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Gene set: V$STAT3_02 (C3:TFAC:0276)
Standard nameV$STAT3_02
Systematic nameC3:TFAC:0276
Brief descriptionGenes with 3'UTR containing motif NNNTTCCN which matches annotation for STAT3: signal transducer and activator of transcription 3 (acute-phase response factor)
CategoryC3: Motif
Sub-categoryTFAC: Transfac
Full description or Abstract

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XX
 XX
 XX
 FA STAT3
 XX
 SY signal transducer
and activator of transcription 3; APRF; acute-phase
 SY response
factor.
 XX
 OS mouse, Mus musculus
 OC eukaryota; animalia;
metazoa; chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria;
rodentia; myomorpha; muridae; murinae
 XX
 XX
 CL C0039;
STAT; 4.2.1.0.3.
 XX
 SZ 770 AA; 88.0 kDa (cDNA), 92 kDa
(SDS) [7], 95 kDa (SDS) [9]
 XX
 XX
 SC SwissProt #P42227

XX
 FT 2 122 PF02865; STAT_prot.
 FT 138 319 PF01017; STAT.

FT 203 231 leucine zipper-like motif (LLILV).
 FT 321 574 PF02864;
STAT_bind.
 FT 406 514 DNA-binding specificity determining
domain [4].
 FT 512 566 SH3 domain.
 FT 580 681 SH2 domain.

FT 584 674 PF00017; SH2.
 FT 705 705 conserved tyrosine residue.

XX
 SF tyrosine-phosphorylation [7] [9]
 XX
 FF activator;

FF functionally related to SIF (c-sis-inducible element-binding
factor) [7];
 FF activated by EGF and IL-6, not by IFN-gamma,
by tyrosine phosphorylation
 FF [7] [9];
 FF also modified
by other cytokines whose receptors share the gp130 component

FF [9];
 FF maximal transcriptional activation after additional
phosphorylation of
 FF Ser-727, possibly by MAP kinase [5];

FF activation induced by IFN-alpha and CSF-1 [6] and IL-10 [3];

FF positive autoregulation of the stat3 gene by the STAT3 factor
[2];
 XX
 IN T01575; STAT1; mouse, Mus musculus.
 IN
T01574; STAT3; mouse, Mus musculus.
 XX
 XX
 XX
 XX

RN [1]; RE0023482.
 RX MEDLINE; 12244095.
 RA Schreiner
S. J., Schiavone A. P., Smithgall T. E.
 RT Activation of STAT3
by the Src family kinase Hck requires a functional SH3
 RT
domain.
 RL J. Biol. Chem. 277:45680-45687 (2002).
 RN [2];
RE0023186.
 RX MEDLINE; 9497331.
 RA Ichiba M., Nakajima
K., Yamanaka Y., Kiuchi N., Hirano T.
 RT Autoregulation of
the Stat3 gene through cooperation with a cAMP-responsive

RT element-binding protein.
 RL J. Biol. Chem. 273:6132-6138
(1998).
 RN [3]; RE0023360.
 RX MEDLINE; 8830676.
 RA
Wehinger J., Gouilleux F., Groner B., Finke J., Mertelsmann R.,
Weber-Nordt
 RA R. M.
 RT IL-10 induces DNA binding activity
of three STAT proteins (Stat1, Stat3,
 RT and Stat5) and their
distinct combinatorial assembly in the promoters of
 RT selected
genes.
 RL FEBS Lett. 394:365-370 (1996).
 RN [4]; RE0003481.

RX MEDLINE; 95293230.
 RA Horvath C. M., Wen Z., Darnell jr
J. E.
 RT A STAT protein domain that determines DNA sequence
recognition suggests a
 RT novel DNA-binding domain
 RL
Genes Dev. 9:984-994 (1995).
 RN [5]; RE0003507.
 RX MEDLINE;
95354205.
 RA Wen Z., Zhong Z., Darnell J. E.
 RT Maximal
activation of transcription by Stat1 and Stat3 requires both

RT tyrosine and serine phosophorylation
 RL Cell 82:241-250
(1995).
 RN [6]; RE0011175.
 RX MEDLINE; 96067132.
 RA
Hill C. S., Treisman R.
 RT Differential activation of c-fos
promoter elements by serum,
 RT lysophosphatidic acid, G proteins
and polypeptide growth factors
 RL EMBO J. 14:5037-5047 (1995).

RN [7]; RE0003503.
 RX MEDLINE; 94188718.
 RA Zhong Z.,
Wen Z., Darnell J. E.
 RT Stat3: a STAT family member activated
by tyrosine phosphorylation in
 RT response to epidermal growth
factor and interleukin-6
 RL Science 264:95-98 (1994).

RN [8]; RE0003504.
 RX MEDLINE; 94255416.
 RA Zhong Z.,
Wen Z., Darnell J. E.
 RT Stat3 and Stat4: members of the family
of signal transducers and activators
 RT of transcription

RL Proc. Natl. Acad. Sci. USA 91:4806-4810 (1994).
 RN [9];
RE0003506.
 RX MEDLINE; 94208062.
 RA Akira S., Nishio Y.,
Inoue M., Wang X. J., Shi W., Matsusaka T., Yoshida
 RA K.,
Sudo T., Naruto M., Kishimoto T.
 RT Molecular cloning of APRF,
a novel IFN-stimulated gene factor 3 p91-related
 RT transcription
factor involved in the gp130-mediated signaling pathway
 RL
Cell 77:63-71 (1994).
 XX
Publication URLna
External linksna
Keywords & MeSH headingsna
OrganismHuman,Mouse,Rat,Dog
Contributed byBroad Institute
Source platformSeq_Accession
Downloadgrp|xml|map
Genes

153 genes, 153 accessions (Toggle view)

AccessionGeneTitleLinks
GRIN2DGRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DSource|GeneCards
HS6ST3HS6ST3heparan sulfate 6-O-sulfotransferase 3Source|GeneCards
EGR3EGR3early growth response 3Source|GeneCards
HOXB4HOXB4homeo box B4Source|GeneCards
THG-1TSC22D4TSC22 domain family, member 4 /// TSC22 domain family, member 4Source|GeneCards
ZNF46ZNF46zinc finger protein 46 (KUP)Source|GeneCards
RBPSUHRBPSUHrecombining binding protein suppressor of hairless (Drosophila)Source|GeneCards
LRP2LRP2low density lipoprotein-related protein 2Source|GeneCards
CA10CA10carbonic anhydrase XSource|GeneCards
ST7LST7Lsuppression of tumorigenicity 7 likeSource|GeneCards
EGR1EGR1early growth response 1Source|GeneCards
TMEM23TMEM23transmembrane protein 23Source|GeneCards
ARF3ARF3ADP-ribosylation factor 3Source|GeneCards
GPC3GPC3glypican 3Source|GeneCards
C10ORF77C10ORF77chromosome 10 open reading frame 77Source|GeneCards
HOXB13HOXB13homeo box B13Source|GeneCards
SOCS1SOCS1suppressor of cytokine signaling 1Source|GeneCards
UBTFUBTFupstream binding transcription factor, RNA polymerase ISource|GeneCards
C17ORF27C17ORF27chromosome 17 open reading frame 27Source|GeneCards
F-LANADERL2Der1-like domain family, member 2Source|GeneCards
PPFIA2PPFIA2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2Source|GeneCards
SHOX2SHOX2short stature homeobox 2Source|GeneCards
CHRM1CHRM1cholinergic receptor, muscarinic 1Source|GeneCards
MNTMNTMAX binding proteinSource|GeneCards
MEIS2MEIS2Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)Source|GeneCards
KIRREL3KIRREL3kin of IRRE like 3 (Drosophila)Source|GeneCards
DD5EDD1E3 ubiquitin protein ligase, HECT domain containing, 1Source|GeneCards
VCLVCLvinculinSource|GeneCards
YY1YY1YY1 transcription factorSource|GeneCards
KAZALD1KAZALD1Kazal-type serine protease inhibitor domain 1Source|GeneCards
MATN4MATN4matrilin 4Source|GeneCards
BNC1BNC1basonuclin 1Source|GeneCards
ZHX2ZHX2transcription factor ZHX2Source|GeneCards
NELL2NELL2NEL-like 2 (chicken)Source|GeneCards
SP6SP6Sp6 transcription factorSource|GeneCards
AP1S2AP1S2adaptor-related protein complex 1, sigma 2 subunitSource|GeneCards
RIS1UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1Source|GeneCards
ARXARXaristaless related homeoboxSource|GeneCards
BMP4BMP4bone morphogenetic protein 4Source|GeneCards
NDST2NDST2N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2Source|GeneCards
FBN2FBN2fibrillin 2 (congenital contractural arachnodactyly)Source|GeneCards
LTALTAlymphotoxin alpha (TNF superfamily, member 1)Source|GeneCards
FLJ33387FLJ33387hypothetical protein FLJ33387Source|GeneCards
MIS12MIS12homolog of yeast Mis12Source|GeneCards
CAPZA1CAPZA1capping protein (actin filament) muscle Z-line, alpha 1Source|GeneCards
FLJ38964FLJ38964hypothetical protein FLJ38964Source|GeneCards
BCL7ABCL7AB-cell CLL/lymphoma 7ASource|GeneCards
IRF1IRF1interferon regulatory factor 1Source|GeneCards
SLICKKCNT2potassium channel, subfamily T, member 2Source|GeneCards
GPHNGPHNgephyrinSource|GeneCards
PTMSPTMSparathymosinSource|GeneCards
FLJ14103CXORF36chromosome X open reading frame 36Source|GeneCards
MGC33864ARL6IP6ADP-ribosylation-like factor 6 interacting protein 6Source|GeneCards
SLC35A5SLC35A5solute carrier family 35, member A5Source|GeneCards
FLJ22405FLJ22405hypothetical protein FLJ22405Source|GeneCards
FLJ14494RPUSD4RNA pseudouridylate synthase domain containing 4Source|GeneCards
CALUCALUcalumeninSource|GeneCards
SV2BSV2Bsynaptic vesicle glycoprotein 2BSource|GeneCards
TJP4TJP4tight junction protein 4 (peripheral)Source|GeneCards
RND1RND1Rho family GTPase 1Source|GeneCards
CENTD1CENTD1centaurin, delta 1Source|GeneCards
NR4A1NR4A1nuclear receptor subfamily 4, group A, member 1Source|GeneCards
MOBKL2CMOBKL2CMOB1, Mps One Binder kinase activator-like 2C (yeast)Source|GeneCards
NXFNPAS4neuronal PAS domain protein 4Source|GeneCards
EIF4G1EIF4G1eukaryotic translation initiation factor 4 gamma, 1Source|GeneCards
COL4A3BPCOL4A3BPcollagen, type IV, alpha 3 (Goodpasture antigen) binding proteinSource|GeneCards
SENP3SENP3sentrin/SUMO-specific protease 3Source|GeneCards
PR1TMEM37transmembrane protein 37Source|GeneCards
CPA4CPA4carboxypeptidase A4Source|GeneCards
SETSETSET translocation (myeloid leukemia-associated)Source|GeneCards
IRX5IRX5iroquois homeobox protein 5Source|GeneCards
TAO1TAOK2TAO kinase 2Source|GeneCards
WNT4WNT4wingless-type MMTV integration site family, member 4Source|GeneCards
CRTAC1CRTAC1cartilage acidic protein 1Source|GeneCards
RGS3RGS3regulator of G-protein signalling 3Source|GeneCards
EPHA7EPHA7EphA7Source|GeneCards
KCNN3KCNN3potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3Source|GeneCards
FBXL3AFBXL3F-box and leucine-rich repeat protein 3Source|GeneCards
HOXC6HOXC6homeo box C6Source|GeneCards
MLLMLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Source|GeneCards
FLRT1FLRT1fibronectin leucine rich transmembrane protein 1Source|GeneCards
ACCN1ACCN1amiloride-sensitive cation channel 1, neuronal (degenerin)Source|GeneCards
NCAM1NCAM1neural cell adhesion molecule 1Source|GeneCards
ZNF342ZNF342zinc finger protein 342Source|GeneCards
UBE4BUBE4Bubiquitination factor E4B (UFD2 homolog, yeast)Source|GeneCards
TNRC6TNRC6ATrinucleotide repeat containing 6ASource|GeneCards
LTBP1LTBP1latent transforming growth factor beta binding protein 1Source|GeneCards
ZFYVE9ZFYVE9zinc finger, FYVE domain containing 9Source|GeneCards
OAZINOAZINornithine decarboxylase antizyme inhibitorSource|GeneCards
ZBTB11ZBTB11zinc finger and BTB domain containing 11Source|GeneCards
HEYLHEYLhairy/enhancer-of-split related with YRPW motif-likeSource|GeneCards
SPON1SPON1spondin 1, (f-spondin) extracellular matrix proteinSource|GeneCards
CTGFCTGFconnective tissue growth factorSource|GeneCards
PCBP4PCBP4poly(rC) binding protein 4Source|GeneCards
SPTBN2SPTBN2spectrin, beta, non-erythrocytic 2Source|GeneCards
SCUBE3SCUBE3signal peptide, CUB domain, EGF-like 3Source|GeneCards
KCNN2KCNN2potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2Source|GeneCards
SDC1SDC1syndecan 1Source|GeneCards
FLJ45530FLJ45530FLJ45530 proteinSource|GeneCards
IL18BPIL18BPinterleukin 18 binding proteinSource|GeneCards
RIMS1RIMS1regulating synaptic membrane exocytosis 1Source|GeneCards
ZBTB9ZBTB9zinc finger and BTB domain containing 9Source|GeneCards
MBD6MBD6methyl-CpG binding domain protein 6Source|GeneCards
KPNB1KPNB1karyopherin (importin) beta 1Source|GeneCards
TCF7L2TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)Source|GeneCards
ZNF161ZNF161zinc finger protein 161Source|GeneCards
UPK2UPK2uroplakin 2Source|GeneCards
MLLT7MLLT7myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7Source|GeneCards
CPLX2CPLX2complexin 2Source|GeneCards
SLCO5A1SLCO5A1solute carrier organic anion transporter family, member 5A1Source|GeneCards
FUT8FUT8fucosyltransferase 8 (alpha (1,6) fucosyltransferase)Source|GeneCards
ADM2ADM2adrenomedullin 2Source|GeneCards
MGC14376MGC14376hypothetical protein MGC14376Source|GeneCards
TNFSF18TNFSF18tumor necrosis factor (ligand) superfamily, member 18Source|GeneCards
TRIB2TRIB2tribbles homolog 2 (Drosophila)Source|GeneCards
MYT1MYT1myelin transcription factor 1Source|GeneCards
RBPSUHLRBPSUHLrecombining binding protein suppressor of hairless (Drosophila)-likeSource|GeneCards
C1ORF16C1ORF16chromosome 1 open reading frame 16Source|GeneCards
FOSBFOSBFBJ murine osteosarcoma viral oncogene homolog BSource|GeneCards
GABRB1GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 1Source|GeneCards
KIAA0913KIAA0913KIAA0913 proteinSource|GeneCards
EIF4EEIF4Eeukaryotic translation initiation factor 4ESource|GeneCards
APG3APG3autophagy Apg3p/Aut1p-likeSource|GeneCards
PAPD1PAPD1PAP associated domain containing 1Source|GeneCards
WEE1WEE1WEE1 homolog (S. pombe)Source|GeneCards
ZNF151ZBTB17zinc finger and BTB domain containing 17Source|GeneCards
FLJ33817FLJ33817hypothetical protein FLJ33817Source|GeneCards
VSNL1VSNL1visinin-like 1Source|GeneCards
NAV2NAV2neuron navigator 2Source|GeneCards
MIG12MID1IP1MID1 interacting protein 1 (gastrulation specific G12-like (zebrafish))Source|GeneCards
S100A14S100A14S100 calcium binding protein A14Source|GeneCards
ACCN4ACCN4amiloride-sensitive cation channel 4, pituitarySource|GeneCards
TM9SF1TM9SF1transmembrane 9 superfamily member 1Source|GeneCards
MGC15677MGC15677hypothetical protein MGC15677Source|GeneCards
HOXC4HOXC4homeo box C4Source|GeneCards
EIF5AEIF5Aeukaryotic translation initiation factor 5ASource|GeneCards
R-SPONDINR-SPONDINR-spondin homolog (Xenopus laevis)Source|GeneCards
KCNH3KCNH3potassium voltage-gated channel, subfamily H (eag-related), member 3Source|GeneCards
BMI1PCGF4polycomb group ring finger 4Source|GeneCards
LOC124245LOC124245hypothetical protein BC001584Source|GeneCards
ARHGAP8ARHGAP8Rho GTPase activating protein 8Source|GeneCards
NR1D1NR1D1nuclear receptor subfamily 1, group D, member 1Source|GeneCards
NAPBNAPBN-ethylmaleimide-sensitive factor attachment protein, betaSource|GeneCards
TRIP10TRIP10thyroid hormone receptor interactor 10Source|GeneCards
AP2B1AP2B1adaptor-related protein complex 2, beta 1 subunitSource|GeneCards
NFAM1NFAM1NFAT activation molecule 1Source|GeneCards
HOXB9HOXB9homeo box B9Source|GeneCards
MAML1MAML1mastermind-like 1 (Drosophila)Source|GeneCards
PGFPGFplacental growth factor, vascular endothelial growth factor-related proteinSource|GeneCards
LULULutheran blood group (Auberger b antigen included)Source|GeneCards
DDIT3DDIT3DNA-damage-inducible transcript 3Source|GeneCards
MGC13053MGC13053hypothetical protein MGC13053Source|GeneCards
NCOA5NCOA5nuclear receptor coactivator 5Source|GeneCards

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