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Gene set: V$RFX1_02 (C3:TFAC:0175)
Standard nameV$RFX1_02
Systematic nameC3:TFAC:0175
Brief descriptionGenes with 3'UTR containing motif NNGTNRCNATRGYAACNN which matches annotation for RFX1: regulatory factor X, 1 (influences HLA class II expression)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA RFX1
 XX
 SY EF-C; RFX; RF-X; enhancer
factor C; hRFX1.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 HO TGT3, EP protein, MDBP,
CeRFX (C.elegans), Sak1 (S.pombe), Crt1
 HO (S.cerevisiae)

 XX
 CL C0023; fork head; 3.3.4.1.1.
 XX

SZ 979 AA; 104.7 kDa (cDNA)
 XX
 XX
 SC SwissProt #P22670

XX
 FT 4 73 glutamine-rich region (16/70).
 FT 13 97 proline-rich
region (34/85).
 FT 85 126 serine-/threonine-rich region (13/42).

FT 127 212 glutamine-rich region (20/86).
 FT 215 227 serine-/threonine-rich
region (7/13).
 FT 215 378 PF04589; RFX1_trans_act.
 FT
230 296 glutamine-rich region (18/67).
 FT 304 380 serine-/threonine-rich
region (31/77).
 FT 381 411 glycine-rich region (25/31).

FT 421 503 PF02257; RFX_DNA_binding.
 FT 438 528 DNA-binding
domain (DBD) [14].
 FT 439 445 alpha-helix 1, H1 [2].
 FT
446 455 beta-strand, S1 [2].
 FT 456 469 alpha-helix 2, H2
[2].
 FT 470 475 connecting loop 1, L1 [2].
 FT 476 486
alpha-helix 3, H3 [2].
 FT 487 490 connecting loop 2, L2 [2].

FT 491 495 beta-strand 2, S2 [2].
 FT 496 501 wing, W1 [2].

FT 502 511 beta-strand 3, S3 [2].
 FT 621 739 domains B and
C, autoinhibitory domains [4].
 FT 621 979 extended dimerization
domain, EDD [5] [6].
 FT 744 979 dimerization domain, repression
domain [7].
 FT 913 936 acidic region, Ac [1].
 FT 937 979
nuclear localization signal, NLS [1].
 XX
 SF member of
winged-helix class of helix-turn-helix superclass of factors [2];

SF the DBD exhibits a weak sequence similarity to the bHLH domain
consensus
 SF and is predicted to constitute two amphipathic
helices and a linking loop
 SF [14];
 SF it binds to DNA
as a dimer, but dimerization is not a prerequisite for
 SF
DNA-binding [14];
 SF both RF-X subunits interact independently
with the X-box(es) [14];
 SF together with MIBP1 ,
RFX1 constitutes the DNA-binding activity
 SF MIF-1 
[9];
 SF secondary structure exhibits three alpha-helical and
one beta-stranded
 SF segments within the DNA-binding domain,
the potential helix III region
 SF being responsible for sequence
specific binding [8];
 SF DNA binding domain has been identified
as winged-helix, hRFX1 uses a
 SF beta-hairpin (or wing) for
DNA recognition instead of recognition helix [2];
 SF DBD consistis
of 3 alpha-helices, 3 beta-strands and 3 connecting loops [2];

SF new mode of DNA binding: beta-strands S2 and S3 and wing W1
make extensive
 SF contacts with the major groove of one half-site
of the symmetric X-box,
 SF alpha-helix H3 interacts with the
minor groove of the other half-site [2];
 SF N-terminal transactivation
domain, but activation potential can be masked
 SF by autoinhibitory
domain [4];
 SF can bind DNA as a homodimer or heterodimer
with RFX2 or RFX3 [4];
 SF possesses a split, extended dimerization
domain which mediated formation of
 SF alternative homodimeric
complexes [5] [6];
 SF EDD is similar to the LBD of nuclear
receptors by several features, it is
 SF independent on DBD,
mediates dimerization and can function in alternative
 SF conformations
[5] [6];
 SF C-terminal acidic region may work as an autoinhibitory
domain relating DNA
 SF binding by RFX1 [1];
 XX
 CP
ubiquitous, highly expressed in primary eosinophils [4]
 XX

FF homodimers can function as activators or repressors depending
on the nature
 FF of interactions between two subunits, two
distinct types of homodimers can
 FF be formed which are different
in their function [5] [7] [6];
 FF preferential binding to
methylated sequences;
 FF binds to X boxes of MHC class II
alpha-chain gene promoters [15] and the
 FF HBV enhancer I
[11];
 FF identical to EF-C [11], but different from NF-X;

FF at the HBV enhancer I, it has to cooperate with liver-specific
factors [11];
 FF it cooperatively binds to the X-Y-box pattern
of MHC gene promoters with
 FF NF-Y [10];
 FF inhibitory
role in the regulation of proliferating cell nuclear antigen

FF (PCNA) expression [3];
 FF DNA binding activity may be regulated
by phosphorylation [1];
 XX
 IN T02313; MIBP1; rat, Rattus
norvegicus.
 IN T01667; RFX2; human, Homo sapiens.
 IN T01669;
RFX2; mouse, Mus musculus.
 IN T01670; RFX3; human, Homo sapiens.

XX
 XX
 XX
 XX
 RN [1]; RE0022531.
 RX MEDLINE;
11358531.
 RA Katan-Khaykovich Y., Shaul Y.
 RT Nuclear
import and DNA-binding activity of RFX1. Evidence for an
 RT
autoinhibitory mechanism.
 RL Eur. J. Biochem. 268:3108-3116
(2001).
 RN [2]; RE0022520.
 RX MEDLINE; 10706293.
 RA
Gajiwala K. S., Chen H., Cornille F., Roques B. P., Reith W.,
Mach B.,
 RA Burley S. K.
 RT Structure of the winged-helix
protein hRFX1 reveals a new mode of DNA
 RT binding.
 RL
Nature 403:916-921 (2000).
 RN [3]; RE0017028.
 RX MEDLINE;
99269075.
 RA Liu M., Lee B. H., Mathews M. B.
 RT Involvement
of RFX1 protein in the regulation of the human proliferating

RT cell nuclear antigen promoter
 RL J. Biol. Chem. 274:15433-15439
(1999).
 RN [4]; RE0022525.
 RX MEDLINE; 10330134.
 RA
Iwama A., Pan J., Zhang P., Reith W., Mach B., Tenen D. G., Sun
Z.
 RT Dimeric RFX proteins contribute to the activity and
lineage specificity of
 RT the interleukin-5 receptor alpha
promoter through activation and repression
 RT domains.

RL Mol. Cell. Biol. 19:3940-3950 (1999).
 RN [5]; RE0022527.

RX MEDLINE; 10556033.
 RA Katan-Khaykovich Y., Spiegel I.,
Shaul Y.
 RT The dimerization/repression domain of RFX1 is
related to a conserved region
 RT of its yeast homologues Crt1
and Sak1: a new function for an ancient motif.
 RL J. Mol.
Biol. 294:121-137 (1999).
 RN [6]; RE0022530.
 RX MEDLINE;
9733744.
 RA Katan-Khaykovich Y., Shaul Y.
 RT RFX1, a single
DNA-binding protein with a split dimerization domain,
 RT generates
alternative complexes.
 RL J. Biol. Chem. 273:24504-24512 (1998).

RN [7]; RE0022528.
 RX MEDLINE; 9278482.
 RA Katan Y., Agami
R., Shaul Y.
 RT The transcriptional activation and repression
domains of RFX1, a
 RT context-dependent regulator, can mutually
neutralize their activities.
 RL Nucleic Acids Res. 25:3621-3628
(1997).
 RN [8]; RE0006617.
 RX MEDLINE; 96315675.
 RA
Emery P., Strubin M., Hofmann K., Bucher P., Mach B., Reith W.

RT A consensus motif in the RFX DNA binding domain and binding
domain mutants
 RT with altered specificity
 RL Mol. Cell.
Biol. 16:4486-4494 (1996).
 RN [9]; RE0006616.
 RX MEDLINE;
95280902.
 RA Reinhold W., Emens L., Itkes A., Blake M., Ichinose
I., Zajac-Kaye M.
 RT The myc intron-binding polypeptide associates
with RFX1 in vivo and binds
 RT to the major histocompatibility
complex class II promoter region, to the
 RT hepatitis B virus
enhancer, and to regulatory regions of several distinct
 RT
viral genes
 RL Mol. Cell. Biol. 15:3041-3048 (1995).
 RN
[10]; RE0003796.
 RX MEDLINE; 94119925.
 RA Reith W., Siegrist
C. A., Durand B., Barras E., Mach B.
 RT Function of major
histocompatibility complex class II promoters requires
 RT
cooperative binding between factors RFX and NF-Y
 RL Proc.
Natl. Acad. Sci. USA 91:554-558 (1994).
 RN [11]; RE0003798.

RX MEDLINE; 94019311.
 RA Siegrist C. A., Durand B., Emery
P., David E., Hearing P., Mach B., Reith W.
 RT RFX1 is identical
to enhancer factor C and functions as a transactivator of

RT the hepatitis B virus enhancer
 RL Mol. Cell. Biol. 13:6375-6384
(1993).
 RN [12]; RE0002144.
 RX MEDLINE; 91232904.

RA Hasegawa S. L., Sloan J. H., Reith W., Mach B., Boss J. M.

RT Regulatory factor-X binding to mutant HLA-DRA promoter sequences

RL Nucleic Acids Res. 19:1243-1248 (1991).
 RN [13]; RE0002729.

RX MEDLINE; 91220738.
 RA Garcia A. D., Ostapchuk P., Hearing
P.
 RT Methylation-dependent and -independent DNA binding of
nuclear factor EF-C
 RL Virology 182:857-860 (1991).
 RN
[14]; RE0000690.
 RX MEDLINE; 91071581.
 RA Reith W., Herrero-Sanchez
C., Kobr M., Silacci P., Berte C., Barras E., Fey
 RA S., Mach
B.
 RT MHC class II regulatory factor RFX has a novel DNA-binding
domain and a
 RT functionally independent dimerization domain

RL Genes Dev. 4:1528-1540 (1990).
 RN [15]; RE0001485.

RX MEDLINE; 90158612.
 RA Kobr M., Reith W., Herrero-Sanchez
C., Mach B.
 RT Two DNA-binding proteins discriminate between
the promoters of different
 RT members of the major histocompatibility
complex class II multigene family
 RL Mol. Cell. Biol. 10:965-971
(1990).
 RN [16]; RE0002442.
 RX MEDLINE; 91017573.

RA Cogswell J. P., Basta P. V., Ting J. P.-Y.
 RT X-box-binding
proteins positively and negatively regulate transcription of

RT the HLA-DRA gene through interaction with discrete upstream
W and V elements
 RL Proc. Natl. Acad. Sci. USA 87:7703-7707
(1990).
 RN [17]; RE0001429.
 RX MEDLINE; 89384536.

RA Ostapchuk P., Scheirle G., Hearing P.
 RT Binding of Nuclear
Factor EF-C to a Functional Domain of the Hepatitis B
 RT Virus
Enhancer Region
 RL Mol. Cell. Biol. 9:2787-2797 (1989).

RN [18]; RE0002392.
 RX MEDLINE; 89264585.
 RA Reith W.,
Barras E., Satola S., Kobr M., Reinhardt D., Sanchez C. H., Mach

RA B.
 RT Cloning of the major histocompatibility complex class
II promoter binding
 RT protein affected in a hereditary defect
in class II gene regulation
 RL Proc. Natl. Acad. Sci. USA
86:4200-4204 (1989).
 RN [19]; RE0000111.
 RX MEDLINE; 88253410.

RA Reith W., Satola S., Herrero-Sanchez C., Amaldi I., Lisowska-Grospierre
B.,
 RA Griscelli C., Hadam M. R., Mach B.
 RT Congenital
Immunodeficiency with a Regulatory Defect in MHC Class II Gene

RT Expression Lacks a Specific HLA-DR Promoter Binding Protein,
RF-X
 RL Cell 53:897-906 (1988).
 RN [20]; RE0000351.

RX MEDLINE; 88004398.
 RA Shaul Y., Ben-Levy R.
 RT Multiple
nuclear proteins in liver cells are bound to hepatitis B virus

RT enhancer element and its upstream sequences
 RL EMBO J.
6:1913-1920 (1987).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

287 genes, 287 accessions (Toggle view)

AccessionGeneTitleLinks
GRIN2DGRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DSource|GeneCards
TSGA10TSGA10testis specific, 10Source|GeneCards
MGC4707MGC4707hypothetical protein MGC4707Source|GeneCards
KIAA0795KLHL18kelch-like 18 (Drosophila)Source|GeneCards
SPATA2SPATA2spermatogenesis associated 2Source|GeneCards
SLC17A6SLC17A6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6Source|GeneCards
FLJ12975FLJ12975hypothetical protein FLJ12975Source|GeneCards
HDAC4HDAC4histone deacetylase 4Source|GeneCards
RREB1RREB1ras responsive element binding protein 1Source|GeneCards
THBS3THBS3thrombospondin 3Source|GeneCards
LOC90557LOC90557hypothetical protein BC016861Source|GeneCards
DOC-1RCDK2AP2CDK2-associated protein 2Source|GeneCards
EML1EML1echinoderm microtubule associated protein like 1Source|GeneCards
E2F3E2F3E2F transcription factor 3Source|GeneCards
GPC3GPC3glypican 3Source|GeneCards
TSNAXIP1TSNAXIP1translin-associated factor X interacting protein 1Source|GeneCards
ZNF532ZNF532zinc finger protein 532Source|GeneCards
FLJ20156LRRC49leucine rich repeat containing 49Source|GeneCards
PUM1PUM1pumilio homolog 1 (Drosophila)Source|GeneCards
C14ORF132C14ORF132chromosome 14 open reading frame 132Source|GeneCards
SPG3ASPG3Aspastic paraplegia 3A (autosomal dominant)Source|GeneCards
PCDHB1PCDHB1protocadherin beta 1Source|GeneCards
NME7NME7non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)Source|GeneCards
SB145LYSMD1LysM, putative peptidoglycan-binding, domain containing 1Source|GeneCards
DKFZP434E2321DKFZP434E2321hypothetical protein DKFZp434E2321Source|GeneCards
PSDPSDpleckstrin and Sec7 domain proteinSource|GeneCards
CDKL2CDKL2cyclin-dependent kinase-like 2 (CDC2-related kinase)Source|GeneCards
YWHAQYWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideSource|GeneCards
CRYZL1CRYZL1crystallin, zeta (quinone reductase)-like 1Source|GeneCards
TU3ATU3ATU3A proteinSource|GeneCards
ITPKAITPKAinositol 1,4,5-trisphosphate 3-kinase ASource|GeneCards
CRB2CRB2crumbs homolog 2 (Drosophila)Source|GeneCards
MGC13024MGC13024hypothetical protein MGC13024Source|GeneCards
NBR2NBR2neighbor of BRCA1 gene 2Source|GeneCards
PCSK1NPCSK1Nproprotein convertase subtilisin/kexin type 1 inhibitorSource|GeneCards
MGC87693MGC87693similar to ZP1 precursorSource|GeneCards
CRIP2CRIP2cysteine-rich protein 2Source|GeneCards
STOML2STOML2stomatin (EPB72)-like 2Source|GeneCards
DTNADTNAdystrobrevin, alphaSource|GeneCards
PAK4PAK4p21(CDKN1A)-activated kinase 4Source|GeneCards
ITGB3BPITGB3BPintegrin beta 3 binding protein (beta3-endonexin)Source|GeneCards
C10ORF27C10ORF27chromosome 10 open reading frame 27Source|GeneCards
OSBPL2OSBPL2oxysterol binding protein-like 2Source|GeneCards
LOC83693LOC83693steroid dehydrogenase-likeSource|GeneCards
SH3GLB2SH3GLB2SH3-domain GRB2-like endophilin B2Source|GeneCards
HNRPFHNRPFheterogeneous nuclear ribonucleoprotein FSource|GeneCards
C10ORF67C10ORF67chromosome 10 open reading frame 67Source|GeneCards
CASKIN1CASKIN1CASK interacting protein 1Source|GeneCards
MGC35450MGC35450hypothetical protein MGC35450Source|GeneCards
SLC10A2SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2Source|GeneCards
ELAVL3ELAVL3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)Source|GeneCards
ZFYVE1ZFYVE1zinc finger, FYVE domain containing 1Source|GeneCards
ETS2ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)Source|GeneCards
FLJ11506FLJ11506hypothetical protein FLJ11506Source|GeneCards
TMIETMIEtransmembrane inner ear proteinSource|GeneCards
FLJ11011UBE2Wubiquitin-conjugating enzyme E2W (putative)Source|GeneCards
TMEM17TMEM17Transmembrane protein 17Source|GeneCards
FLJ25976FLJ25976hypothetical protein FLJ25976Source|GeneCards
FLJ45079FLJ45079FLJ45079 proteinSource|GeneCards
SLC8A3SLC8A3solute carrier family 8 (sodium-calcium exchanger), member 3Source|GeneCards
DKFZP564O243ABHD14Aabhydrolase domain containing 14ASource|GeneCards
MGC48628MGC48628Similar to KIAA1680 proteinSource|GeneCards
QTRT1QTRT1queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase)Source|GeneCards
PTPDC1PTPDC1Protein tyrosine phosphatase domain containing 1Source|GeneCards
FMR1FMR1fragile X mental retardation 1Source|GeneCards
DHX57DHX57DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57Source|GeneCards
C10ORF63C10ORF63chromosome 10 open reading frame 63Source|GeneCards
MGC3200POLR3GLpolymerase (RNA) III (DNA directed) polypeptide G (32kD) likeSource|GeneCards
DP1L1C19ORF32chromosome 19 open reading frame 32Source|GeneCards
MYH2MYH2myosin, heavy polypeptide 2, skeletal muscle, adultSource|GeneCards
HPCAL1HPCAL1hippocalcin-like 1Source|GeneCards
KCNJ16KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16Source|GeneCards
ANK2ANK2ankyrin 2, neuronalSource|GeneCards
RAPGEF3RAPGEF3Rap guanine nucleotide exchange factor (GEF) 3Source|GeneCards
UVRAGUVRAGUV radiation resistance associated geneSource|GeneCards
RNF40RNF40ring finger protein 40Source|GeneCards
THNSL1THNSL1threonine synthase-like 1 (bacterial)Source|GeneCards
TSLRPLRRC6leucine rich repeat containing 6Source|GeneCards
METMETmet proto-oncogene (hepatocyte growth factor receptor)Source|GeneCards
FLJ25955WDR69WD repeat domain 69Source|GeneCards
PTPRRPTPRRprotein tyrosine phosphatase, receptor type, RSource|GeneCards
ICAM5ICAM5intercellular adhesion molecule 5, telencephalinSource|GeneCards
C10ORF87C10ORF87chromosome 10 open reading frame 87Source|GeneCards
BATFBATFbasic leucine zipper transcription factor, ATF-likeSource|GeneCards
CINPCINPcyclin-dependent kinase 2-interacting proteinSource|GeneCards
GNB2GNB2guanine nucleotide binding protein (G protein), beta polypeptide 2Source|GeneCards
GRM1GRM1glutamate receptor, metabotropic 1Source|GeneCards
ODF1ODF1outer dense fiber of sperm tails 1Source|GeneCards
L3MBTL2L3MBTL2l(3)mbt-like 2 (Drosophila)Source|GeneCards
PHOX2BPHOX2Bpaired-like homeobox 2bSource|GeneCards
DNAJA1DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 1Source|GeneCards
LOC220070LOC220070hypothetical protein BC004224Source|GeneCards
PBXIP1PBXIP1pre-B-cell leukemia transcription factor interacting protein 1Source|GeneCards
QIL1QIL1QIL1 proteinSource|GeneCards
TGFB3TGFB3transforming growth factor, beta 3Source|GeneCards
ADKADKadenosine kinaseSource|GeneCards
PHTF1PHTF1putative homeodomain transcription factor 1Source|GeneCards
FLJ35409FLJ35409FLJ35409 proteinSource|GeneCards
PPT2PPT2palmitoyl-protein thioesterase 2Source|GeneCards
GRWD1GRWD1glutamate-rich WD repeat containing 1Source|GeneCards
NOVNOVnephroblastoma overexpressed geneSource|GeneCards
BDP1BDP1B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIBSource|GeneCards
GRCAGPR162G protein-coupled receptor 162Source|GeneCards
SCDR10SCDR10short-chain dehydrogenase/reductase 10Source|GeneCards
USP12USP12ubiquitin specific protease 12Source|GeneCards
TNKS1BP1TNKS1BP1tankyrase 1 binding protein 1, 182kDaSource|GeneCards
KIAA1456KIAA1456KIAA1456 proteinSource|GeneCards
PF20SPAG16Sperm associated antigen 16Source|GeneCards
REM1REM1RAS (RAD and GEM)-like GTP-binding 1Source|GeneCards
ATP1A3ATP1A3ATPase, Na+/K+ transporting, alpha 3 polypeptideSource|GeneCards
C20ORF98C20ORF98chromosome 20 open reading frame 98Source|GeneCards
DHX40DHX40DEAH (Asp-Glu-Ala-His) box polypeptide 40Source|GeneCards
HMGN2HMGN2high-mobility group nucleosomal binding domain 2Source|GeneCards
EPB49EPB49erythrocyte membrane protein band 4.9 (dematin)Source|GeneCards
C20ORF28C20ORF28chromosome 20 open reading frame 28Source|GeneCards
P518P518P518 precursor proteinSource|GeneCards
HPCAL4HPCAL4hippocalcin like 4Source|GeneCards
RPL17RPL17Ribosomal protein L17Source|GeneCards
PHEXPHEXphosphate regulating endopeptidase homolog, X-linked (hypophosphatemia, vitamin D resistant rickets)Source|GeneCards
BBS1BBS1Bardet-Biedl syndrome 1Source|GeneCards
DRD1IPDRD1IPdopamine receptor D1 interacting proteinSource|GeneCards
MPP2MPP2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)Source|GeneCards
BRAFBRAFv-raf murine sarcoma viral oncogene homolog B1Source|GeneCards
TUBB4TUBB4tubulin, beta 4Source|GeneCards
HMGA1L4HMGA1L4high mobility group AT-hook 1-like 4Source|GeneCards
EBNA1BP2EBNA1BP2EBNA1 binding protein 2Source|GeneCards
STX18STX18syntaxin 18Source|GeneCards
LOC146845LOC146845hypothetical protein LOC146845Source|GeneCards
TSPYL4TSPYL4TSPY-like 4Source|GeneCards
BAIAP3BAIAP3BAI1-associated protein 3Source|GeneCards
DKFZP566A1524FAM49Afamily with sequence similarity 49, member ASource|GeneCards
NFATC4NFATC4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4Source|GeneCards
TNKSTNKStankyrase, TRF1-interacting ankyrin-related ADP-ribose polymeraseSource|GeneCards
LOC338692LOC338692hypothetical protein LOC338692Source|GeneCards
FLJ45256FLJ45256FLJ45256 proteinSource|GeneCards
PLEC1PLEC1plectin 1, intermediate filament binding protein 500kDaSource|GeneCards
PER2PER2period homolog 2 (Drosophila)Source|GeneCards
EFHD2EFHD2EF-hand domain family, member D2Source|GeneCards
FLJ45235ANKRD45ankyrin repeat domain 45Source|GeneCards
DJ971N18.2TXNDC13thioredoxin domain containing 13Source|GeneCards
FGD4FGD4FGD1 family, member 4Source|GeneCards
MGC40047MGC40047hypothetical protein MGC40047Source|GeneCards
C6ORF31C6ORF31chromosome 6 open reading frame 31Source|GeneCards
GPR17GPR17G protein-coupled receptor 17Source|GeneCards
NCALDNCALDneurocalcin deltaSource|GeneCards
DKFZP761I1011ATP13A4ATPase type 13A4Source|GeneCards
ELMO1ELMO1engulfment and cell motility 1 (ced-12 homolog, C. elegans)Source|GeneCards
MGC50896CNIH2cornichon homolog 2 (Drosophila)Source|GeneCards
RHOBTB2RHOBTB2Rho-related BTB domain containing 2Source|GeneCards
SPARCSPARCsecreted protein, acidic, cysteine-rich (osteonectin)Source|GeneCards
MGC26979TMEM67transmembrane protein 67Source|GeneCards
PRR3PRR3Proline rich 3Source|GeneCards
RCD-8RCD-8autoantigenSource|GeneCards
MAPK11MAPK11mitogen-activated protein kinase 11Source|GeneCards
RGS6RGS6regulator of G-protein signalling 6Source|GeneCards
RHODRHODras homolog gene family, member DSource|GeneCards
H63CASC4cancer susceptibility candidate 4Source|GeneCards
CHCHD3CHCHD3coiled-coil-helix-coiled-coil-helix domain containing 3Source|GeneCards
BLZF1BLZF1basic leucine zipper nuclear factor 1 (JEM-1)Source|GeneCards
C11ORF8C11ORF8chromosome 11 open reading frame 8Source|GeneCards
AAT1C3ORF15Chromosome 3 open reading frame 15Source|GeneCards
CDW92CDW92CDW92 antigenSource|GeneCards
TUBTUBtubby homolog (mouse)Source|GeneCards
JMJD1AJMJD1Ajumonji domain containing 1ASource|GeneCards
TSGA14TSGA14testis specific, 14Source|GeneCards
FLJ21919C1ORF60chromosome 1 open reading frame 60Source|GeneCards
KCNJ9KCNJ9potassium inwardly-rectifying channel, subfamily J, member 9Source|GeneCards
NUDCNUDCnuclear distribution gene C homolog (A. nidulans)Source|GeneCards
FLJ31818FLJ31818hypothetical protein FLJ31818Source|GeneCards
HYDINHYDINhydrocephalus inducingSource|GeneCards
KIAA0635CDC42EP4CDC42 effector protein (Rho GTPase binding) 4Source|GeneCards
SCNM1SCNM1sodium channel modifier 1Source|GeneCards
C20ORF17C20ORF17chromosome 20 open reading frame 17Source|GeneCards
PIN1PIN1protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1Source|GeneCards
FKRPFKRPfukutin related proteinSource|GeneCards
GRASPGRASPGRP1 (general receptor for phosphoinositides 1)-associated scaffold proteinSource|GeneCards
CXXC5CXXC5CXXC finger 5Source|GeneCards
MGAT4BMGAT4Bmannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme BSource|GeneCards
C2ORF15C2ORF15chromosome 2 open reading frame 15Source|GeneCards
CHL1CHL1cell adhesion molecule with homology to L1CAM (close homolog of L1)Source|GeneCards
PCF11PCF11pre-mRNA cleavage complex II protein Pcf11Source|GeneCards
SEMA4BSEMA4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4BSource|GeneCards
TITF1TITF1thyroid transcription factor 1Source|GeneCards
ARP3BETAACTR3BARP3 actin-related protein 3 homolog B (yeast)Source|GeneCards
FLJ38335FLJ38335hypothetical protein FLJ38335Source|GeneCards
ZNF403ZNF403zinc finger protein 403Source|GeneCards
MTF1MTF1metal-regulatory transcription factor 1Source|GeneCards
NELFNELFnasal embryonic luteinizing hormone-releasing hormone factorSource|GeneCards
FLJ23436FLJ23436hypothetical protein FLJ23436Source|GeneCards
TTLL1TTLL1tubulin tyrosine ligase-like 1Source|GeneCards
ATP2B4ATP2B4ATPase, Ca++ transporting, plasma membrane 4Source|GeneCards
CHD5CHD5chromodomain helicase DNA binding protein 5Source|GeneCards
LOC123872LOC123872similar to RIKEN cDNA 4930457P18Source|GeneCards
WBSCR28WBSCR28Williams-Beuren syndrome critical region 28Source|GeneCards
LOC120379LOC120379hypothetical protein BC019238Source|GeneCards
STX8STX8syntaxin 8Source|GeneCards
MGC42105MGC42105hypothetical protein MGC42105Source|GeneCards
STRN4STRN4striatin, calmodulin binding protein 4Source|GeneCards
PPM1EPPM1Eprotein phosphatase 1E (PP2C domain containing)Source|GeneCards
MGC35206MGC35206hypothetical protein MGC35206Source|GeneCards
KIAA0276DCUN1D4DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)Source|GeneCards
RAGERAGErenal tumor antigenSource|GeneCards
KIAA0893WDR47WD repeat domain 47Source|GeneCards
CAMK1CAMK1calcium/calmodulin-dependent protein kinase ISource|GeneCards
LRRN3LRRN3leucine rich repeat neuronal 3Source|GeneCards
PRKCGPRKCGprotein kinase C, gammaSource|GeneCards
CRKLCRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-likeSource|GeneCards
RABL5RABL5RAB, member RAS oncogene family-like 5Source|GeneCards
C14ORF87C14ORF87chromosome 14 open reading frame 87Source|GeneCards
PHC1PHC1polyhomeotic-like 1 (Drosophila)Source|GeneCards
TTRTTRtransthyretin (prealbumin, amyloidosis type I)Source|GeneCards
KCNIP2KCNIP2Kv channel interacting protein 2Source|GeneCards
C20ORF103C20ORF103chromosome 20 open reading frame 103Source|GeneCards
MGC4093MGC4093hypothetical protein MGC4093Source|GeneCards
LOC161577TEX9testis expressed sequence 9Source|GeneCards
TAIP-2TAIP-2TGF-beta induced apotosis protein 2Source|GeneCards
KATNAL1KATNAL1Katanin p60 subunit A-like 1Source|GeneCards
PKIGPKIGprotein kinase (cAMP-dependent, catalytic) inhibitor gammaSource|GeneCards
PTK2BPTK2BPTK2B protein tyrosine kinase 2 betaSource|GeneCards
FLJ32000WDR65WD repeat domain 65Source|GeneCards
C11ORF4MRPL49mitochondrial ribosomal protein L49Source|GeneCards
IGSF4IGSF4immunoglobulin superfamily, member 4Source|GeneCards
ACTRT1ACTRT1actin-related protein T1Source|GeneCards
AP3M2AP3M2adaptor-related protein complex 3, mu 2 subunitSource|GeneCards
FXYD7FXYD7FXYD domain containing ion transport regulator 7Source|GeneCards
EHD1EHD1EH-domain containing 1Source|GeneCards
TUBE1TUBE1tubulin, epsilon 1Source|GeneCards
GAS7GAS7growth arrest-specific 7Source|GeneCards
DCDC1DCDC1doublecortin domain containing 1Source|GeneCards
CSMD3CSMD3CUB and Sushi multiple domains 3Source|GeneCards
FLJ32783RIBC1RIB43A domain with coiled-coils 1Source|GeneCards
MGC34647MGC34647hypothetical protein MGC34647Source|GeneCards
DMDDMDdystrophin (muscular dystrophy, Duchenne and Becker types)Source|GeneCards
TMP21TMED10transmembrane emp24-like trafficking protein 10 (yeast)Source|GeneCards
PRKACAPRKACAProtein kinase, cAMP-dependent, catalytic, alphaSource|GeneCards
FLJ36268FLJ36268FLJ36268 proteinSource|GeneCards
SPTBN2SPTBN2spectrin, beta, non-erythrocytic 2Source|GeneCards
MGC33211KATNAL2katanin p60 subunit A-like 2Source|GeneCards
FLJ39739FLJ39739FLJ39739 proteinSource|GeneCards
GYLTL1BGYLTL1Bglycosyltransferase-like 1BSource|GeneCards
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)Source|GeneCards
ZSWIM1ZSWIM1zinc finger, SWIM domain containing 1Source|GeneCards
FOXH1FOXH1forkhead box H1Source|GeneCards
POLLPOLLpolymerase (DNA directed), lambdaSource|GeneCards
SYT5SYT5synaptotagmin VSource|GeneCards
ARRDC4ARRDC4arrestin domain containing 4Source|GeneCards
MGC2705SUV420H2Suppressor of variegation 4-20 homolog 2 (Drosophila)Source|GeneCards
LOC57821LOC57821hypothetical protein LOC57821Source|GeneCards
MAPK10MAPK10mitogen-activated protein kinase 10Source|GeneCards
RNF5RNF5ring finger protein 5Source|GeneCards
MOPTMOPTprotein containing single MORN motif in testisSource|GeneCards
NOS1NOS1nitric oxide synthase 1 (neuronal)Source|GeneCards
USF1USF1upstream transcription factor 1Source|GeneCards
CENTG1CENTG1centaurin, gamma 1Source|GeneCards
MGC2744MGC2744hypothetical protein MGC2744Source|GeneCards
DRPLADRPLAdentatorubral-pallidoluysian atrophy (atrophin-1)Source|GeneCards
FGF9FGF9fibroblast growth factor 9 (glia-activating factor)Source|GeneCards
DUSP3DUSP3dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)Source|GeneCards
WFDC3WFDC3WAP four-disulfide core domain 3Source|GeneCards
ITSN1ITSN1intersectin 1 (SH3 domain protein)Source|GeneCards
TP53BP1TP53BP1tumor protein p53 binding protein, 1Source|GeneCards
C7ORF16C7ORF16chromosome 7 open reading frame 16Source|GeneCards
SYT6SYT6synaptotagmin VISource|GeneCards
DKFZP564B167BRP44brain protein 44Source|GeneCards
TRPS1TRPS1trichorhinophalangeal syndrome ISource|GeneCards
PRKCABPPRKCABPprotein kinase C, alpha binding proteinSource|GeneCards
TM9SF1TM9SF1transmembrane 9 superfamily member 1Source|GeneCards
MAPRE3MAPRE3microtubule-associated protein, RP/EB family, member 3Source|GeneCards
ITPR1ITPR1inositol 1,4,5-triphosphate receptor, type 1Source|GeneCards
E2F1E2F1E2F transcription factor 1Source|GeneCards
FXYD1FXYD1FXYD domain containing ion transport regulator 1 (phospholemman)Source|GeneCards
PARG1ARHGAP29Rho GTPase activating protein 29Source|GeneCards
LOC129285LOC129285smooth muscle myosin heavy chain 11 isoform SM1-likeSource|GeneCards
CAMK2ACAMK2Acalcium/calmodulin-dependent protein kinase (CaM kinase) II alphaSource|GeneCards
FLJ42117FLJ42117FLJ42117 proteinSource|GeneCards
FXYD6FXYD6FXYD domain containing ion transport regulator 6Source|GeneCards
AP1S1AP1S1adaptor-related protein complex 1, sigma 1 subunitSource|GeneCards
TTC18TTC18Tetratricopeptide repeat domain 18Source|GeneCards
UNQ6411UNQ6411IIDS6411Source|GeneCards
IRS2IRS2insulin receptor substrate 2Source|GeneCards
BADBADBCL2-antagonist of cell deathSource|GeneCards
RNF139RNF139ring finger 139Source|GeneCards
GNB4GNB4guanine nucleotide binding protein (G protein), beta polypeptide 4Source|GeneCards
TBC1D16TBC1D16TBC1 domain family, member 16Source|GeneCards
BTBD3BTBD3BTB (POZ) domain containing 3Source|GeneCards
NLGN2NLGN2neuroligin 2Source|GeneCards
MINKKCNE1potassium voltage-gated channel, Isk-related family, member 1Source|GeneCards

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