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Gene set: V$RFX1_01 (C3:TFAC:0174)
Standard nameV$RFX1_01
Systematic nameC3:TFAC:0174
Brief descriptionGenes with 3'UTR containing motif NNGTNRCNWRGYAACNN which matches annotation for RFX1: regulatory factor X, 1 (influences HLA class II expression)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA RFX1
 XX
 SY EF-C; RFX; RF-X; enhancer
factor C; hRFX1.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 HO TGT3, EP protein, MDBP,
CeRFX (C.elegans), Sak1 (S.pombe), Crt1
 HO (S.cerevisiae)

 XX
 CL C0023; fork head; 3.3.4.1.1.
 XX

SZ 979 AA; 104.7 kDa (cDNA)
 XX
 XX
 SC SwissProt #P22670

XX
 FT 4 73 glutamine-rich region (16/70).
 FT 13 97 proline-rich
region (34/85).
 FT 85 126 serine-/threonine-rich region (13/42).

FT 127 212 glutamine-rich region (20/86).
 FT 215 227 serine-/threonine-rich
region (7/13).
 FT 215 378 PF04589; RFX1_trans_act.
 FT
230 296 glutamine-rich region (18/67).
 FT 304 380 serine-/threonine-rich
region (31/77).
 FT 381 411 glycine-rich region (25/31).

FT 421 503 PF02257; RFX_DNA_binding.
 FT 438 528 DNA-binding
domain (DBD) [14].
 FT 439 445 alpha-helix 1, H1 [2].
 FT
446 455 beta-strand, S1 [2].
 FT 456 469 alpha-helix 2, H2
[2].
 FT 470 475 connecting loop 1, L1 [2].
 FT 476 486
alpha-helix 3, H3 [2].
 FT 487 490 connecting loop 2, L2 [2].

FT 491 495 beta-strand 2, S2 [2].
 FT 496 501 wing, W1 [2].

FT 502 511 beta-strand 3, S3 [2].
 FT 621 739 domains B and
C, autoinhibitory domains [4].
 FT 621 979 extended dimerization
domain, EDD [5] [6].
 FT 744 979 dimerization domain, repression
domain [7].
 FT 913 936 acidic region, Ac [1].
 FT 937 979
nuclear localization signal, NLS [1].
 XX
 SF member of
winged-helix class of helix-turn-helix superclass of factors [2];

SF the DBD exhibits a weak sequence similarity to the bHLH domain
consensus
 SF and is predicted to constitute two amphipathic
helices and a linking loop
 SF [14];
 SF it binds to DNA
as a dimer, but dimerization is not a prerequisite for
 SF
DNA-binding [14];
 SF both RF-X subunits interact independently
with the X-box(es) [14];
 SF together with MIBP1 ,
RFX1 constitutes the DNA-binding activity
 SF MIF-1 
[9];
 SF secondary structure exhibits three alpha-helical and
one beta-stranded
 SF segments within the DNA-binding domain,
the potential helix III region
 SF being responsible for sequence
specific binding [8];
 SF DNA binding domain has been identified
as winged-helix, hRFX1 uses a
 SF beta-hairpin (or wing) for
DNA recognition instead of recognition helix [2];
 SF DBD consistis
of 3 alpha-helices, 3 beta-strands and 3 connecting loops [2];

SF new mode of DNA binding: beta-strands S2 and S3 and wing W1
make extensive
 SF contacts with the major groove of one half-site
of the symmetric X-box,
 SF alpha-helix H3 interacts with the
minor groove of the other half-site [2];
 SF N-terminal transactivation
domain, but activation potential can be masked
 SF by autoinhibitory
domain [4];
 SF can bind DNA as a homodimer or heterodimer
with RFX2 or RFX3 [4];
 SF possesses a split, extended dimerization
domain which mediated formation of
 SF alternative homodimeric
complexes [5] [6];
 SF EDD is similar to the LBD of nuclear
receptors by several features, it is
 SF independent on DBD,
mediates dimerization and can function in alternative
 SF conformations
[5] [6];
 SF C-terminal acidic region may work as an autoinhibitory
domain relating DNA
 SF binding by RFX1 [1];
 XX
 CP
ubiquitous, highly expressed in primary eosinophils [4]
 XX

FF homodimers can function as activators or repressors depending
on the nature
 FF of interactions between two subunits, two
distinct types of homodimers can
 FF be formed which are different
in their function [5] [7] [6];
 FF preferential binding to
methylated sequences;
 FF binds to X boxes of MHC class II
alpha-chain gene promoters [15] and the
 FF HBV enhancer I
[11];
 FF identical to EF-C [11], but different from NF-X;

FF at the HBV enhancer I, it has to cooperate with liver-specific
factors [11];
 FF it cooperatively binds to the X-Y-box pattern
of MHC gene promoters with
 FF NF-Y [10];
 FF inhibitory
role in the regulation of proliferating cell nuclear antigen

FF (PCNA) expression [3];
 FF DNA binding activity may be regulated
by phosphorylation [1];
 XX
 IN T02313; MIBP1; rat, Rattus
norvegicus.
 IN T01667; RFX2; human, Homo sapiens.
 IN T01669;
RFX2; mouse, Mus musculus.
 IN T01670; RFX3; human, Homo sapiens.

XX
 XX
 XX
 XX
 RN [1]; RE0022531.
 RX MEDLINE;
11358531.
 RA Katan-Khaykovich Y., Shaul Y.
 RT Nuclear
import and DNA-binding activity of RFX1. Evidence for an
 RT
autoinhibitory mechanism.
 RL Eur. J. Biochem. 268:3108-3116
(2001).
 RN [2]; RE0022520.
 RX MEDLINE; 10706293.
 RA
Gajiwala K. S., Chen H., Cornille F., Roques B. P., Reith W.,
Mach B.,
 RA Burley S. K.
 RT Structure of the winged-helix
protein hRFX1 reveals a new mode of DNA
 RT binding.
 RL
Nature 403:916-921 (2000).
 RN [3]; RE0017028.
 RX MEDLINE;
99269075.
 RA Liu M., Lee B. H., Mathews M. B.
 RT Involvement
of RFX1 protein in the regulation of the human proliferating

RT cell nuclear antigen promoter
 RL J. Biol. Chem. 274:15433-15439
(1999).
 RN [4]; RE0022525.
 RX MEDLINE; 10330134.
 RA
Iwama A., Pan J., Zhang P., Reith W., Mach B., Tenen D. G., Sun
Z.
 RT Dimeric RFX proteins contribute to the activity and
lineage specificity of
 RT the interleukin-5 receptor alpha
promoter through activation and repression
 RT domains.

RL Mol. Cell. Biol. 19:3940-3950 (1999).
 RN [5]; RE0022527.

RX MEDLINE; 10556033.
 RA Katan-Khaykovich Y., Spiegel I.,
Shaul Y.
 RT The dimerization/repression domain of RFX1 is
related to a conserved region
 RT of its yeast homologues Crt1
and Sak1: a new function for an ancient motif.
 RL J. Mol.
Biol. 294:121-137 (1999).
 RN [6]; RE0022530.
 RX MEDLINE;
9733744.
 RA Katan-Khaykovich Y., Shaul Y.
 RT RFX1, a single
DNA-binding protein with a split dimerization domain,
 RT generates
alternative complexes.
 RL J. Biol. Chem. 273:24504-24512 (1998).

RN [7]; RE0022528.
 RX MEDLINE; 9278482.
 RA Katan Y., Agami
R., Shaul Y.
 RT The transcriptional activation and repression
domains of RFX1, a
 RT context-dependent regulator, can mutually
neutralize their activities.
 RL Nucleic Acids Res. 25:3621-3628
(1997).
 RN [8]; RE0006617.
 RX MEDLINE; 96315675.
 RA
Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W.

RT A consensus motif in the RFX DNA binding domain and binding
domain mutants
 RT with altered specificity
 RL Mol. Cell.
Biol. 16:4486-4494 (1996).
 RN [9]; RE0006616.
 RX MEDLINE;
95280902.
 RA Reinhold W., Emens L., Itkes A., Blake M., Ichinose
I., Zajac-Kaye M.
 RT The myc intron-binding polypeptide associates
with RFX1 in vivo and binds
 RT to the major histocompatibility
complex class II promoter region, to the
 RT hepatitis B virus
enhancer, and to regulatory regions of several distinct
 RT
viral genes
 RL Mol. Cell. Biol. 15:3041-3048 (1995).
 RN
[10]; RE0003796.
 RX MEDLINE; 94119925.
 RA Reith W., Siegrist
C. A., Durand B., Barras E., Mach B.
 RT Function of major
histocompatibility complex class II promoters requires
 RT
cooperative binding between factors RFX and NF-Y
 RL Proc.
Natl. Acad. Sci. USA 91:554-558 (1994).
 RN [11]; RE0003798.

RX MEDLINE; 94019311.
 RA Siegrist C. A., Durand B., Emery
P., David E., Hearing P., Mach B., Reith W.
 RT RFX1 is identical
to enhancer factor C and functions as a transactivator of

RT the hepatitis B virus enhancer
 RL Mol. Cell. Biol. 13:6375-6384
(1993).
 RN [12]; RE0002144.
 RX MEDLINE; 91232904.

RA Hasegawa S. L., Sloan J. H., Reith W., Mach B., Boss J. M.

RT Regulatory factor-X binding to mutant HLA-DRA promoter sequences

RL Nucleic Acids Res. 19:1243-1248 (1991).
 RN [13]; RE0002729.

RX MEDLINE; 91220738.
 RA Garcia A. D., Ostapchuk P., Hearing
P.
 RT Methylation-dependent and -independent DNA binding of
nuclear factor EF-C
 RL Virology 182:857-860 (1991).
 RN
[14]; RE0000690.
 RX MEDLINE; 91071581.
 RA Reith W., Herrero-Sanchez
C., Kobr M., Silacci P., Berte C., Barras E., Fey
 RA S., Mach
B.
 RT MHC class II regulatory factor RFX has a novel DNA-binding
domain and a
 RT functionally independent dimerization domain

RL Genes Dev. 4:1528-1540 (1990).
 RN [15]; RE0001485.

RX MEDLINE; 90158612.
 RA Kobr M., Reith W., Herrero-Sanchez
C., Mach B.
 RT Two DNA-binding proteins discriminate between
the promoters of different
 RT members of the major histocompatibility
complex class II multigene family
 RL Mol. Cell. Biol. 10:965-971
(1990).
 RN [16]; RE0002442.
 RX MEDLINE; 91017573.

RA Cogswell J. P., Basta P. V., Ting J. P.-Y.
 RT X-box-binding
proteins positively and negatively regulate transcription of

RT the HLA-DRA gene through interaction with discrete upstream
W and V elements
 RL Proc. Natl. Acad. Sci. USA 87:7703-7707
(1990).
 RN [17]; RE0001429.
 RX MEDLINE; 89384536.

RA Ostapchuk P., Scheirle G., Hearing P.
 RT Binding of Nuclear
Factor EF-C to a Functional Domain of the Hepatitis B
 RT Virus
Enhancer Region
 RL Mol. Cell. Biol. 9:2787-2797 (1989).

RN [18]; RE0002392.
 RX MEDLINE; 89264585.
 RA Reith W.,
Barras E., Satola S., Kobr M., Reinhardt D., Sanchez C. H., Mach

RA B.
 RT Cloning of the major histocompatibility complex class
II promoter binding
 RT protein affected in a hereditary defect
in class II gene regulation
 RL Proc. Natl. Acad. Sci. USA
86:4200-4204 (1989).
 RN [19]; RE0000111.
 RX MEDLINE; 88253410.

RA Reith W., Satola S., Herrero-Sanchez C., Amaldi I., Lisowska-Grospierre
B.,
 RA Griscelli C., Hadam M. R., Mach B.
 RT Congenital
Immunodeficiency with a Regulatory Defect in MHC Class II Gene

RT Expression Lacks a Specific HLA-DR Promoter Binding Protein,
RF-X
 RL Cell 53:897-906 (1988).
 RN [20]; RE0000351.

RX MEDLINE; 88004398.
 RA Shaul Y., Ben-Levy R.
 RT Multiple
nuclear proteins in liver cells are bound to hepatitis B virus

RT enhancer element and its upstream sequences
 RL EMBO J.
6:1913-1920 (1987).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

265 genes, 265 accessions (Toggle view)

AccessionGeneTitleLinks
PTPRTPTPRTprotein tyrosine phosphatase, receptor type, TSource|GeneCards
PDCL2PDCL2phosducin-like 2Source|GeneCards
MDH1MDH1malate dehydrogenase 1, NAD (soluble)Source|GeneCards
TSGA10TSGA10testis specific, 10Source|GeneCards
ZNF533ZNF533Zinc finger protein 533Source|GeneCards
C8ORF13C8ORF13chromosome 8 open reading frame 13Source|GeneCards
NSPC1PCGF1polycomb group ring finger 1Source|GeneCards
GABARAPL2GABARAPL2GABA(A) receptor-associated protein-like 2Source|GeneCards
MANEAMANEAmannosidase, endo-alphaSource|GeneCards
PAK6PAK6p21(CDKN1A)-activated kinase 6Source|GeneCards
MYOHD1MYOHD1myosin head domain containing 1Source|GeneCards
SOX3SOX3SRY (sex determining region Y)-box 3Source|GeneCards
BDNFBDNFbrain-derived neurotrophic factorSource|GeneCards
FLJ25444FLJ25444hypothetical protein FLJ25444Source|GeneCards
LMO3LMO3LIM domain only 3 (rhombotin-like 2)Source|GeneCards
ACBD3ACBD3acyl-Coenzyme A binding domain containing 3Source|GeneCards
PDZK4PDZK4PDZ domain containing 4Source|GeneCards
DDX17DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Source|GeneCards
GSK3BGSK3Bglycogen synthase kinase 3 betaSource|GeneCards
CTF1CTF1cardiotrophin 1Source|GeneCards
SEP15SEP1515 kDa selenoproteinSource|GeneCards
PITX2PITX2paired-like homeodomain transcription factor 2Source|GeneCards
GPR119GPR119G protein-coupled receptor 119Source|GeneCards
MR-1MR-1myofibrillogenesis regulator 1Source|GeneCards
YWHAQYWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideSource|GeneCards
GPX1GPX1glutathione peroxidase 1Source|GeneCards
DNAH7DNAH7dynein, axonemal, heavy polypeptide 7Source|GeneCards
PIGAPIGAphosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria)Source|GeneCards
ANXA1ANXA1annexin A1Source|GeneCards
MYH8MYH8myosin, heavy polypeptide 8, skeletal muscle, perinatalSource|GeneCards
MGC13024MGC13024hypothetical protein MGC13024Source|GeneCards
BCL2L1BCL2L1BCL2-like 1Source|GeneCards
PLCB3PLCB3phospholipase C, beta 3 (phosphatidylinositol-specific)Source|GeneCards
DKFZP434A1319C16ORF48chromosome 16 open reading frame 48Source|GeneCards
LOC388389LOC388389Similar to RIKEN 4933439F11Source|GeneCards
DKFZP566M1046DKFZP566M1046hypothetical protein DKFZp566M1046Source|GeneCards
STOML2STOML2stomatin (EPB72)-like 2Source|GeneCards
UBXD3UBXD3UBX domain containing 3Source|GeneCards
TRERF1TRERF1transcriptional regulating factor 1Source|GeneCards
C10ORF27C10ORF27chromosome 10 open reading frame 27Source|GeneCards
MGC26999FAM46Dfamily with sequence similarity 46, member DSource|GeneCards
DKFZP761H079ARL2L1ADP-ribosylation factor-like 2-like 1Source|GeneCards
FLJ44299FAM92Bfamily with sequence similarity 92, member BSource|GeneCards
DNCL1DNCL1dynein, cytoplasmic, light polypeptide 1Source|GeneCards
FIBCD1FIBCD1fibrinogen C domain containing 1Source|GeneCards
FLJ46020FLJ46020FLJ46020 proteinSource|GeneCards
ZFYVE1ZFYVE1zinc finger, FYVE domain containing 1Source|GeneCards
RRAGARRAGARas-related GTP binding ASource|GeneCards
FLJ21159FLJ21159hypothetical protein FLJ21159Source|GeneCards
MDS1MDS1myelodysplasia syndrome 1Source|GeneCards
SLC8A3SLC8A3solute carrier family 8 (sodium-calcium exchanger), member 3Source|GeneCards
C9ORF25C9ORF25chromosome 9 open reading frame 25Source|GeneCards
MGC10731C1ORF89chromosome 1 open reading frame 89Source|GeneCards
WWOXWWOXWW domain containing oxidoreductaseSource|GeneCards
SH3GL3SH3GL3SH3-domain GRB2-like 3Source|GeneCards
FZD1FZD1frizzled homolog 1 (Drosophila)Source|GeneCards
SIX1SIX1sine oculis homeobox homolog 1 (Drosophila)Source|GeneCards
KIRREL2KIRREL2kin of IRRE like 2 (Drosophila)Source|GeneCards
KLP1KLP1K562 cell-derived leucine-zipper-like protein 1Source|GeneCards
SDCBP2SDCBP2syndecan binding protein (syntenin) 2Source|GeneCards
CALB2CALB2calbindin 2, 29kDa (calretinin)Source|GeneCards
UBBUBBubiquitin BSource|GeneCards
KIF17KIF17kinesin family member 17Source|GeneCards
ARL4AARL4ADP-ribosylation factor-like 4Source|GeneCards
BIKBIKBCL2-interacting killer (apoptosis-inducing)Source|GeneCards
NRGNNRGNneurogranin (protein kinase C substrate, RC3)Source|GeneCards
ARFGEF2ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)Source|GeneCards
KIAA0922KIAA0922KIAA0922 proteinSource|GeneCards
CBX8CBX8chromobox homolog 8 (Pc class homolog, Drosophila)Source|GeneCards
ADCK4ADCK4aarF domain containing kinase 4Source|GeneCards
PRICKLE1PRICKLE1prickle-like 1 (Drosophila)Source|GeneCards
FLJ32855FLJ32855hypothetical protein FLJ32855Source|GeneCards
KIAA0296ZNF646zinc finger protein 646Source|GeneCards
NYD-SP28NYD-SP28NYD-SP28 proteinSource|GeneCards
TRAF4TRAF4TNF receptor-associated factor 4Source|GeneCards
PURAPURApurine-rich element binding protein ASource|GeneCards
BMP6BMP6bone morphogenetic protein 6Source|GeneCards
PIK3R4PIK3R4phosphoinositide-3-kinase, regulatory subunit 4, p150Source|GeneCards
PTCHPTCHpatched homolog (Drosophila)Source|GeneCards
MGC39827MGC39827hypothetical protein MGC39827Source|GeneCards
BRODLBRWD3bromodomain and WD repeat domain containing 3Source|GeneCards
IGSF8IGSF8immunoglobulin superfamily, member 8Source|GeneCards
KRTAP11-1KRTAP11-1keratin associated protein 11-1Source|GeneCards
MDH1BMDH1Bmalate dehydrogenase 1B, NAD (soluble)Source|GeneCards
BOP1BOP1block of proliferation 1Source|GeneCards
ZRANB1ZRANB1zinc finger, RAN-binding domain containing 1Source|GeneCards
SPTAN1SPTAN1spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)Source|GeneCards
HECTD1HECTD1HECT domain containing 1Source|GeneCards
IGF1IGF1insulin-like growth factor 1 (somatomedin C)Source|GeneCards
SMC1L2SMC1L2SMC1 structural maintenance of chromosomes 1-like 2 (yeast)Source|GeneCards
SALL2SALL2sal-like 2 (Drosophila)Source|GeneCards
CDC14ACDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Source|GeneCards
SNF1LKSNF1LKSNF1-like kinaseSource|GeneCards
IDSIDSiduronate 2-sulfatase (Hunter syndrome)Source|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
SYT14LSYT14Lsynaptotagmin XIV-likeSource|GeneCards
FLJ35409FLJ35409FLJ35409 proteinSource|GeneCards
AP1M1AP1M1adaptor-related protein complex 1, mu 1 subunitSource|GeneCards
MGC35130UBE2Uubiquitin-conjugating enzyme E2U (putative)Source|GeneCards
GALNT14GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)Source|GeneCards
GJB1GJB1gap junction protein, beta 1, 32kDa (connexin 32, Charcot-Marie-Tooth neuropathy, X-linked)Source|GeneCards
SRRSRRserine racemaseSource|GeneCards
WINS1LINS1lines homolog 1 (Drosophila)Source|GeneCards
KCNJ2KCNJ2potassium inwardly-rectifying channel, subfamily J, member 2Source|GeneCards
HSF1HSF1heat shock transcription factor 1Source|GeneCards
GRIA1GRIA1glutamate receptor, ionotropic, AMPA 1Source|GeneCards
DNCL2BDNCL2Bdynein, cytoplasmic, light polypeptide 2BSource|GeneCards
KIAA0672KIAA0672KIAA0672 gene productSource|GeneCards
GGNGGNgametogenetinSource|GeneCards
TBPL1TBPL1TBP-like 1Source|GeneCards
LOC134548LOC134548hypothetical protein LOC134548Source|GeneCards
TEKT2TEKT2tektin 2 (testicular)Source|GeneCards
BCAP31BCAP31B-cell receptor-associated protein 31Source|GeneCards
MTPMTPmicrosomal triglyceride transfer protein (large polypeptide, 88kDa)Source|GeneCards
WDR17WDR17WD repeat domain 17Source|GeneCards
FLJ32771FLJ32771IIIG9 proteinSource|GeneCards
DRP2DRP2dystrophin related protein 2Source|GeneCards
PSCD2PSCD2pleckstrin homology, Sec7 and coiled-coil domains 2 (cytohesin-2)Source|GeneCards
CNOT10CNOT10CCR4-NOT transcription complex, subunit 10Source|GeneCards
PPP2R2BPPP2R2Bprotein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoformSource|GeneCards
KIAA0971KIAA0971KIAA0971 proteinSource|GeneCards
U5-116KDEFTUD2elongation factor Tu GTP binding domain containing 2Source|GeneCards
FLJ14069C17ORF31chromosome 17 open reading frame 31Source|GeneCards
BBS2BBS2Bardet-Biedl syndrome 2Source|GeneCards
HAT1HAT1histone acetyltransferase 1Source|GeneCards
NPM1NPM1nucleophosmin (nucleolar phosphoprotein B23, numatrin)Source|GeneCards
SMCR7SMCR7Smith-Magenis syndrome chromosome region, candidate 7Source|GeneCards
SMAP-5YIPF5Yip1 domain family, member 5Source|GeneCards
RTDR1RTDR1rhabdoid tumor deletion region gene 1Source|GeneCards
C10ORF53C10ORF53chromosome 10 open reading frame 53Source|GeneCards
GPR109BGPR109BG protein-coupled receptor 109B /// G protein-coupled receptor 109BSource|GeneCards
SCN2A2SCN2A2sodium channel, voltage-gated, type II, alpha 2Source|GeneCards
MGC16309LRRC46leucine rich repeat containing 46Source|GeneCards
TUSC3TUSC3tumor suppressor candidate 3Source|GeneCards
NAB2NAB2NGFI-A binding protein 2 (EGR1 binding protein 2)Source|GeneCards
GPP34RGOLPH3Lgolgi phosphoprotein 3-likeSource|GeneCards
MGC40179MGC40179hypothetical protein MGC40179Source|GeneCards
ABCD1ABCD1ATP-binding cassette, sub-family D (ALD), member 1Source|GeneCards
GRM3GRM3glutamate receptor, metabotropic 3Source|GeneCards
GTF3C4GTF3C4general transcription factor IIIC, polypeptide 4, 90kDaSource|GeneCards
NME5NME5non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)Source|GeneCards
DPAGT1DPAGT1dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)Source|GeneCards
DNAL4DNAL4dynein, axonemal, light polypeptide 4Source|GeneCards
CARSCARScysteinyl-tRNA synthetaseSource|GeneCards
TBX5TBX5T-box 5Source|GeneCards
MGC16186MGC16186hypothetical protein MGC16186Source|GeneCards
C17ORF31C17ORF31chromosome 17 open reading frame 31Source|GeneCards
C10ORF78C10ORF78chromosome 10 open reading frame 78Source|GeneCards
NY-REN-58NY-REN-58NY-REN-58 antigenSource|GeneCards
DIO3DIO3deiodinase, iodothyronine, type IIISource|GeneCards
PARK2PARK2Parkinson disease (autosomal recessive, juvenile) 2, parkinSource|GeneCards
RIT2RIT2Ras-like without CAAX 2Source|GeneCards
C2ORF15C2ORF15chromosome 2 open reading frame 15Source|GeneCards
GBF1GBF1Golgi-specific brefeldin A resistance factor 1Source|GeneCards
FLJ22688FLJ22688hypothetical protein FLJ22688Source|GeneCards
HM13HM13histocompatibility (minor) 13Source|GeneCards
TITF1TITF1thyroid transcription factor 1Source|GeneCards
PVRL4PVRL4poliovirus receptor-related 4Source|GeneCards
CX3CL1CX3CL1chemokine (C-X3-C motif) ligand 1Source|GeneCards
ZNF339ZNF339zinc finger protein 339Source|GeneCards
GSNGSNgelsolin (amyloidosis, Finnish type)Source|GeneCards
TTC10TTC10tetratricopeptide repeat domain 10Source|GeneCards
ADMADMadrenomedullinSource|GeneCards
PRRX1PRRX1paired related homeobox 1Source|GeneCards
PHF15PHF15PHD finger protein 15Source|GeneCards
ZFP36L2ZFP36L2zinc finger protein 36, C3H type-like 2Source|GeneCards
CPXCR1CPXCR1CPX chromosome region, candidate 1Source|GeneCards
FLJ10094FLJ10094hypothetical protein FLJ10094Source|GeneCards
C22ORF11RIBC2RIB43A domain with coiled-coils 2Source|GeneCards
NEDD9NEDD9neural precursor cell expressed, developmentally down-regulated 9Source|GeneCards
FLJ14871CORO6coronin 6Source|GeneCards
PTDSS2PTDSS2phosphatidylserine synthase 2Source|GeneCards
DDX41DDX41DEAD (Asp-Glu-Ala-Asp) box polypeptide 41Source|GeneCards
CAPN3CAPN3calpain 3, (p94)Source|GeneCards
SPA17SPA17sperm autoantigenic protein 17Source|GeneCards
RFC5RFC5replication factor C (activator 1) 5, 36.5kDaSource|GeneCards
MRPL10MRPL10mitochondrial ribosomal protein L10Source|GeneCards
TTC16TTC16tetratricopeptide repeat domain 16Source|GeneCards
TIP39TFIP11tuftelin interacting protein 11Source|GeneCards
ASB7ASB7ankyrin repeat and SOCS box-containing 7Source|GeneCards
CACNA2D3CACNA2D3calcium channel, voltage-dependent, alpha 2/delta 3 subunitSource|GeneCards
FLJ23598AGBL2ATP/GTP binding protein-like 2Source|GeneCards
FILIP1FILIP1filamin A interacting protein 1Source|GeneCards
FLJ35119FLJ35119hypothetical protein FLJ35119Source|GeneCards
F2RL1F2RL1coagulation factor II (thrombin) receptor-like 1Source|GeneCards
ST13ST13suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)Source|GeneCards
PRDM4PRDM4PR domain containing 4Source|GeneCards
PIGWPIGWphosphatidylinositol glycan, class WSource|GeneCards
PACRGPACRGPARK2 co-regulatedSource|GeneCards
PAX6PAX6paired box gene 6 (aniridia, keratitis)Source|GeneCards
SNRPFSNRPFsmall nuclear ribonucleoprotein polypeptide FSource|GeneCards
MGC34648FAM76Afamily with sequence similarity 76, member ASource|GeneCards
PSMF1PSMF1proteasome (prosome, macropain) inhibitor subunit 1 (PI31)Source|GeneCards
FLJ32783RIBC1RIB43A domain with coiled-coils 1Source|GeneCards
MGC35521PELI3pellino 3 alphaSource|GeneCards
FLJ12666C1ORF108chromosome 1 open reading frame 108Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
STMN4STMN4stathmin-like 4Source|GeneCards
FGRFGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homologSource|GeneCards
ASXL2ASXL2additional sex combs like 2 (Drosophila)Source|GeneCards
ZCCHC8ZCCHC8Zinc finger, CCHC domain containing 8Source|GeneCards
HDAC9HDAC9histone deacetylase 9Source|GeneCards
RASGEF1ARASGEF1ARasGEF domain family, member 1ASource|GeneCards
EFNA1EFNA1ephrin-A1Source|GeneCards
CKMT1CKMT1creatine kinase, mitochondrial 1 (ubiquitous)Source|GeneCards
CP110CP110CP110 proteinSource|GeneCards
LOC63929LOC63929hypothetical protein LOC63929Source|GeneCards
SHC3SHC3src homology 2 domain containing transforming protein C3Source|GeneCards
LOC115811IQCDIQ motif containing DSource|GeneCards
FLJ22843EFHC2EF-hand domain (C-terminal) containing 2Source|GeneCards
LOC401565LOC401565similar to 4931415M17 proteinSource|GeneCards
CFL2CFL2cofilin 2 (muscle)Source|GeneCards
ARC92MED25mediator of RNA polymerase II transcription, subunit 25 homolog (yeast)Source|GeneCards
CDIPTCDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)Source|GeneCards
TCF12TCF12transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)Source|GeneCards
GRIK5GRIK5glutamate receptor, ionotropic, kainate 5Source|GeneCards
VEGFVEGFvascular endothelial growth factorSource|GeneCards
SBBI54SBBI54hypothetical transmembrane protein SBBI54Source|GeneCards
RNF25RNF25ring finger protein 25Source|GeneCards
HSPG2HSPG2heparan sulfate proteoglycan 2 (perlecan)Source|GeneCards
C5ORF15C5ORF15chromosome 5 open reading frame 15Source|GeneCards
FLJ40298FLJ40298hypothetical protein FLJ40298Source|GeneCards
PRKCSHPRKCSHprotein kinase C substrate 80K-HSource|GeneCards
DNAI1DNAI1dynein, axonemal, intermediate polypeptide 1Source|GeneCards
LOC90693LOC90693alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetyl-glucosaminyltransferase-likeSource|GeneCards
MGC4825MGC4825hypothetical protein MGC4825Source|GeneCards
SMAD5SMAD5SMAD, mothers against DPP homolog 5 (Drosophila)Source|GeneCards
CITED2CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2Source|GeneCards
XRCC1XRCC1X-ray repair complementing defective repair in Chinese hamster cells 1Source|GeneCards
MIR16MIR16membrane interacting protein of RGS16Source|GeneCards
E2F5E2F5E2F transcription factor 5, p130-bindingSource|GeneCards
MGC48595MGC48595Hypothetical MGC48595Source|GeneCards
MAGED1MAGED1melanoma antigen, family D, 1Source|GeneCards
HOXA10HOXA10homeo box A10Source|GeneCards
HMGCS1HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)Source|GeneCards
CPEB2CPEB2cytoplasmic polyadenylation element binding protein 2Source|GeneCards
TMEM28TMEM28transmembrane protein 28Source|GeneCards
FLJ14154FLJ14154hypothetical protein FLJ14154Source|GeneCards
DUSP4DUSP4dual specificity phosphatase 4Source|GeneCards
BNC2BNC2basonuclin 2Source|GeneCards
KIAA1924KIAA1924hypothetical protein KIAA1924Source|GeneCards
PES1PES1pescadillo homolog 1, containing BRCT domain (zebrafish)Source|GeneCards
FLJ42117FLJ42117FLJ42117 proteinSource|GeneCards
BTRCBTRCbeta-transducin repeat containingSource|GeneCards
FXYD6FXYD6FXYD domain containing ion transport regulator 6Source|GeneCards
ARHGAP15ARHGAP15Rho GTPase activating protein 15Source|GeneCards
DFNB31DFNB31deafness, autosomal recessive 31Source|GeneCards
HS2ST1HS2ST1heparan sulfate 2-O-sulfotransferase 1Source|GeneCards
MYO1CMYO1Cmyosin ICSource|GeneCards
TPCN1TPCN1two pore segment channel 1Source|GeneCards
KIAA0265KIAA0265KIAA0265 proteinSource|GeneCards
DHX8DHX8DEAH (Asp-Glu-Ala-His) box polypeptide 8Source|GeneCards
SMG1SMG1PI-3-kinase-related kinase SMG-1Source|GeneCards
RPS6KA5RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 5Source|GeneCards
POLR3HPOLR3Hpolymerase (RNA) III (DNA directed) polypeptide H (22.9kD)Source|GeneCards
TBC1D16TBC1D16TBC1 domain family, member 16Source|GeneCards
FLJ10546RNF184ring finger protein 184Source|GeneCards
ACTG2ACTG2actin, gamma 2, smooth muscle, entericSource|GeneCards
EFNB3EFNB3ephrin-B3Source|GeneCards
NCOA5NCOA5nuclear receptor coactivator 5Source|GeneCards
PPOXPPOXprotoporphyrinogen oxidaseSource|GeneCards
DNAH9DNAH9dynein, axonemal, heavy polypeptide 9Source|GeneCards
MFN1MFN1mitofusin 1Source|GeneCards
NLGN2NLGN2neuroligin 2Source|GeneCards
BRD2BRD2bromodomain containing 2Source|GeneCards

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