XX
 XX
 XX
 FA AR
 XX
 SY androgen receptor; AR;
NR3C4; dihydrotestosterone receptor.
 XX
 OS rat, Rattus
norvegicus
 OC eukaryota; animalia; metazoa; chordata; vertebrata;
tetrapoda; mammalia;
 OC eutheria; rodentia; myomorpha; muridae;
murinae
 XX
 XX
 CL C0002; CC (rec); 2.1.1.3.1.
 XX

SZ 902 AA; 98.2 kDa (cDNA), 98.9 kDa (SDS)
 XX
 XX
 SC
SwissProt #P15207
 XX
 FT 6 445 PF02166; Androgen_recep.

FT 539 610 SM00399; ZnF_C4.
 FT 540 606 region C, DNA-binding
domain (DBD).
 FT 540 615 PF00105; zf-C4.
 FT 689 853 SM00430;
HOLI.
 FT 692 878 PF00104; hormone_rec.
 XX
 SF can form
multimeric complexes [3]
 XX
 FF regulates androgen-dependent
gene expression by binding to
 FF androgen-responsive elements
(ARE) [4];
 FF its DNA-binding domain can interact with leucine
zipper of AP1 to result in
 FF mutual transrepression [2].;

XX
 XX
 XX
 XX
 RN [1]; RE0002368.
 RX MEDLINE;
89017168.
 RA Chang C., Kokontis J., Liao S.
 RT Structural
analysis of complementary DNA and amino acid sequences of human

RT and rat androgen receptors
 RL Proc. Natl. Acad. Sci. USA
85:7211-7215 (1988).
 RN [2]; RE0023374.
 RX MEDLINE; 9211894.

RA Sato N., Sadar M. D., Bruchovsky N., Saatcioglu F., Rennie
P. S., Sato S.,
 RA Lange P. H., Gleave M. E.
 RT Androgenic
induction of prostate-specific antigen gene is repressed by

RT protein-protein interaction between the androgen receptor and
AP-1/c-Jun in
 RT the human prostate cancer cell line LNCaP.

RL J. Biol. Chem. 272:17485-17494 (1997).
 RN [3]; RE0010237.

RA Kasper S., Rennie P. S., Bruchovsky N., Sheppard P. C., Cheng
H., Lin L.,
 RA Shiu R. P. C., Snoek R., Matusik R. J.

RT Cooperative binding of androgen receptors to two DNA sequences
is required
 RT for androgen induction of the probasin gene

RL J. Biol. Chem. 269:31763-31769 (1994).
 RN [4]; RE0001011.

RX MEDLINE; 91139625.
 RA de Vos P., Claessens F., Winderickx
J., van Dijck P., Celis L., Peeters B.,
 RA Rombauts W., Heyns
W., Verhoeven G.
 RT Interaction of androgen response elements
with the DNA-binding domain of
 RT the rat androgen receptor
expressed in Escherichia coli
 RL J. Biol. Chem. 266:3439-3443
(1991).
 RN [5]; RE0003759.
 RX MEDLINE; 91309548.
 RA
Danzo B. J., Parrot J. A., Skinner M. K.
 RT Analysis of the
steroid binding domain of rat androgen-binding protein
 RL
Endocrinology 129:690-696 (1991).
 RN [6]; RE0001752.
 RX
MEDLINE; 91042631.
 RA Forman B. M., Samuels H. H.
 RT Interactions
among a subfamily of nuclear hormone receptors: the regulatory

RT zipper model
 RL Mol. Endocrinol. 4:1293-1301 (1990).

RN [7]; RE0002369.
 RX MEDLINE; 89098909.
 RA Tilley W.,
Marcelli M., Wilson J. D., McPhaul M. J.
 RT Characterization
and expression of a cDNA encoding the human androgen
 RT receptor

RL Proc. Natl. Acad. Sci. USA 86:327-331 (1989).
 XX