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 FA TCF-4
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 SY Xenopus laevis T-cell
factor 4; T cell factor 4.
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 OS clawed frog, Xenopus
laevis
 OC eukaryota; animalia; metazoa; chordata; vertebrata;
amphibia; lissamphibia;
 OC anura; archeobatrachia; pipoidea;
pipidae
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 CL C0015; HMG.
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 SZ 477 AA; 53.0 kDa
(cDNA); pI 8.74
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 SC taken from EMBL #AF207708

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 FT 344 414 SM00398; HMG.
 FT 345 418 putative HMG box
(revealed by alignment to diverse TCF-4 aa
 FT sequences).

FT 345 413 PF00505; HMG_box.
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 SF high homology to human
and murine TCF-4, C-terminus reveals homology to
 SF splice
variants TCF-4B and TCF-4E, RT-PCR analysis showed that expression

SF of TCF-4 starts from late neurula stages onward [1]
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CP anterior part of the midbrain (shown by whole-mount in situ
hybridisation)
 CP [1]
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 FF serves as nuclear transducer
of the Wnt-/ Wg signaling cascade, upon wnt-/
 FF wg signaling
TCF-4 interacts with beta-catenin and regulates expression of

FF target genes [1]
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 RN [1]; RE0014559.

RX MEDLINE; 10781959.
 RA Koenig A., Gradl D., Kuehl M., Wedlich
D.
 RT The HMG-box transcription factor XTcf-4 demarcates the
forebrain-midbrain
 RT boundary
 RL Mech. Dev. 93:211-214
(2000).
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