XX
 XX
 XX
 FA ER-beta
 XX
 SY estrogen receptor
beta; NR3A2; ESTRB; ESR2.
 XX
 OS human, Homo sapiens

OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda;
mammalia;
 OC eutheria; primates
 XX
 XX
 CL C0002;
CC (rec); 2.1.1.4.2.
 XX
 SZ 530 AA; 59.2 kDa (cDNA)

XX
 XX
 SC translated from EMBL #AB006590
 XX
 FT
1 148 region A/B [1].
 FT 102 106 MAPK phosphorylation site
(at Serin) [3].
 FT 146 217 SM00399; ZnF_C4.
 FT 147 222
PF00105; zf-C4.
 FT 149 213 region C, DNA-binding domain [1]
[3].
 FT 149 169 zinc finger 1 (C-X2-C-X13-C-X2-C).
 FT
185 204 zinc finger 2 (C-X5-C-X9-C-X2-C).
 FT 214 247 region
D [1].
 FT 248 530 region E/F, with ligand binding domain [1].

FT 300 469 SM00430; HOLI.
 FT 303 495 PF00104; hormone_rec.

FT 501 530 region F [3].
 XX
 SF can bind DNA as a homodimer
or as a heterodimer  with ER-alpha
 SF  [4].

XX
 CP (adult:) expressed in thymus, testis, ovary [3]; weak
levels in spleen [3]
 EX blood,basophil granulocyte,Circulatory
System & Hematopoietic
 EX System,adult;detectable; northern
blot; RNA (undefined); [3].
 EX blood,eosinophil granulocyte,Circulatory
System & Hematopoietic
 EX System,adult;detectable; northern
blot; RNA (undefined); [3].
 EX blood,lymphocyte,Circulatory
System & Hematopoietic
 EX System,adult;detectable; northern
blot; RNA (undefined); [3].
 EX blood,monocyte,Circulatory
System & Hematopoietic System,adult;detectable;
 EX northern
blot; RNA (undefined); [3].
 EX blood,neutrophil granulocyte,Circulatory
System & Hematopoietic
 EX System,adult;detectable; northern
blot; RNA (undefined); [3].
 EX ovary (right and left),,,adult;detectable;
RT-PCR; mRNA (poly-A); [1].
 EX ovary (right and left),,,adult;detectable;
northern blot; RNA (undefined);
 EX [1].
 EX ovary (right
and left),,,adult;detectable; northern blot; RNA (undefined);

EX [3].
 EX ovary (right and left),,,adult;high; RT-PCR; RNA
(undefined); [2].
 EX spleen,,,adult;very low; northern blot;
RNA (undefined); [3].
 EX testis (right and left),,,adult;detectable;
RT-PCR; mRNA (poly-A); [1].
 EX testis (right and left),,,adult;detectable;
northern blot; RNA (undefined);
 EX [1].
 EX testis (right
and left),,,adult;detectable; northern blot; RNA (undefined);

EX [3].
 EX testis (right and left),,,adult;high; RT-PCR; RNA
(undefined); [2].
 EX thymus,,,adult;detectable; northern blot;
RNA (undefined); [3].
 XX
 FF agonist: estradiol [3]

XX
 IN T00261; ER-alpha; human, Homo sapiens.
 IN T04651;
ER-beta; human, Homo sapiens.
 XX
 XX
 XX
 XX

RN [1]; RE0016538.
 RX MEDLINE; 98139878.
 RA Ogawa S.,
Inoue S., Watanabe T., Hiroi H., Orimo A., Hosoi T., Ouchi Y.,

RA Muramatsu M.
 RT The complete primary structure of human
estrogen receptor beta (hER beta)
 RT and its heterodimerization
with ER alpha in vivo and in vitro
 RL Biochem. Biophys. Res.
Commun. 243:122-126 (1998).
 RN [2]; RE0022247.
 RX MEDLINE;
9636657.
 RA Moore J. T., McKee D. D., Slentz-Kesler K., Moore
L. B., Jones S. A., Horne
 RA E. L., Su J. L., Kliewer S. A.,
Lehmann J. M., Willson T. M.
 RT Cloning and characterization
of human estrogen receptor beta isoforms.
 RL Biochem. Biophys.
Res. Commun. 247:75-78 (1998).
 RN [3]; RE0016540.
 RX MEDLINE;
96354875.
 RA Mosselman S., Polman J., Dijkema R.
 RT ER
beta: identification and characterization of a novel human estrogen

RT receptor
 RL FEBS Lett. 392:49-53 (1996).
 RN [4]; RE0023363.

RX MEDLINE; 9242648.
 RA Cowley S. M., Hoare S., Mosselman
S., Parker M. G.
 RT Estrogen receptors alpha and beta form
heterodimers on DNA.
 RL J. Biol. Chem. 272:19858-19862 (1997).

XX