XX
 XX
 XX
 FA AhR
 XX
 SY AhR; Ah receptor; dioxin
receptor; XRE-binding factor; aryl hydrocarbon
 SY receptor.

XX
 OS rat, Rattus norvegicus
 OC eukaryota; animalia; metazoa;
chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria; rodentia;
myomorpha; muridae; murinae
 XX
 XX
 CL C0010; bHLH;
1.2.6.0.1.
 XX
 SZ 853 AA; 96.2 kDa (cDNA), 95 kDa (SDS)
[13] [11], 257 (sedim.) [13]; 121
 SZ (sedim., ligand-binding
subunit) [13]
 XX
 XX
 SC conceptually translated from
EMBL/GenBank/DDBJ #U04860
 XX
 FT 31 38 basic region.

FT 33 87 SM00353; HLH.
 FT 36 80 PF00010; HLH.
 FT 39 80
helix-loop-helix domain.
 FT 111 177 SM00091; PAS.
 FT 111
175 PF00989; PAS.
 FT 116 378 PAS domain.
 FT 270 340 SM00091;
PAS.
 FT 346 387 SM00086; PAC.
 FT 346 387 PF00785; PAC.

FT 596 653 glutamine-rich region (20/58).
 XX
 SF 95 kDa:
ligand-binding subunit;
 SF Stokes radius: 7.0 nm;
 SF dissociation
into subunits upon treatment with 0.4 M KCl sedimenting with

SF 4.9-5.6 S [13];
 SF faster dissociation than murine complex
[13];
 SF interacts with hsp90 [9] [8];
 SF DNA-binding
of the heterodimer with Arnt is much stronger than that of Ahr

SF homodimer [4];
 XX
 CP highest levels in liver, lower
in thymus, kidney, lung [2]
 XX
 FF activator, binds to
xenobiotic response element [7];
 FF quickly up-regulated by
aryl hydrocarbons (e.g. TCDD) within 30 min,
 FF down-regulated
requiring an additional, labile factor over the subsequent 2

FF h [1];
 XX
 IN T00992; Hsp90; human, Homo sapiens.

XX
 XX
 XX
 XX
 RN [1]; RE0003540.
 RX MEDLINE;
95198710.
 RA Haas N. B., Cantwell C. A., Johnson P. F., Burch
J. B. E.
 RT DNA-binding specificity of the PAR basic leucine
zipper protein VBP
 RT partially overlaps those of the C/EBP
and CREB/ATF families and is
 RT influenced by domains that
flank the core basic region
 RL Mol. Cell. Biol. 15:1923-1932
(1995).
 RN [2]; RE0004039.
 RX MEDLINE; 94344763.
 RA
Carver L. A., Hogenesch J. B., Bradfield C. A.
 RT Tissue specific
expression of the rat Ah-receptor and ARNT mRNAs
 RL Nucleic
Acids Res. 22:3038-3044 (1994).
 RN [3]; RE0004040.
 RX
MEDLINE; 94344074.
 RA Reick M., Robertson R. W., Pasco D.
S., Fagan J. B.
 RT Down-regulation of nuclear aryl hydrocarbon
receptor DNA-binding and
 RT transactivation functions: requirement
for a labile or inducible factor
 RL Mol. Cell. Biol. 14:5653-5660
(1994).
 RN [4]; RE0005839.
 RX MEDLINE; 94140877.
 RA
Mason G. G. F., Witte A. M., Whitelaw M. L., Antonsson C., McGuire
J.,
 RA Wilhelmsson A., Poellinger L., Gustafsson J. A.

RT Purification of the DNA binding form of dioxin receptor

RL J. Biol. Chem. 269:4438-4449 (1994).
 RN [5]; RE0000879.

RX MEDLINE; 90130485.
 RA Nemoto T., Mason G. F., Wilhelmsson
A., Cuthill S., Hapgood J., Gustafsson
 RA J. A., Poellinger
L.
 RT Activation of the Dioxin and Glucocorticoid Receptors
to a DNA Binding
 RT State under Cell-free Conditions
 RL
J. Biol. Chem. 256:2269-2277 (1990).
 RN [6]; RE0000990.

RX MEDLINE; 91056130.
 RA Elferink C. J., Gasiewicz T. A.,
Whitlock jr J. P.
 RT Protein-DNA interactions at a dioxin-responsive
enhancer
 RL J. Biol. Chem. 265:20708-20712 (1990).
 RN
[7]; RE0002274.
 RX MEDLINE; 89098930.
 RA Hapgood J., Cuthill
S., Denis M., Poellinger L., Gustafsson J.-A.
 RT Specific
protein-DNA interactions at a xenobiotic-responsive element:

RT Copurification of dioxin receptor and DNA-binding affinity

RL Proc. Natl. Acad. Sci. USA 86:60-64 (1989).
 RN [8]; RE0000019.

RX MEDLINE; 88339968.
 RA Denis M., Cuthill S., Wikstroem A.-C.,
Poellinger L., Gustafsson J.-A.
 RT Association of the dioxin
receptor with the Mr 90.000 heat shock protein: a
 RT structural
kinship with the glucocorticoid receptor
 RL Biochem. Biophys.
Res. Commun. 155:801-807 (1988).
 RN [9]; RE0001108.
 RX
MEDLINE; 88330913.
 RA Perdew G. H.
 RT Association of the
Ah receptor with the 90-kDa heat shock protein
 RL J. Biol.
Chem. 263:13802-13806 (1988).
 RN [10]; RE0002273.
 RX MEDLINE;
88190105.
 RA Denison M. S., Fisher J. M., Whitlock jr J. P.

RT Inducible, receptor-dependent protein-DNA interactions at a

RT dioxin-responsive transcriptional activator
 RL Proc. Natl.
Acad. Sci. USA 85:2528-2532 (1988).
 RN [11]; RE0001109.

RX MEDLINE; 87137635.
 RA Cuthill S., Poellinger L., Gustafsson
J.-A.
 RT The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin
in the mouse hepatoma
 RT cell line Hepa 1c1c7
 RL J. Biol.
Chem. 262:3477-3481 (1987).
 RN [12]; RE0004042.
 RX MEDLINE;
87230998.
 RA Fujisawa-Sehara A., Sogawa K., Yamane M., Fuji-Kurijama
Y.
 RT Characterization of xenobiotic response elements upstream
from the
 RT drug-metabolizing cytochrome P450c gene: a similarity
to glucocorticoid
 RT regulatoty elements
 RL Nucleic Acids
Res. 15:4179-4191 (1987).
 RN [13]; RE0001099.
 RX MEDLINE;
86140207.
 RA Denison M. S., Vella L. M., Okeys A. B.
 RT
Structure and function of the Ah receptor for
 RT 2,3,7,8-tetrachlorodibenzo-p-dioxin

RL J. Biol. Chem. 261:3987-3995 (1986).
 XX