XX
 XX
 XX
 FA HNF-1A
 XX
 SY APF; HNF1; HNF-1alpha;
LF-B1; HNF-1A.
 XX
 OS mouse, Mus musculus
 OC eukaryota;
animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia;

OC eutheria; rodentia; myomorpha; muridae; murinae
 XX

CL C0006; homeo; 3.1.1.12.1.1.
 XX
 SZ 628 AA; 67.2 kDa
(cDNA), 92-98 kDa (SDS)
 XX
 XX
 SC SwissProt #P22361

XX
 FT 1 31 dimerization domain (by similarity).
 FT 1 176
PF04814; HNF-1_N.
 FT 161 186 POUs A subdomain homolog.

FT 199 279 homeo domain.
 FT 199 282 SM00389; HOX.
 FT 208
219 helix 1 [1].
 FT 226 240 helix 2 [1].
 FT 261 274 helix
3 [1].
 FT 280 539 PF04812; HNF-1B_C.
 FT 281 318 activation
domain II (ADII).
 FT 289 314 proline-rich region (10/26).

FT 540 628 PF04813; HNF-1A_C.
 FT 546 628 activation domain
I (ADI).
 FT 583 627 serine-/threonine-rich region (20/45).

XX
 SF glycosylation;
 SF similar factor in lung: 110 +
120 kDa (SDS);
 SF dimerizes in the absence of DNA [5];

SF unusual for homeobox genes, gene regions encoding helix 2 and
3 are
 SF separated by an intron [2];
 XX
 CP liver,
intestine, spleen, stomach, kidney
 CN lung
 XX
 FF induced
in F9 cells by RA, plateau after 5d [4]
 XX
 IN T00889;
HNF-1B; rat, Rattus norvegicus.
 IN T00890; HNF-1B; mouse,
Mus musculus.
 XX
 XX
 XX
 XX
 RN [1]; RE0004697.

RX MEDLINE; 93259120.
 RA Leiting B., de Francesco R., Tomei
L., Cortese R., Otting G., Whthrich K.
 RT The three-dimensional
NMR-solution structure of the polypeptide fragment
 RT 195-286
of the LFB1/HNF1 transcription factor from rat liver comprises
a
 RT non-classical homeodomain
 RL EMBO J. 12:1797-1803
(1993).
 RN [2]; RE0004692.
 RX MEDLINE; 92375726.
 RA
Bach I., Pontoglio M., Yaniv M.
 RT Structure of the gene encoding
hepatocyte nuclear factor 1 (HNF1)
 RL Nucleic Acids Res. 20:4199-4204
(1992).
 RN [3]; RE0004693.
 RX MEDLINE; 92131134.
 RA
Kuo C. J., Conley P. B., Chen L., Sladek F. M., Darnell J. E.,
Crabtree G.
 RA R.
 RT A transcriptional hierarchy involved
in mammalian cell-type specification
 RL Nature 355:457-461
(1992).
 RN [4]; RE0000510.
 RX MEDLINE; 91293099.
 RA
Kuo C. J., Mendel D. B., Hansen L. P., Crabtree G. R.
 RT Independent
regulation of HNF-1alpha and HNF-1beta by retinoic acid in F9

RT teratocarcinoma cells
 RL EMBO J. 10:2231-2236 (1991).

RN [5]; RE0000675.
 RX MEDLINE; 91257571.
 RA Mendel D.
B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R.

RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization and homeo
domains, but
 RT not activation domains, and form heterodimers
in vitro
 RL Genes Dev. 5:1042-1056 (1991).
 RN [6]; RE0001582.

RX MEDLINE; 91117244.
 RA Liu J.-K., DiPersio C. M., Zaret
K. S.
 RT Extracellular signals that regulate liver transcription
factors during
 RT hepatic differentiation in vitro
 RL
Mol. Cell. Biol. 11:773-784 (1991).
 RN [7]; RE0001365.

RX MEDLINE; 90287137.
 RA Abraham L. J., Bradshaw A. D., Shiels
B. R., Northemann W., Hudson G., Fey
 RA G. H.
 RT Hepatic
Transcription of the Acute-Phase alpha1-Inhibitor III Gene Is

RT Controlled by a Novel Combination of cis-Acting Regulatory
Elements
 RL Mol. Cell. Biol. 10:3483-3491 (1990).
 RN [8];
RE0002415.
 RX MEDLINE; 91088607.
 RA Kuo C. J., Conley
P. B., Hsieh C.-L., Francke U., Crabtree S.
 RT Molecular cloning,
functional expression, and chromosomal localization of
 RT
mouse hepatocyte nuclear factor 1
 RL Proc. Natl. Acad. Sci.
USA 87:9838-9842 (1990).
 RN [9]; RE0001386.
 RX MEDLINE;
90097936.
 RA Chang H.-K., Wang B.-Y., Yuh C.-H., Wei C.-L.,
Ting L.-P.
 RT A Liver-Specific Nuclear Factor Interacts with
the Promoter Region of the
 RT Large Surface Protein Gene of
Human Hepatitis B Virus
 RL Mol. Cell. Biol. 9:5189-5197 (1989).

RN [10]; RE0001392.
 RX MEDLINE; 90097908.
 RA Tsutsumi
K.-I., Ito K., Ishikawa K.
 RT Developmental Appearance of
Transcription Factors That Regulate
 RT Liver-Specific Expression
of the Aldolase B Gene
 RL Mol. Cell. Biol. 9:4923-4931 (1989).

RN [11]; RE0002595.
 RX MEDLINE; 88042798.
 RA Courtois
G., Morgan J. G., Campbell L. A., Fourel G., Crabtree G. R.

RT Interaction of a liver-specific nuclear factor with the fibrinogen
and
 RT alpha1-antitrypsin promoters
 RL Science 238:688-692
(1987).
 XX