XX
 XX
 XX
 FA CUTL1
 XX
 SY CDP; CCAAT displacement
protein; cut homeodomain protein; Cux; cut-like
 SY homeodomain
protein; Clox.
 XX
 OS human, Homo sapiens
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; primates
 XX
 XX
 HO cut (Drosophila) 

XX
 CL C0006; homeo; 3.1.1.4.1.
 XX
 SZ 1505 AA; 164.4
kDa (cDNA), 180-200 kDa (SDS)
 XX
 XX
 SC SwissProt #P39880

XX
 FT 542 629 PF02376; CUT.
 FT 551 610 Cut-repeat 1 (CR1).

FT 551 610 involved in binding to S/MAR-binding factor SATB1 

FT [1].
 FT 632 653 missing in putative splice variant.

FT 934 1021 PF02376; CUT.
 FT 943 1007 Cut-repeat 2 (CR2).

FT 943 1007 involved in binding to S/MAR-binding factor SATB1

 FT [1].
 FT 1117 1204 PF02376; CUT.
 FT 1135
1190 Cut-repeat 3 (CR3).
 FT 1244 1306 SM00389; HOX.
 FT
1245 1301 homeo domain.
 FT 1245 1301 involved in binding to
S/MAR-binding factor SATB1 
 FT [1].
 FT 1245
1301 PF00046; homeobox.
 XX
 SF the Clox homolog is a splice
variant [5];
 SF the 3 cut repeats also contribute to DNA-binding,
each individual repeat
 SF and each combination exhibiting
slightly different DNA-binding specificity
 SF [4] [2] [5];

SF CR1 exhibits the most restricted resognition pattern [4];

SF KD (CR3-homeo domain) = 0.03 nM, isolated CR3 at least 100-fold
lower
 SF affinity [2];
 XX
 FF repressor [13] [12] [9]
[8] [6] [3];
 FF may regulate S/MAR-binding factor SATB1 
and may be regulated by
 FF it via protein-protein interaction
[1];
 XX
 XX
 XX
 XX
 RN [1]; RE0015021.
 RX
MEDLINE; 99303784.
 RA Liu J., Barnett A., Neufeld E. J., Dudley
J. P.
 RT Homeoproteins CDP and SATB1interact: potential for
tissue-specific
 RT regulation
 RL Mol. Cell. Biol. 19:4918-4926
(1999).
 RN [2]; RE0002973.
 RX MEDLINE; 95097984.
 RA
Harada R., Berube G., Tamplin O. J., Denis-Larose C., Nepveu A.

RT DNA-binding specificity of the cut repeats from the human cut-like
protein
 RL Mol. Cell. Biol. 15:129-140 (1995).
 RN [3];
RE0003999.
 RX MEDLINE; 95279415.
 RA Lievens P. M., Donady
J. J., Tufarelli C., Neufeld E. J.
 RT Repressor activity of
CCAAT displacement protein in HL-60 myeloid leukemia
 RT cells

RL J. Biol. Chem. 270:12745-12750 (1995).
 RN [4]; RE0002967.

RX MEDLINE; 94329595.
 RA Aufiero B., Neufeld E. J., Orkin
S. H.
 RT Sequence-specific DNA binding of individual cut repeats
of the human CCAAT
 RT displacement/ cut homeodomain protein

RL Proc. Natl. Acad. Sci. USA 91:7757-7761 (1994).
 RN [5];
RE0002972.
 RX MEDLINE; 94131277.
 RA Andres V., Chiara
M. D., Mahdavi V.
 RT A new bipartite DNA-binding domain: cooperative
interaction between the cut
 RT repeat and homeo domain of
the cut homeo proteins
 RL Genes Dev. 8:245-257 (1994).

RN [6]; RE0003358.
 RX MEDLINE; 94254882.
 RA Dufort D.,
Nepveu A.
 RT The human Cut homeodomain protein represses transcription
from the c-myc
 RT promoter
 RL Mol. Cell. Biol. 14:4251-4257
(1994).
 RN [7]; RE0005004.
 RX MEDLINE; 94124559.
 RA
Harada R., Dufort D., Denis-Larose C., Nepveu A.
 RT Conserved
cut repeats in the human cut homeodomain protein function as DNA

RT binding domains
 RL J. Biol. Chem. 269:2062-2067 (1994).

RN [8]; RE0005002.
 RX MEDLINE; 93250973.
 RA Neufeld E.
J., Skalnik D. G., Lievens P. M., Orkin S. H.
 RT Human CCAAT
dis-placement protein is homologous to the Drosophila
 RT homeoprotein,
cut
 RL Nat. Genet. 1:50-55 (1992).
 RN [9]; RE0001031.

RX MEDLINE; 91358470.
 RA Skalnik D. G., Strauss E. C., Orkin
S. H.
 RT CCAAT displacement protein as a repressor of the
myelomonocytic-specific
 RT gp91-phox gene promoter
 RL
J. Biol. Chem. 266:16736-16744 (1991).
 RN [10]; RE0002047.

RX MEDLINE; 89385992.
 RA Mantovani R., Superti-Furga G., Gilman
J., Ottolenghi S.
 RT The deletion of the distal CCAAT box
region of the Agamma-globin gene in
 RT black HPFH abolishes
the binding of the erythroid specific protein NFE3 and
 RT
of the CCAAT displacement protein
 RL Nucleic Acids Res. 17:6681-6691
(1989).
 RN [11]; RE0005005.
 RX MEDLINE; 89150259.

RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.

RT The protein CDP, but not CP1, footprints on the CCAAT region
of the
 RT g-globin gene in unfractionated B-cell extracts

RL Biochim. Biophys. Acta 1007:237-242 (1989).
 RN [12]; RE0000346.

RX MEDLINE; 89030605.
 RA Superti-Furga G., Barberis A., Schaffner
G., Busslinger M.
 RT The -117 mutation in Greek HPFH affects
the binding of three nuclear
 RT factors to the CCAAT region
of the gamma-globin gene
 RL EMBO J. 7:3099-3107 (1988).

RN [13]; RE0000079.
 RX MEDLINE; 87273497.
 RA Barberis
A., Superti-Furga G., Busslinger M.
 RT Mutually Exclusive
Interaction of the CCAAT-Binding Factor and of a
 RT Displacement
Protein with Overlapping Sequences of a Histone Gene Promoter

RL Cell 50:347-359 (1987).
 XX