XX
 XX
 XX
 FA CRE-BP1
 XX
 SY HB16; TREB-7; XBP-4;
XBP4; ATF-2 (human); CREBP1.
 XX
 OS mouse, Mus musculus

OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda;
mammalia;
 OC eutheria; rodentia; myomorpha; muridae; murinae

XX
 CL C0008; bZIP.
 XX
 SZ 456 AA; 48.9 kDa (cDNA)

XX
 XX
 SC translated from EMBL #S76657
 XX
 FT 30
53 acidic region (8/24).
 FT 74 98 acidic region (7/25).

FT 100 197 missing in CRE-BP2.
 FT 292 324 basic region.

FT 300 364 PF00170; bZIP.
 FT 300 364 SM00338; BRLZ.
 FT
330 358 leucine zipper (L5).
 FT 387 417 serine-/threonine-rich
region (15/31).
 XX
 SF alternative splice products: CRE-BP2
, CRE-BP3 ;
 SF Thr-69 and Thr-71 are essential
for E1A-induced and CRE-BP1-mediated
 SF transcriptional activation
[2];
 SF lacking the N-terminal zinc finger motif [4];

XX
 CP ubiquitous [4]
 XX
 FF may be transcriptionally
inert, presumably due to the lack of the
 FF N-terminal zinc
finger motif found in human CRE-BP1  [4];
 FF required
for normal skeletal and CNS development, lack of CRE-BP1 leads
to
 FF defects in enchondral ossification and causes ataxy,
hyperactivity, and
 FF decreased hearing [1];
 FF phosphorylation
by a JNK/SAPK kinase of the MAPK family at Thr-69 and -71

FF mediates activation in response to UV or other cellular stresses
[2] [3];
 XX
 IN T00122; c-Fos; mouse, Mus musculus.

IN T01017; CRE-BP2; mouse, Mus musculus.
 XX
 XX
 XX

RN [1]; RE0005264.
 RX MEDLINE; 96138383.
 RA Reimold A.
M., Grusby M. J., Kosaras B., Fries J. W. U., Mori R., Maniwa

RA S., Clauss I. M., Collins T., Sidman R. L., Glimcher M. J.,
Glimcher L. H.
 RT Chondrysplasia and neurological abnormalities
in ATF-2 deficient mice
 RL Nature 379:262-265 (1996).

RN [2]; RE0005261.
 RX MEDLINE; 95255236.
 RA Livingstone
C., Patel G., Jones N.
 RT ATF-2 contains a phosphorylation-dependent
transcriptional activation domain
 RL EMBO J. 14:1785-1797
(1995).
 RN [3]; RE0005263.
 RX MEDLINE; 95255237.
 RA
van Dam H., Wilhelm D., Herr I., Steffen A., Herrlich P., Angel
P.
 RT ATF-2 is preferentially activated by stress-activated
protein kinases to
 RT mediate c-jun induction in response
to genotoxic agents
 RL EMBO J. 14:1798-1811 (1995).
 RN
[4]; RE0005262.
 RX MEDLINE; 92123199.
 RA Georgopoulos
K., Morgan B. A., Moore D. D.
 RT Functionally distinct isoforms
of the CRE-BP DNA-binding protein mediate
 RT activity of a
T-cell-specific enhancer
 RL Mol. Cell. Biol. 12:747-757 (1992).

XX