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Gene set: V$NCX_01 (C3:TFAC:0265)
Standard nameV$NCX_01
Systematic nameC3:TFAC:0265
Brief descriptionGenes with 3'UTR containing motif NNGTAAKTNG which matches annotation for TLX2: T-cell leukemia, homeobox 2
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA Ncx
 XX
 SY HOX11L1; HOX11 like
1; Enx; Tlx2; enteric neuron homeobox.
 XX
 OS mouse, Mus
musculus
 OC eukaryota; animalia; metazoa; chordata; vertebrata;
tetrapoda; mammalia;
 OC eutheria; rodentia; myomorpha; muridae;
murinae
 XX
 XX
 CL C0006; homeo.
 XX
 SZ 284 AA;
30.4 kDa (cDNA)
 XX
 XX
 SC translated from EMBL #M75953

XX
 FT 157 216 homeo domain.
 FT 157 219 SM00389; HOX.

FT 158 214 PF00046; homeobox.
 XX
 SF same optimal binding
sequence as Hox11  [2]
 XX
 CP (cell lines:) C1300,
B16, M12 [3]
 CN (cell lines:) B16, L fibroblasts, M12B [3]

EX distal colon,,,Theiler Stage 28;high; RNA-in situ hybridization

EX (non-radioactive); RNA (undefined); [1].
 EX distal ileum,,,Theiler
Stage 28;high; RNA-in situ hybridization
 EX (non-radioactive);
RNA (undefined); [1].
 EX dorsal root ganglion,,,Theiler Stage
17;detectable; RNA-in situ
 EX hybridization (non-radioactive);
RNA (undefined); [1].
 EX geniculate ganglion of facial nerve
[VII],,,Theiler Stage 17;detectable;
 EX RNA-in situ hybridization
(non-radioactive); RNA (undefined); [1].
 EX glossopharyngeal
ganglion [IX],,,Theiler Stage 17;detectable; RNA-in situ
 EX
hybridization (non-radioactive); RNA (undefined); [1].
 EX
myenteric plexus,,,Theiler Stage 28;high; RNA-in situ hybridization

EX (non-radioactive); RNA (undefined); [1].
 EX parasympathetic
ganglia of the heart,,,Theiler Stage 21;medium; RNA-in situ

EX hybridization (non-radioactive); RNA (undefined); [1].

EX paravertebral ganglia,,,Theiler Stage 21;detectable; RNA-in
situ
 EX hybridization (non-radioactive); RNA (undefined);
[1].
 EX proximal colon,,,Theiler Stage 28;high; RNA-in situ
hybridization
 EX (non-radioactive); RNA (undefined); [1].

EX small intestine,,,Theiler Stage 28;none; RNA-in situ hybridization

EX (non-radioactive); RNA (undefined); [1].
 EX submucous plexus,,,Theiler
Stage 28;high; RNA-in situ hybridization
 EX (non-radioactive);
RNA (undefined); [1].
 EX trigeminal ganglion [V],,,Theiler
Stage 17;detectable; RNA-in situ
 EX hybridization (non-radioactive);
RNA (undefined); [1].
 EX vagal ganglion [x],,,Theiler Stage
17;detectable; RNA-in situ hybridization
 EX (non-radioactive);
RNA (undefined); [1].
 XX
 FF activator [2];
 FF required
for proper positional specification, differantiative cell fate
and
 FF maintenance of proper function of enteric neurons [1]
[4];
 FF Ncx -/- mice exhibit distendend abdomens (megacolon),
myenteric neuronal
 FF hyperplasia, altered NADPH diaphorase
inhibitory neurons in colon ganglia,
 FF hyperinnervated enteric
neurons, retarded growth after weaning and die
 FF between
3-6 weeks [1] [4];
 FF Ncx -/- mice provide a model for human
neuronal intestinal dysplasia (NID)
 FF [1];
 FF expression
is upregulated after retinoic acid stimulation probably due to
a
 FF potential retinoic acid response element (RARE) in the
promoter [3];
 XX
 XX
 XX
 XX
 RN [1]; RE0015860.

RX MEDLINE; 97319588.
 RA Shirasawa S., Yunker A. M., Roth
K. A., Brown G. A., Horning S., Korsmeyer
 RA S. J.
 RT
Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia
and
 RT megacolon
 RL Nat. Med. 3:646-650 (1997).
 RN
[2]; RE0016874.
 RX MEDLINE; 20329977.
 RA Shimizu H., Kang
M., Iitsuka Y., Ichinose M., Tokuhisa T., Hatano M.
 RT Identification
of an optimal Ncx binding sequence required for
 RT transcriptional
activation
 RL FEBS Lett. 475:170-174 (2000).
 RN [3]; RE0015841.

RX MEDLINE; 99377083.
 RA Iitsuka Y., Shimizu H., Kang M. M.,
Sasagawa K., Sekiya S., Tokuhisa T.,
 RA Hatano M.
 RT An
enhancer element for expression of the Ncx (Enx, Hox11L1) gene
in neural
 RT crest-derived cells
 RL J. Biol. Chem. 274:24401-24407
(1999).
 RN [4]; RE0015863.
 RX MEDLINE; 97406010.
 RA
Hatano M., Aoki T., Dezawa M., Yusa S., Iitsuka Y., Koseki H.,
Taniguchi
 RA M., Tokuhisa T.
 RT A novel pathogenesis of
megacolon in Ncx/Hox11L.1 deficient mice
 RL J. Clin. Invest.
100:795-801 (1997).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

177 genes, 177 accessions (Toggle view)

AccessionGeneTitleLinks
ZIM2ZIM2zinc finger, imprinted 2Source|GeneCards
WNT5AWNT5Awingless-type MMTV integration site family, member 5ASource|GeneCards
RPP25RPP25RNase P protein subunit p25Source|GeneCards
CACNA2D2CACNA2D2calcium channel, voltage-dependent, alpha 2/delta subunit 2Source|GeneCards
CCDC6CCDC6coiled-coil domain containing 6Source|GeneCards
SPTLC2SPTLC2serine palmitoyltransferase, long chain base subunit 2Source|GeneCards
SSR1SSR1signal sequence receptor, alpha (translocon-associated protein alpha)Source|GeneCards
FOXD3FOXD3forkhead box D3Source|GeneCards
CA10CA10carbonic anhydrase XSource|GeneCards
TRPV6TRPV6transient receptor potential cation channel, subfamily V, member 6Source|GeneCards
LOC253827LOC253827hypothetical protein LOC253827Source|GeneCards
DUSP2DUSP2dual specificity phosphatase 2Source|GeneCards
SLC24A4SLC24A4solute carrier family 24 (sodium/potassium/calcium exchanger), member 4Source|GeneCards
CDX2CDX2caudal type homeo box transcription factor 2Source|GeneCards
PPP1R16APPP1R16Aprotein phosphatase 1, regulatory (inhibitor) subunit 16ASource|GeneCards
GPC3GPC3glypican 3Source|GeneCards
BDNFBDNFbrain-derived neurotrophic factorSource|GeneCards
ZNF532ZNF532zinc finger protein 532Source|GeneCards
EMX2EMX2empty spiracles homolog 2 (Drosophila)Source|GeneCards
NEUROD6NEUROD6neurogenic differentiation 6Source|GeneCards
KIAA1164FAM63Bfamily with sequence similarity 63, member BSource|GeneCards
LMO3LMO3LIM domain only 3 (rhombotin-like 2)Source|GeneCards
C13ORF22C13ORF22chromosome 13 open reading frame 22Source|GeneCards
ELA1ELA1elastase 1, pancreaticSource|GeneCards
FLJ20257BCDIN3bin3, bicoid-interacting 3, homolog (Drosophila)Source|GeneCards
DHX38DHX38DEAH (Asp-Glu-Ala-His) box polypeptide 38Source|GeneCards
FLJ37266FLJ37266hypothetical protein FLJ37266Source|GeneCards
C5ORF6FAM53Cfamily with sequence similarity 53, member CSource|GeneCards
ARHGAP6ARHGAP6Rho GTPase activating protein 6Source|GeneCards
RBM4RBM4RNA binding motif protein 4Source|GeneCards
DD5EDD1E3 ubiquitin protein ligase, HECT domain containing, 1Source|GeneCards
MLL5MLL5myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)Source|GeneCards
HOXA4HOXA4homeo box A4Source|GeneCards
SPICSPIClikely ortholog of mouse Spi-C transcription factor (Spi-1/PU.1 related)Source|GeneCards
A2MA2Malpha-2-macroglobulinSource|GeneCards
SP7SP7Sp7 transcription factorSource|GeneCards
LOC51057LOC51057hypothetical protein LOC51057Source|GeneCards
GAP43GAP43growth associated protein 43Source|GeneCards
SH3BGRL2SH3BGRL2SH3 domain binding glutamic acid-rich protein like 2Source|GeneCards
KIAA1387KIAA1387KIAA1387 proteinSource|GeneCards
KIAA1007CNOT1CCR4-NOT transcription complex, subunit 1Source|GeneCards
NRAPNRAPnebulin-related anchoring proteinSource|GeneCards
ERGERGv-ets erythroblastosis virus E26 oncogene like (avian)Source|GeneCards
PAK1IP1PAK1IP1PAK1 interacting protein 1Source|GeneCards
NKIRAS2NKIRAS2NFKB inhibitor interacting Ras-like 2Source|GeneCards
TNPO3TNPO3transportin 3Source|GeneCards
ROBO3ROBO3roundabout, axon guidance receptor, homolog 3 (Drosophila)Source|GeneCards
FLJ32447FLJ32447hypothetical protein FLJ32447Source|GeneCards
C8ORF2SPFH2SPFH domain family, member 2Source|GeneCards
PHF12PHF12PHD finger protein 12Source|GeneCards
SESN3SESN3sestrin 3Source|GeneCards
NUP153NUP153nucleoporin 153kDaSource|GeneCards
GNG4GNG4guanine nucleotide binding protein (G protein), gamma 4Source|GeneCards
NXF1NXF1nuclear RNA export factor 1Source|GeneCards
ETV6ETV6ets variant gene 6 (TEL oncogene)Source|GeneCards
LOC387758LOC387758similar to RIKEN cDNA 1110018M03Source|GeneCards
FLJ46154FLJ46154FLJ46154 proteinSource|GeneCards
PEG3PEG3paternally expressed 3Source|GeneCards
PHF15PHF15PHD finger protein 15Source|GeneCards
MAP4MAP4microtubule-associated protein 4Source|GeneCards
DNCL1DNCL1dynein, cytoplasmic, light polypeptide 1Source|GeneCards
TBR1TBR1T-box, brain, 1Source|GeneCards
LTB4R2LTB4R2leukotriene B4 receptor 2Source|GeneCards
GPR23GPR23G protein-coupled receptor 23Source|GeneCards
MORF4L2MORF4L2mortality factor 4 like 2Source|GeneCards
IHPK2IHPK2inositol hexaphosphate kinase 2Source|GeneCards
CIDEBCIDEBcell death-inducing DFFA-like effector bSource|GeneCards
SLC1A7SLC1A7solute carrier family 1 (glutamate transporter), member 7Source|GeneCards
PAX1PAX1paired box gene 1Source|GeneCards
ELAVL4ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)Source|GeneCards
ING3ING3inhibitor of growth family, member 3Source|GeneCards
ASCL3ASCL3achaete-scute complex (Drosophila) homolog-like 3Source|GeneCards
JADE1PHF17PHD finger protein 17Source|GeneCards
EVX1EVX1eve, even-skipped homeo box homolog 1 (Drosophila)Source|GeneCards
PITPNM2PITPNM2phosphatidylinositol transfer protein, membrane-associated 2Source|GeneCards
ANKRD28ANKRD28ankyrin repeat domain 28Source|GeneCards
TIP39TFIP11tuftelin interacting protein 11Source|GeneCards
HOXD3HOXD3homeo box D3Source|GeneCards
GATA4GATA4GATA binding protein 4Source|GeneCards
PTCH2PTCH2patched homolog 2 (Drosophila)Source|GeneCards
PTK2BPTK2BPTK2B protein tyrosine kinase 2 betaSource|GeneCards
MSFPRG4proteoglycan 4, (megakaryocyte stimulating factor, articular superficial zone protein, camptodactyly, arthropathy, coxa vara, pericarditis syndrome)Source|GeneCards
P2RY6P2RY6pyrimidinergic receptor P2Y, G-protein coupled, 6Source|GeneCards
LOC286016LOC286016hypothetical protein LOC286016Source|GeneCards
ANK2ANK2ankyrin 2, neuronalSource|GeneCards
IGSF4IGSF4immunoglobulin superfamily, member 4Source|GeneCards
PLAG1PLAG1pleiomorphic adenoma gene 1Source|GeneCards
DCXDCXdoublecortex; lissencephaly, X-linked (doublecortin)Source|GeneCards
BCORBCORBCL6 co-repressorSource|GeneCards
DLPTXNL4Bthioredoxin-like 4BSource|GeneCards
USP52USP52ubiquitin specific protease 52Source|GeneCards
NR2F1NR2F1nuclear receptor subfamily 2, group F, member 1Source|GeneCards
SEMA5BSEMA5Bsema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5BSource|GeneCards
MGC35212MGC35212hypothetical protein MGC35212Source|GeneCards
AMICAAMICA1adhesion molecule that interacts with CXADR antigen 1Source|GeneCards
PDZK3PDZK3PDZ domain containing 3Source|GeneCards
ETV1ETV1ets variant gene 1Source|GeneCards
HIP2HIP2huntingtin interacting protein 2Source|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
FLJ20315FLJ20315hypothetical protein FLJ20315Source|GeneCards
PRKACAPRKACAProtein kinase, cAMP-dependent, catalytic, alphaSource|GeneCards
RAB39RAB39RAB39, member RAS oncogene familySource|GeneCards
BMXBMXBMX non-receptor tyrosine kinaseSource|GeneCards
DUSP14DUSP14dual specificity phosphatase 14Source|GeneCards
NEUGRINNEUGRINmesenchymal stem cell protein DSC92Source|GeneCards
CLDN17CLDN17claudin 17Source|GeneCards
RBM21RBM21RNA binding motif protein 21Source|GeneCards
HOXC11HOXC11homeo box C11Source|GeneCards
ELAVL2ELAVL2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)Source|GeneCards
RPL4RPL4ribosomal protein L4Source|GeneCards
ISL1ISL1ISL1 transcription factor, LIM/homeodomain, (islet-1)Source|GeneCards
C9ORF77C9ORF77chromosome 9 open reading frame 77Source|GeneCards
PHOX2BPHOX2Bpaired-like homeobox 2bSource|GeneCards
SDK2SDK2sidekick homolog 2 (chicken)Source|GeneCards
LEP6LCE1Flate cornified envelope 1FSource|GeneCards
NRASNRASneuroblastoma RAS viral (v-ras) oncogene homologSource|GeneCards
LRRC8LRRC8leucine rich repeat containing 8Source|GeneCards
TCF1TCF1Transcription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factorSource|GeneCards
IL13RA1IL13RA1interleukin 13 receptor, alpha 1Source|GeneCards
ITGA3ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)Source|GeneCards
PKHD1PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive)Source|GeneCards
SNCAIPSNCAIPsynuclein, alpha interacting protein (synphilin)Source|GeneCards
CDH6CDH6cadherin 6, type 2, K-cadherin (fetal kidney)Source|GeneCards
RAB35RAB35RAB35, member RAS oncogene familySource|GeneCards
CDC14ACDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
EOMESEOMESeomesodermin homolog (Xenopus laevis)Source|GeneCards
MGC5395MGC5395hypothetical protein MGC5395Source|GeneCards
FLJ10759TRIM62tripartite motif-containing 62Source|GeneCards
NOS1NOS1nitric oxide synthase 1 (neuronal)Source|GeneCards
MMP14MMP14matrix metalloproteinase 14 (membrane-inserted)Source|GeneCards
182-FIP182-FIP82-kD FMRP Interacting ProteinSource|GeneCards
C14ORF122C14ORF122chromosome 14 open reading frame 122Source|GeneCards
ESR1ESR1estrogen receptor 1Source|GeneCards
IMMP2LIMMP2LIMP2 inner mitochondrial membrane protease-like (S. cerevisiae)Source|GeneCards
PCDH9PCDH9protocadherin 9Source|GeneCards
SFRS12SFRS12splicing factor, arginine/serine-rich 12Source|GeneCards
PTPN4PTPN4protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)Source|GeneCards
RUNX1RUNX1runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene)Source|GeneCards
AP1GBP1AP1GBP1AP1 gamma subunit binding protein 1Source|GeneCards
PAX3PAX3paired box gene 3 (Waardenburg syndrome 1)Source|GeneCards
THRATHRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)Source|GeneCards
ATP1A3ATP1A3ATPase, Na+/K+ transporting, alpha 3 polypeptideSource|GeneCards
LMO1LMO1LIM domain only 1 (rhombotin 1)Source|GeneCards
DNAJC7DNAJC7DnaJ (Hsp40) homolog, subfamily C, member 7Source|GeneCards
APPBP2APPBP2amyloid beta precursor protein (cytoplasmic tail) binding protein 2Source|GeneCards
SLC6A14SLC6A14solute carrier family 6 (neurotransmitter transporter), member 14Source|GeneCards
RFX3RFX3regulatory factor X, 3 (influences HLA class II expression)Source|GeneCards
BMP5BMP5bone morphogenetic protein 5Source|GeneCards
MAP4K4MAP4K4mitogen-activated protein kinase kinase kinase kinase 4Source|GeneCards
RPP21RPP21ribonuclease P 21kDa subunitSource|GeneCards
KCND2KCND2potassium voltage-gated channel, Shal-related subfamily, member 2Source|GeneCards
MOV10MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)Source|GeneCards
ATP8B4ATP8B4ATPase, Class I, type 8B, member 4Source|GeneCards
HAPLN1HAPLN1hyaluronan and proteoglycan link protein 1Source|GeneCards
CHCHD7CHCHD7coiled-coil-helix-coiled-coil-helix domain containing 7Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
KLF12KLF12Kruppel-like factor 12Source|GeneCards
WNT11WNT11wingless-type MMTV integration site family, member 11Source|GeneCards
PDZRN4PDZRN4PDZ domain containing RING finger 4Source|GeneCards
RNF11RNF11ring finger protein 11Source|GeneCards
ZCWPW1ZCWPW1zinc finger, CW-type with PWWP domain 1Source|GeneCards
HYPBHYPBhuntingtin interacting protein BSource|GeneCards
OTX2OTX2orthodenticle homolog 2 (Drosophila)Source|GeneCards
SAV1SAV1salvador homolog 1 (Drosophila)Source|GeneCards
CTCFCTCFCCCTC-binding factor (zinc finger protein)Source|GeneCards
KLF4KLF4Kruppel-like factor 4 (gut)Source|GeneCards
HBP1HBP1HMG-box transcription factor 1Source|GeneCards
PRKAB1PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunitSource|GeneCards
PLXNC1PLXNC1plexin C1Source|GeneCards
GNASGNASGNAS complex locusSource|GeneCards
FLJ41841FLJ41841FLJ41841 proteinSource|GeneCards
PLAGL1PLAGL1pleiomorphic adenoma gene-like 1Source|GeneCards
FLJ30046FLJ30046hypothetical protein FLJ30046Source|GeneCards
FLJ20225RNF186ring finger protein 186Source|GeneCards
NRXN1NRXN1neurexin 1Source|GeneCards
FEZLZNF312zinc finger protein 312Source|GeneCards
MINKKCNE1potassium voltage-gated channel, Isk-related family, member 1Source|GeneCards

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