XX
 XX
 XX
 FA HOXA5
 XX
 SY Hox-1.3; Hoxa-5; Chox-1.3
(chick).
 XX
 OS mouse, Mus musculus
 OC eukaryota; animalia;
metazoa; chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria;
rodentia; myomorpha; muridae; murinae
 XX
 XX
 HO Scr
(Drosophila)
 XX
 CL C0006; homeo; 3.1.1.2.16.
 XX

SZ 270 AA; 29.2 kDa (cDNA)
 XX
 XX
 FT 176 181 Antp-type
hexapeptide.
 FT 195 254 homeo domain.
 FT 195 257 SM00389;
HOX.
 FT 196 252 PF00046; homeobox.
 XX
 SF phosphorylation
[7];
 SF moderate affinity to homeo domain consensus sequence
(KD = 5 nM) [3];
 SF a cis-regulatory region of 604 bp directs
expression from cervical metamere
 SF 3 to thoracic metamere
2 (C3-T2) in the branchial spinal cord [1];
 XX
 CP (embryo
12.5 days:) CNS caudal to a boundary in the posterior
 CP myelencephalon,
lung (low), dorsal parts of the mantle layer, oesophagus,

CP trachea, stomach, posterior gut, mesonephric/metanephric kidney,
testis [6]
 XX
 FF mutation causes homeotic transformations
in cervical and thoracic regions
 FF [4];
 FF the 7th cervical
vertebra adopts thoracic-like features including the
 FF presence
of a pair of ribs [4];
 FF also expressed in certain kidney
substructures [2] [9];
 XX
 XX
 XX
 XX
 RN [1];
RE0014483.
 RX MEDLINE; 99177148.
 RA Nowling T., Zhou W.,
Krieger K. E., Larochelle C., Nguyen-Huu M. C.,
 RA Jeannotte
L., Tuggle C. K.
 RT Hoxa5 gene regulation: A gradient of binding
activity to a brachial spinal
 RT cord element
 RL Dev.
Biol. 208:134-146 (1999).
 RN [2]; RE0014517.
 RA Davies
J. A., Brandli A. W.
 RT The Kidney Development Database; URL:

RT http://www.ana.ed.ac.uk/anatomy/database/kidbase/tranfack.html

RL Internet : (1997).
 RN [3]; RE0003885.
 RX MEDLINE; 94277058.

RA Pellerin I., Schnabel C., Catron K. M., Abate C.
 RT Hox
proteins have different affinities for a consensus DNA site that

RT correlate with the positions of their genes on the hox cluster

RL Mol. Cell. Biol. 14:4532-4545 (1994).
 RN [4]; RE0003884.

RX MEDLINE; 94040731.
 RA Jeannotte L., Lemieux M., Charron
J., Poirier F., Robertson E. J.
 RT Specification of axial
identity in the mouse: role of the Hoxa-5 (Hox1.3)
 RT gene

RL Genes Dev. 7:2085-2096 (1993).
 RN [5]; RE0002766.
 RX
MEDLINE; 90220580.
 RA Hirsch M.-R., Gaugler L., Deagostini-Bazin
H., Bally-Cuif L., Goridis C.
 RT Identification of Positive
and Negative Regulatory Elements Governing
 RT Cell-Type-Specific
Expression of the Neural Cell Adhesion Molecule Gene
 RL Mol.
Cell. Biol. 10:1959-1968 (1990).
 RN [6]; RE0003983.
 RX
MEDLINE; 90382249.
 RA Gaunt S. J., Coletta P. L., Pravtcheva
D., Sharpe P. T.
 RT Mouse Hox-3.4: homeobox sequence and embryonic
expression patterns compared
 RT with other members of the
Hox gene network
 RL Development 109:329-339 (1990).
 RN
[7]; RE0000655.
 RX MEDLINE; 89232713.
 RA Odenwald W. F.,
Garbern J., Arnheiter H., Tournier-Lasserve E., Lazzarini

RA R. A.
 RT The HOX-1.3 homeo box protein is a sequence-specific
DNA-binding
 RT phosphoprotein
 RL Genes Dev. 3:158-172
(1989).
 RN [8]; RE0003883.
 RX MEDLINE; 88328807.
 RA
Fibi M., Zink B., Kessel M., Colberg-Poley A. M., Labeit S., Lehrach
H.,
 RA Gruss P.
 RT Coding sequence and expression of the
homeobox gene hox 1.3
 RL Development 102:349-359 (1988).

RN [9]; RE0006757.
 RX MEDLINE; 89064559.
 RA Gaunt S. J.

RT Mouse homeobox gene transcripts occupy different but overlapping
domains in
 RT embryonic germ layers and organs: a comparison
of Hox-3.1 and Hox-1.5
 RL Development 103:135-144 (1988).

RN [10]; RE0003882.
 RX MEDLINE; 88056292.
 RA Odenwald
W. F., Taylor C. F., Palmer-Hill F. J., Friedrich jr V., Tani
M.,
 RA Lazzarini R. A.
 RT Expression of a homeo domain
protein in noncontact-inhibited cultured cells
 RT and postmitotic
neurons
 RL Genes Dev. 1:482-496 (1987).
 XX