XX
 XX
 XX
 FA NF-kappaB1
 XX
 SY 243/NFA-kappaB;
EBP-1; H2TF1; KBF1; NF-kappaB (p50); p50.
 XX
 OS mouse,
Mus musculus
 OC eukaryota; animalia; metazoa; chordata; vertebrata;
tetrapoda; mammalia;
 OC eutheria; rodentia; myomorpha; muridae;
murinae
 XX
 CL C0020; Rel; 4.1.1.0.1.2.
 XX
 SZ 50
kDa, 57-63 kDa (SDS)
 XX
 SF synthesized as a 105 kDa precursor
 from which the N-terminal half
 SF comprising the
Rel domain is released as mature p50 by proteolytic clipping

SF [13];
 SF binds to DNA as homo- or heteromer  with,
e. g., RelA/p65 or c-Rel
 SF [4];
 SF the DNA-binding Rel
domain comprises two beta-barrel domains the loops of
 SF which
constitute an extensive DNA contacting surface [1];
 SF using
a symmetric decameric binding site (GGGAATTCCC), a short
 SF
alpha-helical segment performs minor groove contacts in a region
where
 SF augmenting interaction with HMG I(Y) have been observed
[1];
 XX
 CP ubiquitous
 XX
 FF transcriptionally
inert DNA-binding subunit of holo-NF-kappaB ;
 FF trans-activating
induced heterodimes with RelA/p65  [7] or with
 FF
Bcl-3 [5];
 FF at some elements, however, p50 may exert a constitutive
activating function
 FF [8];
 FF bound to this sequence,
p50 adopts a chymotrypsin-resistant conformation
 FF [8];

FF constitutive activating complexes in spleen B-cells and thymocytes
consist
 FF of p50/RelB heterodimers [7];
 FF in pre-B cells,
mainly p50/p65 heterodimers are induced, whereas in mature

FF B cells, p50/c-Rel heterodimers predominate [4];
 FF constitutive
NF-kappaB activity in B-cells partly due to enhanced protease

FF activity degrading IkappaB [2];
 FF upstream signal transducers
for p50 phosphorylation and, presumably,
 FF activation may
be Raf, Src, H-Ras, Mos [6];
 XX
 IN T01928; Bcl-3; human,
Homo sapiens.
 IN T01941; IkappaB-gamma1; mouse, Mus musculus.

IN T01942; IkappaB-gamma2; mouse, Mus musculus.
 IN T01940;
IkappaB-gamma; mouse, Mus musculus.
 IN T01923; NF-kappaB1;
mouse, Mus musculus.
 IN T00595; RelA; mouse, Mus musculus.

IN T01932; RelB; mouse, Mus musculus.
 IN T00897; v-Rel; REV-T,
reticuloendotheliosis virus (strain T).
 XX
 XX
 XX

XX
 RN [1]; RE0004504.
 RX MEDLINE; 95132005.
 RA Ghosh
G., van Duyne G., Ghosh S., Sigler P. B.
 RT Structure of NF-kappaB
p50 homodimer bound to a kappaB site
 RL Nature 373:303-310
(1995).
 RN [2]; RE0004491.
 RX MEDLINE; 94217724.
 RA
Miyamoto S., Chiao P. J., Verma I. M.
 RT Enhanced IkappaBalpha
degradation is responsible for constitutive NF-kappaB
 RT activity
in mature murine B-cell lines
 RL Mol. Cell. Biol. 14:3276-3282
(1994).
 RN [3]; RE0004492.
 RX MEDLINE; 94254849.
 RA
Zhang Q., Didonato J. A., Karin M., McKeithan T. W.
 RT BCL3
encodes a nuclear protein which can alter the subcellular location
of
 RT NF-kappaB proteins
 RL Mol. Cell. Biol. 14:3915-3926
(1994).
 RN [4]; RE0004531.
 RX MEDLINE; 94255469.
 RA
Miyamoto S., Schmitt M. J., Verma I. M.
 RT Qualitative changes
in the subunit composition of kappa-binding complexes
 RT during
murine B-cell differentiation
 RL Proc. Natl. Acad. Sci. USA
91:5056-5060 (1994).
 RN [5]; RE0004510.
 RX MEDLINE; 93321864.

RA Fujita T., Nolan G. P., Liou H.-C., Scott M. L., Baltimore
D.
 RT The candidate proto-oncogene bcl-3 encodes a transcriptional
coactivator
 RT that activates through NF-kappaB p50 homodimers

RL Genes Dev. 7:1354-1363 (1993).
 RN [6]; RE0004520.
 RX
MEDLINE; 94077729.
 RA Bruder J. T., Heidecker G., Tan T.-H.,
Derse D., Rapp U. R.
 RT Oncogene activation of HIV-LTR-driven
expression via the NF-kappaB binding
 RT sites
 RL Nucleic
Acids Res. 21:5229-5234 (1993).
 RN [7]; RE0004522.
 RX
MEDLINE; 94019849.
 RA Lernbecher T., Mueller U., Wirth T.

RT Distinct NF-kappaB/Rel transcription factors are responsible
for
 RT tissue-specific and inducible gene activation
 RL
Nature 365:767-770 (1993).
 RN [8]; RE0004518.
 RX MEDLINE;
92249770.
 RA Fujita T., Nolan G. P., Ghosh S., Baltimore D.

RT Independent modes of transcriptional activation by the p50
and p65 subunits
 RT of NF-kappaB
 RL Genes Dev. 6:775-787
(1992).
 RN [9]; RE0000174.
 RX MEDLINE; 91105848.
 RA
Lewin B.
 RT Oncogenic conversion by regulatory changes in
transcription factors
 RL Cell 64:303-312 (1991).
 RN [10];
RE0000176.
 RX MEDLINE; 91160060.
 RA Nolan G. P., Gosh
S., Liou H.-C., Tempst P., Baltimore D.
 RT DNA binding and
IkappaB inhibition of the cloned p65 subunit of NF-kappaB,

RT a rel-related polypeptide
 RL Cell 64:961-969 (1991).

RN [11]; RE0001632.
 RX MEDLINE; 89343960.
 RA Shirakawa
F., Mizel S. B.
 RT In vitro activation and nuclear translocation
of NF-kappaB catalyzed by
 RT cyclic AMP-dependent protein
kinase and protein kinase C
 RL Mol. Cell. Biol. 9:2424-2430
(1991).
 RN [12]; RE0000169.
 RX MEDLINE; 90367115.

RA Gilmore T. D.
 RT NF-kappaB, KBF1, dorsal, and related matters

RL Cell 62:841-843 (1990).
 RN [13]; RE0000215.
 RX MEDLINE;
90367113.
 RA Ghosh S., Gifford A. M., Riviere L. R., Tempst
P., Nolan G. P., Baltimore D.
 RT Cloning of the p50 DNA binding
subunit of NF-kappaB: homology to rel and
 RT dorsal
 RL
Cell 62:1019-1029 (1990).
 RN [14]; RE0000658.
 RX MEDLINE;
90346296.
 RA Hagman J., Rudin Ch. M., Haasch D., Chaplin D.,
Storb U.
 RT A novel enhancer in the immunoglobulin lambda
locus is duplicated and
 RT functionally independent of NFkB

RL Genes Dev. 4:987-992 (1990).
 RN [15]; RE0001474.
 RX
MEDLINE; 90318374.
 RA Henseling U., Schmidt W., Schoeler H.
R., Gruss P., Hatzopoulos A. K.
 RT A transcription factor
interacting with the class I gene enhancer is
 RT inactive
in tumorigenic cell lines which suppress major histocompatibility

RT complex class I genes
 RL Mol. Cell. Biol. 10:4100-4109
(1990).
 RN [16]; RE0001520.
 RX MEDLINE; 90318374.

RA Henseling U., Schmidt W., Schoeler H. R., Gruss P., Hatzopoulos
A. K.
 RT A transcription factor interacting with the class
I gene enhancer is
 RT inactive in tumorigenic cell lines which
suppress major histocompatibility
 RT complex class I genes

RL Mol. Cell. Biol. 10:4100-4109 (1990).
 RN [17]; RE0002414.

RX MEDLINE; 91062349.
 RA Rustgi A. K., van't Veer L. J., Bernards
R.
 RT Two genes encode factors with NF-kappaB- and H2TF1-like
DNA-binding
 RT properties
 RL Proc. Natl. Acad. Sci. USA
87:8707-8710 (1990).
 RN [18]; RE0000453.
 RX MEDLINE; 90059928.

RA Lenardo M., Rustgi A. K., Schievella A. R., Bernards R.

RT Suppression of MHC class I gene expression by N-myc through
enhancer
 RT inactivation
 RL EMBO J. 8:3351-3355 (1989).

RN [19]; RE0002064.
 RX MEDLINE; 89345084.
 RA Israel A.,
Yano O., Logeat F., Kieran M., Kourilsky P.
 RT Two purified
factors bind to the same sequence in the enhancer of mouse MHC

RT class I genes: one of them is a positive regulator induced
upon
 RT differentiation of teratocarcinoma cells
 RL Nucleic
Acids Res. 17:5245 (1989).
 RN [20]; RE0000090.
 RX MEDLINE;
88194520.
 RA Baeuerle P. A., Baltimore D.
 RT Activation
of DNA-Binding Activity in an Apparently Cytoplasmic Precursor

RT of the NF-kB Transcription Factor
 RL Cell 53:211-217 (1988).

RN [21]; RE0000372.
 RX MEDLINE; 89030606.
 RA Wirth T.,
Baltimore D.
 RT Nuclear factor NF-kB can interact functionally
with its cognate binding
 RT site to provide lymphoid-specific
promoter function
 RL EMBO J. 7:3109-3113 (1988).
 RN [22];
RE0002609.
 RX MEDLINE; 89058614.
 RA Briskin M., Kuwabara
M. D., Sigman D. S., Wall R.
 RT Induction of kappa transcription
by interferon-gamma without activation of
 RT NF-kappaB

RL Science 242:1036-1037 (1988).
 RN [23]; RE0000384.
 RX
MEDLINE; 88111518.
 RA Yano O., Kanellopoulos J., Kieran M.,
Le Bail O., Israel A., Kourilsky P.
 RT Purification of KBF1,
a common factor binding to both H-2 and
 RT beta2-microglobulin
enhancers
 RL EMBO J. 6:3317-3324 (1987).
 XX