XX
 XX
 XX
 FA AML3b
 XX
 SY PEBP2alpha1; Osf2;
PEBP2alphaA; CBF-alpha 1; RUNX2.
 XX
 OS human, Homo sapiens

OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda;
mammalia;
 OC eutheria; primates
 XX
 XX
 CL C0029;
runt.
 XX
 SZ 521 AA; 56.6 kDa (cDNA)
 XX
 XX

SC translated from EMBL #AF001450
 XX
 FT 49 71 glutamine-rich
region (23/23).
 FT 73 89 alanine-rich region (17/17).

FT 99 233 PF00853; Runt.
 FT 101 228 runt domain.
 FT 237
517 proline-/serine-/threonine-rich region (121/280).
 FT 396
422 putative nuclear matrix targeting signal [2].
 FT 517 521
VWRPY motif / Groucho-homology.
 XX
 SF factor was found
to be associated with the nuclear matrix [2]
 XX
 FF related
to human cleidocranial dysplasia (CCD) [1] [3];
 FF mapped
to chromosome region 6p21 [1];
 FF essential for skeletal morphogenesis
[1];
 XX
 XX
 XX
 RN [1]; RE0005889.
 RX MEDLINE;
97325753.
 RA Mundlos S., Otto F., Mundlos C., Mulliken J.
B., Aylsworth A. S., Albright
 RA S., Lindhout D., Cole W.
G., Henn W., Knoll J. H. M., Owen M. J.,
 RA Mertelsmann R.,
Zabel B. U., Olsen B. R.
 RT Mutations involving the transcription
factor CBFA1 cause cleidocranial
 RT dysplasia
 RL Cell
89:773-779 (1997).
 RN [2]; RE0006488.
 RX MEDLINE; 97338089.

RA Zeng C., van Wijnen A. J., Stein J. L., Meyers S., Sun W.,
Shopland L.,
 RA Lawrence J. B., Penman S., Lian J.B., Stein
G. S., Hiebert S. W.
 RT Identification of a nuclear matrix
targeting signal in leukemia and
 RT bone-related AML/CBF-alpha
transcription factors
 RL Proc. Natl. Acad. Sci. USA 94:6746-6751
(1997).
 RN [3]; RE0015248.
 RX MEDLINE; 97351518.
 RA
Lee B., Thirunavukkarasu K., Zhou L., Pastore L., Baldini A.,
Hecht J.,
 RA Geoffroy V., Ducy P., Karsenty G.
 RT Missense
mutations abolishing DNA binding of the osteoblast-specific

RT transcription factor OSF2/CBFA1 in cleidocranial dysplasia

RL Nat. Genet. 16:307-310 (1997).
 XX