XX
XX
XX
FA TFIIA-gamma
XX
SY TFIIA-S.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
OC eutheria; primates
XX
XX
HO TFIIA-S (Drosophila), TOA2 (yeast)
XX
SZ 109 AA (gamma); 12.5 kDa (cDNA), 12 kDa (SDS) [6], 13 kDa (SDS)
[7] [5]
XX
XX
SC SwissProt #P52657
XX
FT 1
49 PF02268; TFIIA_gamma.
FT 51 100 PF02751; TFIIA_gamma_C.
XX
SF assembles active holo-TFIIA either with alpha/beta-precursor
or with alpha
SF and beta subunits [3] [4] by interacting
with the alpha, but not with the
SF beta moiety [4]
XX
CP (HeLa)
EX adrenal gland (right and left),,,adult;very low;
dot blot (RNA); mRNA
EX (poly-A); [1].
EX amygdaloid body,,,adult;very
low; dot blot (RNA); mRNA (poly-A); [1].
EX aorta,,,adult;medium;
dot blot (RNA); mRNA (poly-A); [1].
EX appendix,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX blood,basophil granulocyte,Circulatory
System & Hematopoietic
EX System,adult;detectable; northern
blot; mRNA (poly-A); [1].
EX blood,basophil granulocyte,Circulatory
System & Hematopoietic
EX System,adult;very low; dot blot
(RNA); mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory
System & Hematopoietic
EX System,adult;detectable; northern
blot; mRNA (poly-A); [1].
EX blood,eosinophil granulocyte,Circulatory
System & Hematopoietic
EX System,adult;very low; dot blot
(RNA); mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory
System & Hematopoietic
EX System,adult;detectable; northern
blot; mRNA (poly-A); [1].
EX blood,lymphocyte,Circulatory
System & Hematopoietic System,adult;very low;
EX dot blot
(RNA); mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System
& Hematopoietic System,adult;detectable;
EX northern blot;
mRNA (poly-A); [1].
EX blood,monocyte,Circulatory System &
Hematopoietic System,adult;very low;
EX dot blot (RNA); mRNA
(poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory
System & Hematopoietic
EX System,adult;detectable; northern
blot; mRNA (poly-A); [1].
EX blood,neutrophil granulocyte,Circulatory
System & Hematopoietic
EX System,adult;very low; dot blot
(RNA); mRNA (poly-A); [1].
EX bone marrow,,,adult;very low;
dot blot (RNA); mRNA (poly-A); [1].
EX brain,,,adult;detectable;
northern blot; mRNA (poly-A); [1].
EX brain,,,adult;low; dot
blot (RNA); mRNA (poly-A); [1].
EX brain,,,fetal;very low;
dot blot (RNA); mRNA (poly-A); [1].
EX caudate nucleus,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX cerebellum,,,adult;medium;
dot blot (RNA); mRNA (poly-A); [1].
EX cerebral cortex of
cerebral hemisphere,,,adult;low; dot blot (RNA); mRNA
EX (poly-A);
[1].
EX cerebral cortex,,,adult;low; dot blot (RNA); mRNA
(poly-A); [1].
EX colon,,,adult;detectable; northern blot;
mRNA (poly-A); [1].
EX colon,,,adult;low; dot blot (RNA);
mRNA (poly-A); [1].
EX frontal lobe of medial and inferior
surfaces,,,adult;very low; dot blot
EX (RNA); mRNA (poly-A);
[1].
EX frontal lobe of superolateral face,,,adult;very low;
dot blot (RNA); mRNA
EX (poly-A); [1].
EX heart,,,adult;detectable;
northern blot; mRNA (poly-A); [1].
EX heart,,,adult;high;
dot blot (RNA); mRNA (poly-A); [1].
EX heart,,,fetal;low;
dot blot (RNA); mRNA (poly-A); [1].
EX hippocampus,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX kidney (right and left),,,adult;detectable;
northern blot; mRNA (poly-A);
EX [1].
EX kidney (right
and left),,,adult;medium; dot blot (RNA); mRNA (poly-A); [1].
EX kidney (right and left),,,fetal;low; dot blot (RNA); mRNA (poly-A);
[1].
EX liver,,,adult;detectable; northern blot; mRNA (poly-A);
[1].
EX liver,,,adult;low; dot blot (RNA); mRNA (poly-A);
[1].
EX liver,,,fetal;low; dot blot (RNA); mRNA (poly-A);
[1].
EX lung (right and left),,,adult;detectable; northern
blot; mRNA (poly-A);
EX [1].
EX lung (right and left),,,adult;medium;
dot blot (RNA); mRNA (poly-A); [1].
EX lung (right and left),,,fetal;medium;
dot blot (RNA); mRNA (poly-A); [1].
EX lymph node,,,adult;very
low; dot blot (RNA); mRNA (poly-A); [1].
EX major salivary
glands,,,adult;low; dot blot (RNA); mRNA (poly-A); [1].
EX
mammary gland,,,adult;low; dot blot (RNA); mRNA (poly-A); [1].
EX minor salivary glands,,,adult;low; dot blot (RNA); mRNA (poly-A);
[1].
EX muscles,,,adult;detectable; northern blot; mRNA (poly-A);
[1].
EX muscles,,,adult;high; dot blot (RNA); mRNA (poly-A);
[1].
EX myelencephalon,,,adult;low; dot blot (RNA); mRNA (poly-A);
[1].
EX nucleus accumbens,,,adult;very low; dot blot (RNA);
mRNA (poly-A); [1].
EX occipital lobe of medial and inferior
surfaces,,,adult;very low; dot blot
EX (RNA); mRNA (poly-A);
[1].
EX occipital lobe of superolateral face,,,adult;very
low; dot blot (RNA); mRNA
EX (poly-A); [1].
EX ovary (right
and left),,,adult;medium; dot blot (RNA); mRNA (poly-A); [1].
EX pancreas,,,adult;detectable; northern blot; mRNA (poly-A);
[1].
EX pancreas,,,adult;low; dot blot (RNA); mRNA (poly-A);
[1].
EX pituitary gland of diencephalon,,,adult;high; dot
blot (RNA); mRNA
EX (poly-A); [1].
EX placenta,,,adult;detectable;
northern blot; mRNA (poly-A); [1].
EX placenta,,,adult;high;
dot blot (RNA); mRNA (poly-A); [1].
EX prostate gland,,,adult;detectable;
northern blot; mRNA (poly-A); [1].
EX prostate gland,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX putamen,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX small intestine,,,adult;detectable;
northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX spinal cord,,,adult;medium;
dot blot (RNA); mRNA (poly-A); [1].
EX spleen,,,adult;detectable;
northern blot; mRNA (poly-A); [1].
EX spleen,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX spleen,,,fetal;low;
dot blot (RNA); mRNA (poly-A); [1].
EX stomach,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX substantia nigra,,,adult;medium;
dot blot (RNA); mRNA (poly-A); [1].
EX temporal lobe of medial
and inferior surfaces,,,adult;very low; dot blot
EX (RNA);
mRNA (poly-A); [1].
EX temporal lobe of superolateral face,,,adult;very
low; dot blot (RNA); mRNA
EX (poly-A); [1].
EX testis
(right and left),,,adult;high; northern blot; mRNA (poly-A); [1].
EX testis (right and left),,,adult;very high; dot blot (RNA);
mRNA (poly-A);
EX [1].
EX thalamus,,,adult;low; dot blot
(RNA); mRNA (poly-A); [1].
EX thymus,,,adult;detectable; northern
blot; mRNA (poly-A); [1].
EX thymus,,,adult;low; dot blot
(RNA); mRNA (poly-A); [1].
EX thymus,,,fetal;low; dot blot
(RNA); mRNA (poly-A); [1].
EX thyroid gland,,,adult;very low;
dot blot (RNA); mRNA (poly-A); [1].
EX trachea,,,adult;medium;
dot blot (RNA); mRNA (poly-A); [1].
EX tubular salivary gland,,,adult;low;
dot blot (RNA); mRNA (poly-A); [1].
EX urinary bladder,,,adult;very
low; dot blot (RNA); mRNA (poly-A); [1].
EX uterus,,,adult;detectable;
northern blot; mRNA (poly-A); [1].
EX uterus,,,adult;very
low; dot blot (RNA); mRNA (poly-A); [1].
XX
IN T00794;
TBP; human, Homo sapiens.
IN T02216; TFIIA-alpha/beta precursor
(major); human, Homo sapiens.
XX
XX
XX
XX
RN [1]; RE0017409.
RX MEDLINE; 99292779.
RA Upadhyaya
A. B., Lee S. H., Dejong J.
RT Identification of a general
transcription factor TFIIAalpha/beta homolog
RT selectively
expressed in testis
RL J. Biol. Chem. 274:18040-18048 (1999).
RN [2]; RE0005663.
RX MEDLINE; 95241493.
RA Dejong J.,
Bernstein R., Roeder R. G.
RT Human general transcription
factor TFIIA: Characterization of a cDNA
RT encoding the small
subunit and requirement for basal and activated
RT transcription
RL Proc. Natl. Acad. Sci. USA 92:3313-3317 (1995).
RN [3];
RE0005656.
RX MEDLINE; 95047376.
RA Ozer J., Moore P.
A., Bolden A. H., Lee A., Rosen C. A., Lieberman P. M.
RT
Molecular cloning of the small (gamma) subunit of human TFIIA
reveals
RT functions critical for activated transcription
RL Genes Dev. 8:2324-2335 (1994).
RN [4]; RE0005657.
RX
MEDLINE; 95047377.
RA Sun X., Ma D., Sheldon M., Yeung K.,
Reinberg D.
RT Reconstitution of human TFIIA activity from
recombinant polypeptides: a
RT role in TFIID-mediated transcription
RL Genes Dev. 8:2336-2348 (1994).
RN [5]; RE0005658.
RX
MEDLINE; 94040744.
RA Ma D., Watanabe H., Mermelstein F.,
Admon A., Oguri K., Sun X., Wada T.,
RA Imai T., Shiroya T.,
Reinberg D., Handa H.
RT Isolation of a cDNA encoding the
largest subunit of TFIIA reveals functions
RT important for
activated transcription
RL Genes Dev. 7:2246-2257 (1993).
RN [6]; RE0005659.
RX MEDLINE; 94040742.
RA Dejong J.,
Roeder R. G.
RT A single cDNA hTFIIA/alpha encodes both the
p35 and p19 subunits of human
RT TFIIA
RL Genes Dev. 7:2220-2234
(1993).
RN [7]; RE0005655.
RX MEDLINE; 92107195.
RA
Cortes P., Flores O., Reinberg D.
RT Factors involved in specific
transcription by mammalian RNA polymerase II:
RT Purification
and analysis of transcription factor IIA and identification of
RT transcription factor IIJ
RL Mol. Cell. Biol. 12:413-421
(1992).
XX