XX
 XX
 XX
 FA Pax-4a
 XX
 SY PAX4; mPAX4; Pax-4;
mPax-4.
 XX
 OS mouse, Mus musculus
 OC eukaryota; animalia;
metazoa; chordata; vertebrata; tetrapoda; mammalia;
 OC eutheria;
rodentia; myomorpha; muridae; murinae
 XX
 CL C0018; paired-homeo.

XX
 SZ 349 AA; 38.0 kDa (cDNA); 38 kDa (SDS) [1]
 XX

XX
 SC translated from EMBL #AB010558
 XX
 FT 5 132 paired
domain.
 FT 5 129 PF00292; PAX.
 FT 5 129 SM00351; PAX.

FT 169 228 homeo domain.
 FT 170 232 SM00389; HOX.
 FT 171
227 PF00046; homeobox.
 FT 231 349 leucine-/proline-rich region
(28/119).
 FT 239 252 missing in splice variant Pax-4b.

FT 278 349 activation and repression domain [1].
 FT 278 314
missing in splice variant Pax-4c.
 XX
 SF Pax-4 gene presumably
exists as a single copy in the genome [3];
 SF the activation
domain seems to be E1A-responsive whereas the repression
 SF
domain is general active [1];
 SF three splice variants found
which were not named by the authors [4];
 SF the C-terminal
region (activation/repression domain) shows no significant

SF homology with any other known Pax gene [4];
 XX
 CP MIN6,
betaTC and NIT-1 cells [3]; (embryo 9.5 days:) ventral spinal
cord,
 CP pancreas, (embryo 10.5 days:) dorsal pancreas, (embryo
11.0 days:) ventral
 CP pancres, (newborn:) insulin-producing
beta cells [5]
 CN alphaTC cells [3]; (newborn:) pancreatic
alpha and delta cells [5]
 XX
 FF homozygous knockout mice
die after birth within 3 days showing growth
 FF retardation
and dehydration (apparently as a consequence of insulin
 FF
deficiency) [5];
 FF differentiation of endocrine progenitors
to beta and delta cells [5];
 FF Pax-4 binds to islet hormone
promoters (glucagon, insulin, somastatin) and
 FF can act competitive
to Pax-6 as a repressor [1] [2];
 XX
 XX
 XX
 XX

RN [1]; RE0014123.
 RX MEDLINE; 20036785.
 RA Fujitani Y.,
Kajimoto Y., Yasuda T., Matsuoka T. A., Kaneto H., Umayahara

RA Y., Fujita N., Watada H., Miyazaki J. I., Yamasaki Y., Hori
M.
 RT Identification of a portable repression domain and an
E1A-responsive
 RT activation domain in Pax4: a possible role
of Pax4 as a transcriptional
 RT repressor in the pancreas

RL Mol. Cell. Biol. 19:8281-8291 (1999).
 RN [2]; RE0014138.

RX MEDLINE; 20036784.
 RA Smith S. B., Ee H. C., Conners J.
R., German M. S.
 RT Paired-homeodomain transcription factor
PAX4 acts as a transcriptional
 RT repressor in early pancreatic
development
 RL Mol. Cell. Biol. 19:8272-8280 (1999).
 RN
[3]; RE0014120.
 RX MEDLINE; 98102804.
 RA Matsushita T.,
Yamaoka T., Otsuka S., Moritani M., Matsumoto T., Itakura M.

RT Molecular cloning of mouse paired-box-containing gene (Pax)-4
from an islet
 RT beta cell line and deduced sequence of human
Pax-4
 RL Biochem. Biophys. Res. Commun. 242:176-180 (1998).

RN [4]; RE0014280.
 RX MEDLINE; 98153815.
 RA Inoue H.,
Nomiyama J., Nakai K., Matsutani A., Tanizawa Y., Oka Y.
 RT
Isolation of full-length cDNA of mouse PAX4 gene and identification
of its
 RT human homologue
 RL Biochem. Biophys. Res. Commun.
243:628-633 (1998).
 RN [5]; RE0006104.
 RX MEDLINE; 97238684.

RA Sosa-Pineda B., Chowdhury K., Torres M., Oliver G., Gruss P.

RT The Pax4 gene is essential for differentiation of insulin-producing
beta
 RT cells in the mammalian pancreas
 RL Nature 386:399-402
(1997).
 RN [6]; RE0006130.
 RX MEDLINE; 97305958.
 RA
St-Onge L., Sosa-Pineda B., Chowdhury K., Mansouri A., Gruss P.

RT Pax6 is required for differentiation of glucagon-producing
alpha -cells in
 RT mouse pancreas
 RL Nature 387:406-409
(1997).
 RN [7]; RE0004257.
 RX MEDLINE; 92120664.
 RA
Walther C., Guenet J. L., Simon D., Deutsch U., Jostes B., Goulding
M. D.,
 RA Plachov D., Balling R., Gruss P.
 RT Pax: a murine
multigene family of paired box-containing genes
 RL Genomics
11:424-434 (1991).
 XX