XX
 XX
 XX
 FA LUN-1
 XX
 SY lung.
 XX
 OS
human, Homo sapiens
 OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
 OC eutheria; primates

XX
 XX
 CL C0049; RING.
 XX
 SZ 1045 AA; 119.2 kDa
(calc)
 XX
 XX
 SC translated from EMBL #AB045732

XX
 FT 13 28 PEST sequence [1].
 FT 103 141 RING finger
domain [1].
 FT 103 141 PF00097; zf-C3HC4.
 FT 103 141 SM00184;
RING.
 FT 293 365 putative leucine zipper [1].
 FT 386 432
PEST sequence [1].
 FT 490 509 PEST sequence [1].
 FT 616
645 putative bipartite nuclear localization signal [1].
 FT
616 622 putative NLS (nuclear localization signal) [1].
 FT
700 703 putative SUMO-1 conjugation site [1].
 FT 836 839 putative
SUMO-1 conjugation site [1].
 FT 921 950 PEST sequence [1].

FT 999 1024 PEST sequence [1].
 XX
 SF Zn2+ ions with either
Mg2+, Mn2+ or Ca2+ are essential for the binding of
 SF LUN
to DNA [1];
 SF binds to a palindromic binding consensus (TCCCAgcacttTGGGA)
[1];
 SF splice variant LUN-2 ;
 XX
 CP (cell
lines:) T98, Molt-4, (adult:) most highly expressed in lung (alveolar

CP epithelium), moderade expression in heart, brain, skeletal
muscle, kidney,
 CP liver, spleen, pancreas [1]
 XX

FF might be an important transcriptional regulator for lung cancer-associated

FF genes including E-cadherin and talin [1]
 XX
 XX

XX
 XX
 RN [1]; RE0016839.
 RX MEDLINE; 21216701.

RA Chu D., Kakazu N., Gorrin-Rivas M. J., Lu H. P., Kawata M.,
Abe T., Ueda
 RA K., Adachi Y.
 RT Cloning and characterization
of LUN, a novel ring finger protein that is
 RT highly expressed
in lung and specifically binds to a palindromic sequence
 RL
J. Biol. Chem. 276:14004-14013 (2001).
 XX