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Gene set: V$NFKB_C (C3:TFAC:0133)
Standard nameV$NFKB_C
Systematic nameC3:TFAC:0133
Brief descriptionGenes with 3'UTR containing motif NGGGACTTTCCA. Motif does not match any known transcription factor
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA NF-kappaB1
 XX
 SY 243/NFA-kappaB;
EBP-1; H2TF1; HeLa B factor; KBF1; NF-kappaB (p50);
 SY NF-kappaB1;
p110; TC-IIB.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 CL C0020; Rel; 4.1.1.0.1.2.

XX
 SZ 51 kDa, 57-63 kDa (SDS)
 XX
 FT 19 399 DNA-binding
domain [30].
 FT 43 366 Rel homology region.
 FT 62 62 cysteine
important for DNA-binding [15].
 FT 362 366 RKRQK: nuclear
localization signal.
 FT 719 751 essential for cytoplasmic
retention.
 XX
 SF N-terminal half of a 105 kDa precursor
 [36];
 SF binds to DNA either as homo- or heteromer
 with RelA/p65 
 SF [32];
 SF Cys-62 is
part of a R(F/G)(R/K)YXCE motif found in also other Rel proteins

SF as well as in zinc finger proteins that bind to kappaB sites;

SF it has to be reduced to enable DNA-binding [9], presumably
by a nuclear
 SF thioredoxin system [15] [7] [8];
 SF DNA-binding
domain is largely non-helical [4] [2];
 SF rather, the Rel
domain comprises two beta-barrel domains the loops of which

SF constitute an extensive DNA contacting surface [2];
 SF
there is a major groove-binding recognition loop within the N-terminal

SF subdomain which resembles the p53 DNA-binding domain [2];

SF the C-terminal subdomain exhibits a beta-sandwich structure
resembling
 SF immunoglobulins and is contacted by IkappaB
[2];
 SF though not being a primary target for IkappaB, the
NLS of p50 is masked by
 SF the inhibitor in holo-NF-kappaB/IkappaB
complexes [5];
 SF the homodimer reveals a 10-fold higher affinity
to symmetric sites than the
 SF p50/p65 heterodimer [32];

SF the heterodimer binds more avidly to asymmetric sites: KD =
0.4 pM [32];
 SF binding to some kappaB sites (e. g., IFN-beta
promoter) is significantly
 SF augmented by HMG I(Y) [14];

SF DNA-binding is sensitive towards CpG methylation [28];

SF reported zinc-dependence of DNA-binding is not yet explained
by structural
 SF features [20];
 SF the Rel domain interacts
with the leucine zipper of C/EBPbeta [16] [12],
 SF and probably
also of C/EBP alpha, -gamma-, and delta which also synergize

SF with NF-kappaB [12];
 SF Rel-ZIP interactions have also
been suggested for p50 and ATF-a, CRE-BP1,
 SF ATF-3 [10];

SF the interaction of the Rel domain with the DNA-binding domain
of ER inibits
 SF DNA-binding by p50 [1];
 XX
 CP ubiquitous

XX
 FF primary DNA-binding subunit of NF-kappaB;
 FF homodimers
may repress transcription [19] [23] [13];
 FF hyperposphorylation
in the cytosol of T cells by a 43 kDa protein kinase
 FF which
is associated with the NF-kappaB/IkappaB complex [3] [6];

FF phosphorylation of p50 may contribute to NF-kappaB activation
by enhancing
 FF the DNA-binding capability [3];
 FF upstream
signal transducers may be Raf, Src, H-Ras, Mos [11];
 XX

IN T00052; ATF-a; human, Homo sapiens.
 IN T01313; ATF3; human,
Homo sapiens.
 IN T01928; Bcl-3; human, Homo sapiens.
 IN
T00168; c-Rel; human, Homo sapiens.
 IN T00169; c-Rel; mouse,
Mus musculus.
 IN T01154; c-Rel; chick, Gallus gallus.

IN T00581; C/EBPbeta; human, Homo sapiens.
 IN T00167; CRE-BP1;
human, Homo sapiens.
 IN T00261; ER-alpha; human, Homo sapiens.

IN T01943; IkappaBR; human, Homo sapiens.
 IN T01925; NF-kappaB1
precursor; human, Homo sapiens.
 IN T00593; NF-kappaB1; human,
Homo sapiens.
 IN T01927; NF-kappaB2 precursor; human, Homo
sapiens.
 IN T00394; NF-kappaB2; human, Homo sapiens.
 IN
T00594; RelA; human, Homo sapiens.
 IN T00897; v-Rel; REV-T,
reticuloendotheliosis virus (strain T).
 XX
 XX
 XX

XX
 RN [1]; RE0004503.
 RX MEDLINE; 95379843.
 RA Stein
B., Yang M. X.
 RT Repression of the interleukin-6 promoter
by estrogen receptor is mediated
 RT by NF-kappaB and C/EBPbeta

RL Mol. Cell. Biol. 15:4971-4979 (1995).
 RN [2]; RE0004505.

RX MEDLINE; 95132006.
 RA Mueller C. W., Rey F. A., Sodeoka
M., Verdine G. L., Harrison S. C.
 RT Structure of the NF-kappaB
p50 homodimer bound to DNA
 RL Nature 373:311-317 (1995).

RN [3]; RE0004527.
 RX MEDLINE; 95073993.
 RA Li C.-C.,
Dai R.-M., Chen E., Longo D. L.
 RT Phosphorylation of NF-KB1-p50
is involved in NF-kappaB activation and
 RT stable DNA binding

RL J. Biol. Chem. 269:30089-30092 (1994).
 RN [4]; RE0004529.

RX MEDLINE; 94134740.
 RA Liu J., Sodeoka M., Lane W. S., Verdine
G. L.
 RT Evidence for a non-alpha-helical DNA-binding motif
in the Rel homology
 RT region
 RL Proc. Natl. Acad. Sci.
USA 91:908-912 (1994).
 RN [5]; RE0004487.
 RX MEDLINE;
93154322.
 RA Zabel U., Henkel T., dos Santos Silva M., Baeuerle
P. A.
 RT Nuclear uptake control of NF-kappaB by MAD-3, an
IkappB protein present in
 RT the nucleus
 RL EMBO J. 12:201-211
(1993).
 RN [6]; RE0004496.
 RX MEDLINE; 94075380.
 RA
Hayashi T., Sekine T., Okamoto T.
 RT Identification of a new
serine kinase that activates NFkappaB by direct
 RT phosphorylation

RL J. Biol. Chem. 268:26790-26795 (1993).
 RN [7]; RE0004498.

RX MEDLINE; 93261801.
 RA Matthews J. R., Kaszubska W., Turcatti
G., Wells T. N. C., Hay R. T.
 RT Role of cysteine62 in DNA
recognition by the P50 subunit of NF-kappaB
 RL Nucleic Acids
Res. 21:1727-1734 (1993).
 RN [8]; RE0004499.
 RX MEDLINE;
93266597.
 RA Hayashi T., Ueno Y., Okamoto T.
 RT Oxidoreductive
regulation of Nuclear Factor kappa B (Involvement of a
 RT
cellular reducing catalyst thioredoxin)
 RL J. Biol. Chem.
268:11380-11388 (1993).
 RN [9]; RE0004501.
 RX MEDLINE;
93140783.
 RA Toledano M. B., Ghosh D., Trinh F., Leonard W.
J.
 RT N-terminal DNA-Binding contribute to differential DNA-binding
specifities
 RT of NF-kappaB p50 and p65
 RL Mol. Cell.
Biol. 13:852-860 (1993).
 RN [10]; RE0004521.
 RX MEDLINE;
94019389.
 RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa
P., DeRaemy-Schenk A.-M.,
 RA Chen B. P. C., Hai T., DeLamarter
J. F., Whelan J.
 RT Cyclic AMP-independent ATF family members
interact with NF-kappaB and
 RT function in the activation
of the E-selectin promoter in response to
 RT cytokines

RL Mol. Cell. Biol. 13:7180-7190 (1993).
 RN [11]; RE0004523.

RX MEDLINE; 93377072.
 RA Devary Y., Rosette C., Didonato J.
A., Karin M.
 RT NF-kappaB activation by ultraviolet light
not dependent on a nuclear signal
 RL Science 261:1442-1445
(1993).
 RN [12]; RE0004524.
 RX MEDLINE; 93309429.

RA Stein B., Cogswell P. C., Baldwin jr A. S.
 RT Functional
and physical associations between NF-kappaB and C/EBP family

RT members: a Rel domain-bZIP interaction
 RL Mol. Cell. Biol.
13:3964-3974 (1993).
 RN [13]; RE0004525.
 RX MEDLINE; 93267217.

RA Plaksin D., Baeuerle P. A., Eisenbach L.
 RT KBF1 (p50 NF-kappaB
homodimer) acts as a repressor of H-2Kb gene expression
 RT
in metastatic tumor cells
 RL J. Exp. Med. 177:1651-1662 (1993).

RN [14]; RE0004376.
 RX MEDLINE; 93046682.
 RA Thanos D.,
Maniatis T.
 RT The high mobility group protein HMG I(Y) is
required for
 RT NF-kappaB-dependent virus induction of the
human IFN-beta gene
 RL Cell 71:777-789 (1992).
 RN [15];
RE0004497.
 RX MEDLINE; 92375659.
 RA Matthews J. R., Wakasugi
N., Virelizier J. L., Yodoi J., Hay R. T.
 RT Thioredoxin regulates
the DNA binding activity of NF-kappaB by reduction of
 RT a
disulphide bond involving cysteine 62
 RL Nucleic Acids Res.
20:3821-3830 (1992).
 RN [16]; RE0004517.
 RX MEDLINE; 92390404.

RA LeClair K. P., Blanar M. A., Sharp P. A.
 RT The p50 subunit
of NF-kappaB associates with the NF-IL6 transcription factor

RL Proc. Natl. Acad. Sci. USA 89:8145-8149 (1992).
 RN [17];
RE0000174.
 RX MEDLINE; 91105848.
 RA Lewin B.
 RT Oncogenic
conversion by regulatory changes in transcription factors

RL Cell 64:303-312 (1991).
 RN [18]; RE0000458.
 RX MEDLINE;
91266911.
 RA Urban M. B., Schreck R., Baeuerle P. A.
 RT
NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit

RL EMBO J. 10:1817-1825 (1991).
 RN [19]; RE0000506.
 RX
MEDLINE; 92037544.
 RA Schmitz M. L., Baeuerle P. A.
 RT
The p65 subunit is responsible for the strong transcription activating

RT potential of NF-kappaB
 RL EMBO J. 10:3805-3817 (1991).

RN [20]; RE0000973.
 RX MEDLINE; 91093132.
 RA Zabel U.,
Schreck R., Baeuerle P. A.
 RT DNA binding of purified transcription
factor NF-kappaB
 RL J. Biol. Chem. 266:252-260 (1991).

RN [21]; RE0001632.
 RX MEDLINE; 89343960.
 RA Shirakawa
F., Mizel S. B.
 RT In vitro activation and nuclear translocation
of NF-kappaB catalyzed by
 RT cyclic AMP-dependent protein
kinase and protein kinase C
 RL Mol. Cell. Biol. 9:2424-2430
(1991).
 RN [22]; RE0001872.
 RX MEDLINE; 91204058.

RA Riviere Y., Blank V., Kourilsky P., Israel A.
 RT Processing
of the precursor of NF-kappaB by the HIV-1 protease during acute

RT infection
 RL Nature 350:625-626 (1991).
 RN [23]; RE0001873.

RX MEDLINE; 91343004.
 RA Schmid R. M., Perkins N. D., Duckett
C. S., Andrews P. C., Nabel G. J.
 RT Cloning of an NF-kappaB
subunit which stimulates HIV transcription in
 RT synergy with
p65
 RL Nature 352:733-736 (1991).
 RN [24]; RE0001874.

RX MEDLINE; 92065981.
 RA Fan C.-M., Maniatis T.
 RT Generation
of p50 subunit of NF-kappaB by processing of p105 through an

RT ATP-dependent pathway
 RL Nature 354:395-398 (1991).

RN [25]; RE0002484.
 RX MEDLINE; 91239561.
 RA Toledano
M. B., Leonard W. J.
 RT Modulation of transcription factor
NF-kappaB binding activity by
 RT oxidation-reduction in vitro

RL Proc. Natl. Acad. Sci. USA 88:4328-4332 (1991).
 RN [26];
RE0002489.
 RX MEDLINE; 91126115.
 RA Meyer R., Hatada E.
N., Hohmann H.-P., Haiker M., Bartsch C.,
 RA Roethlisberger
U., Lahm H.-W., Schlaeger E. J., van Loon A. P. G. M.,
 RA
Scheidereit C.
 RT Cloning of the DNA-binding subunit of human
nuclear factor kappaB: the
 RT level of its mRNA is strongly
regulated by phorbol ester or tumor necrosis
 RT factor alpha

RL Proc. Natl. Acad. Sci. USA 88:966-970 (1991).
 RN [27];
RE0002873.
 RX MEDLINE; 92097536.
 RA Blank V., Kourilsky
P., Israel A.
 RT Cytoplasmic retention, DNA binding and processing
of the NF--kappaB p50
 RT precursor are controlled by a small
region in its C-terminus
 RL EMBO J. 10:4159-4167 (1991).

RN [28]; RE0004513.
 RX MEDLINE; 92118717.
 RA Bednarik
D. P., Duckett C., Kim S. U., Perez V. L., Griffis K., Guenther
P.
 RA C., Folks T. M.
 RT DNA CpG methylation inhibits
binding of NF-kappaB proteins to the HIV-1
 RT long terminal
repeat cognate DNA motifs
 RL New Biol. 3:969-976 (1991).

RN [29]; RE0000169.
 RX MEDLINE; 90367115.
 RA Gilmore T.
D.
 RT NF-kappaB, KBF1, dorsal, and related matters
 RL
Cell 62:841-843 (1990).
 RN [30]; RE0000172.
 RX MEDLINE;
90367112.
 RA Kieran M., Blank V., Logeat F., Vandekerckhove
J., Lottspeich F., Le Bail
 RA O., Urban M. B., Kourilsky P.,
Baeuerle B. A., Israel A.
 RT The DNA binding subunit of NF-kappaB
is identical to factor KBF1 and
 RT homologous to the rel oncogene
product
 RL Cell 62:1007-1018 (1990).
 RN [31]; RE0000213.

RX MEDLINE; 90367112.
 RA Kieran M., Blank V., Logeat F., Vendekerckhove
J., Lottspeich F., Bail Le
 RA O., Urban M. B., Kourilsky P.,
Baeuerle P., Israel A.
 RT The DNA binding subunit of NF-kappaB
is identical to factor KBF1 and
 RT homologous to the rel oncogene
product
 RL Cell 62:1007-1018 (1990).
 RN [32]; RE0000726.

RX MEDLINE; 91115086.
 RA Urban M. B., Baeuerle P. A.
 RT
The 65-kD subunit of NF-kappaB is a receptor for IkappaB and a
modulator of
 RT DNA-binding specificity
 RL Genes Dev.
4:1975-1984 (1990).
 RN [33]; RE0001146.
 RX MEDLINE; 90156535.

RA Clark L., Matthews J. R., Hay R. T.
 RT Interaction of enhancer-binding
protein EBP1 (NF-kappaB) with the human
 RT immunodeficiency
virus type 1 enhancer
 RL J. Virol. 64:1335-1344 (1990).

RN [34]; RE0001474.
 RX MEDLINE; 90318374.
 RA Henseling
U., Schmidt W., Schoeler H. R., Gruss P., Hatzopoulos A. K.

RT A transcription factor interacting with the class I gene enhancer
is
 RT inactive in tumorigenic cell lines which suppress major
histocompatibility
 RT complex class I genes
 RL Mol. Cell.
Biol. 10:4100-4109 (1990).
 RN [35]; RE0001520.
 RX MEDLINE;
90318374.
 RA Henseling U., Schmidt W., Schoeler H. R., Gruss
P., Hatzopoulos A. K.
 RT A transcription factor interacting
with the class I gene enhancer is
 RT inactive in tumorigenic
cell lines which suppress major histocompatibility
 RT complex
class I genes
 RL Mol. Cell. Biol. 10:4100-4109 (1990).

RN [36]; RE0001870.
 RX MEDLINE; 91043047.
 RA Bours V.,
Villalobos J., Burd P. R., Kelly K., Siebenlist U.
 RT Cloning
of a mitogen-inducible gene encoding a kappaB DNA-binding protein

RT with homology to the rel oncogene and to cell-cycle motifs

RL Nature 348:76-80 (1990).
 RN [37]; RE0002414.
 RX MEDLINE;
91062349.
 RA Rustgi A. K., van't Veer L. J., Bernards R.

RT Two genes encode factors with NF-kappaB- and H2TF1-like DNA-binding

RT properties
 RL Proc. Natl. Acad. Sci. USA 87:8707-8710 (1990).

RN [38]; RE0002417.
 RX MEDLINE; 91088538.
 RA Molitor J.
A., Walker W. H., Doerre S., Ballard D. W., Greene W. C.
 RT
NF-kappaB: a family of inducible and differentially expressed

RT enhancer-binding proteins in human T cells
 RL Proc. Natl.
Acad. Sci. USA 87:10028-10032 (1990).
 RN [39]; RE0000453.

RX MEDLINE; 90059928.
 RA Lenardo M., Rustgi A. K., Schievella
A. R., Bernards R.
 RT Suppression of MHC class I gene expression
by N-myc through enhancer
 RT inactivation
 RL EMBO J. 8:3351-3355
(1989).
 RN [40]; RE0001376.
 RX MEDLINE; 90014813.

RA Mauxion F., Sen R.
 RT Alteration of a Single Nucleotide
Allows Efficient Binding of H2TF1/KBF1 to
 RT the Immunoglobulin
k Enhancer B Motif
 RL Mol. Cell. Biol. 9:3548-3552 (1989).

RN [41]; RE0001990.
 RX MEDLINE; 89128426.
 RA Clark L.,
Hay R. T.
 RT Sequence requirements for specific interaction
of an enhancer binding
 RT protein (EBP1) with DNA
 RL Nucleic
Acids Res. 17:499-516 (1989).
 RN [42]; RE0002064.
 RX MEDLINE;
89345084.
 RA Israel A., Yano O., Logeat F., Kieran M., Kourilsky
P.
 RT Two purified factors bind to the same sequence in the
enhancer of mouse MHC
 RT class I genes: one of them is a positive
regulator induced upon
 RT differentiation of teratocarcinoma
cells
 RL Nucleic Acids Res. 17:5245 (1989).
 RN [43]; RE0000285.

RX MEDLINE; 89337543.
 RA Baeuerle P. A., Lenardo M., Pierce
J. W., Baltimore D.
 RT Phorbol-ester-induced activation of
the NF-kappaB transcription factor
 RT involves dissociation
of an apparently cytoplasmic NF-kappaB/inhibitor
 RT complex

RL Cold Spring Harbor Symp. Quant. Biol. 53:789-798 (1988).

RN [44]; RE0000357.
 RX MEDLINE; 88329000.
 RA Wu F. K.,
Garcia J. A., Harrich D., Gaynor R. B.
 RT Purification of
the human immunodeficiency virus type 1 enhancer and TAR
 RT
binding proteins EBP-1 and UBP-1
 RL EMBO J. 7:2117-2129 (1988).

RN [45]; RE0000673.
 RX MEDLINE; 89006222.
 RA Clark L.,
Pollock R. M., Hay R. T.
 RT Identification and purification
of EBP1: a HeLa cell protein that binds to
 RT a region overlapping
the core of the SV40 enhancer
 RL Genes Dev. 2:991-1002 (1988).

RN [46]; RE0002328.
 RX MEDLINE; 88124914.
 RA Baldwin jr
A. S., Sharp P. A.
 RT Two transcription factors, NF-kB and
H2TF1, interact with a single
 RT regulatory sequence in the
class I major histocompatibility complex promoter
 RL Proc.
Natl. Acad. Sci. USA 85:723-727 (1988).
 RN [47]; RE0000384.

RX MEDLINE; 88111518.
 RA Yano O., Kanellopoulos J., Kieran
M., Le Bail O., Israel A., Kourilsky P.
 RT Purification of
KBF1, a common factor binding to both H-2 and
 RT beta2-microglobulin
enhancers
 RL EMBO J. 6:3317-3324 (1987).
 RN [48]; RE0001306.

RX MEDLINE; 87172719.
 RA Baldwin jr A. S., Sharp P. A.

RT Binding of a Nuclear Factor to a Regulatory Sequence in the
Promoter of the
 RT Mouse H-2Kb Class I Major Histocompatibility
Gene
 RL Mol. Cell. Biol. 7:305-313 (1987).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

270 genes, 270 accessions (Toggle view)

AccessionGeneTitleLinks
GRIN2DGRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DSource|GeneCards
CD3ZCD3ZCD3Z antigen, zeta polypeptide (TiT3 complex)Source|GeneCards
EGR3EGR3early growth response 3Source|GeneCards
CDK6CDK6cyclin-dependent kinase 6Source|GeneCards
PP1665GDPD5glycerophosphodiester phosphodiesterase domain containing 5Source|GeneCards
FOXD3FOXD3forkhead box D3Source|GeneCards
MGC46719LIX1LLix1 homolog (mouse) likeSource|GeneCards
MAP3K8MAP3K8mitogen-activated protein kinase kinase kinase 8Source|GeneCards
SOX3SOX3SRY (sex determining region Y)-box 3Source|GeneCards
FOXD2FOXD2forkhead box D2Source|GeneCards
MAML2MAML2Mastermind-like 2 (Drosophila)Source|GeneCards
BDNFBDNFbrain-derived neurotrophic factorSource|GeneCards
TSNAXIP1TSNAXIP1translin-associated factor X interacting protein 1Source|GeneCards
MGC31967MGC31967hypothetical protein MGC31967Source|GeneCards
ARHGAP5ARHGAP5Rho GTPase activating protein 5Source|GeneCards
ASH1LASH1Lash1 (absent, small, or homeotic)-like (Drosophila)Source|GeneCards
DDX17DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
PTGS2PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Source|GeneCards
CTAGE4CTAGE4CTAGE family, member 4Source|GeneCards
NLKNLKnemo like kinaseSource|GeneCards
MNTMNTMAX binding proteinSource|GeneCards
EGFEGFepidermal growth factor (beta-urogastrone)Source|GeneCards
PCSK2PCSK2proprotein convertase subtilisin/kexin type 2Source|GeneCards
IL27RAIL27RAinterleukin 27 receptor, alphaSource|GeneCards
TOP1TOP1topoisomerase (DNA) ISource|GeneCards
MR-1MR-1myofibrillogenesis regulator 1Source|GeneCards
GNA13GNA13guanine nucleotide binding protein (G protein), alpha 13Source|GeneCards
ZHX2ZHX2transcription factor ZHX2Source|GeneCards
LNKLNKlymphocyte adaptor proteinSource|GeneCards
HCFC1HCFC1host cell factor C1 (VP16-accessory protein)Source|GeneCards
ARHGEF2ARHGEF2rho/rac guanine nucleotide exchange factor (GEF) 2Source|GeneCards
MSCMSCmusculin (activated B-cell factor-1)Source|GeneCards
BCL2L1BCL2L1BCL2-like 1Source|GeneCards
TRA1TRA1tumor rejection antigen (gp96) 1Source|GeneCards
TNRTNRtenascin R (restrictin, janusin)Source|GeneCards
LIN28LIN28lin-28 homolog (C. elegans)Source|GeneCards
NUP153NUP153nucleoporin 153kDaSource|GeneCards
IRF1IRF1interferon regulatory factor 1Source|GeneCards
LRCH1LRCH1leucine-rich repeats and calponin homology (CH) domain containing 1Source|GeneCards
RHOARHOAras homolog gene family, member ASource|GeneCards
AMOTL1AMOTL1angiomotin like 1Source|GeneCards
SMARCAD1SMARCAD1SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1Source|GeneCards
CXCL10CXCL10chemokine (C-X-C motif) ligand 10Source|GeneCards
RND1RND1Rho family GTPase 1Source|GeneCards
COL11A2COL11A2collagen, type XI, alpha 2Source|GeneCards
EDG5EDG5endothelial differentiation, sphingolipid G-protein-coupled receptor, 5Source|GeneCards
RAB10RAB10RAB10, member RAS oncogene familySource|GeneCards
JPH3JPH3junctophilin 3Source|GeneCards
ASCL3ASCL3achaete-scute complex (Drosophila) homolog-like 3Source|GeneCards
MOBKL2CMOBKL2CMOB1, Mps One Binder kinase activator-like 2C (yeast)Source|GeneCards
HSD3B7HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7Source|GeneCards
EFNA3EFNA3ephrin-A3Source|GeneCards
GATA4GATA4GATA binding protein 4Source|GeneCards
SYMPKSYMPKsymplekinSource|GeneCards
GADD45BGADD45Bgrowth arrest and DNA-damage-inducible, betaSource|GeneCards
SESN2SESN2sestrin 2Source|GeneCards
CAPONNOS1APnitric oxide synthase 1 (neuronal) adaptor proteinSource|GeneCards
S100A10S100A10S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))Source|GeneCards
LCATLCATlecithin-cholesterol acyltransferaseSource|GeneCards
SEMA3BSEMA3Bsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3BSource|GeneCards
SNX15SNX15sorting nexin 15Source|GeneCards
NOS2ANOS2Anitric oxide synthase 2A (inducible, hepatocytes)Source|GeneCards
ANKHD1ANKHD1Eukaryotic translation initiation factor 4E binding protein 3Source|GeneCards
USP52USP52ubiquitin specific protease 52Source|GeneCards
NDRG2NDRG2NDRG family member 2Source|GeneCards
CHD4CHD4chromodomain helicase DNA binding protein 4Source|GeneCards
FGF1FGF1fibroblast growth factor 1 (acidic)Source|GeneCards
NFKBIBNFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, betaSource|GeneCards
IL23AIL23Ainterleukin 23, alpha subunit p19Source|GeneCards
MSX1MSX1msh homeo box homolog 1 (Drosophila)Source|GeneCards
LCN2LCN2lipocalin 2 (oncogene 24p3)Source|GeneCards
AGC1AGC1aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122)Source|GeneCards
PLA1APLA1Aphospholipase A1 member ASource|GeneCards
CD74CD74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)Source|GeneCards
ZNF436ZNF436zinc finger protein 436Source|GeneCards
CTGFCTGFconnective tissue growth factorSource|GeneCards
DNAJA1DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 1Source|GeneCards
FUT7FUT7fucosyltransferase 7 (alpha (1,3) fucosyltransferase)Source|GeneCards
CCL22CCL22chemokine (C-C motif) ligand 22Source|GeneCards
CYB5CYB5cytochrome b-5Source|GeneCards
STAT6STAT6signal transducer and activator of transcription 6, interleukin-4 inducedSource|GeneCards
ANP32AANP32Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member ASource|GeneCards
FOXA3FOXA3forkhead box A3Source|GeneCards
ZNF161ZNF161zinc finger protein 161Source|GeneCards
LOC168850LOC168850hypothetical protein LOC168850Source|GeneCards
IL1RNIL1RNinterleukin 1 receptor antagonistSource|GeneCards
TAZTAZtafazzin (cardiomyopathy, dilated 3A (X-linked); endocardial fibroelastosis 2; Barth syndrome)Source|GeneCards
SLC43A1SLC43A1solute carrier family 43, member 1Source|GeneCards
SFRS15SFRS15splicing factor, arginine/serine-rich 15Source|GeneCards
CDC14ACDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
TP73LTP73Ltumor protein p73-likeSource|GeneCards
HBXAPHBXAPhepatitis B virus x associated proteinSource|GeneCards
TRIB2TRIB2tribbles homolog 2 (Drosophila)Source|GeneCards
RANBP10RANBP10RAN binding protein 10Source|GeneCards
IL18R1IL18R1interleukin 18 receptor 1Source|GeneCards
LRRFIP2LRRFIP2leucine rich repeat (in FLII) interacting protein 2Source|GeneCards
GNAO1GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide OSource|GeneCards
IL2IL2interleukin 2Source|GeneCards
TCEA2TCEA2transcription elongation factor A (SII), 2Source|GeneCards
PPP1R13BPPP1R13Bprotein phosphatase 1, regulatory (inhibitor) subunit 13BSource|GeneCards
IL27IL27Interleukin 27Source|GeneCards
NFKBIANFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaSource|GeneCards
UNC84BUNC84Bunc-84 homolog B (C. elegans)Source|GeneCards
CA9CA9carbonic anhydrase IXSource|GeneCards
IL1AIL1Ainterleukin 1, alphaSource|GeneCards
GRK5GRK5G protein-coupled receptor kinase 5Source|GeneCards
RORCRORCRAR-related orphan receptor CSource|GeneCards
CGGBP1CGGBP1CGG triplet repeat binding protein 1Source|GeneCards
STX4ASTX4Asyntaxin 4A (placental)Source|GeneCards
TIAF1TIAF1TGFB1-induced anti-apoptotic factor 1Source|GeneCards
XPO6XPO6exportin 6Source|GeneCards
ENO3ENO3enolase 3, (beta, muscle)Source|GeneCards
KIAA0672KIAA0672KIAA0672 gene productSource|GeneCards
TNFRSF5CD40CD40 antigen (TNF receptor superfamily member 5)Source|GeneCards
FLJ20309FLJ20309hypothetical protein FLJ20309Source|GeneCards
NFKB2NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)Source|GeneCards
PLP1PLP1proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)Source|GeneCards
SOX5SOX5SRY (sex determining region Y)-box 5Source|GeneCards
PPP3CAPPP3CAprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)Source|GeneCards
TSLPTSLPthymic stromal lymphopoietinSource|GeneCards
C14ORF43C14ORF43chromosome 14 open reading frame 43Source|GeneCards
MGC15677MGC15677hypothetical protein MGC15677Source|GeneCards
ZNF384ZNF384zinc finger protein 384Source|GeneCards
R-SPONDINR-SPONDINR-spondin homolog (Xenopus laevis)Source|GeneCards
TRIM47TRIM47tripartite motif-containing 47Source|GeneCards
ARHGAP8ARHGAP8Rho GTPase activating protein 8Source|GeneCards
TNIP3TNIP3TNFAIP3 interacting protein 3Source|GeneCards
CENTB5CENTB5centaurin, beta 5Source|GeneCards
LASP1LASP1LIM and SH3 protein 1Source|GeneCards
SIX5SIX5sine oculis homeobox homolog 5 (Drosophila)Source|GeneCards
HOXB9HOXB9homeo box B9Source|GeneCards
PRKCDPRKCDprotein kinase C, deltaSource|GeneCards
RIN2RIN2Ras and Rab interactor 2Source|GeneCards
AKR1B1AKR1B1aldo-keto reductase family 1, member B1 (aldose reductase)Source|GeneCards
RAP2CRAP2CRAP2C, member of RAS oncogene familySource|GeneCards
UBE2IUBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)Source|GeneCards
RGL1RGL1Ral guanine nucleotide dissociation stimulator-like 1Source|GeneCards
FOSFOSv-fos FBJ murine osteosarcoma viral oncogene homologSource|GeneCards
HOXB6HOXB6homeo box B6Source|GeneCards
SMOC1SMOC1SPARC related modular calcium binding 1Source|GeneCards
SLC34A3SLC34A3solute carrier family 34 (sodium phosphate), member 3Source|GeneCards
EGR2EGR2early growth response 2 (Krox-20 homolog, Drosophila)Source|GeneCards
WNT10AWNT10Awingless-type MMTV integration site family, member 10ASource|GeneCards
IL13IL13interleukin 13Source|GeneCards
FOXJ2FOXJ2forkhead box J2Source|GeneCards
PAPPAPAPPApregnancy-associated plasma protein ASource|GeneCards
WRNWRNWerner syndromeSource|GeneCards
DACH2DACH2dachshund homolog 2 (Drosophila)Source|GeneCards
LYPLA2LYPLA2lysophospholipase IISource|GeneCards
LOC148898LOC148898hypothetical protein BC007899Source|GeneCards
SNAP25SNAP25synaptosomal-associated protein, 25kDaSource|GeneCards
MAP3K13MAP3K13mitogen-activated protein kinase kinase kinase 13Source|GeneCards
ITGB8ITGB8integrin, beta 8Source|GeneCards
RAD18RAD18RAD18 homolog (S. cerevisiae)Source|GeneCards
DUSP22DUSP22dual specificity phosphatase 22Source|GeneCards
IL1RAPL1IL1RAPL1interleukin 1 receptor accessory protein-like 1Source|GeneCards
BCKDKBCKDKbranched chain alpha-ketoacid dehydrogenase kinaseSource|GeneCards
ARPC5ARPC5actin related protein 2/3 complex, subunit 5, 16kDaSource|GeneCards
LAMB3LAMB3laminin, beta 3Source|GeneCards
TNFSF15TNFSF15tumor necrosis factor (ligand) superfamily, member 15Source|GeneCards
YAPYY1AP1YY1 associated protein 1Source|GeneCards
JAK3JAK3Janus kinase 3 (a protein tyrosine kinase, leukocyte)Source|GeneCards
SP6SP6Sp6 transcription factorSource|GeneCards
PURGPURGpurine-rich element binding protein GSource|GeneCards
LTBLTBlymphotoxin beta (TNF superfamily, member 3)Source|GeneCards
SOCS2SOCS2suppressor of cytokine signaling 2Source|GeneCards
CARTCARTcocaine- and amphetamine-regulated transcriptSource|GeneCards
KCNQ5KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5Source|GeneCards
ID2ID2inhibitor of DNA binding 2, dominant negative helix-loop-helix proteinSource|GeneCards
ECT2ECT2epithelial cell transforming sequence 2 oncogeneSource|GeneCards
SLAMF8SLAMF8SLAM family member 8Source|GeneCards
SIRT2SIRT2sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)Source|GeneCards
ALG6ALG6asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3-glucosyltransferase)Source|GeneCards
PHF6PHF6PHD finger protein 6Source|GeneCards
G3BPG3BPRas-GTPase-activating protein SH3-domain-binding proteinSource|GeneCards
GNG4GNG4guanine nucleotide binding protein (G protein), gamma 4Source|GeneCards
SLICKKCNT2potassium channel, subfamily T, member 2Source|GeneCards
GPHNGPHNgephyrinSource|GeneCards
RALGDSRALGDSral guanine nucleotide dissociation stimulatorSource|GeneCards
UACAUACAuveal autoantigen with coiled-coil domains and ankyrin repeatsSource|GeneCards
SOX10SOX10SRY (sex determining region Y)-box 10Source|GeneCards
PTMSPTMSparathymosinSource|GeneCards
ITGB4ITGB4integrin, beta 4Source|GeneCards
BMFBMFBcl-2 modifying factorSource|GeneCards
NFAT5NFAT5nuclear factor of activated T-cells 5, tonicity-responsiveSource|GeneCards
VCAM1VCAM1vascular cell adhesion molecule 1Source|GeneCards
C1QL1C1QL1complement component 1, q subcomponent-like 1Source|GeneCards
DAP3DAP3death associated protein 3Source|GeneCards
ZADH2ZADH2zinc binding alcohol dehydrogenase, domain containing 2Source|GeneCards
TJP4TJP4tight junction protein 4 (peripheral)Source|GeneCards
FTHL17FTHL17ferritin, heavy polypeptide-like 17Source|GeneCards
ZNF217ZNF217zinc finger protein 217Source|GeneCards
TYRO3TYRO3TYRO3 protein tyrosine kinaseSource|GeneCards
PIGCPIGCphosphatidylinositol glycan, class CSource|GeneCards
OPCMLOPCMLopioid binding protein/cell adhesion molecule-likeSource|GeneCards
NXFNPAS4neuronal PAS domain protein 4Source|GeneCards
C20ORF104PHF20PHD finger protein 20Source|GeneCards
CUEDC1CUEDC1CUE domain containing 1Source|GeneCards
CYLDCYLDcylindromatosis (turban tumor syndrome)Source|GeneCards
APPLAPPLadaptor protein containing pH domain, PTB domain and leucine zipper motifSource|GeneCards
DDR1DDR1discoidin domain receptor family, member 1Source|GeneCards
FLJ10159FLJ10159hypothetical protein FLJ10159Source|GeneCards
RHOGRHOGras homolog gene family, member G (rho G)Source|GeneCards
ICAM1ICAM1intercellular adhesion molecule 1 (CD54), human rhinovirus receptorSource|GeneCards
EHFEHFets homologous factorSource|GeneCards
PTHLHPTHLHparathyroid hormone-like hormoneSource|GeneCards
SMPD3SMPD3sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)Source|GeneCards
LCN7LCN7lipocalin 7Source|GeneCards
FLI1FLI1Friend leukemia virus integration 1Source|GeneCards
FGF17FGF17fibroblast growth factor 17Source|GeneCards
EBFEBFearly B-cell factorSource|GeneCards
CCDC8CCDC8coiled-coil domain containing 8Source|GeneCards
TFE3TFE3transcription factor binding to IGHM enhancer 3Source|GeneCards
LOC92162LOC92162similar to RIKEN cDNA 2600017H02Source|GeneCards
C2ORF11C2ORF11chromosome 2 open reading frame 11Source|GeneCards
MLLT6MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6Source|GeneCards
CLCN1CLCN1chloride channel 1, skeletal muscle (Thomsen disease, autosomal dominant)Source|GeneCards
PFN1PFN1profilin 1Source|GeneCards
BCL3BCL3B-cell CLL/lymphoma 3Source|GeneCards
LOC55565LOC55565hypothetical protein LOC55565Source|GeneCards
IL2RAIL2RAinterleukin 2 receptor, alphaSource|GeneCards
LOC81558LOC81558C/EBP-induced proteinSource|GeneCards
KIAA1747LOC57795hypothetical protein from clone 24828Source|GeneCards
PCBP4PCBP4poly(rC) binding protein 4Source|GeneCards
SPTBSPTBspectrin, beta, erythrocytic (includes spherocytosis, clinical type I)Source|GeneCards
KIAA1173GUP1GRINL1A complex upstream proteinSource|GeneCards
DCAMKL1DCAMKL1doublecortin and CaM kinase-like 1Source|GeneCards
SCRT2SCRT2scratch homolog 2, zinc finger protein (Drosophila)Source|GeneCards
FLJ39739FLJ39739FLJ39739 proteinSource|GeneCards
IFNB1IFNB1interferon, beta 1, fibroblastSource|GeneCards
DKFZP761C169GPBP1GC-rich promoter binding protein 1Source|GeneCards
PTGESPTGESprostaglandin E synthaseSource|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
TAL1TAL1T-cell acute lymphocytic leukemia 1Source|GeneCards
FLJ30296PTCHD1Patched domain containing 1Source|GeneCards
MASK-BP3MASK-BP3MASK-4E-BP3 alternate reading frame geneSource|GeneCards
LOC147111LOC147111hypothetical protein LOC147111Source|GeneCards
VNN3VNN3vanin 3Source|GeneCards
CHX10CHX10ceh-10 homeo domain containing homolog (C. elegans)Source|GeneCards
BAI2BAI2brain-specific angiogenesis inhibitor 2Source|GeneCards
BLR1BLR1Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Source|GeneCards
TNFSF18TNFSF18tumor necrosis factor (ligand) superfamily, member 18Source|GeneCards
SEC14L2SEC14L2SEC14-like 2 (S. cerevisiae)Source|GeneCards
MAGMAGmyelin associated glycoproteinSource|GeneCards
FLJ39370FLJ39370hypothetical protein FLJ39370Source|GeneCards
BHLHB2BHLHB2basic helix-loop-helix domain containing, class B, 2Source|GeneCards
CDH5CDH5cadherin 5, type 2, VE-cadherin (vascular epithelium)Source|GeneCards
BAHD1BAHD1bromo adjacent homology domain containing 1Source|GeneCards
CDC37CDC37CDC37 cell division cycle 37 homolog (S. cerevisiae)Source|GeneCards
C13ORF25C13ORF25chromosome 13 open reading frame 25Source|GeneCards
PTPRJPTPRJprotein tyrosine phosphatase, receptor type, JSource|GeneCards
CXORF21CXORF21Chromosome X open reading frame 21Source|GeneCards
SIN3ASIN3ASIN3 homolog A, transcriptional regulator (yeast)Source|GeneCards
SLC6A12SLC6A12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12Source|GeneCards
TNFSF7TNFSF7tumor necrosis factor (ligand) superfamily, member 7Source|GeneCards
TNIP1TNIP1TNFAIP3 interacting protein 1Source|GeneCards
IL4I1IL4I1interleukin 4 induced 1Source|GeneCards
MRPS6MRPS6mitochondrial ribosomal protein S6Source|GeneCards
EIF5AEIF5Aeukaryotic translation initiation factor 5ASource|GeneCards
TCTATCTAT-cell leukemia translocation altered geneSource|GeneCards
BCL11ABCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Source|GeneCards
CCL5CCL5chemokine (C-C motif) ligand 5Source|GeneCards
IER5IER5immediate early response 5Source|GeneCards
OA48-18
GABPB2GABPB2GA binding protein transcription factor, beta subunit 2, 47kDaSource|GeneCards
PPP2R5EPPP2R5Eprotein phosphatase 2, regulatory subunit B (B56), epsilon isoformSource|GeneCards
EPHB6EPHB6EphB6Source|GeneCards
FLJ21308PARP8Poly (ADP-ribose) polymerase family, member 8Source|GeneCards
FLJ10081FLJ10081hypothetical protein FLJ10081Source|GeneCards
PTD015PTD015PTD015 proteinSource|GeneCards

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