XX
 XX
 XX
 FA STAT1
 XX
 SY STAT91; ISGF3alpha
p91; signal transducer and activator of transcription 1.
 XX

OS mouse, Mus musculus
 OC eukaryota; animalia; metazoa; chordata;
vertebrata; tetrapoda; mammalia;
 OC eutheria; rodentia; myomorpha;
muridae; murinae
 XX
 XX
 CL C0039; STAT; 4.2.1.0.1.1.

XX
 SZ 749 AA; 87.2 kDa (cDNA), 91 kDa (SDS)
 XX
 XX

SC SwissProt #P42225
 XX
 FT 2 122 PF02865; STAT_prot.

FT 136 315 PF01017; STAT.
 FT 199 227 leucine zipper-like motif
(LLVLT).
 FT 317 567 PF02864; STAT_bind.
 FT 505 559 SH3
domain.
 FT 573 674 SH2 domain.
 FT 573 668 PF00017; SH2.

FT 634 701 conserved tyrosine residues.
 XX
 SF tyrosine-phosphorylation;

SF subunit of ISGF-3alpha;
 SF forms homodimers;
 SF forms
heterodimers with STAT3;
 XX
 FF activator of a number of
genes;
 FF homodimer may act as a repressor [1];
 FF mediates
transduction of tyrosine phosphorylation signals to induction
of
 FF interferon-stimulated gene expression [10];
 FF most
likely identical with SIF (c-sis-inducible factor) [11];
 FF
inducible by IFN-alpha and IFN-gamma [9] and also by CSF-1 [4],
other
 FF cytokines except IL-6 [8], growth factors and hormones
[10] [5];
 FF Tyr-phosphorylation promotes formation of ISGF3
complex, nuclear
 FF translocation [9], enables DNA-binding
and trans-activation [9];
 FF Stat1 Tyr-phosphorylation depends
on phosphorylation of Stat2 [2];
 FF modifying protein kinases
are Jak1 (triggered by IFN-alpha and -gamma) and
 FF Jak2 (responding
to IFN-gamma) [9];
 FF is activated by IL-10 and IFNgamma [3];

XX
 IN T01575; STAT1; mouse, Mus musculus.
 IN T01492; STAT1alpha;
human, Homo sapiens.
 IN T01573; STAT1beta; human, Homo sapiens.

IN T01494; STAT2; human, Homo sapiens.
 IN T01574; STAT3; mouse,
Mus musculus.
 IN T00824; TFII-I; human, Homo sapiens.

XX
 XX
 XX
 XX
 RN [1]; RE0018204.
 RX MEDLINE;
21438987.
 RA Hogan J. C., Stephens J. M.
 RT The identification
and characterization of a STAT 1 binding site in the
 RT PPARgamma2
promoter.
 RL Biochem. Biophys. Res. Commun. 287:484-492 (2001).

RN [2]; RE0003816.
 RX MEDLINE; 96104578.
 RA Qureshi S.
A., Leung S., Kerr I. M., Stark G. R., Darnell jr J. E.
 RT
Function of Stat2 protein in transcriptional activation by alpha
interferon
 RL Mol. Cell. Biol. 16:288-293 (1996).
 RN [3];
RE0023360.
 RX MEDLINE; 8830676.
 RA Wehinger J., Gouilleux
F., Groner B., Finke J., Mertelsmann R., Weber-Nordt
 RA R.
M.
 RT IL-10 induces DNA binding activity of three STAT proteins
(Stat1, Stat3,
 RT and Stat5) and their distinct combinatorial
assembly in the promoters of
 RT selected genes.
 RL FEBS
Lett. 394:365-370 (1996).
 RN [4]; RE0011175.
 RX MEDLINE;
96067132.
 RA Hill C. S., Treisman R.
 RT Differential activation
of c-fos promoter elements by serum,
 RT lysophosphatidic acid,
G proteins and polypeptide growth factors
 RL EMBO J. 14:5037-5047
(1995).
 RN [5]; RE0003501.
 RX MEDLINE; 94316659.
 RA
David M., Petricoin III E. F., Igarashi K.-I., Feldman G. M.,
Finbloom D.
 RA S., Larner A. C.
 RT Prolactin activates
the interferon-regulated p91 transcription factor and
 RT the
Jak2 kinase by tyrosine phosphorylation
 RL Proc. Natl. Acad.
Sci. USA 91:7174-7178 (1994).
 RN [6]; RE0003503.
 RX MEDLINE;
94188718.
 RA Zhong Z., Wen Z., Darnell J. E.
 RT Stat3:
a STAT family member activated by tyrosine phosphorylation in

RT response to epidermal growth factor and interleukin-6
 RL
Science 264:95-98 (1994).
 RN [7]; RE0003504.
 RX MEDLINE;
94255416.
 RA Zhong Z., Wen Z., Darnell J. E.
 RT Stat3
and Stat4: members of the family of signal transducers and activators

RT of transcription
 RL Proc. Natl. Acad. Sci. USA 91:4806-4810
(1994).
 RN [8]; RE0003506.
 RX MEDLINE; 94208062.
 RA
Akira S., Nishio Y., Inoue M., Wang X. J., Shi W., Matsusaka T.,
Yoshida
 RA K., Sudo T., Naruto M., Kishimoto T.
 RT Molecular
cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related

RT transcription factor involved in the gp130-mediated signaling
pathway
 RL Cell 77:63-71 (1994).
 RN [9]; RE0003494.

RX MEDLINE; 94077184.
 RA Silvennoinen O., Ihle J. N., Schlessinger
J., Levy D. E.
 RT Interferon-induced nuclear signalling by
Jak protein tyrosine kinases
 RL Nature 366:583-585 (1993).

RN [10]; RE0003498.
 RX MEDLINE; 93391973.
 RA Silvennoinen
O., Schindler C., Schlessinger J., Levy D. E.
 RT Ras-independent
growth factor signaling by transcription factor tyrosine
 RT
phosphorylation
 RL Science 261:1736-1744 (1993).
 RN [11];
RE0003500.
 RX MEDLINE; 93391972.
 RA Ruff-Jamison S., Chen
K., Cohen S.
 RT Induction by EGF and interferon-gamma of tyrosine
phosphorylated DNA
 RT binding proteins in mouse liver

RL Science 261:1733-1736 (1993).
 RN [12]; RE0003523.
 RX
MEDLINE; 93309428.
 RA Kanno Y., Kozak C. A., Schindler C.,
Driggers P. H., Ennist D. L., Gleason
 RA S. L., Darnell J.
E., Ozato K.
 RT The genomic structure of the murine ICSBP
gene reveals the presence of the
 RT gamma-interferon-responsive
element, to which an ISGF3alpha subunit (or
 RT similar) molecule
binds
 RL Mol. Cell. Biol. 13:3951-3963 (1993).
 XX