards
EHD4EHD4EH-domain containing 4Source|GeneCards
ASB5ASB5ankyrin repeat and SOCS box-containing 5Source|GeneCards
ETV5ETV5ets variant gene 5 (ets-related molecule)Source|GeneCards
CCDC3CCDC3coiled-coil domain containing 3Source|GeneCards
RALPRALPrai-like proteinSource|GeneCards
CDC14ACDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
MITFMITFmicrophthalmia-associated transcription factorSource|GeneCards
CACNA1HCACNA1Hcalcium channel, voltage-dependent, alpha 1H subunitSource|GeneCards
EOMESEOMESeomesodermin homolog (Xenopus laevis)Source|GeneCards
BCAR3BCAR3breast cancer anti-estrogen resistance 3Source|GeneCards
HNRPA1HNRPA1heterogeneous nuclear ribonucleoprotein A1Source|GeneCards
CDH5CDH5cadherin 5, type 2, VE-cadherin (vascular epithelium)Source|GeneCards
LOC84661LOC84661dpy-30-like proteinSource|GeneCards
GSH-2GSH-2homeobox protein GSH-2Source|GeneCards
HMGN2HMGN2high-mobility group nucleosomal binding domain 2Source|GeneCards
FOXP1FOXP1forkhead box P1Source|GeneCards
C19ORF4C19ORF4chromosome 19 open reading frame 4Source|GeneCards
KCNJ2KCNJ2potassium inwardly-rectifying channel, subfamily J, member 2Source|GeneCards
C21ORF127C21ORF127chromosome 21 open reading frame 127Source|GeneCards
SLC6A14SLC6A14solute carrier family 6 (neurotransmitter transporter), member 14Source|GeneCards
SIM1SIM1single-minded homolog 1 (Drosophila)Source|GeneCards
ZCWCC2ZCWCC2zinc finger, CW-type with coiled-coil domain 2Source|GeneCards
C14ORF37C14ORF37chromosome 14 open reading frame 37Source|GeneCards
FLJ39075FLJ39075hypothetical protein FLJ39075Source|GeneCards
SKILSKILSKI-likeSource|GeneCards
NPEPL1NPEPL1aminopeptidase-like 1Source|GeneCards
HOXB7HOXB7homeo box B7Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
MGC40178MGC40178hypothetical protein MGC40178Source|GeneCards
MGC22001MGC22001hypothetical protein MGC22001Source|GeneCards
LHX6LHX6LIM homeobox 6Source|GeneCards
ADAM11ADAM11a disintegrin and metalloproteinase domain 11Source|GeneCards
COL6A3COL6A3collagen, type VI, alpha 3Source|GeneCards
JWAARL6IP5ADP-ribosylation-like factor 6 interacting protein 5Source|GeneCards
NQO2NQO2NAD(P)H dehydrogenase, quinone 2Source|GeneCards
DLL1DLL1delta-like 1 (Drosophila)Source|GeneCards
RAP2CRAP2CRAP2C, member of RAS oncogene familySource|GeneCards
FOXP2FOXP2forkhead box P2Source|GeneCards
MGC13053MGC13053hypothetical protein MGC13053Source|GeneCards
SLC4A2SLC4A2solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)Source|GeneCards
URODURODuroporphyrinogen decarboxylaseSource|GeneCards
WNT6WNT6wingless-type MMTV integration site family, member 6Source|GeneCards
POU2F1POU2F1POU domain, class 2, transcription factor 1Source|GeneCards
FUT11FUT11fucosyltransferase 11 (alpha (1,3) fucosyltransferase)Source|GeneCards
BSPRYBSPRYB-box and SPRY domain containingSource|GeneCards
CDK5CDK5cyclin-dependent kinase 5Source|GeneCards

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