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Gene set: V$P53_02 (C3:TFAC:0170)
Standard nameV$P53_02
Systematic nameC3:TFAC:0170
Brief descriptionGenes with 3'UTR containing motif NGRCWTGYCY which matches annotation for TP53: tumor protein p53 (Li-Fraumeni syndrome)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA p53
 XX
 SY p53; RSp53; NSp53; p53as;
ASp53.
 XX
 OS mouse, Mus musculus
 OC eukaryota; animalia;
metazoa; chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria;
rodentia; myomorpha; muridae; murinae
 XX
 XX
 CL 4.3.1.0.1.1.

XX
 SZ 390 AA; 43.5 kDa (cDNA), 53 kDa (SDS)
 XX
 XX

SC SwissProt #P02340
 XX
 FT 7 7 serine phosphorylated by
DNA-PK [34] [37].
 FT 9 9 serine phosphorylated by DNA-PK [34].

FT 10 390 PF00870; P53.
 FT 18 18 serine phosphorylated by
DNA-PK [34] [37].
 FT 37 37 serine phosphorylated by DNA-PK
[34].
 FT 312 312 phosphorylated serine [55] [51] [52].

FT 315 360 transformaion enhancing domain [14].
 FT 315 350
tetramerization domain [14].
 FT 365 390 replaced by 365-381
in splice variant p53as [12].
 FT 389 389 serine phosphorylated
by CK II [50] [47].
 XX
 SF alternative splice variant mRNA:
p53as [29] [12] [4];
 SF several proteins may be synthesized
from each p53 mRNA species [29];
 SF C-terminal part of the
molecule: unspecific DNA-binding [44],
 SF tetramerization,
minimal transformation domain [28];
 SF interaction with short
DNA-fragments can relieve this inhibition [5];
 SF free in
solution, tetramers form and adopt an extended shape [32] [15];

SF DNA-binding as tetramers [15], monomers and dimers, the latter
two (e. g.
 SF in truncated variants) also being able to trans-activate
[20] and binding
 SF in a highly cooperative manner to DNA
if the binding sites are in a
 SF favourable stereoalignment
[6];
 SF tetramers are lower associates bound to distant sites
are able to stack
 SF thus causing looping and enhanced trans-activation
[13];
 SF tetramerization domain coincides with that responsible
for cellular
 SF transformation by certain oncogenes [14];

SF p53 has been found covalently linked to 5.8S rRNA [38] and
in a complex
 SF with Mdm-2, ribosomal protein L5 and 5S rRNA
[10];
 SF also interacts with the proteins 53BP1 and 53BP2
[11];
 XX
 FF activator [46] [30] [31], tumor suppressor
[48] [49] [45] [42],
 FF sequence-specific DNA-binding protein
[31];
 FF homozygous null allele mice develop normally but
spontaneously develop
 FF tumors [39];
 FF due to enhanced
malignant progression rather than to increased initiation

FF [21];
 FF negative regulation of c-myc [33];
 FF positive
autoregulation, probably through an indirect mechanism [16];

FF peak in the G1 phase [12];
 FF several viral regulators
shut off cell cycle control by p53 [41] [30];
 FF inhibitory
interactions have been shown with Mdm-2 [35] [36] [19] the gene

FF of which is activated by p53 [22] [18];
 FF phosphorylation
by casein kinase II (CK II) [27];
 FF phosphorylation at Ser-389
in SV40-transformed cells depends upon large T
 FF antigen
and may be involved in cell transformation [55];
 FF Ser-389
may also be linked to RNA;
 FF phosphate at Ser-312 appears
to be in a phosphodiester bond [55];
 FF at least certain mutated
forms containing mutations in the central core
 FF domain are
active in S/MAR binding [3] [1];
 FF mutant (MethA) interacts
specifically with S/MARs in regions with high
 FF potential
for base-unpairing, binding depends on structural intability [2];

FF mutant (MethA) proposed to promote local base-unpairing in
unwinding S/MAR
 FF regions [2];
 XX
 IN T01549; DP-1;
mouse, Mus musculus.
 IN T01806; p53; mouse, Mus musculus.

IN T02103; p53as; mouse, Mus musculus.
 IN T00788; T-Ag; SV40,
simian virus 40.
 IN T00796; TBP; mouse, Mus musculus.

IN T02351; WT1; mouse, Mus musculus.
 XX
 XX
 XX

XX
 RN [1]; RE0007141.
 RX MEDLINE; 98241021.
 RA Will
K., Warnecke G., Albrechtsen N., Boulikas T., Deppert W.
 RT
High affinity MAR-DNA binding is a common property of murine and
human
 RT mutant p53
 RL J. Cell. Biochem. 69:260-270 (1998).

RN [2]; RE0013401.
 RX MEDLINE; 99030629.
 RA Will K., Warnecke
G., Wiesmueller L., Deppert W.
 RT Specific interaction of
mutant p53 with regions of matrix attachment region
 RT DNA
elements (MARs) with a high potential for base-unpairing
 RL
Proc. Natl. Acad. Sci. USA 95:13681-13686 (1998).
 RN [3];
RE0007121.
 RX MEDLINE; 97001405.
 RA Deppert W.
 RT
Binding of Mar-DNA elements by mutant p53: possible implications
for its
 RT oncogenic functions
 RL J. Cell. Biochem. 62:172-180
(1996).
 RN [4]; RE0005400.
 RX MEDLINE; 95350165.
 RA
Wolkowicz R., Peled A., Elkind N. B., Rotter V.
 RT Augmented
DNA-binding activity of p53 protein encoded by a
 RT carboxyl-terminal
alternatively spliced mRNA is blocked by p53 protein
 RT encoded
by the regularly spliced form
 RL Proc. Natl. Acad. Sci. USA
92:6842-6846 (1995).
 RN [5]; RE0005404.
 RX MEDLINE; 95323958.

RA Jayaraman L., Prives C.
 RT Activation of p53 Sequence-Specific
DNA Binding by Short Single Strands of
 RT DNA Requires the
p53 C-Terminus
 RL Cell 81:1021-1029 (1995).
 RN [6]; RE0005405.

RX MEDLINE; 95198735.
 RA Wang Y., Schwedes J. F., Parks D.,
Mann K., Tegtmeyer P.
 RT Interaction of p53 with its consensus
DNA-binding site
 RL Mol. Cell. Biol. 15:2157-2165 (1995).

RN [7]; RE0005479.
 RX MEDLINE; 95296385.
 RA Bayle J. H.,
Elenbaas B., Levine A. J.
 RT The carboxyl-terminal domain
of the p53 protein regulates sequence-specific
 RT DNA binding
through its nonspecific nucleic acid-binding activity
 RL Proc.
Natl. Acad. Sci. USA 92:5729-5733 (1995).
 RN [8]; RE0004158.

RX MEDLINE; 95045372.
 RA Okamoto K., Beach D.
 RT Cyclin
G is a transcriptional Target of the p53 tumor suppressor protein

RL EMBO J. 13:4816-4822 (1994).
 RN [9]; RE0005467.
 RX
MEDLINE; 95059077.
 RA Zhao J., Schmieg F. I., Simmons D. T.,
Molloy G. R.
 RT Mouse p53 represses the rat brain creatine
kinase gene but activates the
 RT rat muscle creatine kinase
gene
 RL Mol. Cell. Biol. 14:8483-8492 (1994).
 RN [10];
RE0005468.
 RX MEDLINE; 95021270.
 RA Marechal V., Elenbaas
B., Piette J., Nicolas J.-C., Levine A. J.
 RT The ribosomal
L5 protein is associated with mdm-2 and mdmd-2-p53 complexes

RL Mol. Cell. Biol. 14:7414-7420 (1994).
 RN [11]; RE0005469.

RX MEDLINE; 94286584.
 RA Iwabuchi K., Bartel P. L., Lin B.,
Marraccino R., Fields S.
 RT Two cellular proteins that bind
to wild-type but not mutant p53
 RL Proc. Natl. Acad. Sci.
USA 91:6098-6102 (1994).
 RN [12]; RE0005471.
 RX MEDLINE;
94158842.
 RA Kulesz-Martin M. F., Lisafeld B., Huang H., Kisiel
N. D., Lee L.
 RT Endogenous p53 protein generated from wild-type
alternatively spliced p53
 RT RNA in mouse epidermal cells

RL Mol. Cell. Biol. 14:1698-1708 (1994).
 RN [13]; RE0005472.

RX MEDLINE; 95112812.
 RA Stenger J. E., Tegtmeyer P., Mayr
G., Reed M., Wang Y., Wang P., Hough P.
 RA V. C., Mastrangelo
I. A.
 RT p53 oligomerization and DNA looping are linked with
transcriptional
 RT activation
 RL EMBO J. 13:6011-6020
(1994).
 RN [14]; RE0005477.
 RX MEDLINE; 94309638.

RA Wang P., Reed M., Wang W., Mayr G., Stenger J. E., Anderson
M. E., Schwedes
 RA J. F., Tegtmeyer P.
 RT p53 domains:
Structure, oligomerization, and transformation
 RL Mol. Cell.
Biol. 14:5182-5191 (1994).
 RN [15]; RE0005478.
 RX MEDLINE;
95045373.
 RA Wu Y., Liu Y., Lee L., Miner Z., Kulesz-Martin
M.
 RT Wild-type alternatively spliced p53: binding to DNA
and interaction with
 RT the major p53 protein in vitro and
in cells
 RL EMBO J. 13:4823-4830 (1994).
 RN [16]; RE0004313.

RX MEDLINE; 93268290.
 RA Deffie A., Wu H., Reinke V., Lozano
G.
 RT The tumor suppressor p53 regulates its own transcription

RL Mol. Cell. Biol. 13:3415-3423 (1993).
 RN [17]; RE0005388.

RX MEDLINE; 94089685.
 RA Perry M. E., Piette J., Zawakzki
J. A., Harvey D., Levine A. J.
 RT The mdm-2 gene is induced
in response to UV light in a p53-dependent manner
 RL Proc.
Natl. Acad. Sci. USA 90:11623-11627 (1993).
 RN [18]; RE0005390.

RX MEDLINE; 93307649.
 RA Wu X., Bayle J. H., Olson D., Levine
A. J.
 RT The p53-mdm-2 autoregulatory feedback loop
 RL
Genes Dev. 7:1126-1132 (1993).
 RN [19]; RE0005392.
 RX
MEDLINE; 93327769.
 RA Zauberman A., Barak Y., Ragimov N.,
Levy N., Oren M.
 RT Sequence-specific DNA binding by p53:
identifikation of target sites and
 RT lack of binding to p53-MDM2
complexes
 RL EMBO J. 12:2799-2808 (1993).
 RN [20]; RE0005393.

RX MEDLINE; 93327768.
 RA Shaulian E., Zauberman A., Milner
J., Davies E. A., Oren M.
 RT Tight DNA binding and oligomerization
are dispensable for the ability of
 RT p53 to transactivate
target genes and suppress transformation
 RL EMBO J. 12:2789-2797
(1993).
 RN [21]; RE0005455.
 RX MEDLINE; 93386754.

RA Kemp C. J., Donehower L. A., Bradley A., Balmain A.
 RT
Reduction of p53 gene dosage does not increase initiation or promotion
but
 RT enhances malignant progression of chemically induced
skin tumors
 RL Cell 74:813-822 (1993).
 RN [22]; RE0005459.

RX MEDLINE; 93178420.
 RA Barak Y., Juven T., Haffner R., Oren
M.
 RT mdm2 expression is induced by wild type p53 activity

RL EMBO J. 12:461-468 (1993).
 RN [23]; RE0005460.
 RX MEDLINE;
93209538.
 RA Lowe S. W., Ruley H. E.
 RT Stabilization
of the p53 tumor suppressor is induced by adenovirus 5 E1A

RT and accompanies apoptosis
 RL Genes Dev. 7:535-545 (1993).

RN [24]; RE0005461.
 RX MEDLINE; 93209539.
 RA Debbas M.,
White E.
 RT Wild-type p53 mediates apoptosis by E1A, which
is inhibited by E1B
 RL Genes Dev. 7:546-554 (1993).
 RN
[25]; RE0005464.
 RX MEDLINE; 94102539.
 RA Wang Y., Reed
M., Wang P., Stenger J. E., Mayr G., Anderson M. E., Schwedes

RA J. F., Tegtmeyer P.
 RT p53 domains: identification and
characterization of two autonomous
 RT DNA-binding regions

RL Genes Dev. 7:2575-2586 (1993).
 RN [26]; RE0005466.

RX MEDLINE; 93254582.
 RA Mack D. H., Vartikar J., Pipas J.
M., Laimins L. A.
 RT Specific repression of TATA-mediated
but not initiator-mediated
 RT transcription by wild-type p53

RL Nature 363:281-283 (1993).
 RN [27]; RE0005422.
 RX MEDLINE;
93015952.
 RA Filhol O., Baudier J., Delphin C., Loue-Mackenbach
P., Chambaz E. M.,
 RA Cochet C.
 RT Casein kinase II and
the tumor suppressor protein P53 associate in a
 RT molecular
complex that is negatively regulated upon P53 phosphorylation

RL J. Biol. Chem. 267:20577-20583 (1992).
 RN [28]; RE0005423.

RX MEDLINE; 93078759.
 RA Shaulian E., Zauberman A., Ginsberg
D., Oren M.
 RT Identification of a minimal transforming domain
of p53: negative dominance
 RT through abrogation of sequence-specific
DNA binding
 RL Mol. Cell. Biol. 12:5581-5592 (1992).
 RN
[29]; RE0005424.
 RX MEDLINE; 92253421.
 RA Han K.-A., Kulesz-Martin
M. F.
 RT Alternatively splice p53 RNA in transformed and normal
cells of different
 RT tissue types
 RL Nucleic Acids Res.
20:1979-1981 (1992).
 RN [30]; RE0005428.
 RX MEDLINE; 92310577.

RA Farmer G., Bargonetti J., Zhu H., Friedman P., Prywes R., Prives
C.
 RT Wild-type p53 activates transcription in vitro
 RL
Nature 358:83-86 (1992).
 RN [31]; RE0005429.
 RX MEDLINE;
92331922.
 RA Zambetti G. P., Bargonetti J., Walker K., Prives
C., Levine A. J.
 RT Wild-type p53 mediates positive regulation
of gene expression through a
 RT specific DNA sequence element

RL Genes Dev. 6:1143-1152 (1992).
 RN [32]; RE0005435.

RX MEDLINE; 92207320.
 RA Stenger J. E., Mayr G. A., Mann K.,
Tegtmeyer P.
 RT Formation of stable p53 homotetramers and
multiples of tetramers
 RL Mol. Carcinog. 5:102-106 (1992).

RN [33]; RE0005440.
 RX MEDLINE; 93016320.
 RA Moberg K.
H., Tyndall W. A., Hall D. J.
 RT Wild-type murine p53 represses
transcription from the murine c-myc promoter
 RT in a human
glial cell line
 RL J. Cell. Biochem. 49:208-215 (1992).

RN [34]; RE0005441.
 RX MEDLINE; 92262414.
 RA Wang Y.,
Eckhart W.
 RT Phosphorylation sites in the amino-terminal
region of mouse p53
 RL Proc. Natl. Acad. Sci. USA 89:4231-4235
(1992).
 RN [35]; RE0005447.
 RX MEDLINE; 92289676.

RA Barak Y., Oren M.
 RT Enhanced binding of a 95 kDa protein
to p53 in cells undergoing
 RT p53-mediated growth arrest

RL EMBO J. 11:2115-2121 (1992).
 RN [36]; RE0005448.
 RX
MEDLINE; 92315340.
 RA Momand J., Zambetti G. P., Olson D.
C., Levine D., George A. J.
 RT the mdm-2 oncogene product
forms a complex with the p53 protein and
 RT inhibits p53-mediated
transactivatioN
 RL Cell 69:1237-1245 (1992).
 RN [37];
RE0005449.
 RX MEDLINE; 93024450.
 RA Lees-Miller S. P.,
Sakaguchi K., Ullrich S. J., Appella E., Anderson C. W.
 RT
Human DNA-activated protein kinase phosphorylates serines 15 and
37 in the
 RT amino-terminal transactivation domain of human
p53.
 RL Mol. Cell. Biol. 12:5041-5049 (1992).
 RN [38];
RE0005450.
 RX MEDLINE; 93024461.
 RA Fontoura B. M., Sorokina
E. A., David E., Carroll R. B.
 RT p53 is covalently linked
to 5.8S rRNA
 RL Mol. Cell. Biol. 12:5145-5151 (1992).

RN [39]; RE0005451.
 RX MEDLINE; 92204227.
 RA Donehower
L. A., Harvey M., Slagle B. L., McArthur M. J., Montgomery jr
C.
 RA A., Butel J. S., Bradley A.
 RT Mice deficient for
p53 are developmentally normal but susceptible to
 RT spontaneous
tumours
 RL Nature 356:215-221 (1992).
 RN [40]; RE0001171.

RX MEDLINE; 91237835.
 RA Loeber G., Stenger J. E., Ray S.,
Parsons R. E., Anderson M. E., Tegtmeyer
 RA P.
 RT The
zinc finger region of simian virus 40 large T antigen is needed
for
 RT hexamer assembly and origin melting
 RL J. Virol.
65:3167-3174 (1991).
 RN [41]; RE0005412.
 RX MEDLINE; 91303667.

RA Michael-Michalovitz D., Yhiely F., Gottlieb E., Oren M.

RT Simian virus 40 can overcome the antiproliferative effect of
wild-type p53
 RT in the absence of stable large T antigen-p53
binding
 RL J. Virol. 65:4160-4168 (1991).
 RN [42]; RE0005418.

RX MEDLINE; 91260846.
 RA Levine A. J., Momand J., Finlay C.
A.
 RT The p53 tumour suppressor gene
 RL Nature 351:453-457
(1991).
 RN [43]; RE0005419.
 RX MEDLINE; 91256309.

RA Bargonetti J., Friedman P. N., Kern S. E., Vogelstein B., Prives
C.
 RT Wild-type but not mutant p53 immunopurified proteins
bind to sequences
 RT adjacent to the SV40 origin of replication

RL Cell 65:1083-1091 (1991).
 RN [44]; RE0005420.
 RX MEDLINE;
92020204.
 RA Foord O. S., Bhattacharya P., Reich Z., Rotter
V.
 RT A DNA binding domain is contained in the C-terminus
of wild-type p53 protein
 RL Nucleic Acids Res. 19:5191-5198
(1991).
 RN [45]; RE0005427.
 RX MEDLINE; 92066956.

RA Weinberg R. A.
 RT Tumor suppressor genes
 RL Science
254:1138-1146 (1991).
 RN [46]; RE0005411.
 RX MEDLINE;
90371303.
 RA Raycroft L., Wu H., Lozano G.
 RT Transcriptional
activation by wild-type but not transforming mutants of the

RT p53 anti-oncogene
 RL Science 249:1049-1051 (1990).

RN [47]; RE0005431.
 RX MEDLINE; 91006019.
 RA Meek D. W.,
Simon S., Kikkawa U., Eckhart W.
 RT The p53 tumor suppressor
protein is phosphorylated at serine 389 by casein
 RT kinase
II
 RL EMBO J. 9:3253-3260 (1990).
 RN [48]; RE0005425.

RX MEDLINE; 89288309.
 RA Finlay C. A., Hinds P. W., Levine
A. J.
 RT The p53 proto-oncogene can act as a supressor of
transformation
 RL Cell 57:1083-1093 (1989).
 RN [49]; RE0005426.

RX MEDLINE; 90046873.
 RA Eliyahu D., Michalovitz D., Eliyahu
S., Pinhasi-Kimhi O., Oren M.
 RT Wild-type p53 can inhibit
oncogene-mediated focus formation
 RL Proc. Natl. Acad. Sci.
USA 86:8763-8767 (1989).
 RN [50]; RE0005430.
 RX MEDLINE;
88094420.
 RA Meek D. W., Eckhart W.
 RT Phosphorylation
of p53 in normal and simian virus 40-transformed NIH 3T3
 RT
cells
 RL Mol. Cell. Biol. 8:461-465 (1988).
 RN [51]; RE0005442.

RX MEDLINE; 88094420.
 RA Meek D. W., Eckhart W.
 RT Phosphorylation
of p53 in normal and simian virus 40-transformed NIH 3T33

RT cells
 RL Mol. Cell. Biol. 8:461-165 (1988).
 RN [52];
RE0005443.
 RX MEDLINE; 86149247.
 RA Samad A., Anderson
C. W., Carroll R. B.
 RT Mapping of phosphomonoester and apparent
phosphodiester bonds of the
 RT oncogene product p53 from simian
virus 40-transformed 3T3 cells
 RL Proc. Natl. Acad. Sci. USA
83:897-901 (1986).
 RN [53]; RE0005492.
 RX MEDLINE; 87064640.

RA Arai N., Nomura D., Yokota K., Wolf D., Brill E., Shohat O.,
Rotter V.
 RT Immunologically distinct p53 molecules generated
by alternative splicing
 RL Mol. Cell. Biol. 6:3232-3239 (1986).

RN [54]; RE0005493.
 RX MEDLINE; 86149247.
 RA Samad A.,
Anderson C. W., Carroll R. B.
 RT Mapping of phosphomonoester
and apparent phosphodiester bonds of the
 RT oncogene product
p53 from simian virus 40-transformed 3T3 cells
 RL Proc. Natl.
Acad. Sci. USA 83:897-901 (1986).
 RN [55]; RE0005494.

RA Anderson C. W., Samad A., Carroll R. B.
 RT Identification
and characterization of the site phosphorylated in the
 RT
cellular tumor antigen p53 from SV40-transformed 3T3 cells and
in the
 RT DNA-binding protein from adenovirus 2
 RL Cancer
Cells 4:395-404 (1986).
 RN [56]; RE0004315.
 RX MEDLINE;
85027173.
 RA Bienz B., Zakut-Houri R., Givol D., Oren M.

RT Analysis of the gene coding for the murine cellular tumor antigen
p53
 RL EMBO J. 3:2179-2183 (1984).
 RN [57]; RE0005491.

RX MEDLINE; 84272240.
 RA Jenkins J. R., Rudge K., Redmond
S., Wade-Evans A.
 RT Cloning and expression analysis of full
length mouse cDNA sequences
 RT encoding the transformation
associated protein p53
 RL Nucleic Acids Res. 12:5609-5626
(1984).
 RN [58]; RE0005490.
 RX MEDLINE; 84068204.

RA Zakut-Houri R., Oren M., Bienz B., Lavie V., Hazum S., Givol
D.
 RT A single gene and a pseudogene for the cellular tumour
antigen p53
 RL Nature 306:5609-5626 (1983).
 RN [59]; RE0005416.

RX MEDLINE; 79211276.
 RA Linzer D. I. H., Levine A. J.

RT Characterization of a 54K dalton cellular SV40 tumor antigen
present in
 RT SV40-transformed cells and uninfected embryonal
carcinoma cells
 RL Cell 17:43-52 (1979).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

258 genes, 258 accessions (Toggle view)

AccessionGeneTitleLinks
PITX3PITX3paired-like homeodomain transcription factor 3Source|GeneCards
MYH1MYH1myosin, heavy polypeptide 1, skeletal muscle, adultSource|GeneCards
NXPH4NXPH4neurexophilin 4Source|GeneCards
MAP1LC3AMAP1LC3Amicrotubule-associated protein 1 light chain 3 alphaSource|GeneCards
ASE-1CD3EAPCD3E antigen, epsilon polypeptide associated proteinSource|GeneCards
SUMO4SUMO4SMT3 suppressor of mif two 3 homolog 4 (yeast)Source|GeneCards
SOX4SOX4SRY (sex determining region Y)-box 4Source|GeneCards
H3F3AH3F3AH3 histone, family 3ASource|GeneCards
CDYLCDYLchromodomain protein, Y-likeSource|GeneCards
BCL11BBCL11BB-cell CLL/lymphoma 11B (zinc finger protein)Source|GeneCards
CML66NUDCD1NudC domain containing 1Source|GeneCards
CD68CD68CD68 antigenSource|GeneCards
MGC61633SPATC1spermatogenesis and centriole associated 1Source|GeneCards
CHRM1CHRM1cholinergic receptor, muscarinic 1Source|GeneCards
LOC340371LOC340371hypothetical protein LOC340371Source|GeneCards
MEIS2MEIS2Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)Source|GeneCards
LPPLPPLIM domain containing preferred translocation partner in lipomaSource|GeneCards
ATP6AP1ATP6AP1ATPase, H+ transporting, lysosomal accessory protein 1Source|GeneCards
TFDP2TFDP2transcription factor Dp-2 (E2F dimerization partner 2)Source|GeneCards
GPX1GPX1glutathione peroxidase 1Source|GeneCards
LOC144747LOC144747hypothetical protein LOC144747Source|GeneCards
ZHX2ZHX2transcription factor ZHX2Source|GeneCards
MAGEL2MAGEL2MAGE-like 2Source|GeneCards
CNR1CNR1cannabinoid receptor 1 (brain)Source|GeneCards
ANXA1ANXA1annexin A1Source|GeneCards
JMJD2CJMJD2CJumonji domain containing 2CSource|GeneCards
RNF31RNF31ring finger protein 31Source|GeneCards
PLCB3PLCB3phospholipase C, beta 3 (phosphatidylinositol-specific)Source|GeneCards
DTNADTNAdystrobrevin, alphaSource|GeneCards
HIC1HIC1hypermethylated in cancer 1Source|GeneCards
HIPK1HIPK1homeodomain interacting protein kinase 1Source|GeneCards
TRERF1TRERF1transcriptional regulating factor 1Source|GeneCards
TMC7TMC7transmembrane channel-like 7Source|GeneCards
NUP54NUP54nucleoporin 54kDaSource|GeneCards
ASCL4ASCL4class II bHLH protein ASCL4Source|GeneCards
FKSG79GPR174G protein-coupled receptor 174Source|GeneCards
SNIP1SNIP1Smad nuclear interacting proteinSource|GeneCards
MRC2MRC2mannose receptor, C type 2Source|GeneCards
SH3GLB2SH3GLB2SH3-domain GRB2-like endophilin B2Source|GeneCards
FLJ25476FLJ25476FLJ25476 proteinSource|GeneCards
KIAA0152KIAA0152KIAA0152 gene productSource|GeneCards
CACNB2CACNB2calcium channel, voltage-dependent, beta 2 subunitSource|GeneCards
FBXL11FBXL11F-box and leucine-rich repeat protein 11Source|GeneCards
C10ORF26C10ORF26chromosome 10 open reading frame 26Source|GeneCards
HIP1RHIP1Rhuntingtin interacting protein-1-relatedSource|GeneCards
TA-KRPKBTBD8kelch repeat and BTB (POZ) domain containing 8Source|GeneCards
DHX30DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 30Source|GeneCards
PRDM12PRDM12PR domain containing 12Source|GeneCards
MYH11MYH11myosin, heavy polypeptide 11, smooth muscleSource|GeneCards
USP48USP48ubiquitin specific protease 48Source|GeneCards
RPS19RPS19ribosomal protein S19Source|GeneCards
GATA4GATA4GATA binding protein 4Source|GeneCards
POMZP3POMZP3POM (POM121 homolog, rat) and ZP3 fusionSource|GeneCards
AIM2AIM2absent in melanoma 2Source|GeneCards
GADD45BGADD45Bgrowth arrest and DNA-damage-inducible, betaSource|GeneCards
PITPNC1PITPNC1phosphatidylinositol transfer protein, cytoplasmic 1Source|GeneCards
DNALI1DNALI1dynein, axonemal, light intermediate polypeptide 1Source|GeneCards
TRAF4TRAF4TNF receptor-associated factor 4Source|GeneCards
ETV1ETV1ets variant gene 1Source|GeneCards
FLRT1FLRT1fibronectin leucine rich transmembrane protein 1Source|GeneCards
ACCN1ACCN1amiloride-sensitive cation channel 1, neuronal (degenerin)Source|GeneCards
CACNA1ECACNA1Ecalcium channel, voltage-dependent, alpha 1E subunitSource|GeneCards
LZTR1LZTR1leucine-zipper-like transcriptional regulator, 1Source|GeneCards
HMGN3HMGN3high mobility group nucleosomal binding domain 3Source|GeneCards
AKAP6AKAP6A kinase (PRKA) anchor protein 6Source|GeneCards
HAN11WDR68WD repeat domain 68Source|GeneCards
NTRK3NTRK3neurotrophic tyrosine kinase, receptor, type 3Source|GeneCards
ABCA12ABCA12ATP-binding cassette, sub-family A (ABC1), member 12Source|GeneCards
COPBCOPBcoatomer protein complex, subunit betaSource|GeneCards
C20ORF23C20ORF23chromosome 20 open reading frame 23Source|GeneCards
REPIN1REPIN1replication initiator 1Source|GeneCards
CGI-63MECRmitochondrial trans-2-enoyl-CoA reductaseSource|GeneCards
NAPGNAPGN-ethylmaleimide-sensitive factor attachment protein, gammaSource|GeneCards
BMPR2BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)Source|GeneCards
MBD6MBD6methyl-CpG binding domain protein 6Source|GeneCards
SLC12A6SLC12A6solute carrier family 12 (potassium/chloride transporters), member 6Source|GeneCards
VAV3VAV3vav 3 oncogeneSource|GeneCards
MDM2MDM2Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse)Source|GeneCards
MITFMITFmicrophthalmia-associated transcription factorSource|GeneCards
PPP2R4PPP2R4protein phosphatase 2A, regulatory subunit B' (PR 53)Source|GeneCards
PMLPMLpromyelocytic leukemiaSource|GeneCards
PIK3R2PIK3R2phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta)Source|GeneCards
MMP28MMP28matrix metalloproteinase 28Source|GeneCards
EGFREGFRepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)Source|GeneCards
IDN3NIPBLNipped-B homolog (Drosophila)Source|GeneCards
SLC25A17SLC25A17solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17Source|GeneCards
NRG1NRG1neuregulin 1Source|GeneCards
CA9CA9carbonic anhydrase IXSource|GeneCards
LRRK1LRRK1Leucine-rich repeat kinase 1Source|GeneCards
RORCRORCRAR-related orphan receptor CSource|GeneCards
ELK3ELK3ELK3, ETS-domain protein (SRF accessory protein 2)Source|GeneCards
RHOBTB1RHOBTB1Rho-related BTB domain containing 1Source|GeneCards
GPR109AGPR109AG protein-coupled receptor 109ASource|GeneCards
KIAA0672KIAA0672KIAA0672 gene productSource|GeneCards
PRDM8PRDM8PR domain containing 8Source|GeneCards
LOC389119LOC389119similar to RIKEN cDNA 6530418L21Source|GeneCards
ACCN4ACCN4amiloride-sensitive cation channel 4, pituitarySource|GeneCards
SOX5SOX5SRY (sex determining region Y)-box 5Source|GeneCards
FLJ20668MARCH1membrane-associated ring finger (C3HC4) 1Source|GeneCards
DAB2IPDAB2IPDAB2 interacting proteinSource|GeneCards
BRAFBRAFv-raf murine sarcoma viral oncogene homolog B1Source|GeneCards
HNRPA0HNRPA0heterogeneous nuclear ribonucleoprotein A0Source|GeneCards
PAK7PAK7p21(CDKN1A)-activated kinase 7Source|GeneCards
PLCB1PLCB1phospholipase C, beta 1 (phosphoinositide-specific)Source|GeneCards
KPI2LMTK2lemur tyrosine kinase 2Source|GeneCards
GR6GR6putative GR6 proteinSource|GeneCards
OPA3OPA3optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)Source|GeneCards
GCNT2GCNT2glucosaminyl (N-acetyl) transferase 2, I-branching enzymeSource|GeneCards
TGFB1I4TSC22D1TSC22 domain family, member 1Source|GeneCards
TMEFF1TMEFF1transmembrane protein with EGF-like and two follistatin-like domains 1Source|GeneCards
SYT13SYT13synaptotagmin XIIISource|GeneCards
SFRS5SFRS5splicing factor, arginine/serine-rich 5Source|GeneCards
DDIT3DDIT3DNA-damage-inducible transcript 3Source|GeneCards
SH3BP1SH3BP1SH3-domain binding protein 1Source|GeneCards
CDKN1ACDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Source|GeneCards
BSCL2BSCL2Bernardinelli-Seip congenital lipodystrophy 2 (seipin)Source|GeneCards
SLC1A3SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3Source|GeneCards
BTBD14BBTBD14BBTB (POZ) domain containing 14BSource|GeneCards
DEPDC2DEPDC2DEP domain containing 2Source|GeneCards
CMT4B2SBF2SET binding factor 2Source|GeneCards
MGC19531PPM1Jprotein phosphatase 1J (PP2C domain containing)Source|GeneCards
NDUFS2NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)Source|GeneCards
HS6ST3HS6ST3heparan sulfate 6-O-sulfotransferase 3Source|GeneCards
RAP1BRAP1BRAP1B, member of RAS oncogene familySource|GeneCards
RHOBTB2RHOBTB2Rho-related BTB domain containing 2Source|GeneCards
CPNE1CPNE1RNA binding motif protein 12Source|GeneCards
TRIM29TRIM29tripartite motif-containing 29Source|GeneCards
FLJ44691FLJ44691FLJ44691 proteinSource|GeneCards
SCN2A2SCN2A2sodium channel, voltage-gated, type II, alpha 2Source|GeneCards
PPP1R12APPP1R12Aprotein phosphatase 1, regulatory (inhibitor) subunit 12ASource|GeneCards
ACSL5ACSL5acyl-CoA synthetase long-chain family member 5Source|GeneCards
NRXN3NRXN3neurexin 3Source|GeneCards
AKT2AKT2v-akt murine thymoma viral oncogene homolog 2Source|GeneCards
SP8SP8Sp8 transcription factorSource|GeneCards
SFRS6SFRS6splicing factor, arginine/serine-rich 6Source|GeneCards
STARD8STARD8START domain containing 8Source|GeneCards
C18ORF20C18ORF20chromosome 18 open reading frame 20Source|GeneCards
ZCCHC5ZCCHC5zinc finger, CCHC domain containing 5Source|GeneCards
FLJ37357FLJ37357hypothetical protein FLJ37357Source|GeneCards
PPLPPLperiplakinSource|GeneCards
TRIFRNF36ring finger protein 36Source|GeneCards
ABCC5ABCC5ATP-binding cassette, sub-family C (CFTR/MRP), member 5Source|GeneCards
FLJ45651FLJ45651FLJ45651 proteinSource|GeneCards
CTRLCTRLchymotrypsin-likeSource|GeneCards
PRKAG1PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunitSource|GeneCards
FOXG1BFOXG1Bforkhead box G1BSource|GeneCards
KIAA0377KIAA0377KIAA0377 gene productSource|GeneCards
FLJ46072FLJ46072FLJ46072 proteinSource|GeneCards
ARP3BETAACTR3BARP3 actin-related protein 3 homolog B (yeast)Source|GeneCards
DSCAML1DSCAML1Down syndrome cell adhesion molecule like 1Source|GeneCards
NUP93NUP93nucleoporin 93kDaSource|GeneCards
FLJ12484ISG20L1interferon stimulated exonuclease gene 20kDa-like 1Source|GeneCards
PRRX1PRRX1paired related homeobox 1Source|GeneCards
TBX2TBX2T-box 2Source|GeneCards
CXXC4CXXC4CXXC finger 4Source|GeneCards
MAP4MAP4microtubule-associated protein 4Source|GeneCards
GABRR2GABRR2gamma-aminobutyric acid (GABA) receptor, rho 2Source|GeneCards
MGC12965MGC12965similar to Cytochrome c, somaticSource|GeneCards
C14ORF138C14ORF138chromosome 14 open reading frame 138Source|GeneCards
PSME2PSME2proteasome (prosome, macropain) activator subunit 2 (PA28 beta)Source|GeneCards
RARBRARBretinoic acid receptor, betaSource|GeneCards
C10ORF22C10ORF22chromosome 10 open reading frame 22Source|GeneCards
FBS1FBS1Fibrosin 1Source|GeneCards
TTIDTTIDtitin immunoglobulin domain protein (myotilin)Source|GeneCards
MYL3MYL3myosin, light polypeptide 3, alkali; ventricular, skeletal, slowSource|GeneCards
E(Y)2E(Y)2e(y)2 proteinSource|GeneCards
CRAMP1LCRAMP1LCrm, cramped-like (Drosophila)Source|GeneCards
CITED1CITED1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1Source|GeneCards
GNG3GNG3guanine nucleotide binding protein (G protein), gamma 3Source|GeneCards
KRT15KRT15keratin 15Source|GeneCards
SOATSLC10A6solute carrier family 10 (sodium/bile acid cotransporter family), member 6Source|GeneCards
C2ORF4C2ORF4chromosome 2 open reading frame 4Source|GeneCards
HSPC152HSPC152hypothetical protein HSPC152Source|GeneCards
DDR1DDR1discoidin domain receptor family, member 1Source|GeneCards
FILIP1FILIP1filamin A interacting protein 1Source|GeneCards
ESRRGESRRGestrogen-related receptor gammaSource|GeneCards
MDKMDKmidkine (neurite growth-promoting factor 2)Source|GeneCards
ELF4ELF4E74-like factor 4 (ets domain transcription factor)Source|GeneCards
OTX1OTX1orthodenticle homolog 1 (Drosophila)Source|GeneCards
BCORBCORBCL6 co-repressorSource|GeneCards
FOSL1FOSL1FOS-like antigen 1Source|GeneCards
INHBBINHBBinhibin, beta B (activin AB beta polypeptide)Source|GeneCards
SLITRK1SLITRK1SLIT and NTRK-like family, member 1Source|GeneCards
GAD1GAD1glutamate decarboxylase 1 (brain, 67kDa)Source|GeneCards
LOC159091LOC159091hypothetical protein BC017868Source|GeneCards
RAI1RAI1retinoic acid induced 1Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
FLJ12903FLJ12903hypothetical protein FLJ12903Source|GeneCards
DNAJB5DNAJB5DnaJ (Hsp40) homolog, subfamily B, member 5Source|GeneCards
SYT4SYT4synaptotagmin IVSource|GeneCards
ADAMTS4ADAMTS4a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4Source|GeneCards
FLJ38968FLJ38968hypothetical protein FLJ38968Source|GeneCards
KIAA1727KIAA1727KIAA1727 proteinSource|GeneCards
NDPNDPNorrie disease (pseudoglioma)Source|GeneCards
CP110CP110CP110 proteinSource|GeneCards
FLJ45721FLJ45721FLJ45721 proteinSource|GeneCards
CHUKCHUKconserved helix-loop-helix ubiquitous kinaseSource|GeneCards
GRIN2AGRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2ASource|GeneCards
MBNL1MBNL1muscleblind-like (Drosophila)Source|GeneCards
CALD1CALD1caldesmon 1Source|GeneCards
FLJ10997ZNF654zinc finger protein 654Source|GeneCards
HOXA11HOXA11homeo box A11Source|GeneCards
EI24EI24etoposide induced 2.4 mRNASource|GeneCards
ARRDC4ARRDC4arrestin domain containing 4Source|GeneCards
BAI1BAI1brain-specific angiogenesis inhibitor 1Source|GeneCards
RAB1BRAB1BRAB1B, member RAS oncogene familySource|GeneCards
MGC5395MGC5395hypothetical protein MGC5395Source|GeneCards
FGF20FGF20fibroblast growth factor 20Source|GeneCards
TFAMTFAMtranscription factor A, mitochondrialSource|GeneCards
EIF4G2EIF4G2eukaryotic translation initiation factor 4 gamma, 2Source|GeneCards
SSTR3SSTR3somatostatin receptor 3Source|GeneCards
MTA2MTA2metastais-associated gene family, member 2Source|GeneCards
GPD2GPD2glycerol-3-phosphate dehydrogenase 2 (mitochondrial)Source|GeneCards
SLITRK4SLITRK4SLIT and NTRK-like family, member 4Source|GeneCards
ST5ST5suppression of tumorigenicity 5Source|GeneCards
TJP2TJP2tight junction protein 2 (zona occludens 2)Source|GeneCards
GCC1GCC1GRIP and coiled-coil domain-containing 1Source|GeneCards
PKP3PKP3plakophilin 3Source|GeneCards
PTPN22PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)Source|GeneCards
C18ORF4C18ORF4chromosome 18 open reading frame 4Source|GeneCards
MAFMAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)Source|GeneCards
CIDE-3CIDECcell death-inducing DFFA-like effector cSource|GeneCards
LRDDLRDDleucine-rich and death domain containingSource|GeneCards
CITED4CITED4Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4Source|GeneCards
FLJ43093FLJ43093FLJ43093 proteinSource|GeneCards
DYRK1BDYRK1Bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1BSource|GeneCards
SEMA7ASEMA7Asema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7ASource|GeneCards
PTPRGPTPRGprotein tyrosine phosphatase, receptor type, GSource|GeneCards
LOC90668LOC90668hypothetical protein BC008134Source|GeneCards
MIPMIPmajor intrinsic protein of lens fiberSource|GeneCards
ENPP2ENPP2ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin)Source|GeneCards
DGKZDGKZdiacylglycerol kinase, zeta 104kDaSource|GeneCards
TDRD4TDRD4tudor domain containing 4Source|GeneCards
IBRDC2IBRDC2IBR domain containing 2Source|GeneCards
C6ORF62C6ORF62chromosome 6 open reading frame 62Source|GeneCards
RPS27LRPS27Lribosomal protein S27-likeSource|GeneCards
BCL11ABCL11AB-cell CLL/lymphoma 11A (zinc finger protein)Source|GeneCards
OTX2OTX2orthodenticle homolog 2 (Drosophila)Source|GeneCards
WIG1WIG1p53 target zinc finger proteinSource|GeneCards
FLJ12056FLJ12056hypothetical protein FLJ12056Source|GeneCards
NR4A3NR4A3nuclear receptor subfamily 4, group A, member 3Source|GeneCards
BRUNOL6BRUNOL6bruno-like 6, RNA binding protein (Drosophila)Source|GeneCards
ERO1LBERO1LBERO1-like beta (S. cerevisiae)Source|GeneCards
HOXB1HOXB1homeo box B1Source|GeneCards
DFNB31DFNB31deafness, autosomal recessive 31Source|GeneCards
NXPH1NXPH1neurexophilin 1Source|GeneCards
PTHR1PTHR1parathyroid hormone receptor 1Source|GeneCards
PRDX5PRDX5peroxiredoxin 5Source|GeneCards
FLJ22374FLJ22374hypothetical protein FLJ22374Source|GeneCards
MBNL2MBNL2muscleblind-like 2 (Drosophila)Source|GeneCards
CTNND2CTNND2catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)Source|GeneCards
EPB41L1EPB41L1erythrocyte membrane protein band 4.1-like 1Source|GeneCards
LULULutheran blood group (Auberger b antigen included)Source|GeneCards
CRATCRATcarnitine acetyltransferaseSource|GeneCards
CACNG2CACNG2calcium channel, voltage-dependent, gamma subunit 2Source|GeneCards
MAP2K5MAP2K5mitogen-activated protein kinase kinase 5Source|GeneCards
FUT11FUT11fucosyltransferase 11 (alpha (1,3) fucosyltransferase)Source|GeneCards
PPP2R5BPPP2R5Bprotein phosphatase 2, regulatory subunit B (B56), beta isoformSource|GeneCards

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