XX
 XX
 XX
 FA SRY
 XX
 SY sex-determining region
Y gene product; TDF; testis-determining factor.
 XX
 OS
human, Homo sapiens
 OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
 OC eutheria; primates

XX
 XX
 CL C0015; HMG; 4.7.1.0.1.
 XX
 SZ 204 AA;
23.9 kDa (cDNA)
 XX
 XX
 SC SwissProt #Q05066
 XX

FT 57 137 HMG domain.
 FT 59 129 SM00398; HMG.
 FT 60 128
PF00505; HMG_box.
 FT 65 81 alpha-helix 1 [1].
 FT 88 100
alpha-helix 2 [1].
 FT 102 123 alpha-helix 3 [1].
 XX

FF testis-determining factor;
 FF isolated mutants causing
XY females: V60L, M64I, G95R, K106I;
 FF recognizes sharp angles
in DNA (60-120 deg) irrespective of sequence;
 FF when binding
to AACAAAG consensus, it produces a sharp bend;
 FF mutants
with different DNA-binding properties (affinity or induction of

FF structural deformations) have been found in patients with gonadal

FF dysgenesis [2];
 XX
 XX
 XX
 XX
 RN [1]; RE0005081.

RX MEDLINE; 95292338.
 RA Werner M. H., Huth J. R., Gronenborn
A. M., Clore G. M.
 RT Molecular basis of human 46X,Y sex reversal
revealed from the
 RT three-dimensional solution structure
of the human SRY-DNA complex
 RL Cell 81:705-714 (1995).

RN [2]; RE0003119.
 RX MEDLINE; 95112822.
 RA Pontiggia
A., Rimini R., Harley V. R., Goodfellow P. N., Lovell-Badge R.,

RA Bianchi M. E.
 RT Sex-reversing mutations affect the architecture
of SRY--DNA complexes
 RL EMBO J. 13:6115-6124 (1994).

RN [3]; RE0000305.
 RX MEDLINE; 93049201.
 RA Ferrari S.,
Harley V. R., Pontiggia A., Goodfellow P. N., Lovell-Badge R.,

RA Bianchi M. E.
 RT SRY, like HMG1, recognizes sharp angles
in DNA
 RL EMBO J. 11:4497-4506 (1992).
 RN [4]; RE0002703.

RX MEDLINE; 92132550.
 RA Harley V. R., Jackson D. I., Hextall
P. J., Hawkins J. R., Berkovitz G. D.,
 RA Sockanathan S.,
Lovell-Badge R., Goodfellow P. N.
 RT DNA binding activity
of recombinant SRY from normal males and XY females
 RL Science
255:453-456 (1992).
 XX