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Gene set: V$SMAD3_Q6 (C3:TFAC:0334)
Standard nameV$SMAD3_Q6
Systematic nameC3:TFAC:0334
Brief descriptionGenes with 3'UTR containing motif TGTCTGTCT which matches annotation for SMAD3: SMAD, mothers against DPP homolog 3 (Drosophila)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA SMAD-3
 XX
 OS rat, Rattus norvegicus

OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda;
mammalia;
 OC eutheria; rodentia; myomorpha; muridae; murinae

XX
 XX
 CL C0041; SMAD; 4.12.1.0.3.
 XX
 SZ 425 AA;
48.1 (kDa)
 XX
 XX
 SC translated from EMBL #RNU66479

XX
 FT 1 145 MH1 domain [1].
 FT 12 132 PF03165; MH1.

FT 26 134 SM00523; DWA.
 FT 146 231 Linker region [1].

FT 226 403 PF03166; MH2.
 FT 230 401 SM00524; DWB.
 FT 232
421 MH2 domain [1].
 FT 422 425 SSXS motif [1].
 XX

FF C-terminal region (MH2 domain) and conserved glycin residue
(AA 379) in L3
 FF loop, which is proposed to be involved in
protein-protein interaction, are
 FF required for the self-stimulatory
activtity [2];
 FF MH1 domain and four lysin residues at positions
40, 41, 43 and 44 in this
 FF domain are involved in the inhibitory
activity of SMAD-3 [2];
 FF is able to associate with FAST-2.ARE
complex and this association is
 FF dependent on FAST-2 [2];

FF interacts with p300/CBP [3];
 FF co-activation of PAI-1
promoter togehter with SMAD-4  and p300 [3].;
 XX

IN T01318; CBP; mouse, Mus musculus.
 IN T01427; p300; human,
Homo sapiens.
 XX
 XX
 XX
 XX
 RN [1]; RE0015115.

RX MEDLINE; 20231732.
 RA Dick A., Mayr T., Bauer H., Meier
A., Hammerschmidt M.
 RT Cloning and characterization of zebrafish
smad2, smad3 and smad4
 RL Gene 246:69-80 (2000).
 RN [2];
RE0015871.
 RX MEDLINE; 20002644.
 RA Nagarajan R. P., Liu
J., Chen Y.
 RT Smad3 inhibits transforming growth factor-beta
and activin signaling by
 RT competing with Smad4 for FAST-2
binding.
 RL J. Biol. Chem. 274:31229-31235 (1999).
 RN
[3]; RE0016417.
 RX MEDLINE; 98344004.
 RA Janknecht R.,
Wells N. J., Hunter T.
 RT TGF-beta-stimulated cooperation
of smad proteins with the coactivators
 RT CBP/p300.
 RL
Genes Dev. 12:2114-2119 (1998).
 RN [4]; RE0006456.
 RX
MEDLINE; 97075106.
 RA Chen Y., Lebrun J. J., Vale W.
 RT
Regulation of transforming growth factor beta- and activin-induced

RT transcription by mammalian Mad proteins
 RL Proc. Natl.
Acad. Sci. USA 93:12992-12997 (1996).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

243 genes, 243 accessions (Toggle view)

AccessionGeneTitleLinks
PITX3PITX3paired-like homeodomain transcription factor 3Source|GeneCards
GRIN2DGRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DSource|GeneCards
NXPH4NXPH4neurexophilin 4Source|GeneCards
AGERAGERadvanced glycosylation end product-specific receptorSource|GeneCards
MEIS1MEIS1Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)Source|GeneCards
DOCK9DOCK9dedicator of cytokinesis 9Source|GeneCards
RASL11BRASL11BRAS-like, family 11, member BSource|GeneCards
PAK3PAK3p21 (CDKN1A)-activated kinase 3Source|GeneCards
GPC3GPC3glypican 3Source|GeneCards
FGF7FGF7fibroblast growth factor 7 (keratinocyte growth factor)Source|GeneCards
ED1EDAectodysplasin ASource|GeneCards
CSF3CSF3colony stimulating factor 3 (granulocyte)Source|GeneCards
LOC116236LOC116236hypothetical protein LOC116236Source|GeneCards
CHRM1CHRM1cholinergic receptor, muscarinic 1Source|GeneCards
MYCL1MYCL1v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)Source|GeneCards
MLPCSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)Source|GeneCards
SCRG1SCRG1scrapie responsive protein 1Source|GeneCards
ACVR1ACVR1activin A receptor, type ISource|GeneCards
TFDP2TFDP2transcription factor Dp-2 (E2F dimerization partner 2)Source|GeneCards
TOP1TOP1topoisomerase (DNA) ISource|GeneCards
FLJ14050GRRP1glycine/arginine rich protein 1Source|GeneCards
CHDHCHDHcholine dehydrogenaseSource|GeneCards
ZHX2ZHX2transcription factor ZHX2Source|GeneCards
LOC399947LOC399947similar to expressed sequence AI593442Source|GeneCards
PTPN6PTPN6protein tyrosine phosphatase, non-receptor type 6Source|GeneCards
FYFYDuffy blood groupSource|GeneCards
ERGERGv-ets erythroblastosis virus E26 oncogene like (avian)Source|GeneCards
CACNB3CACNB3calcium channel, voltage-dependent, beta 3 subunitSource|GeneCards
FLJ32447FLJ32447hypothetical protein FLJ32447Source|GeneCards
LIN28LIN28lin-28 homolog (C. elegans)Source|GeneCards
PTPN7PTPN7protein tyrosine phosphatase, non-receptor type 7Source|GeneCards
CRABP2CRABP2cellular retinoic acid binding protein 2Source|GeneCards
RUSC1RUSC1RUN and SH3 domain containing 1Source|GeneCards
LAMC2LAMC2laminin, gamma 2Source|GeneCards
MGC4606C16ORF53chromosome 16 open reading frame 53Source|GeneCards
MRC2MRC2mannose receptor, C type 2Source|GeneCards
WNT8BWNT8Bwingless-type MMTV integration site family, member 8BSource|GeneCards
EYA1EYA1eyes absent homolog 1 (Drosophila)Source|GeneCards
FGF23FGF23fibroblast growth factor 23Source|GeneCards
CACNB2CACNB2calcium channel, voltage-dependent, beta 2 subunitSource|GeneCards
NINNINninein (GSK3B interacting protein)Source|GeneCards
COL11A2COL11A2collagen, type XI, alpha 2Source|GeneCards
THBS2THBS2thrombospondin 2Source|GeneCards
GABREGABREgamma-aminobutyric acid (GABA) A receptor, epsilonSource|GeneCards
TDE2LTDE2Ltumor differentially expressed 2-likeSource|GeneCards
TNRC4TNRC4trinucleotide repeat containing 4Source|GeneCards
BAZ2ABAZ2Abromodomain adjacent to zinc finger domain, 2ASource|GeneCards
SSBP3SSBP3single stranded DNA binding protein 3Source|GeneCards
HAPLN2HAPLN2hyaluronan and proteoglycan link protein 2Source|GeneCards
CABP2CABP2calcium binding protein 2Source|GeneCards
SIPA1SIPA1signal-induced proliferation-associated gene 1Source|GeneCards
FZD1FZD1frizzled homolog 1 (Drosophila)Source|GeneCards
HCRTHCRThypocretin (orexin) neuropeptide precursorSource|GeneCards
ARID1AARID1AAT rich interactive domain 1A (SWI- like)Source|GeneCards
TRIPLRRFIP1leucine rich repeat (in FLII) interacting protein 1Source|GeneCards
TLX1TLX1T-cell leukemia, homeobox 1Source|GeneCards
KIAA1468KIAA1468KIAA1468 proteinSource|GeneCards
IRX5IRX5iroquois homeobox protein 5Source|GeneCards
EB-1EB-1E2a-Pbx1-associated proteinSource|GeneCards
SIAT7ESIAT7Esialyltransferase 7 ((alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl galactosaminide alpha-2,6-sialyltransferase) ESource|GeneCards
ZMYND17ZMYND17zinc finger, MYND domain containing 17Source|GeneCards
SKP1ASKP1AS-phase kinase-associated protein 1A (p19A)Source|GeneCards
FAPFAPfibroblast activation protein, alphaSource|GeneCards
TGFB2TGFB2transforming growth factor, beta 2Source|GeneCards
FLJ32855FLJ32855hypothetical protein FLJ32855Source|GeneCards
FOXB1FOXB1forkhead box B1Source|GeneCards
SLC6A9SLC6A9solute carrier family 6 (neurotransmitter transporter, glycine), member 9Source|GeneCards
PURAPURApurine-rich element binding protein ASource|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
C1QTNF5C1QTNF5C1q and tumor necrosis factor related protein 5Source|GeneCards
CROC4C1ORF61chromosome 1 open reading frame 61Source|GeneCards
PFKFB1PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1Source|GeneCards
NNATNNATneuronatinSource|GeneCards
NTRK3NTRK3neurotrophic tyrosine kinase, receptor, type 3Source|GeneCards
RFX5RFX5regulatory factor X, 5 (influences HLA class II expression)Source|GeneCards
LTBP1LTBP1latent transforming growth factor beta binding protein 1Source|GeneCards
KLF7KLF7Kruppel-like factor 7 (ubiquitous)Source|GeneCards
STX16STX16syntaxin 16Source|GeneCards
ZNF537ZNF537zinc finger protein 537Source|GeneCards
ARHGEF19ARHGEF19Rho guanine nucleotide exchange factor (GEF) 19Source|GeneCards
C1QBC1QBcomplement component 1, q subcomponent, beta polypeptideSource|GeneCards
ZRANB1ZRANB1zinc finger, RAN-binding domain containing 1Source|GeneCards
KIAA1191KIAA1191KIAA1191 proteinSource|GeneCards
BMPR2BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)Source|GeneCards
ATP6V1E2ATP6V1E2ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 2Source|GeneCards
RIMS1RIMS1regulating synaptic membrane exocytosis 1Source|GeneCards
CLDN16CLDN16claudin 16Source|GeneCards
GPR10GPR10G protein-coupled receptor 10Source|GeneCards
PABPC5PABPC5poly(A) binding protein, cytoplasmic 5Source|GeneCards
JARID2JARID2Jumonji, AT rich interactive domain 2Source|GeneCards
BCL9LBCL9LB-cell CLL/lymphoma 9-likeSource|GeneCards
FXR1FXR1fragile X mental retardation, autosomal homolog 1Source|GeneCards
MGC50104MGC50104Similar to RIKEN cDNA 1810046K07 geneSource|GeneCards
B3GALT2B3GALT2UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2Source|GeneCards
SMPXSMPXsmall muscle protein, X-linkedSource|GeneCards
POU3F4POU3F4POU domain, class 3, transcription factor 4Source|GeneCards
EYA4EYA4eyes absent homolog 4 (Drosophila)Source|GeneCards
KCTD15KCTD15potassium channel tetramerisation domain containing 15Source|GeneCards
PAX3PAX3paired box gene 3 (Waardenburg syndrome 1)Source|GeneCards
HES7HES7hairy and enhancer of split 7 (Drosophila)Source|GeneCards
SKILSKILSKI-likeSource|GeneCards
CPNE6CPNE6copine VI (neuronal)Source|GeneCards
DDEF1DDEF1development and differentiation enhancing factor 1Source|GeneCards
PPP3CBPPP3CBprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
ALDH4A1ALDH4A1aldehyde dehydrogenase 4 family, member A1Source|GeneCards
PAX2PAX2paired box gene 2Source|GeneCards
R3HDMLR3HDMLR3H domain (binds single-stranded nucleic acids) containing-likeSource|GeneCards
H1F0H1F0H1 histone family, member 0Source|GeneCards
PDE4DPDE4Dphosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)Source|GeneCards
LHX6LHX6LIM homeobox 6Source|GeneCards
SAV1SAV1salvador homolog 1 (Drosophila)Source|GeneCards
TLP19TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum)Source|GeneCards
GADD45GGADD45Ggrowth arrest and DNA-damage-inducible, gammaSource|GeneCards
CNTFRCNTFRciliary neurotrophic factor receptorSource|GeneCards
SMAD6SMAD6SMAD, mothers against DPP homolog 6 (Drosophila)Source|GeneCards
CDKN1ACDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)Source|GeneCards
CDK5CDK5cyclin-dependent kinase 5Source|GeneCards
MN1MN1meningioma (disrupted in balanced translocation) 1Source|GeneCards
ITGAEITGAEintegrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)Source|GeneCards
CSDACSDAcold shock domain protein ASource|GeneCards
NDUFS2NDUFS2NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)Source|GeneCards
HS3ST2HS3ST2heparan sulfate (glucosamine) 3-O-sulfotransferase 2Source|GeneCards
TIMP4TIMP4tissue inhibitor of metalloproteinase 4Source|GeneCards
CLTCCLTCclathrin, heavy polypeptide (Hc)Source|GeneCards
C1ORF21C1ORF21chromosome 1 open reading frame 21Source|GeneCards
WNT10BWNT10Bwingless-type MMTV integration site family, member 10BSource|GeneCards
ASB2ASB2ankyrin repeat and SOCS box-containing 2Source|GeneCards
FGF11FGF11fibroblast growth factor 11Source|GeneCards
SMTNSMTNsmoothelinSource|GeneCards
ABHD7ABHD7abhydrolase domain containing 7Source|GeneCards
LRP2LRP2low density lipoprotein-related protein 2Source|GeneCards
FLJ10350RPRC1arginine/proline rich coiled-coil 1Source|GeneCards
ZFHX1BZFHX1Bzinc finger homeobox 1bSource|GeneCards
LOC283514LOC283514similar to seven in absentia 2Source|GeneCards
JMJD1AJMJD1Ajumonji domain containing 1ASource|GeneCards
NRXN3NRXN3neurexin 3Source|GeneCards
CEAL1CEACAM19carcinoembryonic antigen-related cell adhesion molecule 19Source|GeneCards
ACTN2ACTN2actinin, alpha 2Source|GeneCards
PRKCBP1PRKCBP1protein kinase C binding protein 1Source|GeneCards
LOC56901LOC56901NADH:ubiquinone oxidoreductase MLRQ subunit homologSource|GeneCards
EST1BEST1BEst1p-like protein BSource|GeneCards
TGIF2TGIF2TGFB-induced factor 2 (TALE family homeobox)Source|GeneCards
FIBL-6FIBL-6hemicentinSource|GeneCards
NYXNYXnyctalopinSource|GeneCards
TFAP2BL1TFAP2Dtranscription factor AP-2 delta (activating enhancer binding protein 2 delta)Source|GeneCards
EPB41EPB41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)Source|GeneCards
PIK3R3PIK3R3phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)Source|GeneCards
TITF1TITF1thyroid transcription factor 1Source|GeneCards
CHD2CHD2chromodomain helicase DNA binding protein 2Source|GeneCards
ITIH3ITIH3pre-alpha (globulin) inhibitor, H3 polypeptideSource|GeneCards
APBB2APBB2amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like)Source|GeneCards
DLX3DLX3distal-less homeo box 3Source|GeneCards
KIAA2028PLEKHH2pleckstrin homology domain containing, family H (with MyTH4 domain) member 2Source|GeneCards
BZW2BZW2basic leucine zipper and W2 domains 2Source|GeneCards
HIS1HTN1histatin 1Source|GeneCards
PHF15PHF15PHD finger protein 15Source|GeneCards
EMID1EMID1EMI domain containing 1Source|GeneCards
KIRRELKIRRELkin of IRRE like (Drosophila)Source|GeneCards
POU4F1POU4F1POU domain, class 4, transcription factor 1Source|GeneCards
ANXA9ANXA9annexin A9Source|GeneCards
MORF4L2MORF4L2mortality factor 4 like 2Source|GeneCards
ZADH2ZADH2zinc binding alcohol dehydrogenase, domain containing 2Source|GeneCards
SYNPOSYNPOsynaptopodinSource|GeneCards
CHST9CHST9carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9Source|GeneCards
RARBRARBretinoic acid receptor, betaSource|GeneCards
FGF14FGF14fibroblast growth factor 14Source|GeneCards
TAF6LTAF6LTAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDaSource|GeneCards
ANKMY2ANKMY2ankyrin repeat and MYND domain containing 2Source|GeneCards
MGC40107MGC40107hypothetical protein MGC40107Source|GeneCards
13CDNA7313CDNA73hypothetical protein CG003Source|GeneCards
NR2F2NR2F2Nuclear receptor subfamily 2, group F, member 2Source|GeneCards
JMJD1CJMJD1Cjumonji domain containing 1CSource|GeneCards
FLJ22679FLJ22679hypothetical protein FLJ22679Source|GeneCards
PVRL1PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)Source|GeneCards
MTMR4MTMR4myotubularin related protein 4Source|GeneCards
ESRRGESRRGestrogen-related receptor gammaSource|GeneCards
ELOVL1ELOVL1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1Source|GeneCards
MGC13102MGC13102hypothetical protein MGC13102Source|GeneCards
KIAA0605ADAMTSL2ADAMTS-like 2Source|GeneCards
KCNJ8KCNJ8potassium inwardly-rectifying channel, subfamily J, member 8Source|GeneCards
SNIPSNIPSNAP25-interacting proteinSource|GeneCards
C9ORF67PPAPDC3phosphatidic acid phosphatase type 2 domain containing 3Source|GeneCards
PEPP3PLEKHA6pleckstrin homology domain containing, family A member 6Source|GeneCards
EBFEBFearly B-cell factorSource|GeneCards
EDN1EDN1endothelin 1Source|GeneCards
MGC35521PELI3pellino 3 alphaSource|GeneCards
GIT1GIT1G protein-coupled receptor kinase-interactor 1Source|GeneCards
RAI1RAI1retinoic acid induced 1Source|GeneCards
BAMBIBAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)Source|GeneCards
RNF12RNF12ring finger protein 12Source|GeneCards
LOC81558LOC81558C/EBP-induced proteinSource|GeneCards
MGC33190ATXN7L4ataxin 7-like 4Source|GeneCards
SYT7SYT7synaptotagmin VIISource|GeneCards
LOXLOXlysyl oxidaseSource|GeneCards
HMGB1HMGB1high-mobility group box 1Source|GeneCards
FLJ10997ZNF654zinc finger protein 654Source|GeneCards
S100A16S100A16S100 calcium binding protein A16Source|GeneCards
RFX4RFX4regulatory factor X, 4 (influences HLA class II expression)Source|GeneCards
CMKOR1CMKOR1chemokine orphan receptor 1Source|GeneCards
ZDHHC22ZDHHC22zinc finger, DHHC-type containing 22Source|GeneCards
IL17RBIL17RBinterleukin 17 receptor BSource|GeneCards
MFAP4MFAP4microfibrillar-associated protein 4Source|GeneCards
DMPKDMPKdystrophia myotonica-protein kinaseSource|GeneCards
LOC90313LOC90313hypothetical protein BC004507Source|GeneCards
CGRRF1CGRRF1cell growth regulator with ring finger domain 1Source|GeneCards
MYT1MYT1myelin transcription factor 1Source|GeneCards
SAMD6SAMD6sterile alpha motif domain containing 6Source|GeneCards
ST5ST5suppression of tumorigenicity 5Source|GeneCards
EIF3S1EIF3S1eukaryotic translation initiation factor 3, subunit 1 alpha, 35kDaSource|GeneCards
SHANK1SHANK1SH3 and multiple ankyrin repeat domains 1Source|GeneCards
RIPXRIPXrap2 interacting protein xSource|GeneCards
CDK5R2CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)Source|GeneCards
DUSP3DUSP3dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)Source|GeneCards
PDLIM2PDLIM2PDZ and LIM domain 2 (mystique)Source|GeneCards
IBRDC3IBRDC3IBR domain containing 3Source|GeneCards
MAP2MAP2microtubule-associated protein 2Source|GeneCards
JUBJUBjub, ajuba homolog (Xenopus laevis)Source|GeneCards
FOXP1FOXP1forkhead box P1Source|GeneCards
FLJ44670FLJ44670FLJ44670 proteinSource|GeneCards
OLIG3OLIG3oligodendrocyte transcription factor 3Source|GeneCards
DKFZP586M1120LRRC48leucine rich repeat containing 48Source|GeneCards
NOS3NOS3nitric oxide synthase 3 (endothelial cell)Source|GeneCards
FLJ31579PLCXD2Phosphatidylinositol-specific phospholipase C, X domain containing 2Source|GeneCards
BHLHB3BHLHB3basic helix-loop-helix domain containing, class B, 3Source|GeneCards
S100A14S100A14S100 calcium binding protein A14Source|GeneCards
AGPAT4AGPAT41-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)Source|GeneCards
MGC10986MGC10986hypothetical protein MGC10986Source|GeneCards
MLR2MLR2ligand-dependent corepressorSource|GeneCards
OTX2OTX2orthodenticle homolog 2 (Drosophila)Source|GeneCards
HOXB1HOXB1homeo box B1Source|GeneCards
UNQ6411UNQ6411IIDS6411Source|GeneCards
CBFA2T3CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 3Source|GeneCards
OA48-18
BTBD3BTBD3BTB (POZ) domain containing 3Source|GeneCards
CRATCRATcarnitine acetyltransferaseSource|GeneCards
SLC4A2SLC4A2solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1)Source|GeneCards
FLJ37478FLJ37478hypothetical protein FLJ37478Source|GeneCards
SOX14SOX14SRY (sex determining region Y)-box 14Source|GeneCards
TEAD3TEAD3TEA domain family member 3Source|GeneCards
DCTN2DCTN2dynactin 2 (p50)Source|GeneCards
HCMOGT-1SPECC1spectrin domain with coiled-coils 1Source|GeneCards
NLGN2NLGN2neuroligin 2Source|GeneCards

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